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Mai 16, 2024 The Editor JEMDSA

PO Box 19063, Tygerberg 7505 Dear Sir/Madam

Covering Letter for the review article titled: Mitochondrial Dysfunction and Human Immunodeficiency Virus-infection .

Following a discussion by e-mail with Professor Nigel Crowther, I herewith submit a review paper that I have prepared on the abovementioned topic. The review was prepared as part of my MMed dissertation with the intention of submission for publication and to date has not been submitted or published elsewhere. Thank you for considering this work for publication in your journal.

Details of the manuscript are as follows

 Author: van der Watt G F, MMed(UCT), FCPat(SA)(Chem)

Corresponding author contact details: Dr George van der Watt,

[email protected], Tel +27832685048 (moblile), +27216585224/6 (office), +27216585225 (fax). Chemistry Laboratory, Red Cross Children’s Hospital, Rondebosch, Cape Town, 7700.

 I hereby declare that this work is my own original work and that no-third party sources are included in the submitted work apart from referenced citations to the published literature and that this work has not been published elsewhere.

 As the original author I hereby assign copyright to JEMDSA.

 Ethics committee approval was not required for the work that constitutes a review of the published literature

 As far as I am aware no conflicts of interest exist in the preparation and submission of this work and the work was prepared without external funding outside of the authors own institution.

Thank you

George van der Watt

Division of Chemical Pathology University of Cape Town and NHLS ICH Building 1st Floor

Red Cross Childrens Hospital Rondebosch

Cape Town 7700

Tel 0216585220/4/6 Fax 0216585335

[email protected]

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 Page 2 May 16, 2024

George F van der Watt, M.B.,Ch.B., D.A.(SA)., MMed(UCT), F.C.Path(SA).

Chemical Pathologist

Division of Chemical Pathology Red Cross Children’s Hospital Rondebosh

Cape Town

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