DANH GIA TiNH NHAY C A M COA M U 6 | TRUYDN B E N H SXHD Vdl MOT S6
HOA C H A T D I E T C O N TRUNG DANG SCr DgNG TRONG D y A N SXH QU6C
GIA TAI cAc TlNH TRpNG OI^M SXHD KHU Vl/C M | £ N B A C
Tran Cong Tii, Tran Vu Phong, VQ Trgng Dugc, Tran Nhir Duang, Do Due Lira*, VO Nggc Thiiy, Nguyin Hoing Le, f)inh Van Anh, VQ Trgng T h i n g ,
Tran Chf Cudng, Nguyen Mai Anh, Nguyen Van Soai, Tran Du^c Ddng, Nguyen Thj T r i Giang, Nguyen Thiiy Hoa
Vifn y^ Sinh Dfch T6 Trung Ifffng, Hd Npi
*Trung tdm Yte d{rphdng Nam Djnh
T6M TAT
Trong chiftmg trinh qudc gia phfing chdng binh SXHD t^l Vi$t Nam, cdng t i c phdng chdng djch chu yiu di/a vio bi$n phip di§t bg g i y v i phun h6a chit dift mufll tn/dng thinh. H6a chit dugc sd dgng chfnh trong phflng chfing SXH hlOn nay chii yiu l i Permethrine, Deltamethrine v i Malathion. Trong nam 2010 v i 2011, h6a chit Hantox-200 (Deltamethrin 3%) dugc lya chpn trong c6ng t i c phdng chdng djch cia chifong trinh phdng chdng SXH qudc gia. NghlSn ciju nSy dugc Uigc hi$n d i dinh g i i tinh khing cia mufil Aedes t^l 10 finh tnjng diim v i SXHD cda miin bic vdl 3 loai h6a chit Permethrine. Deltamethrine v i Malathion, ddng thfrl dinh g i i hi$u q u i cCia h6a chil Hantox-200 ddi vdl mudi Aedes tai H i N^i, Ngh^
An. Nam B|nh. H i "TTnh v i Thanh H6a nhim x i c djnh nftng df phun ULV cua hda chit Irong phdng ch6ng SXH difgc tiit kl9m, hi$u qui. Kfit q u i cho thiy, mufil Aedes nh^y cim cao v*l hda chit di§t cdn trting Detamerthrin v i Pemiethrin ft t i t c i cic difim nghiSn ci>u tai 9/10 ttnh khu vi/c mifin bic. Mufli Aedes t^i H i NOi (phudng Thjnh U9t quin Hoing Mai) c6 hiOn tucng ting sue chju di/ng vfti Detamethrin v i khing vfti Pemiethrin. Mufil Aedes khing v i ting si>c di|u di/ng vfti Malathion t^i h i u hfit cdc difim nghiSn ci>u.
Hanlox-200 ft nfing dd pha lofing h o i chit 1/9 c6 hiSu iyc tfit vft) mufil Aedes ft NghO An. Thanh Hda, H i TTnh v i Nam ©Inh. Dfii vfti mufil Aedes cOa H i NOI, hISn tu-ij'ng khing hofi chit du^c ghi nh$n ft nfing flO pha loing 1/9 v i c6 hiSu li/c di$t 95% ft nfing dO pha 1/6, 100% ft nfing dft pha 1/5. Hantox-200 khdng giy kich Crng da v i niSm mac cua ngufti Ouiyc phdng vfin, khdng gdy nguy hgi cho v i t nudi v i mdi tn/ftng xung quanh.
TCr khda: Sfit xuit huyfit dengue, mufil Aedes, hda chit dlfit cdn thiing, Hantox
I. D ^ T VAN D E SXHD. Tuy nhien, sir dyng q u i nhieu mgt l o ^
„ . . , , r it. i >!( ^ 1. h6a ch4t tiong th6i gian d i i se dan d^n s\r xuat Hi$n nay, vi chua c6 thuoc die tr^ hay 6 6
Vic xm SXHD n6n sti d^ng h6a chdt di§t muoi ^^^ v i gia ting miitc d$ khing h6a chit cia van l i bifn phip hi?u q u i frong phdng ch6ng cic loii cdn triing. T^i Vi$t Nam, hi§n tugmg
Tic gii: Tran Cdng Tii Phin bi?n 1: PGS. TS. NguySn Thu Y ^ Dja chi: M^n V? sinh djch te Trung uong Vi§n v$ sinh dich tS trung uong Di^n tiioai: 0919128382 Phin bi^n 2: PGS. TS. Hoing V i n Tfin Email: tiiti;2803 [email protected] Vi$n v§ smh dich t l tnm uong Ngiy nh|n bii: 29/02/2012
Ngiy ding bii; 01/6/2012
32 T a p chi Y hpc dv ph6ng, T^p XXH, s6 3 (130)
ting mtic dg khing v(5i h6a chat di?t con tring thuQC nh6m pyrethroid dang gia ting tiiy theo mtic dg su dung h6a chdt tiong cic chuang tiinh ph6ng ch6ng sot r^t v i SXHD[1,3].
BSn c^mh d6, sti dyng h6a chdt dting theo k6t qui thu khang se la yeu to quylt djnh cho sv thanh cong cua cong tic phong chong djch t^i th\rc dja. Dya vio cic so li^u vh khing h6a chat t ^ cac tinh SXH tigng diem se l i co s6 khoa hgc vung chac de dinh gii va l\ra chgn h6a chat tiong chuong trinh ph6ng chong SXH quoc gia nam 2012, d6ng thdi dua ra cic ket luan nham khuyen cio vdi Bg y te ve mua vi sti dgng hda chdt trong phdng chong cic b ^ S6t Xudt Huyit Dengue. Trong nam 20II, chuong trinh phdng chong SXH qu6c gia da mua v i sti dgng hda chdt Hantox 200 dl phun ULV di^t mudi tiudng thanh tiong cic 6 djch SXHD v i phun chu dgng phdng djch tgi cac vung c6 nguy co cao[7]. Vi viy, can xac dinh do nhg.y cam vdi cic lo?J hda chat dang dugc sti dung, die b i ^ l i Hantox 200 d l dinh hudng cho chien luge sti dung hda chdt theo thdi gian v i dia du cua khu vvc mien Bic.
n . PHUONG P H A P NGHlfiN CtTU 2.1. V i t Ii?u
TSn che phdm (ten tiiuong mai): Hantox -200.
Thinh phdn v i him lugng ho^t chat:
thanh phin Deltamethrin 3%.
Nha sin xudt: Nha miy Hanvet.
Gidy thti do WHO cung cdp dugc sti dgng tiong du i n SXH quic gia bao gom 3 loai: Malatiiion 5%, Permeflirm 0.75% vi Deltamethrin 0.05%.
2.2. ThM gian v i dja diem
Dia dilm nghidn ctiu: 10 tinh tigng dilm (Lo^i A v i L o ^ B) ctia chuong trhih phdng chong SXHD Miln B^c: H i Tinh, Ngh? An, Thanh Hda, H i NOi, Thii Bhih, Nam Dinh,
Vinh Phtic, Hii Duong, Hii Phdng v i Bic Ninh. Moi tinh l\ra chgn tti 1 din 2 dilm de tiiu thap bg gay Aedes. Thdi gian nghien ctiu: tti tilingS-thing 12/2011.
2.3. Phuffng phip
Bdnh gid dQ nh^y cdm vai cdc hoa chat dift con triing cua hai lodi muoi Aedes aegypti vd Aedes albopictus tgi ede tinh trqng diem SXHD Mien Bae.
Bg giy thu tiiip 6 50 hg gia dhih/1 dilm.
Bg giy dugc nudi tiong long s&ch 20 x 20 x 30cm t^i phdng nuoi cua V i ^ VSDTTW. Din nhin ghi khu v\rc, ngiy thing v i the hg (FO).
Hda chat sti dgng: giay tiiti do V/HO cung cdp dugc sti dgng trong d\r an SXH qudc gia bao gom 3 loai: Malathion 5%, Peimethrin 0.75% v i Deltametiirin 0.05%.
Xac dinh ndng dg dap ting cua Aedes aegypti v i Aedes albopictus vdi hda chat Hantox 200 ti8n th\rc dia.
Thti nghi?m hi?u Igc di?t muoi vdi 3 nong dg pha loang cua Hantox la 1/9; 1/6 va 1/5. M6i ndng dg diu dugc tien hinh d 3 hg gia dinh, mdi gia dmh chgn 1 phong cd di?n tich tii 20-30 m^. Chgn 1 gia fflnh dl tieo cic long muSi ddi chting khdng chtia hda chit.
Cic long muoi dugc tieo d cic dg cao 0.5m, lm, 1.5m v i 1.8m. Theo doi so muoi ngi quy d moi long sau khi phim hda chat 60 phtit.
Mudi song sdt frong cic ldng dugc chuyin sang cac long s?ich, khong cd hda chat. Theo doi s l muoi chet sau 24 gid. Dinh gii hi^u qui v i thdi gian ha gyc cua hda chat bing so lugng muoi quy sau 60 phut v i chit sau 24 gid, dong thdi cic long muoi doi chung cung dugc theo doi tiong 24 gid.
Ddnh gid tdc dung phv cua hoa ehat Hantox len con nguai vd vgt nuoi
Dinh gii tiidng qua dinh nghia v i phin Io?i cic lo^i phin ting phy bao g6m: phin ting phg ning v i phin ting phy nhg.
Tap chi Y hpc dv phdng, Tip XXH, s6 3 (130) 33
i n . KfiX QUA ch4t di^t c6n trting duc^c si d\mg trong chuong
Bitth sA dp nhfly cim cia hd loM muSi «nh phbng ch6n8 SXH t»i c4c ttah trpng d i ^ Aedes Aegypti vi Aedes Albopicttis v6i ba h6a yh SXHD khu vyc Mifa B ^
Bing 1. Kit q u i dinh g l i al> nh|y c i m cila muil Aedes v»l h6a chit dlit cSn triing DelUmethrIn, Permethrin v i Malathion t«l mft »t> trnh tr9ng diim SXH miin Bic
TT 0|a dliir
Deltamethrin 0,05% Permethrin 0,75% Malathion 5%
Ty l« T> l i T# l i chit Oinh g l i chit Dinh g l i chit Oinh gli
(%) (%) (%)
1 Thach HOl 2 H6ng Linh 3 Giao Thuy 4 Xuin Tnr&ng 5 Quynh Liru 6 Diin Chdu t Cit Hii
8 Cit Mil 9 Tp Bic Ninh 10 Trin Hi/ngBao 11 Triiu San 12 Hoing H6a 13 Cim Giing 14 Hoing Mai 15 H i Ding
H i TTnh H i Tinh Nam Djnh Nam Oinh Ngh$ An Nghi An Hii Phing Hii Ph6ng Bic Ninh Thii Binh Thanh H6a Thanh Hfia Hii Dirang H i N « i H i N « l
Ae. altjo Ae. elbo Ae. Bibo Ae. BB AB.AB
Ae. ae Ae albo
Ae. ae Ae. Bibo Ae. ae Ae. ae Ae. ae Ae. albo
AB. BB AB. albo
100 100 100 100 100 100 100 100 100 100 100 100 100 95 100
Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Ting sire ch|u di/ng Nhay
100 100 100 100 100 100 100 100 100 100 100 100 100 0 100
Nhay Nhay Nhay Nhay Nhgy Nhay Nhay Nhay Nhay Nhay Nhay Nhay Nhay Khing Nhay
70 75 92,5
10 100 100 98,3 100 90 70 50 67 20 57 55
Khing Khing Ting sire ciliu
dimg Khing Nhay Nhay Nhay Nhay Ting si>c chju
dimg Khing Khing Khing Khing Khing Khing
Ket qui cho thdy, tdt ci cic dilm nghidn khu vyc miln bdc mu3i Aedes nh9.y cim cao ctiu d 10 tinh khu v^c miln bic mu5i Aedes vdi hda chdt di$t cdn triing Permethrin. RiSng nlmy cim cao vdi hda chdt di§t cdn tiling Thinh Li§t, Qu$n Hoii^ Mai, Hi Ngi cd hi|n Detametiuin, rieng vdi Thinh Li§t, Hoing Mai, tugng khing ro r$t vdi hda chat Permettuin (t^
Hi NOi c6 hign tugng ting stic chiu dyng vdi Ig chit li 0%).
hda chdt (ty I? chit li 95%). MuSi Aedes nh^ty cim cao vdi hda chdt Hdu hit cic dilm nghiSn ctiu d 10 tinh di$t cdn tiling Malathion t^i 2 tinh Hii Phdng 34 Tap chi Y hpc dv ph6ng, Tip XXH, s6 3 (130)
vi Nghp An, ting siic chju dvmg vdi h6a chit cia tinh H i Tinh v i 1 di^m tji tinh Nam Djnh, thft (ft nh?y cim v6i h6a chit thii) tai 1 diem 1 di^m * Thii Binh, 1 dilm 6 Thanh H6a, 1 cua tinh Nam Djnh v i tiii tinh B5c Ninh. MuSi diem d Hii Duong, 2 dilm vl H i Npi.
da kliing v6i Malathion t^ii cic diem lay mlu
'vl
i l -
^,
Deltametiirin 0,05% Pemiethrin 0,75% Malathion 5%
Hinh 1. Bin do khing hda chit cua mudi Aedes vdi hda chit di$t cdn trung Deltamethrin, Permethrin v i IMalathion tfii 10 tfnh trvng dilm SXHD Ithu v ^ phia Bic.
3.2. Xic djnh ndng d$ dip ihig cua Aedes aegypti vd Aedes albopictus v i i hda chat Hantox trSn t h ^ dja
Bing 4. TSng hqp k i t q u i khing sau khi phun ULV vbi cic n&ng tf$ pha khic nhau
STT
1
2
3
4
5
D|a diim
H i Nil
Nghi An
Thanh Hfia
Nam Djnh
H i TTnh
T y l i 1:9 Cfi hiiu lire Itim
(54,25%) Cfi hi$u lire tit
(99%) Cfi hi$u lire tit
(95,5%) Cfi hi$u lire t6t
(95%) Cfi hi$u lire tit
(95,5%)
Kit q u i phun ULV T>l#1:6 Cfi hiiu lire tit
(95,5%) Cfi hiiu lire tit
(100%) Cfi hiiu lire tit
(100%) Cfi hiiu lire tdt
(100%) Cfi hiiu lire tit
(100%)
Ty 1^1:5 Cfi hiiu lire tit
(100%)
Vdi nong dg pha hda chdt 1/9, d tat c i cic dd cao khic nhau, ty I^ chit ddi sau 24 gid mu5i thti nghifm ctia Ngh? An, H i Ilnh, Nam Dinh v i Thanh Hda sau khi tilp xtic vdi
hda chdt trong vdng 60 phtit tti 95% den 99%.
Nhu vay vdi 4 tinh niy hda chat Hantox 200 cd hi$u lvc tit vdi muSi giy b$nh SXHD. Rigng vdi H i Npi t^ 1$ muoi dpt quy sau 24h chi Ii T^p chi Y hoc du ph6ng, Tgp XXH, s 5 3 (130) 35
54,3%, hda chdt Hantox 200 cd hi§u Ivrc k6m vdi mu5i gay b§nh SXHD. Kit qui niy cung giong nhu kit qui thti khing hoi chdt tien gidy thti ctia WHO tpi phdng thi nghi?m vdi muoi Ae. aegypti. T^i cic tinh Nghp An, Thanh Hda, Hi TTnh vi Nam Dinh, theo bio cua cic Trung tim y te Dv phdng thih (TTYTDP), ngudi din sti dgng hda chdt rdt di dit, m$t khic vifc giim sit, chi d^o phun hda chdt ctia Vifn Vf sinh Djch tl Trung uong v i TTYTDP thih rdt sit sao nSn vifc phun hda chdt dupe tiln hinh trift dl, dung ning dO do viy tpi diy chua phit hifn thdy hifn tupng khing hda chdt cii&Ae. aegypti [2,6].
Khi ting nong dd ctia hda chdt l€n bing vifc pha loang vdi ty If 1/6, kit qui cho thdy, ty
If mu3i ctia 4 tinh H i Tinh, Thanh Hda, Nghf An, Nam Dinh ddt quy sau khi tiep xuc vdi hda chdt li 100% d tdt c i cic dp cao, tai H i Nfi li 95,5%. Khi ting ndng dO cua hda chdt ien bang vifc pha bang vdi t^ If 1/5, kit qui cho thay, t^
If mu6i ctia H i NOi dOt quy sau khi tilp xtic vdi hda chdt l i 100% d tdt c i cic d^ cao.
Nhu v^y theo quy trinh chudn ve "quy trlnh thti nghifm hifu lvc cua hda chdt dift muoi tiong phdng chong SXH bing phucmg phip thti sinh hpc" cua Bd Y t l ban hinh nim 2010, vSn cdn nh^y cira vdi dp pha loing 1/9 eda Hantox 200 ( 3 % Deltiunetiirin). Dli vdi muSi Aedes ctia H i Ndi, ning dp pha loang cdn tiult Ii 1/6 dl d^t dupe hifu qui dift 95% vi 1/5 dl dift 100%.
Hinh 2. Kit q u i thir sinh h9c v6l thu&c dift cdn tritnq Hantox-200 pha t ; 1$ 1/9 v i 1/6 phin b6 theo tinh
3.3. Dinh gii t i c dyng phy ciia h o i chdt Hantox-200
Ket qui dinh gii tic dvng phv cua hoi chdt Hantox-200 doi vdi con ngudi, v | t nuoi v i mdi tnrdng ximg quanh thdng qua phdng van chu h$ gia dlnh tpi noi cd su dvng hoi chdt d l thti nghifm sinh hpc cho thdy hoi chdt Hantox-200 hoin toin dim bio an toin eho
ngudi tilp xuc. Khdng cd bdt ky phin ting phv dli vdi ngudi tilp xuc dupe ghi nhin, khdng cd mtii khd chiu tiong qua trinh sti dvng. Kit qui cho thdy thuoc Hantox-200 cd It tic dyng phv v i kich ting hon so vdi thuoc DeltaUK dupe sti dvng trong chuong trinh SXHD quic gia nim 2010 [8]. Ket q u i n i y cung tuong tv nhu dinh gii ctia N g u y ^ Thuy Hoa (2011) 36 T^p chi Y hpc dv phbng, T$p XXH, s6 3 (130)
khi tiiti nghifm thuoc Hantox-200 tpi tiivc dia H i Npi [1].
Doi vdi ngudi tivc tilp di phun ctia trung tim y t l du phdng Nam Dinh, kit qui cho thdy hda chit Hantox-200 an toin cho ngudi tilp xtic, khdng mui kho chiu. Itiy nhien hoi kich ting niem mpc (khit khd c l hpng) v i hit hoi khi phun tiiulc d nong dO 1:5.
Khdng ghi nhin bdt cu lopi gia sue, sue vit tiong gia fflnh bi chet Iign quan den vifc sti dyng hoi chat Hantox-200. Khdng cd inh hudng den mdi trudng nudc v i khdng khi do hoi chat Hantox-200 gay ra.
V. K£T L U ^
Muoi Aedes nhpy cim cao vdi hda chat dift cdn trdng Detamerthrin v i Permethrin d tdt e i cic diem nghien ctiu tpi 10 tinh khu vvc miln bic, rieng vdi Hoing Mai, H i Npi cd hifn tupng tang stic chju dvng vdi Detamerthrin, khing vdi Peimethrin. MuSi Aedes nhpy cim cao vdi hda chdt dift edn trung Malathion tpi 2 tinh Hai Phdng va Nghf An, tang stic cluu dvng vdi hda ehat thti tai I dilm ctia Nam Dinh v i Bic Nmh v i khang vdi Malathion tpi cic dilm nghien cuu cdn Ipi.
Hoi chdt Hantox-200 dupe pha vdi nong dp 1:9 cd thl ip dyng tot cho cic tinh lopi B tiong chuong trinh phdng chong SXH quoc gia nhu Nghf An, H i Tmh, Thanh Hoi, Nam Dinh.
Vdi Ha Npi, noi muoi da giim dO nhpy cim vdi hda chat niy nen khi pha loing hoi chdt Hantox-200 vdi nudc theo ty If 1:9 cd hifu qui dift mudi Aedes kdm. Nen pha thuoc vdi ty If 1:6 de cd hifu qui dift muSi tdt (95,5%) hope vdi ly If pha thuoc vdi nudcl:5 ^ If dift muoi l i 100%.
Sau phun 15 phtit, Hantox-200 cd till giy kich ting nh? cho niem mpc doi vdi ngudi trvc tilp phun. Sau phun I gid, Hantox-200 khdng cdn giy kfch tmg da v i ni8m mpc cua
nhiing ngudi dupe phdng vdn, khdng giy nguy hpi cho vit nudi v i mdi trudng xung quanh.
T A I L I | : U T H A M K H A O
1. Nguyen Thtiy Hoa, Trdn Cdng Tti, Trdn Anh DQmg, Nguyin Thi Lien Huong, Nguyin Cdng Tio. DiftmuoiAe. aegypti bdngphun ULV Hantox-200 tgi Hd Ngi. Tpp chi Y hpc dv phdng, tpp XXI, s l 3 (121)/201I. Trang 5 1 - 5 6 .
2. R.TCoUms, B.K. Dash, R.S. Agarwala, K.B. Dhall. 1986. An adaptation of the Gel Diffusion Technique for Identifying the source of mosquito blood meals. Indian Joumal of Malariology, 1986, vol. 23, pp.81-89
3. Tran Van Tien, 2004. Bio cio nghifm thu de tii cap BO: Nghien cthi vai trd truyin bfnh SXHD cua muoi Aedes albopictus tpi mpt so thvc dia mien Bic Vift Nam.
4. Scott Gordon. 2000. Woodmoor Asian Tiger Mosquito Control. Maryland Department of Agricultiire, Mosquito Contiol Section.
5. Vifn Vf suih Dich te Tnmg uong. 2005.
Bio cio ting kit Dv ^ Phdng ching SXHD khu vye phia Bic nim 2005.
6. Vifn Vf smh Dich te Trung uong. 2006.
Bio cio ting kit Dv in Phdng ching SXHD khu vyc phia Bic nim 2006.
7. ^^fnVf sinhDichtlTrunguong.20II.Bio cio tdng kit Dv i n Phdng chdng SXHD khu vvc phia Bic nim 2011.
8. Vu Trpng Dupe, Tran Vu Phong, D 5 Dtic Luu, Nguyen Th; Yen, Trdn Cdng Tfi, Hoing Minh Due, Nguyin Thfiy Hoa, Dmh Th; Vin Anh, Nguyin Thi Mai Anh, Trdn Nhu Duong. Ddnh gid hifu qud thu sink hgc cua hoa chat deltamethrine 2.5%
(Delta UK) tren muoi Aedes aegypti tgi Hd Ngi vd Nghf An ndm 2010. Tpp chi Y hpc dv phdng, t§p XXI, s l 4 (I22)/2011. Trang 6 8 - 7 6 .
T?ip chi Y hpc du phbng, T^p XXH, s6 3 (130) 37
EVALUATE THE RESISTANCE CAPACITY OF DENGUE MOSQUITOES WITH SOME INSECTICIDES IN MAIN PROVINCES IN NORTHERN VIETNAM
Tran Cong Tu, Tran Vu Phong, Vu Tronjj Duoc, Tran Nhu Duong, Do Due Luu*, Vu Ngoc Thuy, Nguyen Hoang Le, Dinh Van Anh, Vu Trong Thang, Tran Chi Cuong, Nguyen Mai Anh, Tran Due Dong, Nguyen Thi Tra Giang, Nguyen Thuy Hoa
National Institute of Hygiene and Epidemiology, Hanoi
*Nam Dinh Preventive Medicine Center
In Vietnam National Dengue contiol program, using insecticide and wiping-out larvae are two of methods that may help interrupt the spreading of dengue outbreaks. The mam insecticides using in National Dengue program are Permethrine, Deltamethrine v i Malathion.
hi 2010 and 2011, Hantox-200 (Deltametiuin 3%) was chosen as the insecticide for control the spreding of Dengue outbreaks in the Dengue contiol program. Therefore, evaluating the resistance capacity of dengue mosquitoes witii Permethrine, Deltamethrine vi Malathion in 10 northern provinces and determining of insecticide susceptibility of Hantox-200 (Deltamethrine 3%) on Aedes are main purposes of this research.
The result showed that, Deltalmethrin and Permethrin have good efficacy in Aedes
mosquitoes m all most of study sites m 10 Nortiiem provinces except Tlunh Liet, Hoang Mai district, Hanoi. The insecticide- resistant population of Aedes with Malathion was recorded in most of study sites. In Nghean, Thanhhoa, Hatinh and Namdinh provinces, Hantox with concentrate 1:9 liters water had effective to control mosquitoes. In Ha Noi, insecticide- resistant was recorded in mosquito population with concentration 1/9; when raising the concentration up to 1/6, mortally proportion was 95% after 24 hours(good efficacy), when raising the concentration until 1/5, mortaUty proportion was 100%.
Hantox-200 was not cause of allergic in skin and mucous membrance of interviewers, was not harm to animals and environment.
38 Tap chi Y hpc dv phbng, TUp X X H , &6 3 (130)
