Thư viện số Văn Lang: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

Contents

Part I Instrument and Data Analysis

1 Advances in 4D Gated Cardiac PET Imaging for Image Quality Improvement and Cardiac Motion and Contractility

Estimation. . . 3 Benjamin M.W. Tsui, Tao Feng, Jizhe Wang, Jingyan Xu, M. Roselle Abraham, Stefan L. Zimmerman, and Thomas H. Schindler

2 The Need for Quantitative SPECT in Clinical Brain

Examinations. . . 17 Hidehiro Iida, Tsutomu Zeniya, Miho Yamauchi, Kazuhiro Koshino, Takashi Temma, Satoshi Iguchi, Makoto Yamazaki, Junichiro Enmi, Naoya Kondo, Nobutoku Motomura, and Jyoji Nakagawara

3 PET Imaging Innovation by DOI Detectors. . . 39 Taiga Yamaya

4 Semiconductor Detector-Based Scanners for Nuclear

Medicine. . . 51 Wataru Takeuchi, Atsuro Suzuki, Yuichiro Ueno, Tohru Shiga,

Kenji Hirata, Shozo Okamoto, Songji Zhao, Yuji Kuge, Naoki Kubo, Kentaro Kobayashi, Shiro Watanabe, Keiji Kobashi, Kikuo Umegaki, and Nagara Tamaki

5 Kinetic Analysis for Cardiac PET. . . 67 Yuuki Tomiyama and Keiichiro Yoshinaga

Part II Biomarker and Molecular Probes

6 How Far Are We from Dose On Demand of Short-Lived

Radiopharmaceuticals?. . . 79 Giancarlo Pascali and Lidia Matesic

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7 Advantages of Radiochemistry in Microliter Volumes. . . 93 Pei Yuin Keng, Maxim Sergeev, and R. Michael van Dam

8 Development of a Microreactor for Synthesis of¹⁸F-Labeled

Positron Emission Tomography Probe. . . 113 Norihito Kuno, Naomi Manri, Norifumi Abo, Yukako Asano,

Ken-ichi Nishijima, Nagara Tamaki, and Yuji Kuge

9 Preclinical Evaluation of a Thymidine Phosphorylase Imaging

Probe, [¹²³I]IIMU, for Translational Research. . . 125 Ken-ichi Nishijima, Songji Zhao, Fei Feng, Yoichi Shimizu,

Hiromichi Akizawa, Kazue Ohkura, Nagara Tamaki, and Yuji Kuge

10 Discovery and Evaluation of Biomarkers for Atherosclerosis. . . 131 Takeshi Sakamoto, Hiroko Hanzawa, Naomi Manri, Mamoru Sakakibara, Yoichi Shimizu, Yan Zhao, Songji Zhao, Shiro Yamada, Kiwamu Kamiya, Yutaka Eki, Akihiro Suzuki, Haruhiko Higuchi, Chiaki Sugano, Hiroyuki Tsutsui, Nagara Tamaki, and Yuji Kuge

11 Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G. . . 141 Yoichi Shimizu, Hiroko Hanzawa, Yan Zhao, Ken-ichi Nishijima,

Sagiri Fukura, Takeshi Sakamoto, Songji Zhao, Nagara Tamaki, and Yuji Kuge

Part III Cardiology

12 Noninvasive PET Flow Reserve Imaging to Direct Optimal

Therapies for Myocardial Ischemia. . . 153 Robert A. deKemp and Rob SB Beanlands

13 The Clinical Value of Cardiac PET in Heart Failure. . . 171 Chi-Lun Ko and Yen-Wen Wu

14 Emerging Trends and Future Perspective of Novel Cardiac

SPECT Technology. . . 183 Masao Miyagawa, Yoshiko Nishiyama, Hayato Ishimura,

Rami Tashiro, Kana Ide, and Teruhito Mochizuki

15 Right Ventricular Metabolism and Its Efficiency. . . 193 Keiichiro Yoshinaga, Hiroshi Ohira, Ichizo Tsujino, Osamu Manabe, Takahiro Sato, Chietsugu Katoh, Katsuhiko Kasai, Yuuki Tomiyama, Masaharu Nishimura, and Nagara Tamaki

16 Usefulness of¹⁸F-FDG PET in Diagnosing Cardiac

Sarcoidosis. . . 209 Osamu Manabe, Keiichiro Yoshinaga, Hiroshi Ohira,

and Noriko Oyama-Manabe

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Part IV Neurology

17 PET Quantification in Molecular Brain Imaging Taking into Account the Contribution of the Radiometabolite Entering

the Brain. . . 219 Masanori Ichise, Yasuyuki Kimura, Hitoshi Shimada, Makoto Higuchi, and Tetsuya Suhara

18 Hypoxia Imaging with¹⁸F-FMISO PET for Brain

Tumors. . . 229 Kenji Hirata, Kentaro Kobayashi, and Nagara Tamaki

19 Evolution and Protection of Cerebral Infarction Evaluated by PET and SPECT. . . 251 Eku Shimosegawa

20 Brain Development and Aging Using Large Brain MRI

Database. . . 263 Yasuyuki Taki

Part V Oncology

21 Back to the Future: Nuclear Medicine Rediscovers Its Therapeutic Roots. . . 277 Rodney J. Hicks

22 Interactive Communication Between PET Specialists and

Oncologists. . . 289 Huiting Che, Ying Zhang, Ying Dong, Wensheng Pan, Ling Chen,

Hong Zhang, and Mei Tian

23 Clinical Efficacy of PET/CT Using⁶⁸Ga-DOTATOC for Diagnostic Imaging. . . 303 Yuji Nakamoto, Takayoshi Ishimori, and Kaori Togashi

24 Correlation of 4⁰-[methyl-¹¹C]-Thiothymidine Uptake with Ki-67 Immunohistochemistry in Patients with Newly Diagnosed and

Recurrent Gliomas. . . 313 Yuka Yamamoto and Yoshihiro Nishiyama

25 Impact of Respiratory-Gated FMISO-PET/CT for the Quantitative Evaluation of Hypoxia in Non-small Cell Lung Cancer. . . 319 Shiro Watanabe, Kenji Hirata, Shozo Okamoto, and Nagara Tamaki

Contents ix

ThiS is a FM Blank Page

Contributors

Norifumi Abo

Hokkaido University, Sapporo, Japan M. Roselle Abraham

Johns Hopkins Medical Institute, Baltimore, MD, USA Hiromichi Akizawa

Showa Pharmaceutical University, Machida, Japan Yukako Asano

Hitachi, Ltd., Tokyo, Japan Rob SB Beanlands

University of Ottawa Heart Institute, Ottawa, ON, Canada Huiting Che

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Ling Chen

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Robert A. deKemp

University of Ottawa Heart Institute, Ottawa, ON, Canada Ying Dong

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Yutaka Eki

Hitachi General Hospital, Hitachi, Japan Junichiro Enmi

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Fei Feng

Hokkaido University, Sapporo, Japan

xi

Tao Feng

Johns Hopkins Medical Institute, Baltimore, MD, USA Sagiri Fukura

Hokkaido University, Sapporo, Japan Hiroko Hanzawa

Hitachi, Ltd., Tokyo, Japan Rodney J. Hicks

The University of Melbourne, Melbourne, VIC, Australia Haruhiko Higuchi

Hitachi General Hospital, Hitachi, Japan Makoto Higuchi

National Institute of Radiological Sciences, Chiba, Japan Kenji Hirata

Hokkaido University, Sapporo, Japan Masanori Ichise

National Institute of Radiological Sciences, Chiba, Japan Kana Ide

Ehime University, Matsuyama, Japan Satoshi Iguchi

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Hidehiro Iida

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Takayoshi Ishimori

Kyoto University, Kyoto, Japan Hayato Ishimura

Ehime University, Matsuyama, Japan Kiwamu Kamiya

Hokkaido University, Sapporo, Japan Katsuhiko Kasai

Hokkaido University, Sapporo, Japan Chietsugu Katoh

Hokkaido University, Sapporo, Japan Pei Yuin Keng

University of California, Los Angeles, CA, USA Yasuyuki Kimura

National Institute of Radiological Sciences, Chiba, Japan

xii Contributors

Chi-Lun Ko

National Taiwan University Hospital, Taipei, Taiwan Keiji Kobashi

Hitachi, Ltd., Tokyo, Japan Kentaro Kobayashi

Hokkaido University, Sapporo, Japan Naoya Kondo

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Kazuhiro Koshino

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Naoki Kubo

Hokkaido University, Sapporo, Japan Yuji Kuge

Hokkaido University, Sapporo, Japan Norihito Kuno

Hitachi, Ltd., Tokyo, Japan Osamu Manabe

Hokkaido University, Sapporo, Japan Naomi Manri

Hitachi, Ltd., Tokyo, Japan Lidia Matesic

ANSTO Life Sciences, Sydney, NSW, Australia Masao Miyagawa

Ehime University, Matsuyama, Japan Teruhito Mochizuki

Ehime University, Matsuyama, Japan Nobutoku Motomura

Toshiba Medical Systems Co Ltd., Otawara, Japan Jyoji Nakagawara

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Yuji Nakamoto

Kyoto University, Kyoto, Japan Ken-ichi Nishijima

Hokkaido University, Sapporo, Japan Masaharu Nishimura

Hokkaido University, Sapporo, Japan

Contributors xiii

Yoshihiro Nishiyama

Kagawa University, Kagawa, Japan Yoshiko Nishiyama

Ehime University, Matsuyama, Japan Hiroshi Ohira

Hokkaido University, Sapporo, Japan Kazue Ohkura

Health Sciences University of Hokkaido, Sapporo, Japan Shozo Okamoto

Hokkaido University, Sapporo, Japan Noriko Oyama-Manabe

Hokkaido University Hospital, Sapporo, Japan Wensheng Pan

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Giancarlo Pascali

ANSTO Life Sciences, Sydney, NSW, Australia Mamoru Sakakibara

Hokkaido University, Sapporo, Japan Takeshi Sakamoto

Hitachi, Ltd., Tokyo, Japan Takahiro Sato

Hokkaido University, Sapporo, Japan Thomas H. Schindler

Johns Hopkins Medical Institute, Baltimore, MD, USA Maxim Sergeev

University of California, Los Angeles, CA, USA Tohru Shiga

Hokkaido University, Sapporo, Japan Hitoshi Shimada

National Institute of Radiological Sciences, Chiba, Japan Yoichi Shimizu

Hokkaido University, Sapporo, Japan Eku Shimosegawa

Osaka University, Suita, Japan Chiaki Sugano

Hitachinaka General Hospital, Hitachinaka, Japan

xiv Contributors

Tetsuya Suhara

National Institute of Radiological Sciences, Chiba, Japan Akihiro Suzuki

Hitachi General Hospital, Hitachi, Japan Atsuro Suzuki

Hitachi, Ltd., Tokyo, Japan Wataru Takeuchi

Hitachi, Ltd., Tokyo, Japan Yasuyuki Taki

Tohoku University, Sendai, Japan Nagara Tamaki

Hokkaido University, Sapporo, Japan Rami Tashiro

Ehime University, Matsuyama, Japan Takashi Temma

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan

Mei Tian

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Kaori Togashi

Kyoto University, Kyoto, Japan Yuuki Tomiyama

Hokkaido University, Sapporo, Japan Benjamin M.W. Tsui

Johns Hopkins Medical Institute, Baltimore, MD, USA Ichizo Tsujino

Hokkaido University, Sapporo, Japan Hiroyuki Tsutsui

Hokkaido University, Sapporo, Japan Yuichiro Ueno

Hitachi, Ltd., Tokyo, Japan Kikuo Umegaki

Hokkaido University, Sapporo, Japan R. Michael van Dam

University of California, Los Angeles, CA, USA

Contributors xv

Jizhe Wang

Johns Hopkins Medical Institute, Baltimore, MD, USA Shiro Watanabe

Hokkaido University, Sapporo, Japan Yen-Wen Wu

National Yang-Ming University, Taipei, Taiwan Jingyan Xu

Johns Hopkins Medical Institute, Baltimore, MD, USA Shiro Yamada

Hokkaido University, Sapporo, Japan Yuka Yamamoto

Kagawa University, Kagawa, Japan Miho Yamauchi

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Taiga Yamaya

National Institute of Radiological Sciences, Chiba, Japan Makoto Yamazaki

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Keiichiro Yoshinaga

National Institute of Radiological Sciences, Chiba, Japan Tsutomu Zeniya

National Cerebral and Cardiovascular Center Research Institute, Suita, Japan Hong Zhang

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Ying Zhang

The Second Affiliated Hospital of Zhejiang University, Hangzhou, China Songji Zhao

Hokkaido University, Sapporo, Japan Yan Zhao

Hokkaido University, Sapporo, Japan Stefan L. Zimmerman

Johns Hopkins Medical Institute, Baltimore, MD, USA

xvi Contributors