VIETNAM MEDICAL JOURNAL N°2 - APRIL - 2018
THITC TRANG SUY DINH DlTaNG TRE EM D i r a i 5 TUOI TAI XA NGHI VAN HUYEN NGHI LOC TINH NGHE AN NAM 2 0 1 7
T O M TAT
Muc tieu: Xac djnh ty le nhe can, ty te gay com va t / le thap COI 6 tre em dUdi 5 tuoi tai xa Nghi Van huyen Nghi Lpc tinh Nghe An nam 20^17. PhUdng phap nghien cdu: Nghien ciru dich te hoc mo ta.
Kei qua: Ty le tre SDD the nhe can la 14,8% trong do nam la 14,2%, nU la 15,4%. t y le tre SDD thap col la 20,6%, trong do nam la 19,9%, xiH la 21,3%. Ty le tre SDD the gay com la 5,7%, trong do nam la 6,1%, nS la 5,0%. Ve ty le tre SDD d eac the tang dan theo nhom tudi.
Td khda: Nhe can; Gay com; Thap coi; Tre em dudi 5 tuoi.
SUMMARY
THE SITUATION OF MALNUTRITION OF THE CHILDREN UNDER 5 YEARS OF AGE I N
NGHI VAN COMMUNE, NGHI LOC DISTRICT, NGHE AN PROVINCE I N 2017
Objectives: Determining the percentage of malnutrition of children under 5 years of age in Nghi Van commune, Nghi Loc district, Nghe An province in 2017. Methods: The descriptive epidemiology method. Results: The percentage of underweight children is 14.8%, in which male and female were 14.2% and 15.4%, respectively. The percentage of stuntang children was 20.6%, in which male and female were 19.9% and 21.3%, respectively. The prevalence of poverty was 5.7%.
Key words: Light weight; Hang out; Stunting;
Children under 5 years of age.
I. DiQkT VAN DE
Suy dinh dUSng (SDD) d tre em hien nay dang la van de sUc khoe cdng dong dang dUdc quan tam d rat nhieu qude gia tren the gidi, dac biet la d eae nUde dang phat trien trong dd ed Viet Nam. Tlieo To chUe Y te the gidi (WHO), qua nghien ciTu 1,6 trteu trudng hdp tU vong d tre em tat eae nUdc dang phat trien nam 1996 cho thay: cd tdi 53% eac trudng hdp tir vong cd lien quan tdi tinh trang SDD va neu gdp ea SDD vdi eae benh thdng thUdng nhU tteu chay, viem phdi, sdt, sdt ret,... thi ty le nay la 74% [2].
_ O Viet Nam, vdt nhuTig thanh tUu trong cdng tac phdng chdng SDD tre em vai tliap ky qua, ty
*Trudng Dal hgc YDddc Thii Binh Chju trach nhiem chinh: Vu Trung Kien Email: [email protected] Ngay nhan bai: 18.2.2018 Ngay phan bien khoa hpc: 30.3.2018 Ngay duySt bai: 11.4.2018
Vu Trung Kien*, Ninh Thj Nhung*
le SDD tre em d the nhe can (can nang/tuoi) da giam tU 51,5% (1985) xudng cdn 14.1% (2015) [2]. Tuy nhien, theo nhan djnh eua Vien Dinii DUdng Qude Gla, viec giam t^ ie SDD tre em cl nUdc ta chUa thi/c sU ben vQ'ng. Ben canh do, van de SDD tre em d the thap edi (ehlBu cao/tuoi) van cdn dang d mUc rat cao 25,4 % [1]. Viec giam ty le SDD tre em d the thap coi nham nang cao tam vdc ngUdi Viet Nam la van de rat khd khan va can dddc quan tam diing mUc hdn.
Tai tinh Nghe An, cdng tae phdng chdng SDD tre em da dddc trien khai va dat diidc nhiing ket qua dang ke, ty le SDD tre em d the nhe can da giam tir 45.9% (1999) xudng edn 16.8% (2016) [7], chieu cao/can nang 28,5 % (2016). Tuy nhien, ty le SDD tre em giam khdng ddng deu giu'a cac dja ban, dae biet la d cae xa viing sau, viing cao v i n edn d mUc rat cao. Vdi mue dicli tim hieu ro hdn ve thUc trang SDD tre em ehung tdi tien hanh nghien cUu nham: Xac dinh ty li nhe can, ty le gay cdm va ty le thap col d tre em dddl 5 tud'i tai xi Nghi Van huyen Nghi Lgc tinh Nghe An nam 2017.
II. OOI TU'pMG VA PHU'ONG PHAP NGHIEN cOU Doi tu'dng va dja ban nghien cihi: La tre em dudi 5 tuoi tai Xa Nghi Van - huyen Nghi Lpc - tinh Nghe An.
Thdi gian nghien ciJu: TU thang 5/2017 den thang 9/2017.
Thiet ke nghien cii'u: Nghien ciTu djch t l hoc md ta qua cude dieu tra cat ngang.
C3 m l u nghien culi: Thay vao cdng thUe t'nh cd mau cho 1 ty le dddc od mau la 934 tre em.
Phu'dng phap chon may
Lap danh sach toan bd tre em dUdi 5 tuoi dang sinh sdng tai xa nglil Van theo dung tieu chuan chpn mau de chpn vao nghien culi danh gla tinh trang dinh dUdng.
Cac kV thuat ap dung trong nghien cifu - Tinh nhom t u o i / Sddyng each iinh tuoi cua WHO dang sd dung d Viet Nam
- Ky thuat can
- Ky thuat do chieu cao: Xac dinh ehieu d^i nam ciia tre dUdi 24 thang tudi va chieu cao dUng ciia tre tren 24 thang.
Phu'dng phap danh gia tinh trang dinh du'dng d t r e e m : SU dung cac sd do nhan trac
36
TAP CHi Y HOC VIET NAM TAP 465 - THANG 4 - SO 2 - 2018 dtnh dudng va phan ioai tre em theo WHO 2907
vdi eac chi sd: Can nang theo tudi (CN/T) (Weight for Age: W/A), Chieu cao theo tudi (CC/T) (Height for Age: H/A), can nang theo chieu cao (CN/CC) (Weight for Height: W/H).
+ Tre em nhe can: khi CN/T < - 2 SD
+ Tre em thap edi la tre em ed CC/T < - 2SD + Tre em gay com la tre em ed CN/CC <-2SD + Tre thif^ can beo phi la tre cd CN/CC > + 2SD Phu'dng phap xu' ly so lieu: SU dung phan mem Anthro 2005 4.0 de phan tich sd lieu nhan trac, so sanh vdi quan the tham khao ciia WHO.
III. KET QUA NGHIEN c i r u
Bang 3.1; Bac diem tre tham gia nghien cdu theo nhdm tudi va gldl tinh STT
1 2 3 4 5 6
Thang tuoi
< 6 thanq 6 - 1 2 thanq 13 - 24 thanq 25 - 36 thanq 37- 48 thanq 49- 60 thanq
Tong
Nam n 37 50 96 104 100 91 4 7 8
%
7,7 10,5 20,1 21,8 20.9 19.0 51,2
Nu- n 33 48 89 92 95 99 4 5 6
%
7,2 10,5 19,5 20,2 20,8 21,7 48,8
Chung n 70 98 185 196 195 190 934
%
7,5 10,5 19,8 21,0 20,9 20,3 100 TnDng so 934 tre du'cfc can do, co sir chenh lech giO^ tre nam va tre nu', tre trai chiem ty le nhieu hdn tre gai (51,2% va 48,8%). Sir ptian bo cac doi tUdng nghien cu'u tu'dng doi dong deu d cac nhdm tuoi 25-36 thang; 37-48 thang; 49-60 thang. Thap hdn d nhom 0 -12 thang va 13-24 thang.
Bang 3. 2. Phan bo tinh trang dmh dddng cua tre theo gidi tinh Cac the SDD
Gldl tinh SL
Gay com Ty le(%)
Thap coi
Ty le(%) Ty le(%l
Nam (n= 478) 19,9
Nif (n= 456)
Chung Cn=934) 21,3
52 5,7 192 20,6 138 14,8
P>0,05
Co SI/ l<hac nhau theo gidi tinh ve phan bo tinh trang dinh dirdng cua tre: the nhe can va thap coi d tre ni^ chiem ty le cao hdn la 15,4% va 21,3% con d nam chi chiem 14,2% va i 9 , 9 % , ty le suy dinh duSng the gay com tre nff cao hdn tre nam (0,6% - 0,5%). Tuy nhien sU khac nhau nay i<h6ng CO y nghla thong l<e vdi p> 0,05.
TT 1 2 3 4 5 6
Thang tuoi
< 6 thanq 6 - 1 2 thanq 13 - 24 thang 25-36 thanq 37 - 48 thanq 49 -60 thanq
Tong n 70 98 185 196 195 190 9 3 4
Gay com SL
0 2 4 11 19 16 52
Ty le(%) 0 2,0 2,2 5,6 9,7 8,4 5,7
Thap coi SL
9 21 53 47 34 28 192
Ty le{%) 12,9 21,4 28,6 24,0 17,4 14,7 20,6
Nhe can SL
6 11 31 34 24 32 138
Ty le(%) 8,6 11,2 16,7 17,3 12,3 16,8
..W..
Theo nhdm tuoi: Ty le SDD d tre dUdi 6 thang tudi la thap nhat ddi vdi ca 3 the (nhe can, thap cdi va gay cdm), sau do SDD tang dSn. Thdi ki tre 11-36 thang la thdi ki cd nguy cd bj SDD cao nhat. SDD tiie nhe can eao nhat d Mia tuoi 25-36 thang; the thap cdt cao nhat d \\ia tudi 13-24 thang;
va the gay cdm cao nhat d lite tuoi 37-48 thang.
Ty ie SDD d tre em the nhe can (can nang/
tudi) d "mire thap (14,8%), (<2b). J"y le SDD tre em d the thap cdt (ehieu cao/ tuot) d mUe cao (20,6%) va the gay cdm (can nang/ ehieu cao) d mire trung binh (5,7%). Ty le SDD tre^em phan bd d cae nhdm tudi, SDD tre e m j 3 the nhe can chiem ty le eao nhat d nhdm tudi 25-36 thang
(17,3%), trong khi ty le SDD tre em d the thap edi lai chiem ty ie cao nhat d nhdm 13 - 24 thang (28,6), ty ie SDD tre em d the gay com cao nhat d nhom 37 - 48 thang tudi (9,7%).
Ty le SDD d the Gay com d dp tudi dUdl 6 thang khdng xuat hien, tir nhdm tuoi tren 6 thang tudi bat dau xuat hien va cao nhat d nhdm tudi 37- 48 thang (9,7%), sau dd cd chieu hUdng giam d nhdm tuoi 49-60 thang (8,4%); ty le SDD d tre em the Nhe can thap nhat d nhdm tudi dudi 6 thang tudi (8,6%), va tang dan cao nhat d nhdm tudi 25-36 thang (17,3%), giam d nhdm tuoi 37-48 thang (12,3%) va cd ehieu hUdng tang dan d nhdm tuoi tir 49 - 60 thang (16,8%);
VIETNAM MEDICAL JOURNAL N°2 • APRIL - 2018
ty le SDD tre em 6 the Thap coi thap nhat d dan va d nhdm tuoi 49-60 thang tuoi d mfc nhdm tuoi du'di 6 thang tuoi (12,9%), cao nhat d 14,7%).
nhom tuoi 13-24 thang (28,6%), sau do giam
M i ^mMJm§^Wi
Bang
Bii'u do 3.1: Phan bdcac the SDD theo nhdm tudi 3. 4.TyleVo SDD the nhe can theo nhdm tudi va gldl tinh Thang tuoi
< 6 thanq 6 - 1 2 thanq 13 - 24 thanq 25-36 thanq 37 - 48 thanq 49 -60 thanq
Tong
Nam n
37 50 96 104 100 91 4 7 8
SL 2 4 14 18 11 19 68
%
5,4 8,0 14,6 17,3 11,0 20,9 14,2
Nff n
33 48 89 92 95 99 4 5 6
SL 4 7 17 16 13 13 7 0
%
12,1 14,6 19,1 17,4 13,7 13,1 15,4 Qua bang ta thay co sir phan bd khac nhau giij'a cac nhdm tudi d the nhe can, ty le SDD d nhom tuoi tCr 13-36 thang tiep dd la nhdm tuoi tir 37 - 60 thang.
Bang 3. 5. Ty le Vo SDD the Gay com theo nhdm tudi va gldl tinh Thang tuoi
< 6 thanq 6 - 1 2 thaiiq 13 - 24 thanq 25-36 thanq 37 - 48 thanq 49 -60 thanq
Tong
Nam n
37 50 96 104 100 91 4 7 8
SL 0 0 1 8 11 9 29
% - -
1,0 7,7 11,0 9,9 6 , 1
Nu' n 33 48 89 92 95 99 4 5 6
SL 0 2 3 3 8 7 23
% -
4,7 3,4 3,3 8,4 7,1 5,0 Co sir l<hac nhau ve phan bo ty le SDD the gay com theo nhdm tuoi: nhdm tuoi tir 25 den 36 thang tuoi, tir 37 den 48 thang va tir 49 den 60 thang cao hdn cd y nghTa thdng ke vdi p<0,05.
Bang 3.6. Ty le Vo SDD the Thap coi theo nhdm tudi va gldl tinh Thang tuoi
< 6 thanq 6 - 1 2 thanq 13 - 24 thanq 25-36 thanq 37 - 48 thanq 49 -60 thanq
Tong
Nam n
37 50 96 104 100 91 4 7 8
SL 4 12 21 27 19 12 95
%
10,8 24,0 21,9 26,0 19,0 13,2 19,9
Nff n 33 48 89 92 95 99 4 5 6
SL 5 9 32 20 15 16 97
%
15,2 18,8 36,0 21,7 15,8 16,2 21,3 _^Co sU khae nhau ve phan bo ty le SDD the thap cdi theo nhom tuoi: nhdm tuoi tU 13 den 24 thang tudi, tU 25 den 36 thang va tir 49 den 60 thang cao hdn.
IV. BAN LUAN
Trong nhdm dot tUdng nghien cirtj la tre dUdi 5 tudi, tre trat chiem ty le nhteu hdn tre gai (51,2% va 48,8%). SU phan bd cac ddi tUdng
nghien cii'u tUdng dot dong deu, tuy nhien nhOTi tudi tir 0-12 thang va 13-24 thang chiem ty le thap hdn (Bang 3.1).
Ty le SDD theo gidl tfnh tre nam va tre ntfo
38
TAP CHt Y HOC VIET NAM TAP 465 - T H A N G 4 - SO 2 - 2018
cac the khdng cd sU chenh lenh qua idn, d the nhe can va the thap cdi ty le tre nu" eao hdn tre namj;i5.5%-21,3%) va (14,2%- 19,9%), nhUng d the gay cdm thi tre nam cao hdn tre nU (0,6%
- 0,5%). Nghien cUu ciia ehung tdi thay chUa cd mdi lien quan giii^ gidi tinh tre vdi tinh trang dinh dudng cua tre (p>0,05). Day cting la nhan dinh bt)ng cac khao sat ciia Nguyen Thi Hai Anh, Le Thi Hdp va cdng sUtai tinh Lio Cai [1]. (Bang 3.2).
Sd lieu (Bang 3.3) cho thay the gay com, tre d nhdm tudi dUdi 6 thang khdng xuat liien, nhUng tang dan tU nhdm tudi tren 6 thang tudi va cao nhat d nhom tudi tir 37-48 thang (9,7%);
ty le SDD the thap cdi tre em deu xuat hien d tat ca cac nhom tudi song tang nhanh tU nhdm tuoi 13-24 thang va ia dp tudi cao nhat (28,6%) va bat dau giam dan; t^ le SDD the nhe can cuang xuat hien d tat ca cac nhdm tre song cao nhat la d nhdm tre tU dp tudi 13- 36 thang (16,7 - 17,3%), sau dd giam d dp tudi 37-48 thang (12,3%), nhUng lai tiep tuc tang d nhdm 49-60 thang (16,8%). Ket qua dteu tra eiia Tran Van Ha, Pham Van Phii, Pham Duy TUdng tat xa Viet Long va Phii Ninh, Sdc Sdn, Ha Npi cijng thay sU khac biet SDD theo nhdm tudi cd y nghTa thdng ke d ca 2 the nhe can va thap cdi; trong dd tre nhe can eao nhat d nhdm 48-59 thang; edn tre thap edi eao nhat d nhdm 36-48 thang tuoi.
Ty le SDD the nhe can theo nhdm tuot qua (Bang 3.4) cho thay d nhdm tudi dUdi 12 thang tudi cd sU khac biet ve ty le SDD gtiTa tre nam va tre nu", tre nij" cd ty le eao hdn, va tang dan d cac nhdm tudi tU 13-36 thang; giam dan tU dp tudi 37-60 thang tudi ddi vdi ea tre nam va tre nd . Ty le SDD the nhe can eiia tre em dUdI 5 tuot tai xa Nghi Van d mUc (14,8). Theo phan loai ciia WHO thi xa Nghi Van cd t / le SDD tre em d mire thap (<20%). Tuy nhien, sd tre thUc te SDD d the nay tai Nghi Van la 138 tre. Ty le SDD d Nghi Van thap hdn so vdi ty ie SDD tre em trong pham vi toan tinh Nghe An nam 2016 (16,8%) va eao hdn so vdi toan huyen Nghi Loe nam 2016 (14%). Neu so sanh vdi ty le SDD tre em dudi 5 tudi d khu vdc mien nui thi ty le SDD tre em d xa Nghi Van da giam kha nhieu so vdi cae nghien cUu trUdc day. Tuy nhien, neu so sanh vdi khu vUc dong bang thi nghien euli ciia Nguyen Thj Vu Thanh d Sdn Dong, Hoai Qdc, Ha Tay tir nam 2005 cho thay ket qua la 26,83%
(cung d m u t trung binh) [ 6 ] .
Chi sd nay eho thay tre vira bi thieu can nang iai thieu ehieu cao, qua (Bang 3.5) cho thay ty ie SDD the gay edm d nhdm tuoi dUdi 12 thang tan suat xuat hien it chi ed 02 tre nd d nhdm tudi
nay; sang nhdm tuoi tU 13-48 thang d tre nam tan suat xuat hien cang cao; trong khi dd d tre nu" cao nhat la d nhdm tudi 37-48 thang. Sau dd deu cd sU giam dan d ca hai gidi ciia tre. Ket qua nghien cUu cho thay ty le SDD the gay cdm d Nghi Van la 5,7% (bang 3.3), ket qua nay cho thiiy tUdng dUdng sd lieu cua Vien dinh dudng Trung Udng nam 2015 Nghe An la 5,6%. Theo phan ioai cua WHO thi ty le SDD can nang theo chieu cao ciia Nghi Van nam 2016 la d mUc trung binh. So vdi ty le SDD can nang theo ehieu eao ciia toan qude nam 2010 (8,2%) va ket qua nghien cUu tai eiia Nguyin Kim Dung thUe hien tai xa Phiing HUng, huyen Khoai Chau, HUng Yen nam 2013 (5,9%) va nghien cUu ciia Nguyen Thi Vu Thanh tai Sdn Ddng, Hoai DUc, Ha Tay nam 2013 (9,59%)[6]... thi ty le nay eiia Nghi Van la dap irng tinh trang ehung ciia ca nUdc .
Chieu eao la thude do ve tien sU phat trien ciia tre. Mpt diTa tre bj thieu chieu eao so vdi tudi chirng td trUdc day nd bj thieu dinh dUdng thudng xuyen va thudng xay ra d cae quan the cd dan thieu an keo dai gay nen SDD man tfnh.
Qua (Bang 3.6) cho thay ty ie SDD the Thap cdi xuat hien d tat ca eae nhdm tudi va cd sU tang dan eao nhat d tre nam la nhdm tudi 25 - 36 thang (28,4%), edn d tre nir cao nhat d nhdm tudi tU 13 -24 thang tudi (33,0%) 6 thdi ky nay, tre em trong giai doan an sam va bat dau ehuyen sang ehe dp an nhu ngudi tdn. Do vay, nguy cd bj nhiem benh qua mdi trUdng, an udng ciia tre em tang ten, hdn nu'a viee eham sde dinh dudng eung bj han che hdn va nguon cung cap cae chat dinh dudng tU ngudn an bo sung khdng dii ve lUdng va chat so vdi thdi ky trUdc, sau dd ea hai gidi de giam tuy nhien tre nam cd sU giam ro ret hdn (12,7%) sd vdi^tre nif (16,5%) d nhdm tuoi 49 - 60 thang tudi. Ket qua khao sat cho thay ty ie SDD the thap cdi ciia tre em dUdi 5 tudi tai i^ghi Van, theo phan loai ciia WHO thi ty le Si3D chieu cao theo tudi ciia xa Nghi Van nam 2016 la d mUc cao (20,6%) (Bang 3.3). Ket qua nay thap hdn ca ket qua cdng bd ve t / le SDD ehieu eao theo tudi nam 2016 tren pham vi toan tinh Nghe An (28,5%), thap hdn ket qua khao sat tai My Hoa, Tan Lac nam 2007 (32,2%) [5] va cao hdn rat nhieu d Sdn Odng, Hoai Qdc, Ha Tay nam 2005 (17,4%) [6].
V. KET LUAN
- Ty ie tre SDD the nhe can ia 14,8% trong dd nam la 14,2%, nd la 15,4%.
- Ty le tre SDD thap edi la 20,6%, trong dd nam la 19,9%, nff la 21,3%.
VIETNAM MEDICAL JOURNAL N°2 - APRIL - 2018 - Ty le tre SDD the gay cdm la 5,7%, trong
dd nam la 6 , 1 % , nd la 5,0%.
- Ve ty le tre SDD d cac the tang dan theo nhdm tuot.
KIEN NGHI
Can da dang hda eac loai hinh truyen thdng nang cao ki§n thdc va thUc hanh cham sde tre cho eac ba me ed con dudi 5 tuoi nham cat thien tinh trang dinli dUdng cho tre em tai xa Nghi Van ndi rieng va ngUdi Viet Nam ndi chung.
TAI LIEU THAM KHAO
1. Nguyin Thi Hai Anh, Le Thj Hdp va con^ su*
(2006), "Tinh trang dinh du&ng va mgt so yeu td lien guan den suy dinh dudng tre eni dudi 5 tuoi b'nh Lao Cai nim 2003', Tap chi Dinh Du9ng va ThUc Pham so 3 + 4, thang 11 nam 2006, Hoi nghi khoa hoc Hoi Dinh DUSng Viet Nam lan thir 3 nam 2006.
^. \^^\&i;imi),^Oiudngt3inh phong chong SDD iji em nim 2(X)7, To thU ky ChUdng tnnh Phong chdng Suy dinh du8ng tre em, 48 Tang Bat Ho, Ha Noi.
3. Nguyen Kim Dung (2004), ''Thu'c trang suy dinh duSng d tre dt/di 5 tuoi vi mot so yeu to lien qm den tinh trang do taixa Phung Hutig, huygn Khoi Oliu, Hutig Yen nam 2004", Oe tai thUc dia qiat doan 1^ khoa eao hpc 7, TrUOng Dai hpc Y te Craig corig Ha Noi, nam 2004.
4. Nguyen t h i NhuT Hoa (2011), Tmh tmng mti du&ng vi mot so yeu to lien guan cua tre em dif$
5 tuoi huyen Yen Thuy tinh Hoa Binh, Khoa luan tot nghiep bac sT y khoa, Dai hoc Y Ha Not, 5. Ngo Thj Phu'dng (2007), Thut irang tfmlf
du&ng tre em du&i 5 tudi vi kien thdc, thuth^nli ve cham sdc tre cua bi me tai xa My Hda, huyen Tan Lac, tinh Hda Binh, Luan v3n chuyen khoa I TrUdng,dai hoc y te eong cong
6. Nguyen Thj Vu Thanh (2005), " Thu'c trang va mgt so yeil to inh hu&ng den tmh trang siiydinl) du&ng d tre em dudi 5 tuoi tai xa Sdn Dong, huyin Noil Ddc, Hi Tay, nam 2005'. Luan van tot nghiep Thac sy Y te cong ddng TrUdng Dai hoc Y te Coiig Cgiig nam 2005.
' - Trung tam CSSKSS tinh Nghg An "Bao cao tdng ket cong tac PCSDDTE nam 2016 trien Wiai ke hoach nam 2017".
DANH GIA TAC DUNG KHANG MOT SO DONG TE BAO UNG THU' CtA ALTRETAMIN TONG HO'P TAI VIET NAM
Pham Thi Man', Nguyen Son Nam^ Vu Binh Dirffng'
T 6 M TAT
Muc tieu: nghien euTu tac dung khang te bao ung thu VU(^ ung thU bieu mo phe nang A549, te bao ung thu buong trirng Ovcar-3 ciia Altretamin trong invitro.
Doitddnf va phddng phap nghien cuU: danh gia t^C dung Uc che sU phat trien ciia te bao ung thU ciia altretamin tdnci hpp tren cac dong te bao T-47D, A549, Ovarc bang thU nghiem Trypan Blue. Oanh gia tac dung khang eae dong te bao ung tJiU T-47D, A549, Ovcar-3 ciia altretamin bang thU nghiem MTT. Ket qui: ThU nghiem Trypan Blue, ty le te bao ung thU chet va tdng so te bao d cac gieng nuoi te bao giu^ sir dung chat mi Altretamin tong hpp d eac nong dd 10 pg/ml, 5pg/inl va 1 pg/ml, 0,5pg/ml va Doxombicafi 10 pg/ml khong eo sU khac biet (p>0,05). ThU nghiem WXT eho thay Albetamin tong hpp ire che sU phat trien ciia ^ bao ung thU vu d thdi diem 72 gi6 vdi nong do lO^ig/ml, 5ug/ml (p<0,05); te bao ung thU bieu mo phe nang dong A549 6 thdi diem 24 gid vdi nong dp lOpg/ml, thdi diem 48 gid va 72 gid vd\ cac nong dp lOpg/ml, 5pg/ml va Ipg/ml, 0,5pg/ml (p<0,05). Tac dung gay dut gay DNA te bao ung thU
'B^h vien lao khoa Tmng trddng
^Benh vien TWQuin ddi 108
^Hgc vien Quin y
Chiu trach nhiem chinh: Vu Binh DUdng Email: [email protected] Ngay nhan bai: 17.2.2018 Ngay ph^n bien khoa hoc: 29.3.2018 Ngay duyet bai: 5.4.2018
V(S cac dong vdi cac dong te bao T-47D, A549, Ovarc eiia Altretamin khong cd sU khae biet vdi nhom chimg.
Ket luan: Altretamin co tae dung khang te bao ung thU tUdngjJUdng vdi Doxorubicin; Altretamin ii'c che sU phat trien va tac dung gSy dirt gay DNA te bao ung:
thU vdi cac dong vdi cae dong te bao T-47D, A549;
Ovarc tren thUc nghiSm invitro.
Tdkhda: Altretamin tong hpp, Uc ehS t? bao ung thU tren invitro
SUMMARY
TO EVALUATE RESISTANCE EFFECT WITH SOME CANCER CELLS OF SYNTHESIZED
ALTRETAMINE I N VIET NAM Objeciiires: To study resistance effect of Altretamine with breast cancer cells, AS49 alveolar carcinoma cells, and Ovear-3 cancer cells in invitro.
Subject and method: To evaluate resistance effect of synthesized Altretamine with evolution of T-47D, A549, Ovarc cells by Trypan Blue trial. To evaluate resistance effect of altretamine with T-47D, A549, Ovcar-3 tumor cells by MTT trial. Results: The Trypan Blue trial, the rate of death cancer cells and the total number of cells in the cell culture wells were were not significantly different (p> 0.05) between the synthesized Altretamine reagents with concentrations of lOpg/mt, 5pg/ml and Ipg/mi, 5pg/ml and Doxorubicin lOMg/ml). The MTT trial showed that synthetic altretamine inhibited the evolution of breast cancer cells at 72 hours with concentration of lOpg/ml, 5pg/ml (p <0.05); of A549 alveolar epithelial
40