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Brain Uptake of Neurotherapeutics after Intranasal versus Intraperitoneal Delivery in Mice

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Figure 2A: Uptake of I-125 labeled anti–Aß antibodies in the cerebral cortex at different time-points after intranasal (IN) or intraperitoneal (IP) delivery in mice expressed as cpm/100 µg brain tissue and presented as Mean ± SD.
Figure 4A: Uptake of I-125 labeled antitissue and presented as Mean ± SDcerebellum at different timeintraperitoneal (IP) delivery in mice expressed as cpm/1–Aß antibodies in the -points after intranasal (IN) or 00 µg brain .
Table 1: Increased brain uptake of various neurotherapeutics after intranasal (IN) delivery.[All values for IN delivery were significantly higher than those for IP delivery ([Values expressed as Ration of Brain-Regional Uptake of Neurotherapeutics after IN vs IP delivery which is expressed as fold-increase (↑)]p<0.0001, all brain regions, all time points]

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Brain Uptake of Neurotherapeutics after Intranasal versus Intraperitoneal Delivery in Mice

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