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January 2017, Vol. 107, No. 1 JANUARY 2017 VOL. 107 NO. 1

FROM THE EDITOR

3 Climate change – no denial B Farham

GUEST EDITORIAL

4 A novel blood test for tuberculosis prevention and treatment A Penn-Nicholson, T J Scriba, M Hatherill, R G White, T Sumner

CORRESPONDENCE

6, 7 Transoral robotic surgery (TORS) in South Africa J J Fagan, J Wetter, C Joseph, B Donde; C A Joseph

8, 10 Cost considerations in determining the affordability of adjuvant trastuzumab in breast cancer M Sereda, response from R P Abratt; W Szpak, response from R P Abratt

12 Yes, we can eradicate tuberculosis in South Africa W Shasha

13 From an exasperated pathologist R D Mohanlal

IZINDABA

14 30 days in medicine B Farham OBITUARIES

16 Steve Lawn

17 Pieter Stephanus Bothma 18 Theo Berkowitz

EDITORIALS

19 Missed opportunities for circumcising boys P S Millard, N Goldstuck

20 South Africa’s salt reduction strategy: Are we on track, and what lies ahead?

J Webster, C Crickmore, K Charlton, K Steyn, E Wentzel-Viljoen, P Naidoo CME

GUEST EDITORIAL 22 Anaemia (part 1)

N Alli ARTICLE

23 Anaemia: Approach to diagnosis N Alli, J Vaughan, M Patel

IN PRACTICE

CLINICAL UPDATE

28 Cutting the cost of South African antiretroviral therapy using newer, safer drugs

W D F Venter, B Kaiser, Y Pillay, F Conradie, G B Gomez, P Clayden, M Matsolo, C Amole, L Rutter, F Abdullah, E J Abrams, C P Casas, M Barnhart, A Pillay, A Pozniak, A Hill, L Fairlie, M Boffito, M Moorhouse, M Chersich, C Serenata, J Quevedo, G Loots

31 Outbreak of carbapenem-resistant Providencia rettgeri in a tertiary hospital V S Tshisevhe, M R Lekalakala, N Tshuma, S Janse van Rensburg, N Mbelle ISSUES IN PUBLIC HEALTH

34 Tackling the climate targets set by the Paris Agreement (COP 21): Green leadership empowers public hospitals to overcome obstacles and challenges in a resource-constrained environment E Weimann, B Patel

HEALTHCARE DELIVERY

39 The National Health Insurance, the decentralised clinical training platform, and specialist outreach R I Caldwell, C Aldous

EDITOR

Bridget Farham, BSc (Hons), PhD, MB ChB EDITORS EMERITUS

Daniel J Ncayiyana, MD (Groningen), FACOG, MD (Hon), FCM (Hon) JP de V van Niekerk, MD, FRCR ASSOCIATE EDITORS

Q Abdool Karim, A Dhai, N Khumalo, R C Pattinson, A Rothberg, A A Stulting, J Surka, B Taylor, M Blockman, J M Pettifor HMPG

CEO AND PUBLISHER Hannah Kikaya |

Email: [email protected] MANAGING EDITORS Ingrid Nye Claudia Naidu TECHNICAL EDITORS Emma Buchanan Paula van der Bijl PRODUCTION MANAGER Emma Jane Couzens DTP AND DESIGN Clinton Griffin Travis Arendse

CHIEF OPERATING OFFICER Diane Smith | Tel. 012 481 2069 Email: [email protected] SALES MANAGER (CAPE TOWN) Azad Yusuf

JOURNAL ADVERTISING Charles William Duke Reneé Hinze Ladine van Heerden Kenni Gambo Charmalin Simpson Ismail Davids ONLINE SUPPORT Gertrude Fani FINANCE Tshepiso Mokoena Makhadzi Mulaudzi HMPG BOARD OF DIRECTORS Prof. M Lukhele (Chair), Dr M R Abbas, Dr M J Grootboom, Mrs H Kikaya, Prof. E L Mazwai, Dr M Mbokota, Dr G Wolvaardt

ISSN 2078-5135

SAMA website: www.samedical.org Journal website: www.samj.org.za

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January 2017, Vol. 107, No. 1 CASE REPORTS

41 The intraocular CD4/CD8 ratio in a black South African patient with Behçet’s disease uveitis A Makgotloe

43 Pulmonary nocardiosis caused by Nocardia otitidiscaviarum in an adult asthmatic female patient: The presence of acid-fast branching filaments is always significant

A Mahgoub, S A Gumaa, M R P Joseph, M S Saleh, A H A Elsheikh, A I Elkhalifa, E Elhaj, R R M Salih, M E Hamid

RESEARCH

46 Classifying snakebite in South Africa: Validating a scoring system D Wood, B Sartorius, R Hift

52 Immunisation coverage in the rural Eastern Cape – are we getting the basics of primary care right? Results from a longitudinal prospective cohort study

K le Roux, O Akin-Olugbade, L S Katzen, C Laurenzi, N Mercer, M Tomlinson, M J Rotheram-Borus

56 Surveillance of healthcare-associated infection in hospitalised South African children:

Which method performs best?

A Dramowski, M F Cotton, A Whitelaw

64 Retinopathy of prematurity in a cohort of neonates at Groote Schuur Hospital, Cape Town, South Africa

Q Keraan, C Tinley, A Horn, T Pollock, J Steffen, Y Joolay

70 Characteristics and outcome of long-stay patients in a paediatric intensive care unit in Cape Town, South Africa

T L Nupen, A C Argent, B M Morrow

76 Supernumerary registrar experience at the University of Cape Town, South Africa S Peer, S A Burrows, N Mankahla, J J Fagan

80 A novel FKRP-related muscular dystrophy founder mutation in South African Afrikaner patients with a phenotype suggestive of a dystrophinopathy

M M Mudau, F Essop, A Krause

83 Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review

K York, N C Dlova, C Y Wright, N P Khumalo, P E Kellett, R Kassanjee, A Mosam CPD QUESTIONS

Background photo: Waiting to receive healthcare at the Manenberg Clinic, Cape Town | City Press,

Jaco Marais

Box photos: TB graphic | Nauma; Uveitis | ARZTSAMUI; Preventing hospital-associated

infection | ThamKC

ISSN 2078-5135 JANUARY 2017 VOL. 107 NO. 1

GUEST EDITORIAL

A novel TB blood test

RESEARCH COP 21 and public hospitals – an opportunity for change Healthcare-associated infection in hospitalised children – what works best?

CASE REPORT

Behçet disease uveitis: CD4/CD8

CME Anaemia (part 1)

ONLINE CONTENTS LISTED IN Index Medicus (Medline) Excerpta Medica (EMBASE) Biological Abstracts (BIOSIS) Science Citation Index (SciSearch) Directory of Open Access Journals (DOAJ) Current Contents/Clinical Medicine SAMJ SUBSCRIPTION RATES Local subscriptions ZAR 1 488.00 p.a.

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Members of the South African Medical Association receive the SAMJ only on request, as part of their membership benefit.

Subscriptions: Tel. 012 481 2071 Email: [email protected]

The SAMJ is published monthly by the Health and Medical Publishing Group (Pty) Ltd, Co. registration 2004/0220 32/07, a subsidiary of SAMA.

HEAD OFFICE

Health and Medical Publishing Group (Pty) Ltd Block F, Castle Walk Corporate Park, Nossob Street, Erasmuskloof Ext. 3, Pretoria, 0181

Tel. 012 481 2069 Email: [email protected] EDITORIAL OFFICE Suite 11, Lonsdale Building, Lonsdale Way, Pinelands, 7405 Tel. 021 532 1281 | Cell. 072 635 9825 Email: [email protected] Please submit all letters and articles for publication online at

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© Copyright: Health and Medical Publishing Group (Pty) Ltd, a subsidiary of the South African Medical Association Use of editorial material is subject to the Creative Commons Attribution – Non-commercial Works Licence.

https://creativecommons.org/licenses/by- nc/4.0

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