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Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants

reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator

Item Type Article

Authors Abdallah, Abdallah; Weerdenburg, Eveline M.; Guan, Qingtian;

Ummels, Roy; Borggreve, Stephanie; Adroub, Sabir; Malas, Tareq Majed Yasin; Naeem, Raeece; Zhang, Huoming; Otto, Thomas D.;

Bitter, Wilbert; Pain, Arnab

Citation Abdallah AM, Weerdenburg EM, Guan Q, Ummels R, Borggreve S, et al. (2019) Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. PLOS ONE 14: e0211003. Available:

http://dx.doi.org/10.1371/journal.pone.0211003.

Eprint version Publisher's Version/PDF

DOI 10.1371/journal.pone.0211003

Publisher Public Library of Science (PLoS)

Journal PLOS ONE

Rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Download date 19/06/2023 03:03:19

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Item License http://creativecommons.org/licenses/by/4.0/

Link to Item http://hdl.handle.net/10754/631047

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S4 Fig 32 (7%)

68 (14%)

72 (15%)

88 (18%)

16 (3%) 132 (28%)

24 (5%)

50 (10%)

Virulence, Detoxification, Adaptation Lipid metabolism

Information pathways Cell wall and Cellprocesses PE/PPE

Intermediary metabolism and respiration Regulatory proteins

Conserved hypotheticals

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