89
February 2017, Vol. 107, No. 2 FEBRUARY 2017 VOL. 107 NO. 2
FROM THE EDITOR
91 Infectious diseases – the next big challenge B Farham
IZINDABA
92 30 days in medicine B Farham OBITUARY
94 Jeanne Marie Erica de Villiers (née Du Plessis)
CONTINUING MEDICAL EDUCATION
GUEST EDITORIAL 95 Anaemia (part 2)
N Alli ARTICLE
96 Anaemia: Approach to diagnosis (part 2) N Alli, J Vaughan, M Patel
IN PRACTICE
CLINICAL UPDATE
101 The prevalence of skin scars in patients previously given intramuscular diclofenac injections attending the Pain Clinic at Universitas Academic Hospital, Bloemfontein, South Africa D Tarloff, G Lamacraft, G Joubert
MEDICINE AND THE LAW
106 Exporting DNA – striking a balance between preventing exploitation and promoting innovation M S Pepper
108 Should doctors provide futile medical treatment if patients or their proxies are prepared to pay for it?
D J McQuoid-Mason CASE REPORTS
110 Metabolic acidosis in a patient with metformin overdose I Ebrahim, M Blockman
112 Intentional intravenous mercury injection G Yudelowitz
RESEARCH
115 Sustained reduction in antibiotic consumption in a South African public sector hospital:
Four-year outcomes from the Groote Schuur Hospital antibiotic stewardship programme T H Boyles, V Naicker, N Rawoot, P J Raubenheimer, B Eick, M Mendelson
119 Antibiotic prescription patterns of South African general medical practitioners for treatment of acute bronchitis
N B Q Ncube, G C Solanki, T Kredo, R Lalloo
123 Adenovirus-associated pneumonia in South African children: Presentation, clinical course and outcome
M Zampoli, Z Mukuddem-Sablay
127 The influence of HIV infection on the age dependence of squamous cell carcinoma of the skin in South Africa
B L Diffey, M Norval, P N Albers, C Y Wright
130 The spectrum of gastric cancer as seen in a large quaternary hospital in KwaZulu-Natal, South Africa
F Benamro, B Sartorius, D L Clarke, F Anderson, E Loots, L Olinger
134 The spectrum and outcome of surgical sepsis in Pietermaritzburg, South Africa
S Green, V Y Kong, D L Clarke, B Sartorius, J Odendaal, J L Bruce, G L Laing, P Brysiewicz, W Bekker, E Harknett
137 An investigation of diverticular disease among black patients undergoing colonoscopy at Dr George Mukhari Academic Hospital, Pretoria, South Africa
M Vally, M Z Koto, M Govender
EDITOR
Bridget Farham, BSc (Hons), PhD, MB ChB EDITORS EMERITUS
Daniel J Ncayiyana, MD (Groningen), FACOG, MD (Hon), FCM (Hon) JP de V van Niekerk, MD, FRCR ASSOCIATE EDITORS
Q Abdool Karim, A Dhai, N Khumalo, R C Pattinson, A Rothberg, A A Stulting, J Surka, B Taylor, M Blockman, J M Pettifor, W Edridge
HMPG
CEO AND PUBLISHER Hannah Kikaya |
Email: [email protected] MANAGING EDITORS Ingrid Nye Claudia Naidu TECHNICAL EDITORS Emma Buchanan Kirsten Morreira Naadia van der Bergh Paula van der Bijl PRODUCTION MANAGER Emma Jane Couzens DTP AND DESIGN Clinton Griffin Travis Arendse
CHIEF OPERATING OFFICER Diane Smith | Tel. 012 481 2069 Email: [email protected] SALES MANAGER (CAPE TOWN) Azad Yusuf
JOURNAL ADVERTISING Charles William Duke Reneé Hinze Ladine van Heerden Charmalin Simpson Ismail Davids ONLINE SUPPORT Gertrude Fani FINANCE Tshepiso Mokoena Makhadzi Mulaudzi HMPG BOARD OF DIRECTORS Prof. M Lukhele (Chair), Dr M R Abbas, Dr M J Grootboom, Mrs H Kikaya, Prof. E L Mazwai, Dr M Mbokota, Dr G Wolvaardt
ISSN 2078-5135
SAMA website: www.samedical.org Journal website: www.samj.org.za
90
February 2017, Vol. 107, No. 2 140 Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy
S Sebastian, H F Jordaan, J W Schneider, M R Moosa, M R Davids
145 Analysis of mutations causing familial hypercholesterolaemia in black South African patients of different ancestry
U K Ibe, R Whittall, S E Humphries, G Pilcher, F Raal
149 Burden, genotype and phenotype profiles of adult patients with sickle cell disease in Cape Town, South Africa
G D Pule, K Mnika, M Joubert, S Mowla, N Novitzky, A Wonkam
156 Is it possible to differentiate tuberculous and cryptococcal meningitis in HIV-infected patients using only clinical and basic cerebrospinal fluid characteristics?
J E Vidal, E J F Peixoto de Miranda, J Gerhardt, M Croda, D R Boulware
160 Readiness to adopt a performance measurement system for substance abuse treatment:
Findings from the Service Quality Measures initiative
B Myers, P Petersen Williams, K Johnson, R Govender, R Manderscheid, J R Koch CPD QUESTIONS
Background photo: The friendly Sister Beukes on night shift, Clanwilliam Hospital | Ingrid Nye Box photos: Extensive scar from IM diclofenac injection | Tarloff et al.; Squamous cell carcinoma |
David Litman; Sickle cell anaemia | Kateryna Kon
FEBRUARY 2017 PRINT EDITION
CME
Anaemia (part 2)
RESEARCH Antibiotic stewardship: 4-year outcomes from GSH HIV infection and age dependence of squamous cell skin carcinoma Gastric cancer in KwaZulu-Natal Adult sickle cell disease in Cape Town CASE REPORT
Metabolic acidosis in metformin overdose IN PRACTICE
Skin scarring after IM diclofenac injections
ISSN 2078-5135
ONLINE CONTENTS LISTED IN Index Medicus (Medline) Excerpta Medica (EMBASE) Biological Abstracts (BIOSIS) Science Citation Index (SciSearch) Directory of Open Access Journals (DOAJ) Current Contents/Clinical Medicine SAMJ SUBSCRIPTION RATES Local subscriptions ZAR 1 488.00 p.a.
Foreign subscriptions ZAR 3 408.00 p.a.
Single copies ZAR124.00 local, ZAR 284.00 foreign
Members of the South African Medical Association receive the SAMJ only on request, as part of their membership benefit.
Subscriptions: Tel. 012 481 2071 Email: [email protected]
The SAMJ is published monthly by the Health and Medical Publishing Group (Pty) Ltd, Co. registration 2004/0220 32/07, a subsidiary of SAMA.
HEAD OFFICE
Health and Medical Publishing Group (Pty) Ltd Block F, Castle Walk Corporate Park, Nossob Street, Erasmuskloof Ext. 3, Pretoria, 0181
Tel. 012 481 2069 Email: [email protected] EDITORIAL OFFICE Suite 11, Lonsdale Building, Lonsdale Way, Pinelands, 7405 Tel. 021 532 1281 | Cell. 072 635 9825 Email: [email protected] Please submit all letters and articles for publication online at
http://www.editorialmanager.com/samj
© Copyright: Health and Medical Publishing Group (Pty) Ltd, a subsidiary of the South African Medical Association Use of editorial material is subject to the Creative Commons Attribution – Non-commercial Works Licence.
https://creativecommons.org/licenses/by- nc/4.0
Printed by TANDYM PRINT