Associate Professor Dr. Mok Pooi Ling Page 1 CURRRICULUM VITAE
1. PERSONAL DATA
Name: Dr. Mok Pooi Ling
Email: [email protected]
2. ACADEMIC/PROFESSIONAL PARTICULARS
(a) Field of Specialization: Major Field of Specialization, Fine Field Specialization Pathology with Specialization in Stem Cells and Gene Therapy
(b) Academic Qualifications Degree, Major, Year, University, Country, Dissertation Title, GPA
Ph. D. Major Pathology Year of graduation: 2012
Ph. D. Specialization
Field Stem Cells and Gene Therapy
Title of Thesis In vitro expression of erythropoietin by nucleofection into human bone marrows mesenchymal stem cells.
University Universiti Kebangsaan Malaysia Country: Malaysia
Master Major Field Pathology Year of graduation: 2005
Master Specialization Stem Cells
Title of Thesis Isolation and Characterization of Human Mesenchymal Stem Cells from Adult Bone Marrow
University Universiti Kebangsaan Malaysia,
Malaysia Country: Malaysia
Bachelor's Degree specialization
Biomedical Sciences (Hons), CGPA: 3.74
Year of graduation: 2001 University Universiti Kebangsaan Malaysia Country: Malaysia
(c) Academic Honors and Awards
1. The Dean’s Award (1998 – 2001) from Faculty of Allied Health Sciences, National University of Malaysia for excellent scholastic performance.
Associate Professor Dr. Mok Pooi Ling Page 2 2. Zamalah Scholarship (2002 – 2004) from Centre for Graduate Studies, National University of Malaysia The Malaysia Toray Science Foundation 2004 Science and Technology Research Grant (2004) from the Malaysia Toray Science Foundation for research in gene expression study in mammalian cells.
3. Selected by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan to attend the 27th A-IMBN-AMBO International Training Course, 2004, Osaka University, Osaka, Japan.
4. The Becton-Dickinson Award for Best Poster Presentation in the 7th Annual Scientific Meeting of College of Pathologists, Academy of Medicine, 2006, Kuantan, Malaysia.
5. Best Poster Award in the Stem Cell Research and Application, 2008, Singapore.
6. Best Poster Award in Stem Cell Research Seminar, 2009, International Medical University, Malaysia
7. Merck Young Scientist Award 2009 (Malaysia) - endorsed by the Ministry of Science, Technology and Innovation, Ministry of Higher Education and the Institute of Chemistry Malaysia.
8. 1st Prize for Poster Presentation in the category of Laboratory Hematology in the 9th Malaysian Society of Hematology Meeting, 29th April-1st May 2011, Kuching, Sarawak, Malaysia.
9. 27th A-IMBN-AMBO International Training Course, 8th Asia Pacific Symposium on Neural Regeneration in conjunction with the 5th Pan Pacific Symposium on Stem Cells and Cancer Research & the 1st Cross-Strait Biotechnology Forum (APSNR&PPSSC), Taipei, Taiwan, April 2012.
10. Two Best Oral Awards in the Malaysia Medical Genetics Congress, Perdana University, Malaysia, August, 2015.
11. Best Awards in Industrial and Community Service, Universiti Putra Malaysia, 2016.
12. Best Service Awards, Universiti Putra Malaysia 2016.
13. Best Awards in Industrial and Community Service, Universiti Putra Malaysia, 2017.
14. Research Excellence Award, Jouf University, 2018 15. Research Excellence Award, Jouf University, 2019 (d) Membership of Professional Bodies
Associate Professor Dr. Mok Pooi Ling Page 3 1. Malaysian Society of Haematology (Life Member No: MSH07/L086) – Associate
member
2. Armenian Association of Hematology and Oncology (Full Member No: MA0001) – Life member
3. Malaysian Stem Cell for Research and Therapy (Life Member since April 2015) – Founding Vice President (2015-2017) & Life member
(e) Language Proficiency List of spoken/written languages and level of proficiency English Excellent in both spoken and written language
Malay Excellent in both spoken and written language Mandarin Good in spoken language
3. CAREER DETAILS
(a) Academic Positions
1. Assistant Professor (1st Jul 2013 till Jul 2019) Department of Biomedical Sciences,
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia,
43400 UPM Serdang, Malaysia.
2. Associate Professor (August 2019) Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia,
43400 UPM Serdang, Malaysia.
3. Assistant Professor (25th September till now) Department of Clinical Laboratory Sciences, College of Applied Medical Sciences,
Jouf University, Sakaka, Kingdom of Saudi Arabia.
Associate Professor Dr. Mok Pooi Ling Page 4 (b) Professional/Industrial Positions
1. Guest Lecturer (June 2011-May 2012) Universiti Tunku Abdul Rahman, Faculty of Medicine & Health Sciences, Sungai Long, Malaysia
(c) Administrative Positions Held
1. Committee Member of Quality Assurance, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
2. Committee Member of Student’s Internship, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
3. Committee Member of Teaching Monitoring, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
4. Technical Manager, Flow cytometry for ISO17025 for Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2015-2017)
5. Laboratory Manager, Stem Cell Research Laboratory for Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2013-2017)
6. Club Advisor, Graduate Student’s Club, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2014-2016)
7. Committee Member of Faculty English Activity, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2014-2016)
4. TEACHING
(a) Summary of Courses Coordinated Universiti Putra Malaysia, Malaysia
1. 2013/2014 Semester 1 Medical Genetics HGD5502 Post Graduate 2013/2014 Semester 2 Special Topics in Human Genetics HGD5509
Post Graduate
2. 2014/2015 Semester 1 Medical Genetics HGD5502 Post Graduate 3. 2014/2015 Semester 2 Special Topics in Human Genetics HGD5509
Post Graduate
4. 2015/2016 Semester 1 Medical Genetics HGD5502 Post Graduate 5. 2015/2016 Semester 2 Gene Expression SPP3241 Undergraduate 6. 2016/2017 Semester 1 Gene Expression SPP3241 Undergraduate
Associate Professor Dr. Mok Pooi Ling Page 5 7. 2017/2018 Semester 1 Gene Expression SPP3241 Undergraduate
Jouf University, Kingdom of Saudi Arabia
1. 2017/2018 Semester 1 Immunohematology CLSE443 Undergraduate 2. 2017/2018 Semester 1 General Pathology CLS325 Undergraduate 3. 2017/2018 Semester 2 Immunohematology CLSE443 Undergraduate 4. 2017/2018 Semester 2 General Pathology CLS325 Undergraduate 5. 2018/2019 Semester 1 Immunology CLS414 Undergraduate 6. 2019/2020 Semester 1 Pathophysiology CLS421 Undergraduate 7. 2019/2020 Semester 1 Physiology PHYS211 Undergraduate 8. 2019/2020 Semester 2 Pathophysiology CLS421 Undergraduate 9. 2019/2020 Semester 2 Physiology PHYS211 Undergraduate
(b) Participation in Academic Accreditation
1. Committee Member of Quality Assurance and Accreditation, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
2. Curricullum Reviewer for Biomedical Sciences. Universiti Putra Malaysia (Year 2016) 3. External Examiner for the Programme of Bachelors of Science Biotechnology (Hons) of
MAHSA University, Seremban, Negeri Sembilan, Malaysia.
(c) Research Students Supervised/Trained
Graduated supervised students: Main Supervisor a. Mohamad Izzuddin Bin Mohd Norizan. BSc. (2016)
Diferentiation o f Human Adult Dental Pulp Stem Cells (Dpscs) Into Photoreceptor Cells Using Taurine Induction Medium.
b. Siti Nadirah Binti Che Wel. BSc. (2016)
Diferentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Into Photoreceptor Cells.
c. Shirley Ding Suet Lee. MSc. (2015-2017)
Human Mesenchymal Stem Cells Genetically Engineered to Express Erythropoietin Promote Recovery Of Glutamate Excitotoxicity In A Retinal Neuron Cell Line.
d. Rusheni Munisvaradass. MSc. (2015-2017)
Human CD3+ T cells with chimeric antigen receptor exhibit efficient targeting and induce apoptosis in Erbb2 overexpressing breast cancer cell.
Associate Professor Dr. Mok Pooi Ling Page 6 Graduated supervised students: Co Supervisor
a. Pooorani Krishnan. MSc. (2015-2017)
Antitumor effect and gene expression profiling of HT29, HeLa and A549 carcinoma cells treated with β -Cyclodextrin-EDTA-Fe2O3 conjugated carriers for the anticancer drug Camptothecin.
b. Sakinah Bt Maideensa Syed Gulam. MSc. (2015-2017)
Promising stem cell therapy to protect during dengue infection.
c. Hiba Amer Fadhil. MSc. (2015-2018)
Dental pulp derived mesenchymal stem cells rescue visual function in spraque dawley rats.
d. Lawal Danjuma. PhD. (2015-2018)
A study of the gene expression changes of CD271 positive mesenchymal stem cells infected with mycobacterium tuberculosis.
e. Dr. Sivan Padma Priya. PhD. (2015-2018)
Promising stem cell therapy for communicable and non-communicable diseases.
(d) Participation in Thesis and Oral Examination Committees Examiner for PhD thesis:
Raji P. PhD thesis. Sathyabama Institute of Science and Technology, Tamil Nadu, India.
Screening, evaluation and application of phytochemicals of some selected plants.
(e) Training Activity
1. Blackcboard Teaching & Learning Tool. 2016. Jouf University, Saudi Arabia.
2. Problem-based Learning, 2013, Universiti Tunku Abdul Rahman, Malaysia 3. Teaching And Learning Outcomes, 2013, Universiti Putra Malaysia, Malaysia
5. RESEARCH (a) Research Interests
Project 1: Stem Cells Treatment for Ocular Disorders
Neuronal degeneration of the retina and retinal pigment epithelium (RPE) in inherited retinal disorder such as retinitis pigmentosa, is the leading cause of blindness worldwide. Recent studies have shown the potential of mesenchymal stem cells (MSC) from various origins in
Associate Professor Dr. Mok Pooi Ling Page 7 rescuing the visual functions and slowing the progress of degeneration. MSC are multipotent, self-renewing cells that reside mainly in the bone marrow. MSC can also be found in umbilical cord, amniotic fluid, peripheral blood, fallopian tube, cornea, adipose, synovial tissue, dental pulp, placenta, bone, liver and lung. It is believed that MSC are remnants of embryonic stem cells (ESC) that persist in adult life as they exhibit ESC genetic markers of Oct-4, Rex-1, Nanog, GATA-4 and SSEA-1. MSC were hypothesized to be re-distributed via the blood stream to other organs or tissues to maintain stem cells homeostasis in a microenvironment or mobilized upon receiving chemokine signals released by damaged organs and tissues for regenerative purposes. Optimism to use MSC in ocular disorders is based on suggestions that MSC can differentiate into neurons and specifically retinal neurons in vivo following damages caused by chemical induction or burn with laser. Thus, we aim to study and determine the efficiency of MSC to delay degeneration of photoreceptors in an animal model of retinitis pigmentosa (RP).
Project 2: Targeting Breast Cancer with CAR-T cells
Adoptive immuno cell therapy for malignancy involves the transfer of ex vivo expanded immune cells as means to augment immune responses to eradicate tumour cells. Few types of immune cells including T-cells have been primed in vitro with cells expressing tumour- specific (TSA) or -associated antigen (TAA) and culture expanded before infusion into autologous receipient. It is hoped that the abundant T-cells in the infusion would be able to launch another sequence of attack on tumour cells. With CAR technology, T-cells would be able to recognize antigen in a similar fashion to B-cells via B-cell receptor (BCR) and could be activated even without presentation by the major histocompatibiliity complex (MHC) molecule by the tumour cells or antigen presenting cells. There are ample researches going on in human trials to target on B cell malignancy, sarcoma, neuroblastoma, prostate cancer, mesothelioma¸ ovarian cancer, head and neck cancer and glioma, and the results have been very promising as the infusion of CAR transduced T-cells were successfully able to induce remission in the cancer patients. Despite the progress in the field of adoptive immune cell therapy using T-cells, such a research has never been carried out in Malaysia and therefore, we would like to take the effort to initiate such research. We aim to transduce a chimeric antigen receptor with specificity to target on erbb2 surface marker on breast cancer cells and to assess its efficacy in eradicating this tumour cells inboth in vitro and in vivo study.
Project 3: CRISPR/Cas Targeting for Cancer Killing
CRISPR editing for genome manipulation can induce site-specific DNA cleavage and has emerge as a promising tool for gene knock-down in genetic diseases and cancers. Numerous studies has reported the use of CRISPR/Cas9 technology to knock down defective genes in these circumstances. For instance, it has been shown that the deletion of genes NANOG and NANOGP8 can down-regulate the metastatic potential in prostate cancer cells. Besides that, CRISPR/Cas9 has been utilized to suppress the proliferation of human papillomavirus (HPV) cervical cancer cells both in vitro and in vivo. CRISPR tool has also been used in the treatment of lung cancer due to mutations in the epidermal growth factor receptor (EGFR). In our project, we aimed to target on small-cell lung cancer (SCLC), a remarkably aggressive malignancy with poor prognosis. Given the exceptionally high proliferative index and strong
Associate Professor Dr. Mok Pooi Ling Page 8 tendency for early metastasis, SCLC is of particular interest as compared to other solid tumors. Previous studies to characterize the genomic changes occur in SCLC have identified high prevalence of inactivating mutations in SOX2, TP53 and RB1. We aimed to target on these few genes to inhibit the growth of SCLC eells.
Project 4: A study of the gene expression changes on CD271+ Bone marrow mesenchymal stem cell and wistar rats infected with Mycobacterium tuberculosis and therapeutic potential of stem cell
Bacterial infections have become a major health problem in recent years, since they are very difficult to treat leading to an increase in morbidity and mortality in both economically developed and under developed countries (Samuel et al. 2011). Particularly, the disease called tuberculosis kills nearly 2 million people worldwide each year (Gursimrat et al. 2011, Philippe et al. 2006). Although antibiotics clears off infection and improve the health, for some infections, the courses of therapy last for several months and do not completely eradicate the disease, which frequently reoccurs years or decades after the initial treatment (Bikul Das et al. 2013).
In this project we aimed to study the reoccurrence of TB and also to study the genetic and chromosomal defects that occur when Mycobacterium fused with the host cell through microarray technique. With the data from microarray, level of gene expression changes could be determined. Comparative data analysis will identify the new pathways and defected pathways. Understanding the changes will empower us to elucidate important pathways in diseases and generate novel insight into treatments. Integrative analysis of multiple datasets of genome-wide interaction networks will help us to cross-validate experimental results and elucidate important pathways in diseases and generate novel insight into treatments. So we need to find out and disclose what mechanisms and what are the various gene expression changes in the host cell when Mycobacterium fused with stem cells. The investigational data alone are not enough for understanding the multiple layered biological mechanisms of complex by infectious diseases. Though normal molecular biology, has no obvious idea to work on particular phenotypic or genotypic consequence and it is difficult to study their pathway which down regulated by the encroachment of stem cells with Mycobacterium. High through put data aims to understand the relation between genotype and phenotype of each pathway. This research has broad implications for understanding the impact of various pathways on directive to different organs of the human body system.
Project 5: Promising stem cell therapy to protect during dengue infection
Dengue is one of the most widely spreading virus which is a major challenge and concern to public health. In patients with severe dengue fever, the virus causes rupture of the inner lining of blood vessels. Interaction with the platelets, a type of cell responsible for blood coagulation, will further exaggerate the condition and lead to non-stop and excessive bleeding. Possible complications include damage in the liver, and brain. These conditions lead to reduced efficiency in removing the virus by human immune system, body dehydration and eventually may result in death. The advancement in science and technology has lead to the invention of stem cell , new concept for the regeneration of damaged tissues. Several
Associate Professor Dr. Mok Pooi Ling Page 9 reports on the success of stem cell therapy and its practical application in regeneration of damaged tissues prompted to perform a preclinical study to determine its potential in managing the tissue damages caused by dengue virus infection. Haematopoetic stem cells (HSC) can generate blood cells, including platelets, while endothelial progenitor cells (EPC) are cells circulating in the blood stream responsible for the new blood vessels formation or repair. There are ample evidences indicating tissue repair or regeneration by the release of trophic factors or differentiation of stem cells into the damaged cell types.
We propose a novel study to determine the capability of co-infusion of HSCs and EPCs in protecting the tissue damages during dengue virus infection in a murine model. We hypothesize that the damaged organs (blood vessels, brain, and liver) of dengue virus- infected mice could be resolved or improved by treatment with HSC and EPC infusion. We expect restoration of platelet counts, reduction in body fluid leakage from the lungs by the improvement in vascular permeability and protection from further tissue damage by the infection of dengue virus. The current study may lead to new modality or replace current treatment for patients, hence reduce mortality rates due to dengue virus infection in the future.
Project 6: Antitumor Effect and Gene Expression Profiling of Hepg2,MDA-231and A549 Carcinoma Cells to ß-Cyclodextrin-EDTA Conjugated Carriers for the Anticancer Drug Camptothecin.
Camptothecin (CPT), originally isolated from Camptotheca acuminate, is a potent broad- spectrum anticancer agent that inhibits type I DNA topoisomerase to induce apoptosis in rapidly dividing tumor cells. However, the application of CPT as a therapeutic agent has been severely hampered due to its poor aqueous solubility, which can lead to rapid blood clearance and unpredictable efficacy (e.g., myelosuppression and gastrointestinal toxicity) following intravenous administration. During circulation in blood, which is weakly alkaline and contains abundant serum albumin, the therapeutically active lactone of CPT tends to open the lactone ring to generate the inactive and toxic carboxylate species. In addition, serum albumin can preferentially bind to the carboxylate form which strongly forces lactone–
carboxylate equilibrium toward the formation of carboxylate. To address these challenges, CPT has been successfully conjugated to a variety of solid lipid nanoparticles, polymeric micelles, liposomes and microemulsions. Unfortunately, the application of these delivery technologies in health-related fields have been greatly limited due to their required use of organic solvents and surfactants as well as homogenization or sonication.
Recently, porous inorganic materials have induced interest as the basis of a new class of drug delivery systems. One reason behind this is that inorganic materials offer high chemical and mechanical stability under physiological conditions, and also enable sustained, controlled release. Considering this, a soluble form of Camptothecin (CPT) is synthesized by incorporating CPT in Fe3O4 particles conjugated with Cyclodextrin-EDTA. This newly synthesized nanocompound will be evaluated for its effectives as a potential anticancer drug in various cancer cell lines. The target cell lines are HepG2, MDA 231 and A549 carcinoma cell lines. To investigate its antitumor activity on cancer cell line, various assays including drug cytotoxicity assay (MTT Assay) to study on the inhibitory effects on cell growth will be performed. Also, to determine the apoptosis inducing potential, mitochondrial membrane potential assay, caspase-3
Associate Professor Dr. Mok Pooi Ling Page 10 assay and Annexin-V will be performed. To further evaluate the effect of Cyclodextrin-EDTA- Fe3O4-CPT on cancer cell lines gene expression profiling of Hepg2, MDA-231 and A549 in response to this compound will also be studied and reported.
Project 7: Whole-genome analysis of Leptospira sp. – Malaysian serovar to identify potential biomarkers against leptospirosis
Leptospirosis is a zoonotic infection that occurs globally and the most widespread zoonosis in the world. Humans usually become ill after contact with infected urine, or through contact with water, soil or food that has been contaminated with leptospira organisms which come from rodents and domestic animals. Tropical countries such as Malaysia would provide a conducive environment for the survival and spread of leptospiral infection because of its climate. There are no precise estimates of the human leptospirosis cases due to it is a challenging to diagnose. The illness may progress to kidney or liver failure, aseptic meningitis, life-threatening pulmonary haemorrhage and other syndromes. Leptospirosis is also known as “the Great Mimicker” due to its presentations as other diseases at the early phase such as fever, severe headache and myalgia making it difficult to diagnose on early stage. Leptospirosis can be treated only if it is diagnosed early to avoid complication. Untreated patient can lead to a more severe and potentially fatal stage. In Malaysia, an increasing number of reported cases and outbreaks which had resulted in significant number of deaths due to late diagnosis. The goal of this project is to obtain whole genome analysis of Malaysian serovar and compare with international serovar. One local serovar (Sarawak) and two international serovar (Hardjo and Batavia) will be use in this study. The entire genomic sequence is determine using MiSeq reagent kit. These findings were further analyzed with a focus on individual genes, which was important for a better understanding of the diffrence between local serovar and international serovar. This study will later help in production of diagnostic kit that suited with Malaysian patient and help in detecting leptospirosis at the early stage.
(b) Publications/Citations Data
Type of Publication Number of Publications
Articles in International Refereed Journals 52 Conference Papers
Books/Book Chapters 2
Edited Books 1 (ongoing) Patents 2
Others (specify) Newsletter 1
Citation Source Number of Citations
Associate Professor Dr. Mok Pooi Ling Page 11
Google scholar citation 780
(c) Research Grants Type of Grant Principal investigator
Total number of secured grants as a Principal Investigator: 8 Total amount of grant funding: RM 740,800.00
Project no. Project Title Role Year Source of
Fund
Amount (RM) Status
Number of published papers Malaysia Toray
Science Foundation, Science and Technology Research Grant
In vitro expression of erythropoietin by human mesenchymal stem cells
Principal investiga tor
2004- 2006
Universiti Kebangsaa n Malaysia, Malaysia
35,000 Completed 3
FRGS FRGS/2/2013/
SKK01/UPM/02/
11
T-cells armed with chimeric antigen receptor (CAR) to eradicate erbb2 antigen expressing breast cancer and CD19 expressing B cell lymphoma
Principal investiga tor
2014- 2017
Ministry of Higher Education
150,000 Completed 6
Putra Grant GP- IPM/2014/94363 00
Development of a recombinant viral vector to enhance functionality of chimeric antigen receptor (CAR) on T-cells
Principal investiga tor
2014- 2015
Universiti Putra Malaysia, Malaysia
50,000 Completed 7
ScienceFund (02- 01-04-SF2405)
Rescue of photoreceptors degeneration by human mesenchymal stem cells expressing erythropoietin in a rat model of retinitis pigmentosa
Principal investiga tor
2017- 2018
Ministry of Science, Technology and Innovation.
Malaysia
169,200 Completed 4
Putra Grant-IPS GP-
IPS/2016/950390 0
Paracrine effects of transplanted mesenchymal stem cells genetically modified to express erythropoietin on the retinal transcriptome in a rat model of retinal degeneration
Principal investiga tor
2017- 2018
Universiti Putra Malaysia, Malaysia
20,000 Completed 3
Kingdom of Saudi Arabia Jouf University (39/181)
Retinal Transcriptomic Profiling Following Transplantation of Mesenchymal Stem Cells
Principal Investiga tor
2018- Prese nt
Ministry of Higher Education, Kingdom of Saudi Arabia
26,400 Completed 1
Kingdom of Saudi Arabia Jouf Unicersity (40/G/03)
Regenerative Medicine Research Group – CRISPR/Cas for cancer targeting
Principal Investiga tor
Jan 2019
Ministry of Higher Education, Kingdom of Saudi Arabia
200,000 Ongoing 1
Kingdom of Saudi Arabia Jouf Unicersity (CV-15-41)
Bioinformatics approach for identification of anti-viral drug and receptor ligand for the treatment of coronavirus disease.
Principal Investiga tor
May 2020
Ministry of Higher Education, Kingdom of Saudi Arabia
30200 Ongoing 1
Ministry of Education Jouf University 375213500
Regenerative properties of dental pulp stem cells and craniofacial research
Principal Investiga tor
Octob er 2020
Ministry of Higher Education, Kingdom of Saudi Arabia
50000 Ongoing 0
Associate Professor Dr. Mok Pooi Ling Page 12 Co-researcher
Project no. Project Title Role Year Source of
Fund
Amount (RM) Status
Number of published &
unpublished papers
UTAR Research Fund G200G10
In vitro cloning or generation of human hair follicles from isolated hair follicle stem cells
Co- research er
2011
Universiti Tunku Abdul Rahman, Malaysia
50,000 Completed 1
UTAR Research Fund 6200G07
Generation of induced pluripotent stem cells from keratinocytes isolated from plucked human hair follicles
Co- research er
2011
Universiti Tunku Abdul Rahman, Malaysia
50,000 Completed 1
UKM-Cryocord Fund
Preservation of visual function in a rat model of retinitis pigmentosa by the use of human mesenchymal stem cells
Co- research er
2011
Cryocord Sdn. Bhd., Universiti Kebangsaa n Malaysia, Malaysia
200,000 Completed 1
BKP Research Grant Awards University Malaya
Arming Jurkat Cells with Chimeric Antigen Receptor (CAR) for ErbB2 Expressing Breast Cancer Cell Line
Co- research er
2014- 2015
University Malaya, Malaysia
37,000 Completed 1
UPM/700- 2/1/GP- IPS/2016/947020 0
Transcriptomic Approach Study to Understand the Stem Cell Treatment on Dengue Infection
Co- research er
2016- 2018
Universiti Putra Malaysia, Malaysia
17,000 Completed 2
UPM/700- 2/1/GP-IPS/2017
Transcriptomic Approach Study to Understand the Dental Stem Cell Treatment on Dengue Infection
Co- research er
2017- 2019
Universiti Putra Malaysia, Malaysia
20,000 Ongoing 1
UPM/700- 2/1/GP- IPS/2017/954430 0
The Regenerative Potential of Dental Pulp Stem Cells in Treating Damaged Retinal Tissue of Sprague Dawley Rat Model
Co- research er
2017- 2019
Universiti Putra Malaysia, Malaysia
20,000 Completed 2
Total number of secured grants as co-researcher: 7 Total amount of grant fundings: RM 394,000.00 (b) Patents
1. Mok PL*, Suresh Kumar S, SL Shirley Ding. ‘Composition for treatment of ocular diseases and preparation thereof: Treatment of ocular disorders using human wharton’s jelly mesenchymal stem cells expressing erythropoietin’ – PI2016701648.
2. Mok PL, Suresh Kumar S*, Narcisse Joseph. ‘The Detection of Leptospirosisin Early Stage by Using Multiplex Droplet Digital PCR (ddPCR)’ - PI2019006024.
*Corresponding author Total number of patent: 2
(c) Participation in Regional & International Conferences
1. Mok Pooi Ling, KH Chua, CF Leong, SK Cheong. Stable expression of a new non-viral vector encoding erythropoietin for stem cell-based gene therapy. Stem Cell Research and Application, August 2008, Singapore.
2. Mok PL, Cheong SK, Leong CF, Chua KH, Ainoon O. Human mesenchymal stem cells maintain their phenotypes and differentiation capacity to adipogenic and osteogenic
Associate Professor Dr. Mok Pooi Ling Page 13 lineages after manipulation with nucleofection. 2010 Tissue Engineering National Meeting. October 2010, Kuala Lumpur, Malaysia. Medical Journal of Malaysia 65:70- 1.
3. Mok Pooi Ling, KH Chua, CF Leong, SK Cheong. Erythropoeitin expression in mesenchymal stem cells successfully enhance erythropoiesis. 9th Malaysian Society of Hematology Meeting, 29th April-1st May 2011, Kuching, Sarawak, Malaysia.
4. Mok Pooi Ling, KH Chua, CF Leong, SK Cheong. Erythropoeitin expression in mesenchymal stem cells may promote hair growth. 5th Pan Pacific Symposium on Stem Cells and Cancer Research & the 1st Cross-Strait Biotechnology Forum (APSNR&PPSSC), Taipei, Taiwan, April 2012.
5. S. Leow, P Mok, Hairul Nizam et al. Subretial transplantation with huma umbilical cord- derived mesenchymal stem cells delays retinal degeneration in royal college of surgeon rats. 19th Annual ISCT Meeting, Auckland New Zealand. April 2013.
6. PL Mok. Induction of dermal papilla properties in mesenchymal stem cells by using 3D culture. Biochemistry and Molecular Biology in Transition: from Basic to Translational. Taipei, Taiwan. 2014
7. PL Mok. Reprogramming of human hair follicular keratinocytes into induced pluripotent stem cells. Biochemistry and Molecular Biology in Transition: from Basic to Translational. Taipei, Taiwan. 2014
8. Rusheni Munisvaradass, Mok Pooi Ling, Suresh Kumar, Syahril Abdullah, Shalini Vellasamy. Generation of anti ErbB2 Chimeric Antigen Receptor (CAR) transduced human T-cells. 11th Malaysian Genetics Congress, August 2015. Kuala Lumpur, Malaysia.
9. Shirley Ding, Mok Pooi Ling, Suresh Kumar. Erythropoietin-Engineered Mesenchymal Stem Cells (MSC) Restore Vision in Retina Degeneration. 11th Malaysian Genetics Congress, August 2015. Kuala Lumpur, Malaysia.
10. Syahril A, PL Mok, Thilakavathy K. Focus on Genes: Maximise on Impact. 11th Malaysian Genetics Congress, August 2015. Kuala Lumpur, Malaysia.
11. R Munisvaradass, S Kumar, SL Shirley Ding, S. Vellasamy, S. Abdullah, EH Avin Koh, PL Mok. Transduction of human T-cells with chimeric antigen receptor. 6th MTERMS 2017. November 2017, Pulau Pinang, Malaysia.
12. Saritha Ramachandran, Moon Nian Lim, Pooi Ling Mok, Kamal Shaik Fakiruddin, Noor Atikah Fakharuzi and Zubaidah Zakaria. Generation of neural stem cells from human peripheral blood derived induced pluripotent stem cells. 6th MTERMS 2017.
November 2017, Pulau Pinang, Malaysia. Frontiers in Bioengineering and Biotechnology. doi:10.3389/conf.FBIOE.2016.02.00022.
13. Thena Rasi Mohan, Moon Nian Lim, Pooi Ling Mok, Rahimah Ahmad, Jameela Satar and Zubaidah Zakaria. Reprogramming of peripheral blood from Malaysian beta thalassaemia patients to induced pluripotent stem cell. 6th MTERMS 2017. November 2017, Pulau Pinang, Malaysia. Frontiers in Bioengineering and Biotechnology.
doi:10.3389/conf.FBIOE.2016.02.00025
14. Avin Koh, HA AlSaeedi, MR Munira, CS Lam, MH Hairul Nizam, MLC Bastion, HM Isa, KY Tben, MG Ng, CD Luu, Suresh Kumar, Mok Pooi Ling. Establishment of a chemically-inducible retinitis pigmentosa rat model for stem cell therapy of retinal disorders. International Anatomical and Biomedical Sciences August 2017. Kuala Lumpur, Malaysia.
Associate Professor Dr. Mok Pooi Ling Page 14 15. Malak Khalid & Mok Pooi Ling. Application of stem cells for regenerative medicine. 6th
Annual Scientific Forum. Jouf University, Sakaka, Saudi Arabia, 2018.
16. Teh Seoh Wei, Mok Pooi Ling & Suresh Kumar. Environmental factor inducing osteogenic differentiation of human mesenchymal stem cells. 2nd International Conference on Fostering Interdisciplinary Research in Health Sciences 2019. 14-15th September 2019. AIMST University, Malaysia.
17. A.E.H Koh, H.A. Alseedy, M.R. Munirah, C.S. Lam, M.H. Hairul Nizam, M.L.C.
Bastion, K.Y. Then, M.H. Ng, S. Kumar & P.L. Mok. Progression of retinal dysfunction following sodium iodate administration in a rat model: An electrophysiology and histological assessment. 2nd International Conference on Fostering Interdisciplinary Research in Health Sciences 2019. 14-15th September 2019. AIMST University, Malaysia.
18. Sharmilah Kumari Kumaran, Bala Sundaram Muthuvenkatachalam, Mok Pooi Ling &
Suresh Kumar Subbiah. Bioinformatics approach in identifying potental gene for leptospirosis molecular diagnostics. 2nd International Conference on Fostering Interdisciplinary Research in Health Sciences 2019. 14-15th September 2019.
AIMST University, Malaysia.
Total number of paper presentation: 18
6. SERVICE
(a) Membership of Institutional, National, or International Scientific Advisory Boards 1. Visiting Researcher, Bharath University (1st October 2020 to 30 September 2021) 2.
(b) Membership of Conference Committees
1. Committee member. Curicullum auditing for Bachelor of Biomedical Science 2018.
UPM Serdang, Malaysia. 2018.
2. Committee member. National Stem Cells Application in Clinical Setting. UPM Serdang, Malaysia. 10 October 2017.
3. Committee member/ Judge. 2nd International Anatomcaql and Biomedical Scientific Conference 2017. UPM Serdang, Malaysia. 10 October 2017.
4. Committee member & workshop rapporteur. IBRO Global Neuroscience Advocacy Workshop 2016. UPM Serdang, Malaysia. March 2016.
5. Committee member. 1st MSCRT Stem Cell Symposium 2016. 11th October 2016. Kuala Lumpur, Malaysia.
Associate Professor Dr. Mok Pooi Ling Page 15 6. Committee member & Judge. 6th MTERMS 2016 and 2nd Malaysian Stem Cell Meeting.
Pulau Pinang, Malaysia. November 2016.
7. Facilitaqtor. National Infectious Diseases Seminar and Workshop 2016. UPM Serdang, Malaysia. 31 May-1 June 2016.
8. Committee Member. Majlis Syarahan Inaugural Professor Dr. Rozita Rosli 2015. UPM Serdang, Malaysia. October 2015.
9. Chairman. Workshop on Application for Animal Research Ethics Approval & LIVE Imaging System (FOBI). Faculty Excellence Month 2015. UPM Serdang, Malaysia. July 2015.
10. Founding Vice President. Malaysian Stem Cell for Research and Therapy. 2015-2017 11. Judge. Poster Simposium Bulan Kecemerlangan Fakulti 2015. UPM Serdang, Malaysia.
26 August 2015.
12. Coordinating Scientist & State Level Question Committee. National Science Challenge.
Semi-final 2014. Kuala Lumpur, Malaysia.
13. Facilitator. Responsile Conduct of Reserch Workshop on Research Misconduct, Perdana University. Kuala Lumpur, Malaysia. March 2014.
14. Coordinating Scientist. National Science Challenge. Semi-final 2013. Kuala Lumpur, Malaysia.
15. Committee member / Facilitator. Advances in Stem Cell Therapy Seminar 2009.
International Medical University, Malaysia. December 2009.
16. Committee member / Facilitator. 8thDr. Ranjeet Bhagwan Singh National Fellowship
‘Human embryonic stem cell: Culture and Maintenance. International Medical University, Malaysia. December 2009.
17. Committee member. Cell-based Therapy Workshop. Hospital Universiti Kebangsaan Malaysia, Malaysia. November 2008.
18. Coordinator. The 1st Public Forum on Blood Cancer and Stem Cell Transplantation, Hospital Universiti Kebangsaan Malaysia, Malaysia March 2007.
19. Coordinator. Adult Stem Cell Workshop. Hospital Universiti Kebangsaan Malaysia, Malaysia. October 2003.
Associate Professor Dr. Mok Pooi Ling Page 16 (c) Service as Reviewer of Journals
1. European Journal of Medical Research 2. Cytotherapy
3. International Journal of Cancer Research 4. Cytotechnology
5. Regenerative Research 6. PLOSOne
7. International Journal of Molecular Medicine 8. FEBS Open Bio
(d) Membership of Journal Editorial Boards
Guest Editor for Research Topics for Frontiers of Cellular Neuroscience (Status: Proposal Submission
(e) Invited Presentations at Scientific Meetings/Workshops
1. Manipulation of Stem Cells for Clinical Application. Annual Mini Symposium of Malaysian Association for Cellular Therapy, April 21st, 2016, Sunway Convention Centre, Selangor, Malaysia.
2. Stem Cell Therapy for Ocular Disorders. Malaysia Genetics Congress. August 23-25th 2015, Perdana University, Selangor, Malaysia.
3. Safety and Efficiency of Human Wharton’s Jelly Derived Mesenchymal Stem Cells for Ocular Disorders. Neuroscience Seminar, August 23rd 2013, Faculty of Medicine &
Health Sciences, Universiti Putra Malaysia.
4. Human Mesenchymal Stem Cells and Its Clinical Application. August 3rd 2012, Universiti Sains Malaysia, Kota Bahru, Malaysia.
5. Non-viral delivery of erythropoietin gene into a mouse model using human mesenchymal stem cells. UTAR Mini Symposium on Stem Cell & iPSC Research. 25th June, 2012.University of Tunku Abdul Rahman, Kuala Lumpur, Malaysia.
6. Transfection of stem cells using non-viral techniques. Stem Cell Seminar. 21st Apr, 2010. University of Tunku Abdul Rahman, Kuala Lumpur, Malaysia.
7. Homing of mesenchymal stem cells. 15th National Conference on Medical Health Sciences. 21-22 July 2010. Kota Bahru, Kelantan, Malaysia.
Associate Professor Dr. Mok Pooi Ling Page 17 8. Transduced mesenchymal stem cells for hemophilia treatment. Advances in Stem Cell Therapy Seminar. 12-14th Dec, 2009. International Medical University, Kuala Lumpur, Malaysia.
Total number of given lectures: 8
(f) University Service
1. Committee Member of Quality Assurance, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
2. Committee Member of Student’s Internship, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
3. Committee Member of Teaching Monitoring, College of Applied Medical Sciences, Jouf University, Kingdom of Saudi Arabia (Sept 2017-present).
4. Technical Manager, Flow cytometry for ISO17025 for Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2015-2017)
5. Laboratory Manager, Stem Cell Research Laboratory for Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2013-2017)
6. Club Advisor, Graduate Student’s Club, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2014-2016)
7. Committee Member of Faculty English Activity, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia. (2014-2016)
(g) Service to Profession/Industry
1. Conducting research for National Cancer Council, Malaysia as Scientific Officer (2002 to 2012)
2. Conducting pre-clinical research for Cryocord Sdn. Bhd, Malaysia as Research Officer (2011-2012)
(h) Public Service Appointment
1. Founding Vice President, Malaysian Society for Stem Cell Research and Therapy (April 2015 to September 2017)
2. Reference Scientist for Interlaboratory Cell Viability Testings for Stem Cell Company - Stemtech Sdn. Bhd. (2014-2017) and Cryocord Sdn. Bhd. (2014-2017).
Associate Professor Dr. Mok Pooi Ling Page 18 3. Trainer. CRISPR-Cas. Stemtech Annual Staffs Training Stemtech Sdn. Bhd. Cyberjaya,
Selangor, Malaysia. September 2017.
4. Trainer. CRISPR-Cas. Cryocord Annual Staffs Training. Cryocord Sdn. Bhd. Cyberjaya, Selangor, Malaysia. September 2017.
7. LIST OF PUBLICATIONS Published articles:
1. Mok PL, Leong CF & Cheong SK. Isolation and identification of Mesenchymal Stem Cells from human bone marrow. 2003. Malays. J. Pathol. 25(2): 121-127. (IF: -, 2003/IF:
0.554, Q4, 2017)
2. Choong PF, Mok PL, Leong CF & Cheong SK. Generating neuron-like cells from bone marrow-derived Mesenchymal Stromal Cells (MSC) in vitro. 2007. Cytother. 9(2): 170- 183. (IF: 3.553, Q-, 2007/IF: 3.993, Q2, 2017)
3. Choong PF, Mok PL, Leong CF & Cheong SK. Mesenchymal Stromal Cell-like characteristics of corneal keratocytes. 2007. Cytother. 9(3): 252-258. (IF: 3.553, Q-, 2007/IF: 3.993, Q2, 2017)
4. Wong CY, Cheong SK, Mok PL, Leong, CF. Differentiation of human mesenchymal stem cells into mesangial cells in murine renal glomeruli. 2008. Pathology 40(1): 56-62.
(IF: 2.324, Q2, 2008/IF: 3.068, Q2, 2017)
5. Mok PL, Leong CF & Cheong SK. In vitro differentiation on isolated human Mesenchymal Stromal Cells. 2008. Malays. J. Pathol. 30(1): 11-19. (IF: -, 2008/IF:
0.554, Q4, 2017)
6. Mok PL, Leong CF, Cheong SK & Ainoon O. In vitro expression of erythropoietin from transfected human Mesenchymal Stromal Cells. 2008. Cytother. 10(2): 116-124. (IF:
3.471, Q-, 2008/IF: 3.993, Q2, 2017)
7. Mok PL, Cheong SK, Leong CF, Chua KH & Ainoon O. Human Mesenchymal Stem Cells maintain their phenotypes and differentiation capacity to adipogenic and osteogenic lineages after manipulation with nucleofection. 2010. Med. J. Malaysia. 65:70-71. (IF:
0.031)
8. Mok PL, Cheong SK, Leong CF, Chua KH & Ainoon O. Extended and stable erythropoietin gene expression via nucleofection of MIDGE construct into adult marrow Mesenchymal Stromal Cells. 2012. Cytotechnol. 64: 203-216. (IF: 1.315, Q3, 2012/IF:
1.461, Q3, 2017)
9. Mok PL, Cheong SK, Leong CF, Chua KH & Ainoon O. Human mesenchymal stromal cells could deliver erythropoietin and migrate to the basal layer of hair shaft when
Associate Professor Dr. Mok Pooi Ling Page 19 subcutaneously implanted in a murine model. 2012. Tissue Cell. 44(4): 249-256. (IF:
1.095, Q4, 2012/IF: 1.438, Q2, 2017)
10. Mok PL, Leong CF & Cheong SK. Cellular mechanisms of emerging applications of mesenchymal stem cells. 2013. Malays. J. Pathol. 35 (1): 17-32. (IF: -, 2013/IF: 0.554, Q4, 2017)
11. Leow SN, Luu CD, Nizam MH, Mok PL, Ruhaslizan R, Wong HS, Halim WH, Ng MH, Ruszymah BH, Chowdhury SR, Bastion ML. Safety and efficacy of human Wharton's Jelly-derived mesenchymal stem cells therapy for retinal degeneration. 2015. PLoS One.
10(6): e0128973. (IF: 3.057, Q1, 2015/IF: 2.766, Q1, 2017)
12. Priya SP, Higuchi A, Fanas SA, Mok PL, Neela VK, Sunil PM, Saraswathi TR, Murugan K, Alarfaj AA, Munusamy MA, Kumar S. Odontogenic epithelial stem cells: hidden sources. 2015. Laboratory Investigation. 95 (12): 1344-52. (IF: 4.202, Q1, 2015/IF:
4.254, Q1, 2017)
13. Ding SS, Leow SN, Munisvaradass R, Koh EH, Bastion ML, Then KY, Kumar S, Mok PL. Revisiting the role of erythropoietin for treatment of ocular disorders. Eye. 2016 Oct 1;30(10):1293-309. (IF: 2.478, Q2, 2016/IF: 2.275, Q2, 2017)
14. Sivan PP, Syed S, Mok PL, Higuchi A, Murugan K, Alarfaj AA, Munusamy MA, Awang Hamat R, Umezawa A, Kumar S. Stem cell therapy for treatment of ocular disorders. Stem cells international. 2016 May 15;2016.b (IF: 3.540, Q2, 2016/IF: 3.989, Q2, 2017)
15. Ali F, Taresh S, Al-Nuzaily M, Mok PL, Ismail A, Ahmad S. Stem cells differentiation and probing their therapeutic applications in hematological disorders: a critical review.
European review for medical and pharmacological sciences. 2016 Oct;20(20):4390-400.
(IF: 1.778, Q3, 2016/IF: 2.387, Q3, 2017)
16. Sakinah S, Priya SP, Kumari S, Amira F, Poorani K, Alsaeedy H, Ling MP, Chee HY, Higuchi A, Alarfaj AA, Munusamy MA. Impact of dengue virus (serotype DENV-2) infection on liver of BALB/c mice: A histopathological analysis. Tissue and Cell. 2017 Feb 28;49(1):86-94. (IF: 1.438, Q2, 2017)
17. Lim SJ, Ho SC, Mok PL, Tan KL, Ong AH, Gan SC. Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning. PeerJ. 2016 Nov 10;4:e2695. (IF: 2.118, Q2, 2017)
18. Krishnan P, Rajan M, Kumari S, Sakinah S, Priya SP, Amira F, Danjuma L, Ling MP, Fakurazi S, Arulselvan P, Higuchi A. Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug. Scientific Reports. 2017 Sep 8;7(1):10962. (IF: 4.122, Q1, 2017)
Associate Professor Dr. Mok Pooi Ling Page 20 19. Munisvaradass R, Kumar S, Govindasamy C, Alnumair KS, Mok PL. Human CD3+ T-
Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells. International journal of molecular sciences. 2017 Sep 8;18(9):1797. (IF: 3.687, Q1, 2017)
20. Kumaran SK, Bakar MF, Mohd-Padil H, Mat -Sharani S, Sakinah S, Poorani K, Alsaeedy H, Peli A, Wei TS, Ling MP, Hamat RA. 3D modelling of the pathogenic Leptospira protein LipL32: A bioinformatics approach. Acta Tropica. 2017 Dec 1;176:433-9. (IF: 2.509, Q2, 2017)
21. Priya SP, Sakinah S, Sharmilah K, Hamat RA, Sekawi Z, Higuchi A, Ling MP, Nordin SA, Benelli G, Kumar SS. Leptospirosis: Molecular trial path and immunopathogenesis correlated with dengue, malaria and mimetic hemorrhagic infections. Acta Tropica.
2017 Dec 1;176:206-23. (IF: 2.509, Q2, 2017)
22. Danjuma L, Ling MP, Hamat RA, Higuchi A, Alarfaj AA, Benelli G, Arulselvan P, Rajan M, Subbiah SK. Genomic plasticity between human and mycobacterial DNA: A review. Tuberculosis. 2017 Dec 1;107:38-47. (IF: 2.727, Q3, 2017)
23. Rusheni Munisvaradass, Suresh Kumar, Shalini Vellasamy, Syahrilnizam Abdullah1, Shirley Ding Suet Lee, Avin Ee Hwan Koh, Abdullah A. Alarfaj, Mok Pooi Ling.
Overcoming the Challenge of Transduction of Human T-cells with Chimeric Antigen Receptor (CAR) Specific for ERBB2 Antigen. Sains Malaysiana 2017. 46(10): 1831-8.
(IF: 0.565, Q3, 2017)
24. Ding SL, Kumar S, Mok PL. Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases. International Journal of Molecular Sciences. 2017 Jul 28;18(8):1406. (IF: 3.687, Q1, 2017)
25. Priya SP, Sakinah S, Ling MP, Chee HY, Higuchi A, Hamat RA, Neela VK, Alarfaj AA, Munusamy MA, Hatamleh AA, Al-Sabri AE. Micro-anatomical changes in major blood vessel caused by dengue virus (serotype 2) infection. Acta tropica. 2017 Jul 31;171:213-9. (IF: 2.509, Q2, 2017)
26. Mok PL , Leow SN, Koh AE, Mohd Nizam HH, Ding SL, Luu C, Ruhaslizan R, Wong HS, Halim WH, Ng MH, Idrus RB. Micro-Computed Tomography Detection of Gold Nanoparticle-Labelled Mesenchymal Stem Cells in the Rat Subretinal Layer.
International journal of molecular sciences. 2017 Feb 8;18(2):345. (IF: 3.687, Q1, 2017) 27. Cheah PS, Abdullah S, Bahari H, Chau DM, Habib O, Hasan S, Khalid M, Mok PL,
Nordin N, Tan NJ, Veerakumarasivam A. International Brain Research Organization (IBRO) global neuroscience advocacy programme: Four imperative resolutions to strengthen neuroscience research and development in Malaysia. IBRO Reports. 2017 Jun 30;2:41-6.
Associate Professor Dr. Mok Pooi Ling Page 21 28. Mariappan Rajan, Poorani Krishnan, Periyakaruppan Pradeepkumar, Mayandi
Jeyanthinath, Murugaraj Jeyaraj, Mok Pooi Ling, Palanisamy Arulselvan, Akon Higuchi, Murugan A. Munusamy, Ramitha Arumugam, Giovanni Benelli, Kadarkarai Muruganmo and S. Suresh Kumar. Magneto-chemotherapy for cervical cancer treatment with camptothecin loaded Fe 3 O 4 functionalized β-cyclodextrin nanovehicle. RSC Adv. 2017; 7 (1). 1-15. DOI:10.1039/C7RA06615E. (IF: 2.936, Q2, 2017)
29. Zhang Xiang, Kaijun Wang, Weizhi Zhang, Seoh Wei The, Amira Peli, Pooi Ling Mok, Akon Higuchi, S. Suresh Kumar. Gold Nanoparticles Inducing Osteogenic Differentiation of Stem Cells: A Review. J. Clust. Sci. 2018. 29(1):1-7.
DOI:10.1007/s10876-017-1311-0 (IF: 1.715, Q3, 2017)
30. Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3- yl)phenyl)urea Scaffold-Based Compounds.Molecules. 2018. 22: 297;
doi:10.3390/molecules23020297 (IF: 3.098, Q2, 2017)
31. Saritha Ramachandran, Moon Nian Lim, Pooi Ling Mok, Kamal Shaik Fakiruddin, Noor Atikah Fakharuzi and Zubaidah Zakaria*. Generation of neural stem cells from human peripheral blood derived induced pluripotent stem cells. Frontiers in Bioengineering and Biotechnology, 6th MTERMS 2016, Penang, Malaysia, 18-19 Nov 2016 (accepted on 19 Jan 2017) (IF: 0.17, 2017)
32. Thena Rasi Mohan, Moon Nian Lim, Pooi Ling Mok, Rahimah Ahmad, Jameela Satar and Zubaidah Zakaria*. Reprogramming of peripheral blood from Malaysian beta thalassaemia patients to induced pluripotent stem cell. Frontiers in Bioengineering and Biotechnology, 6thMTERMS 2016, Penang, Malaysia, 18-19 Nov 2016 (accepted on 19 Jan 2017) (IF: 0.17, 2017)
33. Teh, S.W.; Mok, P.L.; Abd Rashid, M.; Bastion, M.-L.C.; Ibrahim, N.; Higuchi, A.;
Murugan, K.; Mariappan, R.; Subbiah, S.K. Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review. Int. J. Mol. Sci.2018, 19, 558.
(IF: 3.687, Q1, 2017)
34. Ali Khan MS, Ahmed N, Misbah, Arifuddin M, Zakaria ZA, Al-Sanea MM, Khundmiri SUK, Ahmed I, Ahmed S, Mok PL. Anti-nociceptive mechanisms of flavonoids-rich methanolic leaf extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves. Food and Chemical Toxicology 2018. DOI: 10.1016/j.fct.2018.03.021 (IF: 3.977, Q1, 2017)
35. Lawal Danjuma, Mok Pooi Ling, Akon Higuchi, Abdullah A. Alarfaj, Rukman Awang Hamat, Palanisamy Arulselvan, Mariappan Rajan, K. Natarajaseenivasan, Sarva Mangala Praveena, Arivudai Nambi, Kiruthiga Vijayaraman and Suresh Kumar Subbiah.
Modulatory and Regenerative Potential of Transplanted Bone Marrow-Derived Mesenchymal Stem Cells on Rifampicin-Induced Kidney Toxicity. Regenerative Therapy. 2018. (IF: 1.182, Q4, 2017)
Associate Professor Dr. Mok Pooi Ling Page 22 36. Mohammed SafwanAli Khan, Misbah, Nishat Ahmed, Mohammed Arifuddin, Abdullah Rehman, Mok Pooi Ling. Indole alkaloids and anti-nociceptive mechanisms of Tabernaemontana divaricata (L.) R. Br. flower methanol extract. Food and Chemical Toxicology. doi.org/10.1016/j.fct.2018.06.007 (IF: 3.977, Q1, 2017)
37. Mohammed Safwan Ali Khan, Syeda Umme Kulsoom Khundmiri, Syeda Rukhaiya Khundmiri, Mohammad M. Al-Sanea, Mok Pooi Ling. Fruit derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms.
Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.00569 (IF: 3.831, Q1, 2017)
38. Nazilah Abdul Satar, Kamal Shaik Fakiruddin, Moon Nian Lim, Pooi Ling Mok, Norashikin Zakaria, Noor Atiqah Fakharuzi, Ahmad Zuhairi Abd Rahman, Zubaidah Zakaria, Badrul HishamYahaya and Puteri Baharuddin. Novel triple positive markers identified in human non-small cell lung cancer cell line with chemotherapy-resistant and
putative cancer stem cell characteristics. Oncology
Reports. doi.org/10.3892/or.2018.6461. (IF: 2.976, Q3, 2017)
39. Shi Qiang, Hiba Amer Alsaeedi, Cheng Yuhong, Hao Yang, Li Tong, Suresh Kumar, Akon Higuchi, Abdullah A Alarfaj, Rusheni Munisvaradass, Mok Pooi Ling, Pei Cheng.
Morphological and genetical changes of endothelial progenitor cells after in-vitro conversion into photoreceptors. Journal of Photochemistry and Photobiology B: Biology.
doi: 10.1016/j.jphotobiol. 2018.04.003 (IF: 3.165, Q2, 2017)
40. Suet Lee Shirley Ding, Suresh Kumar Subbiah2, Mohammed Safwan Ali Khan, Chandramohan Govindasamy, Khalid S Alnumair and Pooi Ling Mok. Human Mesenchymal Stem Cells Expressing Erythropoietin Enhance Survivability of Retinal Neurons Against Oxidative Stress: An In-Vitro Study. Frontiers in Cellular Neuroscience.
DOI: 10.3389/fncel.2018.00190 (IF: 4.3, Q1, 2017)
41. S. Sakinah, Sharmilah Kumari, Rusheni Munisvaradass, Pooi-Ling Mok, Hui-Yee Chee, Arivudainambi Seenichamy, Kiruthiga P.V, Akon Higuchi, Mariappan Rajan, K.
Nataraja Seenivasan, Marlina, Palanisamy Arulselvan, Giovanni Benelli & S. Suresh Kumar (2018) Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences, Pathogens and Global Health, DOI: 10.1080/20477724.2018.1492765 (IF:1.703, Q2, 2017)
42. Ding, S.S.L., Subbiah, S.K., Khan, M.S.A., Farhana, A., Mok, P.L. Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders. Int. J. Mol. Sci. 2019, 20, 1784. (IF:4.183, Q2, 2018)
43. A.E.H. Koh, H.A.A Alseedi, M.A. Rashid, C.S. Lam, M.H.N. Harun, M.F.M. Saleh, C.D.
Luu, S.S. Kumar, M.H. Ng, H.M.Isa, S.N. Leow, K.Y. Then, M-L C. Bastion, M.S.A.
Khan & PL Mok. Retinal degeneration rat model: A study on the structural and functional changes in the retina following injection of sodium iodate. Journal of
Associate Professor Dr. Mok Pooi Ling Page 23 Photochemistry and Photobiology, B. Biology. doi.org/10.1016/j.photobiol.2019.111514 (IF:4.067, Q1, 2018)
44. S.W. Teh, PL Mok & S.Kumar. Misunderstanding of Leptospirosis. Acta Tropica. 197 (2019): 105046. (IF: 2.629, Q1, 2018)
45. SLS Ding, AE Koh, S Kumar, MS Ali Khan, B Alzaharani, PL Mok. Genetically- modified human mesenchymal stem cells to express erythropoietin enhances differentiation into retinal photoreceptor: An invitro study. Journal of Photochemistry and Photobiology B: Biology. 195 (June 2019): 33-38. (IF:4.067, Q1, 2018)
46. Alsaeedi H & Mok PL. Dental pulp stem cells therapy overcome photoreceptor cell death and protects the retina in a rat model of sodium iodate-induced retinal degeneration.
Journal of Photochemistry and Photobiology, B. Biology. 2019; 198: 111561 doi.org/10.1016/j.jphotobiol.2019.111561 (IF:4.067, Q1, 2018)
47. PL Mok, SLS Ding, Aisha F, Badr A, Mohammed Safwan AK, S. Kumar. Photoreceptor Therapy: Generatioin of neurosphere-like cells from human mesenchymal stem cells expressing erythropoietin. Sains Malaysiana 2020. (IF: 0.540, Q2 2019 SJR)
48. Hiba AA, Lam CS, Koh AEH, Teh SW, Mok PL, Higuchi A, Then KY, Bastion MLB, Alzahrani B, Farhana A, Muthuvenkatachalam BS, Samrot AV, Swamy KB, Marraiki N, Elgerban AM, Subbiah SK. Looking into dental pulp stem cells in the therapy of photoreceptors and retinal degenerative disorders. Journal of Photochemistry and Photobiology B: Biology. 2020; 203: 111727. (IF:4.067, Q1, 2018)
49. Yan Chao Cui, Yu Sheng Qiu, Qiong Wu, Gang Bu, Seoh Wei Teh, Guo Zhong He, Pooi Ling Mok, Antony V. Samrot, Rajan Mariappan, Akon Higuchi, Palanisamy Arulselvan, Sanjiv Rampal Lekhraj Rampal, Bala Sundaram Muthuvenkatachalam, K. B. Swamy, Zhong Sun, Kok Pian Ang, Kong Yong Then, and S. Suresh Kumar . Hypoxic-Mediated Oxidative Stress Condition and Hydroxyapatite-Inducing Osteogenic Differentiation of Human Mesenchymal Stem Cells: A Mathematical Modeling Study. J.
Biomed. Nanotechnol. 16, 910–921 (2020) (IF: 5.280, Q1 2019 SJR)
50. Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model. Accepted in Tissue Engineering and Regenerative Medicine (October 2020) 10.1007/s13770-020- 00312-1. (IF: 1.671; Q2 2019 SJR)
51. Mok et al. Metabolic utilization of human osteoblast cells under normoxic and hypoxic conditions: A phenotypic microarray analysis. Experimental Biology and Medicine. (IF:
3.139, Q1 2019 SJR)
52. Antony V. Samrot, Tan Chuan Sean, Karanam Sai Bhavya, Chamarthy Sai Sahithya, SaiPriya C., Raji P., Emilin Renitta Robinson, Suresh Kumar Subbiah and Pooi Ling Mok. Leptospiral Infection, pathogenesis and its Diagnosis – A Review. Pathogens (IF: 3.405; Q2, 2019)
Associate Professor Dr. Mok Pooi Ling Page 24
Submitted articles
53. Mok PL et al. Computational drug screening against the SARS-CoV-2 Saudi Arabia isolates through a multiple-sequence alignment approach. Submitted to Saudi Journal of Biological Sciences in October 1st 2020.
54. Mok et al. Potential treatments for COVID-19 in current clinical trials: Mechanisms of action and hepatotoxicity. Submitted to the Journal of Pathology: Clinical Research
55. Mok et al. CRISPR/Cas9-Mediated Gene Knockout of MMP8 Decreases the Invasion and Migration Potential of Lung Cancer Cells. Submitted to Experimental Biology and Medicine
56. Mok et al. Mechanisms And Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds – A Review. Submitted to Medicina
57. Mok et al. Adsorption Efficiency of Chemically Synthesized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on Crystal Violet Dye. Submitted to Magnetochemistry.
Summary of publication information
Total number of Publications: 52
Total number;
of CIJ and ISI
50
Research publication details can be obtained from the following URLs:
1. https://www.researchgate.net/profile/Pooi_Mok
2. https://scholar.google.com/citations?user=qkYeidsAAAAJ&hl=en
Book chapters:
1. S.Saknah, Sharmilah Kumari, Mok Pooi Ling, Akon Higuichi, Giovanni Benelli, Suresh Kumar. Dengue: a silent killer, a worldwide threat. Mosquito-borne Diseases.
Parasitology Research Monographs. Springer, Cham. 2018.
2. Cheah Pike See, Tan Niu Jin, Mok Pooi Ling, Leong Pui Yee, Ling King Hwa. Little Man Inside Us. NYAWA. 2016. Universiti Putra Malaysia.
Total number of book chapters: 2
Associate Professor Dr. Mok Pooi Ling Page 25 Newsletter:
1. Mok PL. Transduced Mesenchymal Stem Cells for hemophilia treatment. MSH Newsletter. Jan 2011:7-9.
Total number of newsletter: 1
8. ACADEMIC REFEREES:
a. Professor Dr. Cheong Soon Keng Dean
Faculty of Medicine and Health Sciences Universiti Tunku Abdul Rahman
Malaysia
Email: [email protected] Contact number: +6012-2328959 b. Professor Dr. Suresh Kumar
Pro-Vice Chancellor
Bharath Institute of Higher Education and Research Bharath University
Chennai 600073, Tamil Nadu India
Email: [email protected] Contact number: +919361723864 c. Dr. Badr Alzahrani
Dean,
College of Medical Applied Sciences Jouf University, Qurrayat,
Kingdom of Saudi Arabia Email: [email protected] Contact number: +966553139444
