• NghiencLFu - Ky thuat
Nghien cmi tac dung cua san pham kem rang Nha chu Saman co nguon goc du'O'c lieu\
tren ngu'oi bj viem nha chu
Nguyen Xuan Truong'*, Hoang Van Sam^, Hoang Don Hoa-
'Truang Cao ddng Dupc Phii Thp -Vien Y hpc bdn dia liet Nam 'E-mail: xti-uangl958(Qigmail.com
Summary
4 selected medicine types, denoted as X39, X29, X37 andXI6, were researched for use as tartar-dissolving material in production of the anti-periodontitis active toothpaste "Saman periodontal". The pericxiontai toothpaste Saman was used by 200 volunteers for 4 successive weeks. The periodontal inflammation alleviated rapidly and reduced significantly Many periodontitis symptoms went away completely This proved a strong curative power for periodontal diseases, that deserves to recommend wide use of the toothpaste.
Keywords: Dental tartar, periodontitis, periodontal Sa man, 200 volunteers.
Dat van de
Benh nha chu la met benh thudng gap, theo mdt bap cae nam 2013, 90% dan sd Viet Nam mic benh nha chu. Hien nay benh ngay cang phd biin nhung khd phat hien do benh tiin triin thim lang vdi nhirng trieu chirng it dupc ngudi benh chu y, d i bd qua. Nguyen nhan chinh d i n tdi viem nha ehu la su hinh thanh cac mang bam rang (cao rang). Benh nha ehu pha buy eae md nang dd xung quanh rang, lam tieu xuong d rang, lung lay rang, hdi mieng, chay mau chan rang, ngira, rang cd the xin den, bin P'... lam ngudi benh mit tu tin trong giae tiip, khd khan treng an udng va niu khdng dupc diiu trj kjp thdi ed the gay mit rang va viem lan vao d xuong, anh hudng r i t Idn tdi ehit luong cude sing.
Cd nhliu bien phap phdng va dieu tri cac benh v i rang mieng de tranh tiin trien thanh viem nha chu nhu ve sinh rang mieng thudng xuyen, dung each, kham rang djnh ky 6 thang mdt lin, diiu tri sdm cac trudng hap viem laJH... Treng dd, bien phap sir dung ngudn duac lieu theo kinh nghiem tir eae bai thude dan gian eung nhu theo met sd tai lieu i^^ cd tac dung tdt vdi cac benh rang mieng ed y nghTa thuc tien Idn ddi vdi cdng ddng. Tuy nhien, viec sir dung eae cay thudc thee kinh nghiem cdn nhiiu ban ehi nhu sir dung don le met cay thudc, each diing, phuong phap bao chi... din tdi hieu qua vdi benh viem nha chu ndi chung khdng dat nhu mong mudn... Xuit phat tCf thue trang va ly de tren, chung tdi tien hanh de tai: "Nghien ciru tae dung cua san pham kem rang Nha ehu Saman cd
ngudn gdc duoe lieu tren ngudi bi viem nha ehu".
De tai gdm 2 muc tieu:
1. Nghien ciru kha nang lam tan bgt eao rang eiia eae duvc lieu.
2. Danh gia tae dung eiia san phim kem rang cd ngudn gdc dugc lieu tren ngudi tinh nguyen.
Doi tu'O'ng, dung cu va phirong phap nghien CIPU
Ddi tu'ong nghien ciru
Duac lieu: 20 loai (bang 1), cac dupc lieu nay theo kinh nghiem dan gian va mdt sd tai lieu d i u cd tac dung chong viem lai, chu'a dau rang P"=I.
Kem danh rang Nha chu Saman, thanh phin gdm 4 loai duac lieu la: Lupc vang 250 mg, thdng dd 600 mg, re ehe Shan tuyit 250 mg, cue luc lang 250 mg. Mdi loai dupc lieu duac s i y khd, ehiit treng nude, cd thanh cae, s i y khd thanh eao dae rdi nghiin mjn, ray qua ray sd 125/90, sau dd cir 1350 mg bdt dupc lieu thi phdi hp-p vdi 135 g kem P/S lam thanh kem, ddng vae typ rang P/S gpi la kem rang Nha ehu Saman.
Trang thiet bj, dung cu nghien cu'u
Can dien tir BL- 220H, tii s i y Galy B-024M, ddng hd bim giay, giiy Ipc, dng nghiem, den cdn, ede cd md, dng dong, dua thiiy tinh, phiu Ipc...
Phu'O'ng phap nghien ciru
Nghien ciru kha nang lam tan bgt eao rang cOa 20 loai dugc lieu
Sir dung phuong phap thuc nghiem khdi lupng d i danh gia va se sanh hieu suit lam tan t>dt
TAP CHI DiraC HOC - 6/2016 (SO 482 NAM 561 61
Nghien
CIFU- Ky thuat
cao rang ciia 20 dugc lieu nghien eiru. Chpn lay mau duoe lieu cd hieu suit lam tan bdt eao rang cao nhit de sir dung san xuit kem danh rang Nha chu Sa man.
Dtnyc lieu nghien eiru
Cd 20 leai dupc lieu duac ki hieu tu' X2 d i n X40).
s i y duac lieu; cae duae lieu duac siy khd trong til siy galy B-024M, ed ham am ddng mu'c 12%.
Chiit dugc lieu: moi loai dugc lieu dugc can 7 g, eat nhd, chiit trong 80 ml nude d 100°C treng 60 phut, Ipc, thu djeh chiit, bleu chinh djch chiet dugc lieu bang nudc cit din dii 80 ml.
Bpf eao rang
Dugc liy tu' cac benh nhan liy eao rang d met sd phdng kham nha khoa khu vuc, sau dd dugc ngam rira trong nudc cit, siy khd din khdi lugng khdng doi, nghien mjn va trdn ddng nhit, rdi dugc can tren can dien tir ed dp chinh xae 10"^g.
Tiin hanh
Nghien eiru duge tien hanh trong eae dng nghiem va dugc chia lam 2 Id mau:
Ld mau thir nghiem vdi duge lieu (ki bleu X):
n = 20 duge lieu va Id miu chirng vdi nude mudi sinh ly (NaCI 0,9%), n = 20 miu, gdm cac budc sau:
Cho vao mdi dng nghiem 40 mg bdt cac rang da dugc siy khd tdi khdi lugng khdng ddi, gdl vao treng giiy Ipc, can dugc m^ (mg), rdi lin lugt cho vao moi dng nghiem 5 ml dung djeh duge lieu vira chiit, ngam cae gdl bdt cao rang treng djch ehiit dugc lieu treng thdi gian 6 gid, sau mdi gid lie nhe 50 lin.
Sau 6 gid, rira lai gdi bdt cap rang bang nudc cit, rdi dem gdi bdt siy khd den khdi lugng khdng ddi, duge m^ (mg) la khdi lugng bdt cae rang cdn lai.
Khdi lugng bdt cap rang da tan la m = m, - m^
Tinh ti le phan tram lugng bdt eao rang da tan (T%) theo edng thirc: T%, = m/m, x 100.
Moi miu dugc lieu dugc lam 3 lin, liy trung binh cdng kit qua cua 3 lin thir nghiem, thu dugc kit qua eudi eung.
Vdi miu chu'ng: lam tuong tu miu thir, chi thay djch ehiit dugc lieu bing dung djeh NaCI 0,9%.
Danh gia tac dung cua kem rang Nha Chu Saman tren nguoi tinh nguyen
Tieu chuin lua ehgn nguai ttnh nguyen Khdng phan biet gidi tinh, trinh dp, nghi nghiep, khdng mie benh tiiu dudng, khdng bj sau rang;
dd tudi tu' dil 18-45; Igi, rang ed mdt hpae t i t ca cac trieu chirng: mang bam rang, cae rang; viem Igi; chay mau chan rang; lung lay rang; rang sin, den hoae d; hdi mieng, thd hdi do viem Igi.
62
Tieu ehuan loai trir
Dudi 18 tudi va tren 45 tudi; rang sin, den 6 do bim sinh hoac do di chu'ng dung thudc de lal.
Co mau nghien ciru
Theo tieu ehuan lua chpn va loai tru', chung tdi chgn 200 ngudi tinh nguyen.
Tiin hanh
Kiem tra tinh trang rang, Igi thee tieu chi va pH nudc bpt ciia ngudi tinh nguyen.
Sir dung kem rang Nha ehu Saman ve sinh rang mieng 2- 3 lin/ngay va dung trong 4 tuin; moi lan danh rang phai cha xat diing ky thuat tu' 2- 3 phut, tuang duong khoang 200- 250 lin cha xat.
Kiim tra lai tinh trang rang, Igi theo eae tieu ehi lua chpn, pH nudc bpt lin/tuin x 4 lin, tdng 5 lin, ke tu- khi bat dau sir dung san phim.
Thu thap thdng tin, sd lieu khao sat qua phiiu thee ddi ngudi tinh nguyen.
Phu'O'ng phap xir ly so lieu
Sir dung thuat tean thing ke sinh hpc d i xii ly cac sd lieu nghien ciru.
K i t qua nghien CLFU
Danh gia kha nang lam tan bot cao rang cua 20 loai du'O'c lieu
Kit qua nghien ciru lam tan bdt cae rang ciia 20 dugc lieu d ea mau thir va miu chirng x i p theo thir tu tir thip d i n eao duge trinh bay d bang 1
Bang 1: Kit qua nghien ciru kha nang lam tan bdt eao rang eua eae miu thii' va miu chimg
STT Ten dirgrc lieu
1 Day dau xu'ang 2 Rau ma 3 Cau dang 4 Cay mat gau 5 Ngai cifu 6 DaJbJ 7 Ctiam meo 8 Cay rau rong 9 Cap gai den 10 Bach dong nCf 11 Muong trau 12 Tru'lJnh 13 Thong thao 14 Tam bop 15 Made 16 La che xanh 17 Cue luc lang 18 Lugcvang 19 R i che Shan tuylt 20 Thong do
Ky hieu DL X5 X40 X20 X6 X34
X2 X23 X33 X8 X7 X3 X22 X9 X4 X18 X24 X39 X29 X37 X16
Mire tan trung binh mau thir (%)
0,82 2,23 2,53 3,32 3,75 4,17 4,76 5,67 5,82 6,94 7,53 8,32 9,32 10,10 11,20 12,21 12,39 12,57 13,71 14,47
Mirc tan trung binh m l u ehimg (%)
0,15 0,20 0,12 0,12 0,15 0,17 0,16 0,15 0,12 0,14 0,19 0,12 0,13 0,11 0,14 0,13 0,16 0,12 0,15 0,15
TAP CHI I>\ir<-\t~- XIl-V*-'
Nghien
CIFU- Ky thuat
Kit qua d bang 1 ehe thiy: kha nang hda tan bpt cao rang d cac miu dugc lieu dao ddng kha nhieu, tu' 0,82% din 14,47%, cac miu tir so thir tu 14 din sd 20 cd dp hda trfi bdt cao rang tuong ddi cao > 10%; treng dd mau sd 20 cd dp hda tan cap nhit 14,47%. Treng khi dd, cac miu chu'ng cd dp hda tan dap ddng it va thip trong khoang tu' 0,11 % din cao nhit la 0,20%.
Tu' kit qua nghien ciru, chung tdi lua chpn 4 dugc lieu cd dp hda tan bdt eao rang cae nhit la cac duge lieu: cue luc lang, lugc vang, re che Shan tuyit va thdng dd de lam kem rang Nha ehu Saman.
Kit qua nghien cu'u tac dung cua kem rang Nha chu Saman tren ngu'O'i tinh nguyen
Cae trieu chirng thudng gap eiia viem nha chu va tac dung ciia san pham kem rang Nha chu Saman tren 200 ngudi tinh nguyen dugc trlnh bay d bang 2.
Bang 2: Kit qua tae dung ciia kem rang Nha chu Saman tren ngudi tinh nguyen
(n: so luvng nguai tinh nguyen)
Trieu chifng
Mang bam rang Cao rang Viem toi Chay mau chan rang Rang lung lay Rang xin den, 6 vang Hoj mieng Hoi tho hoi do viem toi pH nu'oc bpt
Tnrdc dieu fri n 178 190 183 57 41 29 87 67 5,30
Tyle (%) 89,00 95,00 91,50 28,50 20,50 14,50 43,50 33,50 -6,50
Khoisau dieu tri n 178 172 160 57 37 29 87 67
Tyle(%) 100 90,53 87,43 100 90,24 100 100 100 6,80-750
GhichO
So con do nhieu So con Sa nhjeu
86 con do nhilu
Nhan xet: Ket qua nghien ciru d bang 2 ehe thiy, sau 4 tuin diing kem rang Saman, cac trieu chirng eua viem nha chu giam nhanh va ro ret.
100% ngudi benh ed eae trieu chirng mang bam rang, chay mau chan rang, rang xin den, d vang, hdi mieng, hoi thd hdi de viem Igi da khdi hoan toan. Cac trieu chirng cap rang, viem Igi, rang lung lay cung khdi vdi ty le cac tu' 87,43 din 90,53%; sd ngudi benh cdn lai chua khdi bean tean chiim ty IS rit it nhung cae trieu chirng eung giam rit rd ret.
Sau thdi gian diiu trj, pH nudc bpt tang nhe tU' 5,30 - 6,50 den 6,80 - 7,50, d kheang nay thi pH nudc bot ed tinh kiim nhe.
Ban luan
Benh rang mieng la benh phd biin, thudng gap d mpi ddi tugng. Bh tai nghien ciru v i tae dung ciia cac dugc lieu vdi cac benh v i rang mieng la rit cd y nghTa thuc tiin. Cac miu dugc lieu dugc chpn tir X2-X40 d i u la nhirng dugc lieu duge kinh nghiem dan gian xac nhan hcae cd trcng cac tai lieu diing d i ehi>a viem rang lgi.
Kit qua nghien ciru che thiy eae duge lieu diu ed kha nang hda tan bdt cao rang vdi cae ty le khac nhau, dang chu y la cae dugc lieu eiie lue lang, lugc vang, re ehe Shan tuyit va thdng dd cd kha nang lam tan bdt cao rang tdt nhit lin lucrt vdi cae ty le 12,39; 12,57; 13,71 va 14,47%. Day la cac dugc lieu sin cd, vi vay rit thuan Igi ehe viee khai thac sir dung lam nguyen lieu san xuit thudc danh rang Saman.
Kit qua thir tren 200 ngudi tinh nguyen cho thiy cae trieu chirng cua viem nha chu diu giam nhanh, rd ret. Sau thdi gian 4 tuin dung kem rang Saman, eae trieu chirng mang bam rang, chay mau chan rang, rang xin den, d vang, hdi mieng, hoi thd hdi de viem Igi da khdi 100%, cac trieu chirng cdn lai cung khdi vdi ty le cae tren 85%. Cac kit qua tren chirng td ring, san phim kem danh rang Nha chu Saman ed tae dung rd ret vdl cae benh rang mieng, do vay nen duge sir dung rdng rai de nang cap sire khde edng ddng.
Kit luan
Treng 20 miu duge lieu nghien ciru, da xac djnh dugc 4 miu duge lieu cd hieu suit lam tan bdt eao rang cao nhit la cue luc lang, lugc vang, re ehe Shan tuyit va thdng dd.
San phim kem danh rang Nha ehu Saman cd tae dung tot vdi viem nha chu. Sau 4 tuin diiu trj, cac trieu chirng mang bam, rang d, sin, chay mau chan rang, hdi mieng, hoi thd hdi diu hit 100%.
Cac trieu chirng khac dat kit qua eao, dae ddng trong khoang 90%.
Tai lieu tham khao
1. Nguyin Toai va CS, "Benh hpc nha chu", Giao trinh Rang - Ham - h/lat, Bd mon Rang - Ham - Mat, Tnj'O'ng Dai hoc Y khoa Hul, trang 31.
2. Mai Dinh Hung va CS (2006), "Benh hpc quanh rang", Bai giang Rang - Ham - Mat, NXB Y hoc. Ha Noi, tap 1, trang 23.
3.06 Huy Bich va CS (2004), Cay thudc va ddng vat lam thuoc d Viet Nam, tap II, NXB Khoa hoc va kT thuat.
Ha Npi.
4. Vd Van Chi (2012), Tir diin cay thudc Viet Nam (Bp moi), tap I, II, NXB Y hpc. Ha Npi.
5. DS Tat Lpi (2004), Nhimg cay thuoc va vi thuoc Viet Nam, NXB Y hoc, Ha Npi.
{Ngay nhan bai: 06/04/2016 - Ngay duyet dang: 02/06/2016)
TAP CHI DlTOC HOC - 6/2016 (SO 482 NAM 56) 63