TRP Channels in Skin Biology and Pathophysiology
3. Conclusions
In summary, numerous TRP channels are expressed in the cell types that constitute the skin, and they contribute in multiple ways to skin physiology under healthy conditions and to the pathological changes that occur in the setting of skin disease. Consequently, strategies aimed at this functionally diverse family of ion channels might provide useful means of combatting disorders of cutaneous homeostasis, sensation, and neoplasia.
Acknowledgments: Supported by the Neurosurgery Pain Research Institute at Johns Hopkins School of Medicine.
Author Contributions: Z.P. and M.J.C. both contributed to the writing of the manuscript.
Conflicts of Interest:M.J.C. is an inventor on a patent related to TRPV1 and TRPV2 that is licensed through The University of California, San Francisco and Merck, and may be entitled to royalties on that patent. He has also previously served on the Scientific Advisory Board of Hydra Biosciences, which works on products related to TRP Channels. These conflicts are being managed by the Johns Hopkins Office of Policy Coordination. No one beyond the authors of this review played a role in the writing of the manuscript or the decision to publish the results.
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