VIETNAM MEDICAL JOURNAL N''2 - APRIL - 2018 al. (2011). "Male drcumcision and human
papillomavirus infection in men: a systematic review and meta - analysis". 3. Infect. Dis. 204 (9), 1575 -1390.
•*. Ashfield JE, Nickel KR, Siemens DR et al (2003) Treatment of phimosis with topical steroids in 194 children. J Urol, 169.1106 - 1108.
5. Tran Ngoc Bich (2008). "Ky thuat cat bo vong
that bao qui dau chij'a hep bao qui dau (de xuat mot ky thuat md)", Y hoc TP Ho Chi Minh, 12, tr 445-450
. Cuckow P (2006). Phimosis and buried penis, Pediatric Surgery, pp 557-568.
. Kaplan GW (1983). Complications of Circumcision, Urologic Clinics of North America/
10, pp 543-549.
NGHIEN CmJ THU' KICH ITNG DA, NIEM MAC VA KHA NANG LAM LANH VET THiraNG COA BAI THUOC VLI
DANG CON THUOC TREN THITC NGHIEM
L8 Thi Minh Nguyet*, Pham Ba Tuyen*, Tran Trong Duffng**
I. OAT VAN OE
Viem ldi la ton thu'dng viem cap tinh hay man tinh xay ra d t d chiTc phan mem xung quanh rang. Ton thu'dng chi khu tru d ldi (bd, nhu liji, ldi dinh) ma khdng anh hu'dng den xu'dng o rang. TuT xu'a trong dan gian ed nhti'ng bai thuoc chda dau rang viem ldi nhu' vd duoi ngam riTdu de ngam, nu'dc sae ngai cu'u sue mieng, nu'dc sac vd cay sao den, cay dai, dieu tri viem ldi va mpt so san pham dieu trj viem ldi bang che pham thuoe YHCT du'di dang tan bpt boi tai cho, thudc cham tai cho nhu" Eupolin, Sindolor, BT9B, RK94, lu'dng dien hu'dng...
Xuat phat tii nhu cau dieu trj ngay cang ci ma cac nguon thudc ngoai nhap ddi vdi chuye i khoa rang ngay cang dat va khan hiem,lam the nao de dung cac san pham thudc y hpc co truyen v u ^ giam gia thanh dieu trj benh rang mieng, tinh an toan eao nhuTig chat lu'dng dam bao. Chinh vl vay chung tdi nghien eij'u tae dung bai thude chu'a viem ldi V U . De danh gia tac dung CLia bai thudc tren lam sang, bu'dc dau chung tdi nghien cirtj thii' kich u'ng da, niem mac va kha nang lam lanh vet thu'dng cua bai thuoc VLI dang con thuoc tren thd thu'c nghiem, -
J II. OOl TUQNG VA PHITCTNG PHAP N G H I I N ( j | )
*D61 Wdng nghien cdu tren t/wc nghi0m: tho trang nang l,800g - 2000g, khong
phan biet du'c cat. , ^
*Chat lieu nghien cud: Bai thuoc VLi dang con thudc diTdc san xuat tai Khoa Du'dc - Benh vien Y hpc co truyen - Bp Cdng an, dong trong io thiiy ttnh mau sam, da du'dc kiem nghiem dat tieu chuan ed sd. Cong thu'c bai thuoc:
Hoang lien 3g Tetan 3g Dinh hddng 2g Con 55° 5ml TOM TAT
Nghien ciitJ thLf ki'ch iing da, mem mac va kha nana lam lanh vet thu'Ong ciia bai thuoc VLI dang ran thuoc tren Oio thu'c nghiem. Nghien CLTU du'dc tien hanh tren tho trang nang l,800g - 2000g, khong phan biet du'c cai. Nghien C'LTU thii kich iim da va kha nang lam l^nh vet thuUng cua VLI: tien hanh tao vet thu'dng tren da tho, boi VLI vao vet thUdngS lan/ngay trong 3 ngay, so sanh vdi vet thu'dng boi niidc muoi dang tru'dng. Nghien ciili thif kfch il'ng niem mac, boi thuoc ISn niem mac hau mon thd, so sanh vdi boi nu6c muoi sinh ly'. Ket qua nghien euli cho thay Con thuoc VLI khi su' dung vdi lieu cham 3 lan/1 ngay khong gay kich uYig da va niem mac hau mon tho va c6 tae dung lam lanh vet thu'dng.
Tdichoa: VLI, kich thich da, niem mac, lanh vet thu'dng
SUMMARY
STUDY ON SKIN I R R I T A T I O N , MUCOSAL AND POSSIBILITY OF WOUND HEALING OF
V L I PRESCRIPTION DRUGS I N EXPERIMENT Study on the skin irritation, mucosa! and wound healing of VLI drug in experimental rabbit. The study was conducted on white rabbits weighing ISOOg - 2000g, regardless of male. Examination of sidn irritation and wound healing of VLI: wound healing on rabbit skin, VLI applied to the wound 3 times a day for 3 days, compared with isotonic saline wound.
Study on mucosal in-itation, application to rabbit anal mucosa, compared with physiological saline. Research results showed that VLI tablet when used with 3 doses /day did not irritate skin and rabbit anus and wound healing effect.
keyword: VLI, skin irritation, mucosal and wound healing.
*Binh vien Yhoccdbvyen, BdCdngan
**Cuc Y te, Bg Cdng an
Chiu trach nhiem chinh: Tran Trgng DUdng Email: [email protected] Ngay nhan bai: 11/3/2018 Ngay phan bien: 3/4/2018 Ngay duyet bai: 15/4/2018
TAP CHl Y HOC V | £ T NAM TAP 465 - T H A N G 4 - SO 2 - 2018
* Nghien cuU thUc nghiem:
Thd kfch ihig da - kha nang lam lanh vet thddng:
-Tien hanh thi nghiem tren 03 con thd trang.
- Cao sach Idng thd bang dao eao, khdng lam tray xu'dc da thd.
- Tao vet thu'dng tren da thd bang dung cu tiet trung: Tren mot eon thd tao 2 vet thuttng hinh chii' thap cd v| trf, kich thudc tu'dng td nhau.
- Bdi dung djch nu'dc mudi dang tru'dng tiet trung ten ca hai vet thudng va theo doi thd trong 3 gid.
- Xac dinh dp rdng ciia quang dd bang thu'dc ky thuat.
- Dp rdng ciia quan do d mot vet thu'dng du'dc tinh bang cdng thiTc:
r. + 7-, + /-, + r.
- Sau 3 gid, do dp rdng quang dd d moi vet thu'dng (ro).
- I^pt vet thu'dng bdi dung dich nu'dc mudi dang trifdng tiet trung 3 lan/ngay trong 3 ngay, ghi iai thdi gian bat dau sir dung dung djch ddi chieu cua moi thd.
- Mdt vet thu'dng bdi dung djeh thiT 3 lan/ngay trong 3 ngay, ghi lai thdi gian bat dau sir dung dung djch thu' cua moi thd.
- Quan sat cac vet thu'dng va xac djnh do rdng eiia quang do d cae thdi diem 24 gid, 48 gid va 72 gid va so sanh vdi ro.
Thd kich dng niem mac hau mdn ihd:
- Tien hanh thi nghiem tren 06 eon thd trang.
- Cao sach Idng thd d vung hau mon bang dao cao thfch hdp, de quan sat du'dc niem mac hau mdn thd va khdng lam tray xu'dc da thd.
- Quan sat hau mdn thd ghi iai tinh trang ciia niem mac hau mdn thd tru'dc khi t h i i nghiem.
- Tien hanh thir nghiem, chia thd lam hai nhdm, moi nhdm 03 con:
+ Nhdm chii'ng: Bdi nu'dc mudi sinh ly ten niem mac hau mon.
+ Nhdm tiiij': Bdi thude len niem mac hau mdn.
Ghi lai tiidi gian bat dau thif nghiem ciia tirtig thd.
- Mdt gid sau ru^ saeh hau mdn ciia thd d ca hai nhdm bang nu'dc cat.
- Quan sat va ghi lai tinh trang ciia niem mac hau mdn thd sau 24 gid, 48 gid va 72 gid.
II. KET Bant T h o
1 2 3
QUA NGHIEN CI^U VA BAN LU$N
7 3.1; Bd rdng quang do cua vet thu'dng sau 24 gid D u n g d i c h NaCI 0 , 9 %
To ( m m ) 1,88 2,38 1,75
r j , ( m m ) 2,25 2,75 2,12
^24 " Tg ( m m ) 0,4 0,4 0,4
Dung dich thu*
ro ( m m ) 2,38 2,13 1,75
r 2 4 { m m ) 1,5 1,38 1,13
tjA - ta ( m m ) -0,9 -0,8 -0,6 Nhan xet: Do rdng quang dd ciia vet thu'dng: Thd 1: Dung djeh NaCl 0,9%: rO: 1,88 mm, r24:
2,25mm; Thd 2: rO: 2,38mm, r24: 2,75mm; Thd 3: rO: 1,75mm, r24: 2,12 mm. Dung dich thiT: Thd 1: rO: 2,38mm, r24: 1,5mm; Thd 2: rO: 2,13mm, r24: 1,38mm; Thd 3: rO: 1,75mm, r24: i,13mm.
Bang 3.2: Md fc? vet thUdng sau 24 gid T h o
1
2
3
Dung d i c h NaCI 0,9o/o Vet thu'dng hdi tay nhe, mieng vet thu'dng u'dt, khdng cd ban dd d vimg da xung quanh.
Vet thu'dng hdi tay nhe, mieng vet thu'dng u'dt, khdng cd ban do d viing da xung quanh.
Vet thu'dng hdi tay nhe, mieng vet thu'dng u'dt, khdng <^ ban dd d vung da xung quanh.
Dung d i c h thuf Quang dd ciia vet thu'dng da thu nhd lai, mieng vet thu'dng kho, khdng cd ban dd d
viing da xunq quanh.
Quang dd ciia vet thu'dng da thu nhd iai, mieng vet thu'dng khd, khdng cd ban do d
viing da xung quanh.
Quang dd cita vet thu'dng da thu nhd lai, mieng vet thu'dng tdid, khdng ed ban dd d
viinq da xunq quanh.
Nhan xet: Sau 24 gid: Dot vdi dung dieh NaCi 0,9%: Thd 1: Vet thu'dng hdt tay nhe, mieng vet thu'dng u'dt, khdng cd ban do d viing da xung quanh (Dung djch thif: Quang dd ciia vet thu'dng da thu nhd lai, mieng vet thu'dng kho, khdng cd ban dd d viing da xung quanh.); Thd 2: Vet thu'dng hdi tay nhe, mieng vet thu'dng u'dt, khdng cd ban dd d viing da xung quanh (Dung djch thif: Quang dd ciia vet thu'dng da thu nhd lai, mieng vet thu'dng khd, khdng cd ban dd d viing da xung quanh); Thd 3: Vet thu'dng hdi tay nhe, mieng vet thu'dng u'dt, khong cd ban dd d viing da xung quanh (Dung djch thif: Quang dd ciia vet thu'dng da thu nhd lai, mieng vet thu'dng kho, khdng cd ban dd d viing da xung quanh).
VIETNAM MEDICAL JOURNAL N°2 • APRIL - 2018
Bang 3.3: Dp rdng quang dd cua vet thddng sau 48 gid Dung djch NaCI 0,9*'/o
ro ( m m ) 1,81 2,38
r^tifmm) 1,63
2,0
r^B - fp ( m m ) -0,3 -0,4
ro ( m m )
D u n g djch thuf 2,38
2,13
r 4 s ( m m ) 1,0
r48" rp (mm) -1,4 -1,3
Nhan xet: Do rdng eua quang dd sau 48 gid: Dot vdi dung djch NaCl 0,9%: Thd 1: rO: 1,88mm, r48:
163mm; Thd 2: rO: 2,38 mm, r48: 2,0mm; Thd 3: rO: 1,75mm, r48: 1,88mm. Dung djch thiT: Thd 1; rO:
2i38mm, r48:1,0mm; Thd 2: rO: 2,13mm, r48: 0,88mm; Thd 3: rO: 1,75mm, r48: 0,88mm.
' Ba/ig 3.4: Md ta vet thddng sau 48 gid
Tho Dung d j c h NaCI 0 , 9 % D u n g d j c h thuf Vet thu'dng khdng cdn tay nhu'ng van dd,
mieng vet thu'dng u'dt, khdng cd ban dd d viing da xung quanh.
Quang dd cua vet thu'dng da thu nhd nhieu, mieng vet thu'dng khd, khong cd ban dd d
vung da xung quanh.
Vet thu'dng khdng cdn tay nhutig van dd, khdng ed ban dd d viing da xung quanh.
Quang dd ciia vet thu'dng da thu nhd nhieu, mieng vet thu'dng khd, khdng ed ban do d
viing da xung quanh.
Vet thu'dng khdng cdn tay nhutig van dd, mieng vet thu'dng u'dt, khong cd ban dd d
vLing da xung quanh.
Quang dd ciia vet thu'dng da thu nhd nhieu, mieng vet thu'dng khd, khdng ed ban dd 6
vung da xung quanh.
Nhan xet: Sau 48 gid: Ddi vdi dung djeh NaCI 0,9%: Thd 1: Vet thu'dng khdng edn tay nhu'ng van dd, mieng vet thu'dng u'dt, khdng cd ban dd d vung da xung quanh (Dung djch thi^: Quang do cua vet thiidng da thu nhd nhieu, mieng vet thu'dng khd, khdng cd ban dd d vung da xung quanh); Thd 2: Vet thudng khdng cdn tay nhuiig van do, khdng ed ban do d viing da xung quanh (Dung djch thiy;
Quang dd cda vet thu'dng da thu nhd nhieu, mieng vet thu'dng khd, khdng cd ban do d viing da xung quanh); Thd 3: Vet thu'dng khdng cdn tay nhu'ng v i n dd, mieng vet thu'dng u'dt, khdng cd ban do cl viing da xung quanh (Dung djch thif: Quang dd ciia vet thu'dng da thu nhd nhieu, mieng vet thu'dng khd, khdng cd ban dd d vimg da xung quanh).
Bang 3.5: Dg rdng quang dd cua vei thUdng sau 72 gid Tho
1 2 3
Dung dich NaCl 0 , 9 % ro ( m m )
1,88 2,38 1,75
r72(mm) 1,50 1,75 1,63
'n • To ( m m ) -0,4 -0,6 -0,1
D u n g d i c h thuT ro ( m m )
2,38 2,13 1,75
r 7 2 ( m m ) 0,63 0,63 0,63
r „ - r „ (mm) -1,8 -1,5 -1,1 NhanxetiDo rdng quang dd eua vet thu'dng sau 72 gid: Doi vdt dung djeh NaCI 0,9%: Thd 1: rO;
1,88mm, r72: 1,5mm; Thd 2: rO: 2,38mm, r72: 1,75mm; Thd 3: rO: 1,75mm, r72: 1,63mm. Odi vdi dung dich thif: Thd 1: rO: 2,38mm, r72: 0,63mm; Thd 2: rO: 2,13mm, r72: 0,63mm; Thd 3: ri);
1,75mm; r72; 0,63mm.
Bang 3.6: Md ia vet thddng sau 72 gid
Tho Dung dich NaCI 0 , 9 % Dung d i c h thu*
Vet thu'dng van dd, mieng vet thu'dng u'dt, khdng cd ban dd d vting da xung quanh.
Vet thu'dng gan nhu" khdng cdn quang dd, mieng vet thu'dng khd, khong cd ban dd d viing da
xung quanh, Vet thu«ng van dd, mieng vet thu'dng u'dt,
khdng cd ban dd d viing da xung quanh.
Vet thu'dng gan nh\i khdng cdn quang dd, mieng vet thu'dng khd, khdng cd ban dd d viJng da
xung quanh.
AUiiy quaiui.
Vet thu'dng gan nhu' khdng cdn quang dd, mieng vet thu'dng kho, khong cd ban dd d viing '^='
xung quanh.
Vet thu'dng van dd, mieng vSt thu'dng u'dt, khdng cd ban dd d vijng da xung quanh.
_ Nhan xet: Vet thu'dng 72 gid: Ddi vdi dung djch NaCl 0,9%: Thd 1: Vet thu'dng van dd, mi|n9 vet thu'dng u'dt, khong cd ban do d viing da xung quanh (Dung dich thu"; Vet thu'dng gan nhu* khong eon quang dd, mieng vet thu'dng khd, khdng cd ban dd d viing da xung quanh); Thd 2: Vet thu'dng
TAP CHl Y HQC VIET NAM TAP 465 - THANG 4 - SO 2 - 201B
van dd, mieng vet thu'dng u'dt, khong cd ban dd d viing da xung quanh (Dung dich thu": Vet thu'dng gan nhd khdng cdn quang dd, mieng vet thu'dng khd, khdng cd ban dd d vimg da xung quanh); Thd 3: Vet thu'dng van dd, mieng vet thu'dng u'dt, khdng ed ban do d vimg da xung quanh (Dung djeh thiy: Vet thu'dng gan nhu' khong cdn quang dd, mieng vet thu'dng khd, khdng cd ban do d viing da xung quanh).
Bang 3.7: /fie^ qua ihd kich dng niem mac T h d
1
2
3
N h o m chu'ng ( D u n g d u n g d i c h NaCI 0 , 9 % ) 24 g i d
Niem mac khdng thay doi mau sae
Niem mac khdng thay dot mau sac Niem mac khdng thay doi mau sac
4 8 g i d Niem mac khdng thay ddi mau sac
Niem mac khdng thay ddi mau sac Niem mac khdng thay dot mau sac
72 g i d Niem mac khdng thay dot mau sae Niem mac khdng thay dot mau sac
Niem mac khdng thay ddi mau sac
Nhom thur ( D u n g t h u o c ) 24 g i d
Niem mae hau mdn khdng thay ddi so vdi tru'dc khi diinq thuoe Ntem mac hau mon khdng thay ddi so vdi tru'dc khi diinq thudc Niem mae hau mdn khdng thay ddi so vdi tru'dc khi diinq thuoc
4 8 g i d Niem mae hau mdn khdng thay ddi so vdi tru'dc khi diinq thuoc Ntem mac hau mdn khdng thay doi so vdi tru'dc khi diinq thudc Niem mac hau mdn khdng tiiay ddi so vdt tru'dc khi diinq thudc
7 2 g i d Ntem mae hau mdn khdng thay dot so vdi tru'dc khi diinq thuoe Niem mac hau mdn khdng thay dot so vdi tru'dc khi diing thudc Niem mac hau mdn khdng tiiay dot so vdi tru'dc khi diinq thude IV. KET LUiQiN
- Con thudc VLI khi su' dung vdi lieu bdi 3 lan/ngay trong 3 ngay khdng gay ki'eh ufng tren da va CO tac dung Iam lanh vet thu'dng.
- Con thuoc VLI khdng gay ki'eh ifng ntem mac hau mdn thd.
TAI LIEU THAIVl KHAO
1. Bang Vu Hal (2002)^ Cac chi so trong tham kham va dieu tri benh viem quanh, rang.
2. Ph^m Thi Tuyet Nga (1994)^ ung dung dieu tri Eupoiin-12 dieu trj viem ldi cap va dot cap eiia viep quanh rang, Luin van tot nghiep BSCKII.
3. Do Tat Ldi (1999), NhD'ng cay thuoc va vi thuoc Viet Nam, Nxb. Yhoc.
BiraC DAU DANH GlA VAI TRO CONG Hird-NG TIT TRONG MOI LIEN QUAN GIU'A R A C H VONG Sffl VA T H O A T VI DIA DEM
C O T SONG THAT LU'NG 6* NGU'CTI CAO TUOI
Le Dii-c Nam*, Dang VTnh Hiep**, Nguyin Qu6c Dung*
T O M TAT
Muc ddu: nghien eirljvai trd ciia cgng hu'dng tiJf cdt song th3t lung trong xac djnh so lu'dng vong sdi rach, Gn sulit ciia 3 loai rich vdng sdi va danh gia moi lien quan giO'a rach vong sdi vdi thoat vi dia dem, DSi iu^ng vi phUUng phip nghien cdu. nghien afu hoi OAJ, mo ta cat ngang 81 BN tren 60 tuoi cd dau cot song that lu'ng da du'dc chyp ehup cong hu'dng tif. Chiing tdi tien hanh khao sat 405 dia dem, ehia cae dia dem thanh hai nhdm la phinh va thoat yi dTa dem. Trorig moi nhdm noi tren, chung tdi phat
*Benh vien HuU Nghj, Ha Ngi
**fru&ng Dal hgc Ykhoa Pham Nggc Thach Chiu trach nhiem ehinh: LS Difc Nam Email: [email protected].
Ngay nhan bai: 4/3/2018 Ngay phan bien khoa hoc: 1/4/2018 Ngay duyet b^i: 14/1/2018
hien rach vdng sdi eac dia dem va phan chia thanh 3 loai: rach trung tam (loai i j , rach tda tron (loai 2), rach ngang (loai 3). Chung toi tien hanh nghien ciru moi ii6n quan giij'a rach vong sdi vdi thoat vi va phinh dTa dem. Kei qui: trong 81 BN nghien ciru (32 nam va 49 nuO, tuoi trung binh la 74,15 ± 6,43 (tif 60-90 tuoi). Trong so 405 dTa dem du'dc khao sat, rach vong sdi thay trong 287 dia dem cliiem 70,8%, trong do rach loai ngang .chiem 52,2%. So s^nh va ddi chi^u giiJa phinh hay thoat vj dia dem cd va khong cd rach vong sdi chiing toi thay ring: thoat vj dia dem lien quan mat thiet vdi rach vong sdi va rach vong sdi ed the lam qua trinh thoat vj dTa dem dien ra nhanh hdn.
Kei luin: d ngu'di eao tudi, rach vdng sdi la thu'dng gap. Hinh anh tang tin hieu tren chuoi xung T2W dang trd thanh tieu chuan van^ de ehan doan rach vdng sdi. Cgng hu'dng tif giiip xae dinh tot moi quan he mat thi&t giCfa raeh vong sdi va thoat vi dia dem.
71/' khda: Thoai hda dia dem, thoat vi dia dem, phinh dia dem, rach vong sdi.
