fmHHHHHHHHHHHHHHHHIm Trang 15
SAN :^UAT THUOC T C I / BCNU CiiC CA^' TCON© T l / IDAC N A N O
Bqe Id mqt kim loqi cd tfnh sdt khudn cao so vdl cdc kim loqi khac, khi d kich thUdc nano, hoqt tinh sdt khudn cCia bqe tdng len khodng 60.000 lan so vdi dung dich bqe. Gan ddy nano bqe dang dUdc nghien citu dediet mqt so'virut. Nano bqe cd rdt nhieu Ong dung trong cdc finh vUc: dUdcphdm, mdi trUdng vd sinh y hqc. Cho den nay hdng loqt cdc sdn phdm khac nhau chda nano bqe dUdc sdn xudt vd thUdng mqi, trong sddd chda bdng (Anticoat) cua hdng Smith Nephew. Nhieu hdng dUdc phdm tren the gidi cung dang sdn xudt bdng gqc, dung dich rCfa vet thudng, thudc tri benh tieu chdy... chOa nano bqe. Ngodi ra, sdn phdm cd ten id Micoodyn (gelatin chUa nano bqe) dang dUdc bdn tqi My dung pha nUdc sdt khudn rau cho mdn dn salad.
Vdi nhQng tfnh ndng Qu viet eua Bqe nano, trong ndm 2006 2007, Vien Khoa Hpc Vdt Lieu Qng Dung (KHVLLfD) dd nghien cQu thQ nghiem d i tdi; Nghien cQu e h i tqo keo nano bqe dung chdt bdo vp chitosan tan Idm thude Bdo Ve Thge Vqt (BVTV), Cdc k i t qud thQ hieu ige cua thude tren ddi vdi benh dqo dn, lem lep hqttren lua, ben ndm hdng tren edy cao su, heo ru tren rau mdu dpt k i t qud td't d ndng dp Ag sQ dung 3ppm lOppm, Cdc k i t qud nghien cQu v i cdng nghe dd dupe hodn thien, ddc tfnh c u a thud'c dd dUde Vipn Pasteur Dd Lqt kiem tra vd xdc djnh Id sdn phdm khdng ddc, thdn thipn vdi mdi trUdng,
Cong nghe sdn xudt thudc BVTV chdro bqe nano Id cong nge mdi boo gom ba cdng doqn:
Cong doqn 1: Tdng hpp polymer dn djnh (Chitosan tan trong nUdc), qud trinh ndy gdm ede bade: Hod tan Chitosan trong acid hQu c d , /\xeetyl chitosan bdng anhydrit acetic, k i t tua thu chitosan tan bdng cdn, sdy vd thu hdi sdn phdm. Sd dd cdng nghe eua qud trinh dUde the hipn nhu hinh ve sou:
Cong doqn 2: Che tqo bqe nano/ehitosan tan, hod tan chitosan tan, AgNOj trong nUdc Ipe ion, chieu xq gamma Co-60 vdi sud't l i i u 1,3 kGy/h tdi l i i u xq chuyen hod bdo hod dUdc dung djch bqe nano,
Cong doqn 3: Pha dung djch bqe nano d cdng doqn tren vdi chd't hoqt ddng b i mqt, chd't dn djnh vd c d c phu gia khde cung vdi nUde Ipe ion de thu dupe sdn phdm thude BVTV
NH, NH, NH, ' NH, C(0)CH, acetyl hoi bing Anhydrite Acetic Add (CH,CaO),0
' NH, ' NH I ^NH, I ^NH
Sof do c6ng ngti§ cua c6ng doan 2 va 3 niiir sau:
CIS tan Chat bit goc tu do (3)_
Hoa tan
^r ^r
Dung dich AgN03 (4) Dung djch
Chieu xa Ganfima Chitosan-
(CTS)
H,0 Axit
Hoa Tan
San pham MIfum
Bong chai
^
i
Pha dung dich
Bo sung chcft HDBM (CH300),0
Dung Djcli CIS
C,H,OH Dung Djcli CIS Tan
Tiiu Hdi Cdn
say CIS Tan
Hinh 1; So do cong ngh$ son xudt chitosan tan
Stf Khoa Hoc va C6ng Nghe Binh Phifdc
Hinh 2: So do cong nghe sdn xudt thudc BVTV Ag NANO
Chitosan Id sdn phdm d i acetyl hod ehitin bdng dung dich k i i m ddc, Chitosan khdng tan trong nUde md ehl tan trong mdi trUdng acide vi v d y dd hqn ehe phqm vi Qng dung eua chitosan, d d c biet Id trong linh vge y - sinh hpc, Cdc cdng trinh nghien cQu e h i tqo oligoehitosan tan trong nUdc chu y e u Id c d t mgch chitosan bdng phUdng phdp hod hpc, bQc xq enzim, Theo k i t q u d nghien cQu khd'i lapng phdn tCf (KLPT) c u a oligoehitosan IV1„ = 2,700 thi se tan hodn todn trong
WWWWWWWWWWWWWWWWW S o : 0 6 / 2 0 1 1
nude pH=7. Chitosan tan trong nUde (CHN) Id mdt dqng edu true mdi eua chitosan dUdc nghien cQu che tqo theo phUdng phdp axetyl hod chitosan bdng anhydrit axetie vd k i t tua bdng etanol, CTTN khdng phdi Id oligomer md Id chitosan ed KLPT khd eao 1 - 5x10', dp d i axetyl (DDA) ~ 45-55% vd tan trong nUde pH tQ 5-8. CHN rdt trien vpng de Qng dung trong n h i i u ITnh vge dqc biet Id Idm chd't dn djnh (stabilizer), chd't bdt gd'c t g do (free radical scavenger) de che tqo hqt nano kim loqi (Au, Ag,.,,), chd't kfeh khdng benh (ellcitor) vd tdng trUdng thge vdt bdng phUdng phdp chieu xq,
PhUdng phdp che tqo Chitosan tan: Acetyl hod Iqi dung dich chitosan bdng (CH3CCX))2, nhdn dupe chitosan ed dp Deaeetyl hod khodng 50%, c d edu true vd djnh hinh nen hod tan trong nUde,
Do qud trinh acetyl hod d i i u chinh 2 loqi nhdm chQc d i u ddn dpc theo sUdn chitosan, vd neu Bang so sdnh cdc sdn phdm ti/dng ijrng
dqt dp DDA ~ 50% thi chitosan se tan trong nUde (-50% nhdm NH^ vd -50% nhdm acetyl).
Do nano b q e ed tfnh khdng khudn eao, n i u tUdng hdp vdi Chitosan tan ed hipu Qng t q o khdng sinh thge v q t se Id e d e sdn phdm ed hieu lgc diet khudn c a o de Qng dung trong ndng nghiep,
Ddc biet Viet Nam ed nen kinh t i ndng nghip, ddn sd ndng nghiep chiem khodng 70%, Vec dUa cdng nghe sdn xud't thud'c BVTV chQa bqe nano dem Iqi hieu qud kinh te xd hdi cho ngUdi ddn bdi:
Viec sQ dung ngudn nguyen lieu vd cdng nghd trong nUde nen sdn phdm ed gid re, ngUdi ndng ddn se gidm ehi phf thude BVTV so vdi sdn phdm nhdp ngogi, Sdn phdm ed tfnh an todn nen khdng dnh hudng d i n ngUdi ndng ddn, Viec di vdo sdn xud't giup ngUdi ndng ddn c d them sg iga chpn thude BVTV vdi gid hdp iy md hieu lgc ndng hpc eao.
STT
01
02
03
05
06
07
TEN SAN P H A M
Fusai 5 SL
Arcado
Hoa t i i n 50 SP
Agronil 75WP
Benzo 50 W P
M i f u m 0.6 D D
DVT
1.000 lit 1.000
irt
1.000 kg 1.000
kg 1.000
kg
SO LL/ONG Nam
2004
7.000
9.500
6.000
Nam 2005
9.500
8.500
10.000
Nam 2006
13.000
10.200
12.500
10.200
10.200
G I A THOfI D I E M H I E N
TAI
•
94.000 d/L/ha
98.000 d/L/ha
86.000 d/kg/ha
89.000 d/kg/ha
84.000 d/kg/ha
65.000 d/L/ha
SPCUA
Cong ty CP Vat Tir Hoa Bmh
Bayer Viet Nam Ltd (BVL) Cty TNHH 1TV Bao Ve Thifc Vat
• • •
Sai Gon Cty TNHH J i an on Biotech
Cty TNHH Trifcfng Thjnh San Pham thuoc
BVTV chufa bac nano Vdy vdi ly do d d , viec Sdn xudt thud'c BVTV chQa b q e nano dem Iqi hieu q u d kinh te cho nggdi ndng ddn,xd hdi,
Mqnh Hung (tong hqlp)