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Fig. 1. Effect of simmondsin on food intake. Simmondsin wasadded to the diet in the concentrations shown in the legend.Fresh diet with simmondsin as a first exposure was given torats at the onset of dark
Fig. 3. Effect of i.p. lorglumide on intake of food after i.p.simmondsin. Overnight-fasted animals were given injections ofnot affected by simultaneous administration of lorglumide, adrug that blocks CCKmeanvehicle, simmondsin 600 mg/kg or simmondsin with
Fig. 5. Mean body weights of animals chronically treated with simmondsin. The animals fed the control diet gained weightprogressively throughout the experiment
Fig. 7. Metabolic rates and respiratory quotients of ratstreated with simmondsin. Values represent means�S.E.M.
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