N g h i e n cmi Y hoc ^ Hp<^ TP. H o Chi M i n h * Tap 15 * So 3 * 2011
%jedmens in APTTMA Affia^-s. Volume 45, pages 2434-2438. 16S rRNA. Volume 39, Pages 1429-1425
3. Koumans EH. (2002). Companson of Methods for Detection of a Nguyen Hoang Chirong (2005). Xay dung qu\ trinh PCR piiat Chlamifdia fracfemw* and Neisseria gmwnhceae Using hien papillomavirus (hpv) trong dich phet am dao. Y Hpe TP.
Commeroallv Available Nudeic A a d Amplification Tests a n d a H 6 C h i M m K T a p 9 , » I .
LiqijidPap5inearMediunLVolume41,Pagesl507-1511. 6 Whiley PJ, et al (2004). A new eonfinnalory Ndssena 4. Mahony JB, Song X CbcHig S., Faught M., Sabnga T , Kapala J. gonon-hoeae real-time PCR assay DM. targeting the porA
(2001). Evaluation of the N u d S e n s Basic Kit for Detectior of pseudogene.
Chkim/dia tradumtatis and Neisseria gananhaeae m Genital T r a d Specimens L a n g Nucleic Add Sequence-Based Amplification of
TAN SUAT NGUY CO MAC TIEN DAI THAO DlJONG VA KHA NANG RUT NGAN THCJI GIAN THi/C HIEN NGHIEM PHAP
DUNG NAP GLUCOSE
Trdn Ngoc Thanh*. Nguyen Tlti Le**
TOMTAT
Ma ddu: Viet Nam nam tiong n)wm nude co tif le benh ddi thdo dieong (DTD) tdng nlianh nlmi tren the giai. Tlieo hdo cdo ciia Trung tam dinh duang TPHCM c/io biH, co tie 40 - 50% co bieh chieng & th&i diem chan dodn. Trong do, so ngieai du&i 30 tuoi mdc benh ngdy cdng gia tang, thgm chi co nhung tre du&i 10 turn cdng mac binh vd nhu vgy Id ti le mac ticn DTD con cao han niia.. Do do, viec tdm sodt tien DTD mang lgi mot ich lgi quan trgng trong bot cdnh chua co nhieu nghiin cieu ve van de ndy. Ngfiiem phdp dung ngp glucose duang umg Id mot trong ba cdch gidp chdn dodn DTD vd la cdch dephdt hiin tien DTD. Tuy nhien, thai gian 2 gia can cho viec thuc hien nghiem phdp Id khd Idu vd Id mgt trong nhihig rdo cdn doi vai viec ieng dung nghiem phdp ndy trong thiec tenen can thiei phdi ddnh gid Idid ning cdi tieh.
Muc tiett: Xdc dfnh ian suat rm logn dung ngp glucose vd khd ndng rut ngan thai gian thuc him nghiem phdp dung ngp glucose.
Dot tuang - phttang phdp n^iett dhu nghiin cieu cdt ngang trin 98 hgc vien de'n thuc tap tgi Bo man sinh lyhgc- Dgi hoc Y Dugc thdnh pho Ltd Chi Minh.
KA qud: Tdn suat roi logn dung ngp glucose (tiin ddi thdo dieong) Id 26,5%. Tan suat rdi logn dung ngp glucose CO liin quan v&i tien cdn gia dinh mac tien ddi thdo du&ng hogc ddi thdo du&ng. (RR= 2,69), v&i viec chai the thao (RR= 3,23); Ghi nhdn tdn sudi ndy co gia tdng theo htoi. Co khd ndng nit ngdn th&i gian thuc hien nghiem phdp dung ngp glucose ddnh cho cdc doi tugng co kei qud binh thu&ng tgi thai dian 90 phut vd ti li tneang hgp co tlie dugc nit ngdn la 49%.
Tit khoa: nghiim phdp dung ngp glucose, duang huycl luc doi tien ddi thdo du&ng, rdi logn dung ngp glucose.
ABSIKACT
PREVALENCE OF PRE-DIABETES BY ORAL GLUCOSE TOLERANCE TEST AND THE PROBABILTTY OF SHORTERNING TEST TIME
Tran Ngoc Thanh, Nguyen Thi Le * Y hoc TP. Ho Chi Minh * Vol. 15 - No. 3 - 2011:176 - 182 Background: Vietnam is one ofthe nwst increasing prevalmce of diabetes mellitus countries. According to HCMC Cmterfor Nutrition, approximately 40-50% diabetes patimts have had complications at diagnosis. The numbei- of under 30 year old patimts is increasing with pre-diabetes. Therefore, screming and defining the
* BQ moan Sinh Li Hoc. D^i Hpe Y Khoa Pham Ngoc Thach, *• Bo moan Sinh Li Hoc. Dai Hpe Y Duoc TP.HCM.
Tdc via lien lgc: TS. Nguyin Thi L^ DT: 0903311507 Email: [email protected](mi 178
Y Hoc TP. H o Chi M i n h * T a p 15 * So 3 * 2011 N g h i e n c m i Y hoc
prevalmce of pre-diabetes are veiy important while there are few studies about it in Vietnam. Oral glucose tolerance test (OGTT)is one ofthe ways to diagnose diabetes diseases and pre-diabetes. 2-hour test time is too long for using this test in community and needs to be improved.
Objective: To define the prevalence qf pre-diabetes by using OGTT and to evaluate the probability of shortening test time.
Method: Cross-sectional study on 98 students practicing at Department of Physiology in the University of Medicine and Pharmacy at HCMC.
Results: The prevalence (^impaired glucose tolerance (pre-diabetes) by using OGTT was 26.5%. Theixwere correlations between this prevalence and family history qf pre-diabetes, diabetes (RR=2.69) and state of playing sport (3.23). We also noted that the higher age was, the higher this prevalmce was. This study shoioed that there was a probability qf shortening tesf time and this might be usedfor people having normal result at 90"' minute qf test The prevalmce qf people who can be stopped at 90'' minute of test was 49%.
Key words: oral glucose tolerance test, fasting glucose test, pre-diabetes, impaired glucose tolerance.
mang lai mpt ich lpi quan trpng trong boi canh chua cd nhieu nghien cuu ve van de nay.
Nghiem phap dung nap glucose dudng uong la mdt trong ba each giup chan DTD va cung la each de phat hi^n hen DTDP).
Muc tieu de tai
Xac dinh tan suat roi loan dung nap glucose va kha nang rut ngan thdi gian thvrc hien nghiem phap dung nap glucose.
EJOm/ONG -PHU'ONG PHAP NGHIEN CUtl DATVANDE
Dai thao dudng (DTD) la mdt rdi loan chuyen hda do nhieu nguyen nhan phuc tap.
Hau qua ciia DTD la nhihig ton thuong keo dai, roi loan va suy chiic nang ciia cac co quan khac nhau'^'^*. Hien tren toan the gidi cd khoang 180 trieu ngudi mac benh DTD. To chuc y te the gidi (World Health Organization - WHO) du bao den nam 2030, con so nay se tang len 366 trieu ngudi. Vdi ty le tang ti> 8- 20% mdi nam, Viet Nam nam trong nhdm nude cd ty le benh DTD tang nhanh nhat tren the gidi'"'. Theo bao cao ciia Trung tam dinh dudng TPHCM, cd tir 40 - 50% benh nhan DTD cd bien chiing d thdi diem chain doan, nguyen nhan chinh la do benh dugc phat hien mupn*^'. Ti le mac DTD cdn cao, h le phat hien mupn con nhieu da lam gia tang them ganh nang cho ban than ngudi benh va xa hgi. Mat khac, trong tinh hinh phat trien ciia nen kinh te hien nay, che dp dinh dudng nhieu chat beo, thira nang luong, thieu van ddng va beo phi, day ciang la nguyen nhan gia tang benh DTD o ngudi tie'"', sd ngudi dudi 30 tudi mSc benh ngay cang gia tang'^^' va nhu vay la ti Ie mac tien DTD cdn cao hon niia. Tuy nhien, cd the ngan ngira hoac Iam cham qua trinh tien trien tien DTB tiianh DTD typ 2, va tham chi cd the trd lai miic dudng huyet binh thudng""!^!. Do do, viec tam soat tien DTD
Doi tugng nghien cuu
Gdm 98 hgc vien den thy'c tgp tai Bd mdn sinh ly hoc - Dai hgc Y Dupc thanh pho Ho Chi Minh.
Tieu chuan thu nhgn'^^>
Cd che dp an khdng gidi han (trong dd chiia it nhat 150g carbohydrate mdi ngay) trong it nhat 3 ngay va cd hogt dpng the Iuc trudc khi thuc hien nghiem phap.
Ngung dua nang lugng vao co the toi thieu 8 gid trudc khi thuc hien nghiem phap (ke' ca viec hiit thuoc la va dimg ca phe).
Cd the tham gia thuc hien nghiem phap mdt each lien tyc trong thdi gian la 2 gid budi sang.
Hoan toan khde manh va khdng cd dau hieu lo lang hay cdthai.
Tieu chuan logi ttit
Ngudi cd benh ly hoac dang dieu tri benh ly
N g h i e n cmi Y hoc Y Hoc TP. H o Chi M i n h * Tap 15 "^ So 3 * 2011
ndi, ngoai khoa.
Dang diing thudc thiazide, t h u d c ngira thai d u d n g uong, cac corticoteroid hoac cac thudc khac d u g c biet la cd a n h h u d n g den glucose mau.
Ngudi nghien ca phe, thuoc la.
Benh nhan khdng thu thap dii chi tieu theo thiet ke nghien ciiu
Phuofng phap nghien cuu Thiei kf nghien ciiu.
Phuang phap nghien aiu: Ti&i ciiu - cat ngang md ta.
Cdmdu'^>
Cd mau dugc tinh theo cdng thiic:
z ^ ^ p ( l - p )
Ddnh gid kei qud do duong huye¥^-^>
Vdi a = 0,05, Z = 1,96 gia tri tai dp tin cay 95%, P = 0,65 ty le udc doan, d = 0,05
Co mau can cho nghien ciiu nay la n = 91 Trong do p = 0,65 la ty le udc doan dua vao ket qua nghien ciiu ciia Levent Odemir va cs.*^^*.
Quy trinh nghien cuu
Tat ca cac doi tugng dugc nghien ciiu se dugc hudng dan cac ndi dung can tuan thii.
Cac ddi tugng tiida cac dieu kien se dugc thu thap cac thdng tin co ban, nhan trac va cac thdng tin ve yeu to nguy co ciia dai thao dudng, giai thich lai quy trinh lay mau va ghi lai ket qua thuc hien.
Do huyei dp
Phan loai huyet ap Iheo tieu chuan JNC VH.
Tinh chi sokhoi ca the (BMI)
Tinh BMI theo tieu chuan ciia hiep hpi dai thao dudng Ddng Nam A.
< 126 mg/dl »
I
alOOffig/dl ^
< 200 mg/dl ^
I
' l l O m g / d t ^
Ddi tugng dupc chan doan la cd mac tien dai thao dudng khi ket qua tiiuc hien do:
- Glucose liic ddi la tiong khoang > 100 mg/dl den < 126 mg/dl (5,6-7,0 mmolA)
- Hoac nghiem phap dung nap glucose bang dudng udng tir > 140mg/dl den < 200 mg/dl. (7,8- 11,1 mmol/1) va dudng huyet liic ddi < 126 mg/dl (7,0 mmolA)
Ndng dp glucose mau toan phan thap hon ndng do glucose mau huyet thanh khoang tir 10% den 12%. Do dd, cac doi tugng co ket qua do glucose mau mao mach cd gia tri dudng huyet ngoai miic binh thudng se dugc danh gia la cd nguy co mSc tien dai thao dudng hoac dai thao dudng.
Xu ly so lieu
Phan ti'ch sd lieu: phan mem EXCEL 2007 va SPSS 16.0
KETQUANGHIEN CUtf
Chiing tdi tien hanh chgn 98 hgc vien tien 114 hpe vien dupc mdi vao nghien ciiu (dgt 92%).
l a n suat nguy co mac tien dai thao duong Trong nghien a i u ciia chiing tdi, tan suat nguy CO mac tien dai thao dudng tai thdi diem do dudng huyet liic ddi (liic 0 phiit) la 23,5%, khdng phat hien truong hpp nao cd dai thao dudng. So vdi ket qua dudng huyet sau thuc hien nghiem phap dung nap glucose (liic 120 philt), & i suat nay la 26,5% va ciing khdng phat hien trudng hpp nao cd dai tiiao dudng.
180
Y Hoc T P . H o C h i M i n h * T a p 15 * So 3 * 2011 N g h i e n c u u Y h o c
vd tuoi
f 1. TUn suai nguy co mdc tien ddi thdo du&ng
^ ^ ^ ^ Tuo Kit q u a ^ ^ ^
Dung ngp binh thuffng Tien dai tiiao
difcmg Tong
21.30 25 77,3%
7 22%
32 100%
31.40 45 73,8%
16 26,2%
61 100%
41-50 2 66,7%
1 33,3%
3 100%
>so
0 0%
2 100%
2 100%
Tong 72 73,5%
26 26,5%
98 100%
Bdng 2. Tan suat nguy va giai
^~' - ^ ^ ^ Gidl Kit qua . , . ^ Dung nap binii tiiudng
Tien dai thao (Juong Tong
CO miic tien dai tlldo duang
Nam 33 76.7%
10 23.3%
43 100%
Ni>
39 70,9%
16 29,1%
55 100%
Tfing 72 73,5%
26 26,5%
98 100%
Tiin suat nguy ca mac tien dai thao dudng tang theo tuoi, chua tim thay su lien quan cd y nghla thdng ke giira tan suat mac tien dai thao dudng (x^ = 3,01, p=0,39).
Bdng3. Tan suof nguy co mac tien ddi thdo du&ng v&i tien can hut thuo'c la, cd phe vd gia dinh Chua tim thay sij lien quan cd y nghia thong ke giiia tan suat mSc tien dai thao dudng va gidi trong nghien ciiu nay (x^ = 0,271, p=0.672)
KM qua Dung ngp binh
thuwig Tiln dii thao
duong T6ng
Hut thudc la Khong hut
59 69,5%
26 30,5%
86 100%
Co hut 13 100%
0 0%
13 100%
Tfing 72 73,5%
26 26,5%
98 100%
Caphe Khdng dung
36 67,9%
17 30,5%
53 100%
Co diing 36 80%
9 20%
45 100%
Tfing 72 73.5%
26 26,5%
98 100%
Gia dinh (mic DTD ho^c tiln DTD) Khong c6
66 78%
19 20%
85 100%
Co 6 46,2%
7 53,8%
13 100%
Tfing 72 73,5%
26 26.5%
98 100%
Khdng cd su lien quan cd y nghia thong ke giiia (an suat mic tien dai thao dudng vdi tiiuoc la (x^ - 3,734, p=0.672), ca phe (x^ = 1,482,
p=0.223) nhung cd su lien quan vdi tien can gia dmh (x^ = 4,508, p=0.034) (RR=2.69)
Bang 4, TSn suai
^ ^ ^ T l i l d y c K l t q u i ^ ^ ^ ^
Dung nap binh thu&ng Tien dai thao duong
Tong
nguy ca mac tien ddi thdo ducfng v&i hoat diing T i l l dye
Khfing 46 66,7%
23 33,3%
69 100%
Cfi 26 89,7%
3 10.3%
29 100%
helitc, BMI va tinh trang huyei dp BMi
<18.5 8 72.8%
3 272%
11 100%
18.5.22.9 46 75,4%
15 24,6%
61 100%
23- 24.9 8 58.2%
6 42.8%
14 1X%
>25 10 83.3%
2 16.7%
12 100%
Huydt ap Binh thumig
43 81,1%
10 18,9%
63 100%
Khong binh thufimg 29 89,7%
16 35,5%
45 100%
Tan suat nguy co mic tien dai thao dudng d nhdm khdng cd choi hoac tap luyfn the thao cao hon nhdm cdn lai (33,3% so vdi 10,3%).
Cd su lien quan giiia viec choi the thao va tan suat m i c tien dai thao dudng (x^ = 4,508, p = 0,034) (RR = 3,23).
Chua tim thay sy lien quan co y nghla thdng ke giua tan suat mac tien dai thao dudng va chi so khoi co the trong nghien ciiu nay (Y=-0,03, p=0,901).
Tan suat nguy co mac tien dai thao dudng
tang theo huyet ap, tii 18,9% d nhdm ngudi cd huyet ap binh tiiudng den 35,5% d nhom ngudi cd huyet ap vugt miic binh thudng (tien tang huyet ap va tang huyet ap). Chua tim thay su lien quan cd y nghia thong ke giiia tan suat mac tien dai thao dudng va huyet ap trong nghien cihi nay (x^ = 2,378, p=0,123).
Kha nang rut ngin tiioi gian lam nghiem phap dung nap glucose
Cd 48 ddi tugng nghien ciiu cd miic dudng huyet trd ve binh thudng d phiit thii 90, trong
Nghien cihi Y hoc Y Hoc TP. Ho Chi Minh * Tap 15 * So 3 * 2011
do CO 93,7% (n-42) dat gia tri binh thucmg cho den Idii thvr hi?n xong nghiem phap. Chi so kappa khi so sanh ket qua quan sat tai thoi diem 90 phiit va 120 phiit la 0,393.
Kitqua fiphut
120
Dung nap binh thufing Dung nap bat
thuong Tong
Kit qua 0- phiit 90 Dung nap
binh thu&ng
45 93,7%
03 6,3%
48 100%
Dung n^p bit t h u ^ g
27 54%
23 46%
50 100%
Tfing
72 73.5%
26 26.5%
98 100%
BANLUAN
I ^ suat nguy ca mac tien dai thao dtrcmg Tfln sudi nguy ca
Ti le nguy co mac tien dai dudng trong mau nghien ciiu tai thdi diem 0 phiit la 23,5%, khdng ghi nhan trudng hgp nao cd dai thao dudng.
Sau khi thye hien xong nghiem phap, chiing toi xac dinh dugc tan suat nguy co mac tien dai tiiao dudng la 26,5%. Tan suat nay tang len do CO mpt so ddi tugng dugc danh gia la bmh thudng tai thdi diem 0 phiit va cd ket qua nguge Iai sau 120 phiit tiiuc hien nghiem phap. Dieu nay ciing phu hpp vdi nhiing ghi nhan trong y van ve danh gia hieu qua ciia nghiem phap dung nap glucose*^"'. Do dd, trong thuc hanh tam soat tien dai tiiao dudng cho cac ddi tijpng nguy CO cao trong cdng dong, nghiem phap dung nap glucose van cdn c"an thiet. So vdi bao cao oia Tran Van Binh"«), nam 2002, nghien ciiu dau tien ve mat do phan bd ciia dai thao dudng (DTD) tai benh vien ngi tiet tiring uong cho tiiay mat do nay tai ndng tiidn la 2,7% va tiianh tiii la 4,4%. Den 2006, mat do phan bd benh nay la 2,6%, ti le rdi logn dung ngp glucose la 7,3%.
Nam 2007, tiieo bao cao a i a Sd Y Te tinh Bmh Dmh, ldi loan dudng huyet liic ddi 20,34%, rdi loan dung ngp Glucose 11,07%. Nam 2009, U Quang Minh, Phgm Thi Hong Van, Nguyen Minh Tuan phat hien 18,9% cd roi logn dung ngp glucose mau; 24,9% rdi logn glucose mau
liic ddi; 22% nam gidi va 17% nir cd roi logn dung nap glucose mau'^l
tan suat nguy ca tten ddi thdo duang vd mot so'yeu to lien quan
Ve tien can gia dinh, chiing toi ghi nhgn tan suat nguy co mac tien dai thao dudng d nhdm cd tien can gia dinh (cha me, anh chi em rudt, con rupt) mac tien dai thao dudng hoac dai thao dudng cao hon nhdm cdn lgi (53,8% so vdi 20%).
Cd su lien quan giiia tien can gia dinh va tan suat mac tien dai thao dudng (x^ = 4,508, p=0,034)(RR=2,69). Nhu vgy, ngudi cd tien can gia dinh mac tien dai thao dudng hoac dai thao dudng cd nguy co mac tien dai thao dudng cao gap 2,69 Ian so vdi ngudi khdng cd tien can nay.
Nhu vgy, tam soat tien dai thao dudng can chii y tiiuc hien d doi tugng nay.
Ve van dpng tiie luc, chiing tdi ghi nhan tan suat nguy ca mac tien dai thao dudng d nhdm khdng cd choi hogc tap luyen the thao hon nhdm cdn lai (33,3% so vdi 10,3%). Co su lien quan giiia viec choi the thao va tan suat mSc tien dai tiiao dudng (x^ = 4,508, p=0,034)(RR=3,23).
Nhu vay, ngudi cd loi sdng tihh tgi, khdng tham gia cac hogt ddng hoac tap luyen the due cd nguy CO mac tien dai thao dudng cao gap 3,23 lan so vdi ngudi cd tham gia cac hoat ddng nay.
Nhu vay, tam soat tien dai thao dudng can chii y thuc hien d doi tugng nay va khuy«i khich hon niia viec tap the due.
Ve chi so khdi co the^ chiing tdi chua tim thay sy lien quan cd y nghia thong ke giira tan suat mac tien dai thao dudng va chi so khoi co the trong nghien Cliu nay (y=-0,03, p=0,901)
Ve huyet ap, tan suat nguy co mac tien dai thao dudng tang theo tinh trgng huyet ap, tir 18,9% d nhdm ngudi co huyet ap binh thudng d&i 35,5% d nhdm ngudi cd huyet ap vugt mirc binh thudng (theo JNC VII). Chua tim thay su hen quan cd y nghia thong ke giiia ihx suat mac tien dai thao dudng va tinh tiang huyet ap tiong nghien o i u nay (x^ = 2,378, p=0,123). Tuy nhien, do chiing tdi chi tien hanh thu nhan cac trudng hgp khdng dimg thudc va tiong quan the
Y Hoc T P . H o C h i M i n h * Tap 15 * So 3 * 2011 N g h i e n cmi Y h o c
nghien cuu oia chiing tdi da sd la d miic tien tang huyet ap nen cd the chiing tdi chua xac dinh dugc moi lien quan giiia tien dai thao dudng va tang huyet ap. EHeu nay can dugc tiiuc hien tren mot nghien cihi cd quy md hon niia.
Theo nghien ciiu ciia Dd Thi Tinh®, huyet ap ddng mgch, chi so khdi co the va chi so vdng eo/vdng hdng a i a nhdm DTD va roi loan dung ngp glucose deu cao hon so vdi nhdm ngudi Hnh thudng.
Kha nang rut ngan thoi gian lam n g ^ e m phap dimg n ^ glucose
De so sanh ket qua do dudng huyet mao mgch tgi thdi diem 90 phiit va 120 phiit, chiing tdi tinh chi so kappa khi so sanh ket qua quan sat tgi tiidi diem 90 phut va 120 phut la 0,393, nghla la chua cd su dong nhat cao ve mat ket qua chung. Do dd, tai ca cac ket qua tgi thdi diem 90 phiit khdng the dai dien cho thdi diem 120 phiit dupc. Dieu nay ding da dugc ghi nhgn trong y van va nhieu nghien ciiu khac nhau.
Tuy nhien, khi xet rieng cac tnrdng hgp dugc danh gia la binh thudng d phiit 90, chiing tdi ghi nhgn cd 48 doi tugng nghien ciiu cd miic dudng huyet trd ve binh thudng d thdi diem nay, trong dd cd 93,7% (n=45) dat gia tri binh thudng cho den khi tiiuc hien xong nghiem phap (phiit 120).
N h u vgy, cd mdt ti le cao cac trudng hgp cd gia tri binh thudng d phiit 90 va duy tii d a i phiit 120. Do dd, ta cd tiie can nhae d&i kha nang nit ngan thdi gjan thuc hien nghiem phap glucose tir 120 phiit cdn 90 phiit danh cho cac doi tirgng cd ket qua binh thudng tai thdi diem 90 phiit.
Dieu na\' cd y nghia quan trpng vi nd gdp phan gjiip ich cho cac nha nghien ciiu lam sang, dich te hgc \'a doi tugng tham gia nghien ciiu. Doi vdi cac nha nghien ciiu, khi nghiem phap dupc nit ngan se gdp phan giam chi phi va tiidi gian.
Trong nghien ciiu nay, 49^o (n=48) doi tugng nghien ciiu dupc danh gia binh thudng d phiit thii 90 nen cd the tiet kiem den gan 50% chi phi cho Ian thuc hien cudi cimg trong toan bp qua trinh lam nghiem phap. Doi vdi cac ddi tugng
tham gia se giam bdt dugc mdt Ian thirc hien mdt ky thuat xam lih \ a gay dau, dong thdi ding gia tang su thoai mai va tiet kiem thdi gian. Theo ket qua tren, cd den gan 50% cac ddi tupng cd tiie dimg lai tgi phiit 90. Tuy nhien, can cd nhieu nghien cuu quy md hon niia de xac dinh them ve kha nang va phgm vi nit ngan thdi gian thuc hien nghiem phap.
Chiing tdi cho ring thdi gian 2 gid can cho viec thye hien nghiem phap la kha lau va la mot trong nhihig rao can doi vdi viec iing dung nghiem phap nay trong khi hieu qua sang lgc,
^ m soat cua nghiem phap nay la rat tot. Chiing tdi hy vpng kha nang nit ngin tiidi gian lam nghiem phap nay se giiip giam bdt rao can trong viec iing dung de tam soat tien dai thao dudng, gdp phan giam ganh ngng chi phi cho ca nhan va xa hdi.
KETLUAN
Qua nghien ciiu 98 hpe vien den thuc tap tai Bp mdn sinh ly hpe - Dai hpe Y Dugc thanh pho Ho Chi Minh, chiing tdi nit ra nhiing ket luan sau:
Tan suat roi loan dung nap glucose {tien dai thao dudng) la 26,5%
- Ngudi cd tien can gia dmh cd nguy ca mic tien dai tiiao dudng cao gap 2.69 Ian so vdi ngudi khdng cd tien can nay.
- Cd sy lien quan giua viec choi the thao va fei suat m3c tien dai thao dudng. Ngudi cd loi sdng finh tai, khdng tiiam gia cac hogt ddng hoac tap luyen the due cd nguy co mic tien dai Ihao dudng cao gap 3.23 Ian so voi ngudi cd tham gia cac hogt ddng nay.
- Ghi nhan tan suat nay cd gia tang theo tud'i.
Cd kha nang nit ngan thdi gian thuc nghidm phap dung nap glucose danh cho cac doi tugng cd ket qua binh thudng tgi thdi diem 90 phiit va ti le trudng hpp dugc nit ngan la 49%.
TAI UEUTHAM KHAO
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