NONG DO UPID M A U TREN BENH NHAN VAY NEN

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NGHIEN Cirtj KHOA HQC

NONG DO UPID M A U TREN BENH NHAN VAY NEN

TAI B E N H V I E N D A L l l u T H A N H PHO HO CHI MINH

Nguyen Tat Thang*, Le Minh Phuc*

T6MTAT

M d d a u t V I ' y nen la m d t benh da viem man tfnh I n h hudng de'n h o n 2% d i n sd,cd the lien quan den su gia t i n g benh s u i t va t d suat eCia e l e bien ed t i m mach, hdi chdng chuyen hda, rdi loan lipid m a u . . . Nghien edu nay giup d i n h g i i ndng dp lipid m i u tren benh nhan vay nen tai Benh vien Da lieuTRHCM, t d d d giup ich t r o n g viec tam s o l t v l dieu tri sdm rdi loan lipid m i u n h i m phdng ngda xd m d ddng mach tren benh nhan vay nen.

Muc t i e u : So s i n h ndng d p lipid cua benh nhan v l y nen vdi ngudi binh t h u d n g , t i m mdi lien quan gida ndng do lipid mau vdi c l e yeu t d nguy co, thdi gian benh va dp nang cua benh.

P h u o n g p h a p : Nghien edu cat ngang phan tich tren 50 benh nhan vay nen v l 50 ngUdi blnh t h u d n g .

Ket q u i

Ndng dp triglyceride d benh nhan vay nen eao hdn ngudi binh t h u d n g (p =0,02).

Ndng dp HDL d benh nhan vay nen thap hon ngudi binh t h u d n g (p =0,001).

Khdng cd sU khae biet ve ndng d p cholesterol TP, LDL.

Khdng cd m d i t u o n g quan gida n d n g d d lipid mau eua benh nhan vay nen va eae yeu t d nguy CO, thdi gian benh.

Ndng d p LDL ed lien quan den d d nang cua benh vay nen (p =0,02).

Ket luan: Can tam s o l t rdi loan lipid m i u tren benh nhan vay nen nham phdng n g d a x o m d d d n g maeh va eac bien chdng eOa nd.

TCr k h o a : v l y nen, rdi loan lipid m i u .

I. M d o A u tang stress oxy hda, giam k h i n i n g ehdng oxy Vay nen I I m d t benh da viem man t i n h I n h

hudng den h o n 2 % d i n sd. Benh cd the lien

hda "^'•^'^' va nhdng yeu t d nguy ca k h i c nhU t i n g huyet ap, beo phi, tieu d u d n g lien quan den vay nen.

quan den sU gia t a n g benh sua't va tOr sua't ciia g . ^ ^ ^ . ^ ^, ^ g , ^ . . ^ ^ ^ ^ ^^.^ ^^^^^ ^ ^ . ^ cac bien co t i m nnach, dac biet la 6 nhOng tradng ^,jy „ - „ ^ ^ ^ ,^=1^ ^^ f^^^„ gg, „ g p g j ^ ^ j ^ H p y hop vay nen nang va Iceo d a i ' " . Co nhieu yeu to g j y ^o vCfa mach n h u tang triglyceride, tang n h u nong dp lipid va lipoprotein bat t h u d n g , cholesterol toan phan, t a n g LDLc, tang VLDLc,

va giam nong d o HDLc i'U'in«J"i.mu'!l.

• Bo mdn Da lieu, Bai lioc Yduac TPHCM. Theo hieu biet cua chung t o i , hien chua Co Phin biin Ichoa hoc PGS. TS Tran Lan Anh. nghien cufu nao ve van de tren tai Viet Nam, vi

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NGHliN CLTU KHOA HOC

vly chung tdi tien hanh nghien edu so sinh ndng dp lipid miu tren benh nhin vay nen so vdi ngUdi blnh thudng khde manh. Nghien cdu niy giup danh gia ndng dp lipid miu tr^n b^nh nhan vly n^n tai B$nh vien Da lieu TR HCM, td dd giiip ich trong viec tam soat va dilu trj sdm rdi loan lipid mau nhim phdng ngda xo md ddng mach tren benh nhin v^y nen, cli thien tien lupng sdng va chat lUpng cudc song cho benh nhin.

Muc tiiu nghien edu

So sinh ndng dp lipid cua benh nhin vly nen vdi ngudi binh thudng, tim mdi lien quan gida nong do lipid miu vdi cac yeu td nguy cd, thdi gian benh va dp nang cua benh.

II. D6\ Tl/GTNG VA PHl/ONG PHAP NGH|£N COTU Thiet ke nghien cdu

Cit ngang phan tich

d'

n = 50

Tieu chuan chon mau Tiiu chf chgn vdo

Khdng thupc tieu chi loai trd.

Nhdm ngudi binh thudng duoc chpn bit cSp vdi nhdm benh ve tudi v l gidi tinh.

Tiiu chf logi trd

Khdng ddng y tham gia nghien cdu.

NgUdi cd benh gay tang lipid mau thiJ phat nhu. nhupc giap, tieu dUdng, hdi chdng than hu, suy than man, benh md lien ket.

• Trong vdng 6 thang trd lai cdsd dung Ccic thudc: dc che beta, thiazide, corticosteroid, retinoids, cyclosporine, va nhdng thudc ha lipid miu.

Chi sd khdi CO the (BMI) >30.

Cd thai hole dang eho eon bu.

III. K^TQUA NGHIEN CUTU

DAC DIEM DjCH TE VA YEU TO NGUY CO

Bdngl. Dgc diem dich te vdyeu tdnguy ecf cua ddi tUc/ng nghiin edu

Dac diem Gidi

Nam Na

Tuoi

Huyet ap tam thu (mmHg)

<140 140-159

>160

Huyet ap tam trUtfng (mmHg)

<90 9 0 - 9 9 BIVII (kg/m')

Nhom benh In = 50)

37 (74%) 13(26%) 40,76114,34

(tC;15-80)

41 (82%) 8(16%)

1(2%)

40 (80%) 10(20%) 21,53 ±2,9 ( t i n 6 - 2 8 )

Nhom ngucri binh thucmg (n = 50)

37 (74%) 13 (26%) 40,20 ±10,53

(tir 1 7 - 6 5 )

46 (92%) 4(8%) 0(0%)

45 (90%) 5(10%) 22,34 ± 2,8 (til 1 7 - 3 0 )

So sanh

Khong khac biet

p = 0,82

p = 0,14

p = 0,16

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NGHIEN CI/U KHOA HOC

Hoat dong the luc Kh6ng deu 1 lan/tuin

> 1 lan/tu^n Hut thuoc 1

Khong bao gid Hang ngay Thinh thoang Trade day (da bo) Uong ri/0u, bia

Khong bao gid 1 lan/thang 2 - 4 l a n / t h a n g

^ - 3 lan/tuan

> 3 lan/tuan

30 (60%) 4(8%) 16(32%)

23 (46%) 19(38%) 3 (6%) 5(10%)

22 (44%) 5(10%) 12(24%) 9(18%) 2(4%)

31 (62%) 7(14%) 12(24%)

28 (56%) 11 (22%) 6(12%) 5(10%)

19(38%) 12(24%) 14(28%) 3(6%) 2(4%)

p = 0,5

p = 0,31

p = 0,18

Nhgn xet: cdc dgc diem chung giOa 2 nhdm khac biit khong co y nghia thong ke (p > 0,05)

M p T S O D A C D I E M L l g N QUAN D^N BENH VAY NEN Thdi gian benh

Thdi gian benh t r u n g binh la 7,48 ± 6,52 nam, trong d d benh nhan m i c benh keo d i i it nhat la 1 nam, nhieu nhat I I 27 n i m .

Chi so PASI

Td 2,7 de'n 37,3 va t r u n g binh; 18,88 ± 10,18

P h i n loai: mdc d p nhe: 15 benh (30%), mdc do vda: 35 benh (70%) Phan loai lam sang

Vay nen m I n g : 38 (76%), vay nen giot: 2 (4%), vay nen m u : 4 (8%), do da toan t h i n do vay nen: 6 (12%).

SO SANH N d N G D O LIPID MAU GlffA BENH N H A N VAY N^N VA NGUOl B ) N H T H U O N G Bdng 2. So sdnh nong dp lipid mdu gida benh nhdn vdy nin va ngUcfi binh thUcmg

Loai lipid (mmol/dl) Triglyceride Cholesterol TP HDL LDL

Nhom vay nen (n = 50) 1,64 ±0,98 4,15 ±1,16 1,36 ±0,65 2,04 ±1,20

Nhom ngudi blnh thucmg (n = 50)

1,23 ±0,73 4,26 ± 0,95 1,84+0,77 1,86 + 0,98

So sanh p = 0,02 p = 0,61 p = 0,001 p = 0,41 Nhan xet: nong do triglyceride nhom benh cao han nhom ngudi binh thudng cd •y nghia thong ki (p = 0,02);

nong dp HDL nhom binh thdp han nhdm ngUdi binh thudng co y nghta thong ke (p = 0,001)

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NGHIEN Ciftl KHOA HOC

IVI61 L I C N Q U A N GICJA N 6 N G 0 0 L I P I D M A U V A T H t f I GIAN B E N H

Bdng 3. Nong So lipid mdud benh nhdn vay nen theo thdi gian benh

Loai lipid (mmol/dl) Triglyceride Cholesterol TP HDL LDL

Nhdml ( # 2 n J m |

n = 1 6 1,59 ±0,61 3,91 ±0,98 1,38 ±0,58 1,81 ±1,04

Nhom II (> 2 - 9 nam)

n = 18 1,98 ±1,44 4,30 ±1,02 1,63 ±0,85 1,77±1,01 .

Nhom III (> 9 nam) n = 16 1,32 ±0,42 4,23 ±1,49 1,05 ±0,22 2,.58±1,42

So sanh

p = 0,14 p = 0,60 p = 0,049

p = 0,09 Nhan xet: nong 66 lipid mau gida cdc khodng thdi gian b^nh khdc biit khong co j? nghia thong ke (p > 0,05)

M 6 | Utti QUAN GlO^A N 6 N G D d LIPID M A U V A D O NANG C O A B £ N H

Bdng 4. Nong dp lipid mdu d binh nhdn vdy nen theo dp ndng cda benh (chi sdPASI) Loai lipid

(mmol/dl) Triglyceride Cholesterol TP HDL LDL

Nhe (PASI: 0 , 1 - 1 0 , 9 ) n = 15 1,44 ±0,50 3,69 ± 0,87 1,62 ±0,88 1,42 ±0,80

VUa (PASI: 11 - 49,9) n = 3 S 1,73 ±1,12 4,35 ±1,23 1,25 ±0,51 2,31 ± 1,25

So sanh p = 0,98 p = 0,06 P = 0,12 p = 0,02 Nhdn xet: nong do LDL nhom mdc do vda cao han nhdm mdc dp nhe co y nghia thong ki (p - 0,02}

MOI LIEN QUAN GlffA NONG D O LIPID M A U V O I C A C YEU TO NGUY CO 6 BENH N H A N VAY NEN Bdng 5. Lipid mdu vd HA tdm thu

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

H A T A M T H U

<140 140-159

N 41 8 41 8 41 8 41 8

N 6 N G D d (mmol/dl) 1,61 ±0,98 1,83 ±1,05 4,12±1,18 4,19 ±1,18 2,05 ±1,19 1,96 ±1,36 1,33 ±0,66 1,39 ±0,56

SO S A N H p = 0,76

p=0,78

p = 0,98

P = 0,35

Nhan xet: Nong do lipid mdud benh nhdn vay nen gida cdc mdc huyet dp tdm thu khdc biet khong co y ngUia fhong ke

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^ ^ ^ NGHIEN ctiu KHOA HQC

B d n g 6. Lipid mau vd HA tdm trUdng

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

H A T A M T R I / O N G

<90 90-99

N 40 10 40 10 40 10 40 10

N 6 N G S 6 (mmol/dl) 1,66 ±1,08 1,54 ±0,36 4,14±1,21 4,16 ±0,99 1,92 ±1,25 2,20 ±1,00 1,39 ±0,68 1,24 ±0,51

SO S A N H P = 0,71

p = 0,98

p = 0,62

P = 0,54

Nhan xet: NSng 36 lipid mdu d binh nhdn vdy nen gida cdc mdc huyet dp tdm tnrang khdc biet khong co y nghia thong ki.

Bdng 7. Lipid mdu vd BMI

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

BMI

<25

>25

<25

>25

<25

>25

<25

>25

N 44 6 44 6 44 6 44 6

NdNGOO (mmol/dl) 1,67 ±1,02 1,42 ±0,55 4,18 ±1,20 3,88 ± 0,80 2,00 ±1,24 2,30 ± 0,87 1,42 ±0,67 0,93 ± 0,21

SO S A N H p = 0,56

P = 0,55

P = 0,57

p = 0,08

Nhan xet: NSng do lipid mdu dbenh nhdn vdy nen gida nhdm co BMI <25 vd nhom co BMI >25 khdc biet khong coy nghia thong ke.

Bdng 8. Lipid mdu vd udng rUgu bia

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

UONG RL/cru Khong

Co Khong

Co

N 22 28 22 28 22 28 22 28

N d N G S p (mmol/dl) 1,43 ±0,52 2,07 ±1,34 4.23 + 1,30 4,64±1,12 2,34 ±1,28 2,28 ±1,48 1,23 ±0,38 1,42 ±0,66

S O S A N H P = 0,35

P = 0,52

P=0,91

p = 0,40

Nhdn xet: Nong dp lipid mdu d binh nhdn vay nen gida ngUdi co uong va ngUdi khong uong ruau bia khdc biet khong co y nghia thdng ke.

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NGHIEN CUU KHOA HOC

Bdng 9. Lipid mdu vd hiit thuSc Id

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

H 0 T T H U 6 C

KhSng C6 Khang

C6 Khing

C6 Khong

Co

N 23 27 23 27 23 27 23 27

NdNG D d (mmol/dl) 1,43 ±0,51 1,82 ±1,23 4,33 ± 1,25 3,99 ±1,07 2,27 ±1,30 1,83 + 1,08 1,41 ±0,76 1,32 ±0,55

SO S A N H P = 0,13

p = 0,29

p = 0,20

p = 0,63

Nhdn xet: Nong do lipid mdu d benh nhdn vdy nen gida ngUdi c6 hut thuoc Id va ngudi khong hut thuoc khdc biit khong c6 y nghia thong ke.

Bdng 10. Lipid mdu vd hogt dpng thelUc

TRIGLYCERIDE

CHOLESTEROL

LDL

HDL

HOTT Khong deu

1 lan/tuan

> 1 lan/tuan Khong deu 1 lan/tuan

> 1 lan/tuan Khong deu

1 ian/tuan

> 1 lan/tuan Khong deu

1 lan/tuan

> 1 lan/tuan N 30 4 16 30 4 16 30 4 16 30 4 16

NdNG O d (mmol/dl) 1,72±1,16 1,42 ±0,28 1,55 ±0,68 4,32 ±1,23 4,37 ±1,06 3,77 ±1,00 2,08 ±1,29 1,84 ±1,00 2,04 ±1,20 1,45 + 0,78 1,20 ±0,43 1,22 ±0,34

SO S A N H p = 0,77

P = 0,29

P = 0,57

p = 0,46

Nhan xet: Nong dp lipid mdu d benh nhdn vdy nen gida cdc mdc do hoat dgng the ldc khdc biit khong c6f nghia thong ke.

IV. BAN LUAN

Cae die diem djch te va yeu td nguy co (tudi, gidl tinh, huyet ap, chi sd khdi ca the, BMI, hoat ddng the lUc, hut thude II, udng rupu bia) dUpc phin tich d tren cd the anh hudng den c l benh

vay nen lan ket q u i ndng dp lipid mau cCia ck ddi tupng nghien cdu. Su phan bd cic die dilm tren gida nhdm benh vay nen v l nhdm ngiJdi binh thudng trong nghien cdu cua chiing toi khdng thay sU khac biet ed y nghta thong ke

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NGHIEN CUU KHOA HOC

(Bang 1). Do v l y chung tdi cd t h e so sanh n d n g dp lipid m i u gida 2 n h d m vdi sU han che tdi da cac yeu t d gay nhieu. Tuy nhien, cung ed the do cd mau nghien cdu chua d u Idn, nen neu cd dieu kien ehung ta cd t h e t i e n hanh nghien cdu vdi cd mau Idn hon de ket qua nghien cdu ed g i i t n v l dp tin e l y cao hon.

Trong sd 5 loai lipid m i u dupe xet nghiem, ndng dp triglyceride cOa n h d m benh cao hdn n h d m ngudi binh t h u d n g , t r o n g khi n d n g do HDL n h d m benh thap hdn n h d m ngudi binh t h u d n g cd y nghTa t h d n g ke (p < 0.05). Ndng dp cholesterol TP va LDL khdng ed sU khac biet cd y nghia t h d n g ke (p > 0.05). IVlae du su khac biet khdng ed y nghTa t h d n g ke nhUng nong d d cholesterol TP n h d m benh lal hoi thap so vdi nhdm ngudi binh t h u d n g ( B i n g 2).

Cd nhieu nghien cdu ve n d n g dp lipid m i u tren benh n h i n vay nen so vdi ngUdi binh t h u d n g khde manh nhung cho ke't qua khdng thdng nha't Su khac biet cd y nghTa t h d n g ke cua cac tri sd lipid mau gida benh nhan vl'y nen va ngudi blnh t h u d n g thay ddi theo t d n g nghien cdu d khap noi tren t h e gidi nhU: khac biet ve nong dp cholesterol TP ed y nghTa [m&umu]^ khac biet ve n d n g dp LDL cd y nghTa '^^••^'''"', g i i m HDL cd y nghTa cua n h d m benh so vdi n h d m ngudi bTnh t h u d n g '^'''", khac biet cd y nghTa cua VLDL "''"I't^', va triglyceride i^^'™'". Chi mpt sd ft nghien cdu eho ket q u i khdng cd sU khac biet ve nong dp lipid mau gida n h d m vay nen va n h d m ngudi binh t h u d n g '"'•'". Nhdng ket q u i khdng nhat quan ke tren ed the do sU bien ddi nhanh chdng n d n g dp lipid mau, I n h hUdng cua che dp an, theo mua, ehCing tdc, di truyen, hormone va nhdng yeu t o k h a c c h u a biet r d . V I khdng mdt nghien cdu nao ed the kiem soat het t a t c a cac yeu t d nay.

Ndng dp cac lipid mau eua benh n h i n vay nen xet theo e l c yeu t d nguy co la huye't ap t i m t h u , huyet ap tam t r u o n g , chi sd khdi c o t h e BlVli,

hoat d d n g the luc, d n h trang hut thudc I I va udng rupu bia t r o n g nghien cdu eua ehung tdi la khac biet khdng cd y nghTa t h d n g ke (Bang 5,6,7,8,9,10). 6 benh n h i n vay nen, n g o i i bat t h u d n g lipid mau cdn ed t h e m nhieu yeu t d nguy co mdi t r u d n g khac g d p phan vao viec lam tang bien cd t i m maeh n h u eae yeu t d nguy CO ma ehung tdi vda k h I o sat. Qua ket q u i tren ta thay nhdng yeu t d nay trong nghien cdu cua chung tdi khdng I n h hUdng den ke't qua ndng dp cac lipid mau cua benh nhan vay nen. Do vay, ngudi ta cho rang bat t h u d n g lipid m i u tren benh nhan vay nen cd le do di truyen quyet d m h hon la do mac phai.

Ndng do lipid m i u gida c i c k h o i n g thdi gian benh k h i c biet khdng ed y nghTa thong ke (Bang 3). Dieu nay ed nghTa la khdng ed sU lien quan gida ndng dp cae loai lipid mau vdi thdi gian benh t r o n g nghien cdu eCia ehung tdi, Ket qua nay tUOng dUOng vdi m d t sd nghien cdu Reynoso " " , Zari '^^', Trong mpt nghien cdu tai Iran, ehi LDL cd moi lien quan vdi t h d i gian benh '". Bieu nay cd the do khoang t h d i gian benh thay ddi khac nhau gida c l e benh nhaniatUOng ddi Idn nen khd phat hien mdi lien quan gida nong dp cac loai lipid mau theo thdi gian benh.

Vay nen la benh da viem mang tinh di truyen phdc tap, CO che sinh benh van ehUa dUpc biet rd. IVIdt sd tac g i i cho rang vay nen, gidng nhU xo vda d p n g maeh', la m d t benh t u mien. Hien nay cd rat nhieu bang chdng lam s i n g va thUe nghiem Cing hd vai t r d quan t r p n g eCia te bao T trong sinh benh hpc cua vl'y nen va xO vda ddng mach. Lam sang cCia 2 benh deu la hien t u p n g viem c o t h e d o e a e c y t o k i n e t e baoT,dac t r u n g cho d i p dng cua te bao T-helper 1. Chinh x l c khang nguyen nao khdi phat vay nen van ehua duoc xae dinh. Tuy nhien, gan d i y ngUdi ta thay vai t r d eua bat t h u d n g lipid tU nd eung tac d d n g len he t h d n g mien dieh. Cle tU khang the chdng LDL oxy hda d l dUpc t i m thay trong

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NGHIEN CUtJ KHOA HOC

benh vay nen. Theo n h d n g k h i m p h i nay, b i t t h u d n g lipid t r o n g benh vay nen vda khdi p h i t hien t u p n g xo vda d d n g maeh vda p h i t trien va duy tri p h i n dng viem tai da. Oieu t h i i vi la ndng dp khang t h e c h d n g LDL oxy hda ed tUdng quan vdi dp nang cCia b^nh t h d n g qua chl sd PASI "*'. Oieu nay p h u h p p vdi nghien edu cua ehung tdi ( B i n g 4), eung cho tha'y m d i li^n quan gida n d n g dp LDL vdi chi sd PASI, dan den g i i thuyet ve vai trd eua LDL t r o n g d d nang ci!ia benh. N g o i i LDL ra, n d n g d p cac loai lipid khac (triglyceride, cholesterol TP, HDL, VLDL) k h d n g cd sU lien quan vdi PASI.

V. KET LUAN

- Qua nghien cdu c h u n g tdi t h l ' y cd sU t a n g ndng dp triglycerid va giam HDL tren benh n h i n vl'y nen.

Khdng ed su khac biet ve ndng d p cholesterol toan phan, LDL.

- Khdng thay m d i t u o n g quan gida nong dp lipid m i u cua b e n h nhan v l y nen vdi cae yeu to n g u y c o , t h d i gian bj b e n h .

- Cd m d i lien quan vdi t a n g LDL vdi dp nang eCia b e n h .

Ki^n nghj

1. C l e benh n h i n vay n e n can dupe tam soat v l dieu trj sdm rdi loan lipid m i u n h i m phong ngda xo m d d d n g mach va c l e bien chdng cfla nd.

2. Ngoai ra, neu cd dieu kien c h u n g ta nen tien h l n h t h e m n h d n g n g h i e n c d u s l u honve hpi c h d n g chuyen hda, yeu t o n g u y co tim mach tren b e n h n h i n vay nen d Viet Nam cung nhU d i n h g i i vai t r d cua c l e t h u o c ha lipid m i u tren dien tien l i m sang eua b e n h , t d d d ed the ap d u n g de cai t h i e n t i e n l u p n g v l ehat lupng cuoc sdng cho b e n h n h i n vay nen.

TAI L I | U T H A M K H A O

1. Akhyani IVl, Ehsani AH, Robad RM, Robati AM (2007), "The lipid profile in psoriasis: a controlled study", J Eur Acad Dermatol Venereal, (21),pp1330-1332.

2. Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyeroviteh J (2008), "Association between psoriasis and t h e metabolic syndrome".

Dermatology, ('216), pp. 152-155.

3. Farshchian M, Zamanian A, Farshchian M, Monsef AR, Mahjub H (2007), "Serum lipid level in Iranian patients w i t h psoriasis", (21), pp. 8 0 2 - 805.

4. Feretti G, Simonetti O, Offidani A M , et al (1993), "Changes of plasma lipids and erythrocyte m e m b r a n e fluidity in psoriatic children", Pediatr Res, 33 (5), pp. 506-509.

5. Gisondi P, Tessari G, Conti A, Kane D, Lowe G, Melnnes IB (2007), "Prevalence of metabolic

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SUMMARY

THE LIPID PROFILE IN PATIENTS WITH PSORIASIS AT HOSPITAL OF DERMATO-VENEROLOGY IN HO CHI MINH CITY

Background: Psoriasis is a chronic inflammatory dermatosis which affects more than 2% of the population. This disease may be associated with an increased morbidity and mortality from cardiovascular events, metabolic syndrome, serum lipid abnormalities, etc. This study takes part in evaluating the lipid profiles in patients with psoriasis in Dermatology hospital in HCM city, which helps t o diagnosis and treat hyperlipidaemia early in patients w i t h psoriasis t o prevent the atherosclerosis.

Objective:To compare the lipid profiles in psoriatic patients w i t h non-affected individuals, to find correlation w i t h risk factors, induration and severity.

Method: Performing a analyzed cross-sectional study in 50 psoriatic patients and 50 healthy people.

Results: The serum triglyceride was significantly higher (p =0.02), and serum HDL was significantly lower in patients w i t h psoriasis (p = 0,001, respectively).

The serum cholesterol and LDL of psoriatic patients were not significantly different from those of healthy people.

There were no significant correlation between the lipid profiles and risk factors, and induration in psoriatic patients.

The correlation b e t w e e n LDL and PASI were significant (p = 0.02).

Conclusion: It is necessary t o do creening and treatment o f hyperiipidaemia early in patients with psoriasis to prevent t h e atherosclerosis and its complications.

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