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Alatas, H., Tambunan, T., Trihono, P.P., Pardede, S.O. 2002.Buku Ajar Nefrologi Anak.Edisi 2.Ikatan Dokter Anak Indonesia. Jakarta.

Amzad. Z., Iqbal. M.Z., Shoro. A.A. 2013. Lead-Induced Reduction in Body and Kidney Weight of Wistar Albino Rats Ameliorated by Ginko biloba Extract (Egb 761). Biochemistry & Physiology. Research Articel.

Volume . Issue 2. 1000113.

Andriani., Darmono., Kurniawati. W., 2007. Pengaruh Asam Asetat dan Asam Laktat Sebagai Antibakteri Terhadap Bakteri Salmonella sp. Yang Diisolasi Dari Karkas Ayam. Seminar Nasional Teknologi Peternakan Dan Veteriner 2007.

Anggraini, D.R., 2008. Gambaran Mikroskopis dan Makroskopis Hati dan Ginjal Mencit Akibat Pemberian Plumbum Asetat. Sekolah Pasca Sarjana.

Universitas Sumatera Utara. Medan.

Ardyanto, D. 2005. Deteksi Pencemaran Timah Hitam (Pb) Dalam Darah Masyarakat yang Terpajan Timbal (Plumbum). Jurnal Kesehatan Lingkungan, Vol. 2, No. 1, Juli 2005 67-76.

Banks. W.J. 1986. Applied Veterinery Histology, 2nd ed.USA. The Williams and Wilkins Company.

Bailey. S.A., Zidell. R. H., Perry. R.W. 2004. Relationship Between Organ Weight and Body/Brain Weight in The Rat : What is The BestAnalytical Endpoint?. Socitey of Toxicologc Pathology. Toxycologic Pathology, 32:448-466, juni 2004. Publish by ; SAGE. www.sagepublications.com.

Diunduh 16 Agustus 2013.

Chang. J. 1986. Synopsis of Pathology. Printed Abraham Publication. P; hal 26-27.

Christensen, E.I., Bim, H. 2002. Megalin ang Cubilin : Multifunctional endocytic receptors. www. Nature. Com/nm/journal/v3/n4/box/nm778_BX2. html.

Diunduh tanggal 18 Januari 2013.

Daniel. 2009. Pembuatan Dan Karaterisasi Membran Kitosan Yang Berasal Dari Kulit Udang Sungai Mahakam. Mulawarman Scientifie, Volume 8. No.

1, April 2009. ISSN 1412-498X

Danuari, H. 2009. Analisa Enzim Alanin Amino Transfer (ALAT), Aspartat Amino Transfer (ASAT), Urea Darah dan Histopatologis Hati dan Ginjal Tikus Putih Galur Sprague-dawley Setelah Pemberian Angkak. J. Teknol Dan Industri Pangan. Vol. XX No. 1. Th 2009.

Darmono.2009. Farmasi Forensik dan Toksologi. Universitas Indonesia. Jakarta.

Dwiyatmoko, B. Naturalkos (Manfaat Dari Chitosan). Jurnal Badan Pengawas Obat dan Makanan (BPOM) RI. Vol III/ No.7, Mei 2008.

Fernandez-Kim. 2004. Phisicochemichal and Fungtional Properties of Crawfish Chitosan as Effected by Different Processing Protocols. The Depertement of food Science. Soul National University. Diunduh tanggal 22 Desember 2012.

Federer, W.Y. 1963. Experimental Design Theory and Application. New York, Mac Millan. p: 544

Frandson, R.D. 1992. Anatomi dan Fisiologi Ternak. Edisi ke-4.Yogyakarta.

Gadjah Mada University Press.

Frank, B. D. V. M. 1954. Pathology of The Dog and Cat. American Veterinary Publication Inc. Evanston. Illionis.

Granovsky, D. 2011. Articels. Stem cell Transplants Help Kidney Damage.

http;//repairstemcell. Wordpress.com/2011/02/18/stem-cell-transplants-help-kidney-damage. Diunduh tanggal 18 Januari 2012.

Hardjito., Linawati. 2006. Ganti Formalin Dengan Khitosan (Suara Merdeka Edisi Minggu 22 Januari).

Hargono.2008. Pembuatan Kitosan dari Limbah Cangkang Udang Serta Aplikasinya Dalam Mereduksi Kolesterol Lemak Kambing. Semarang.

UNDIP.

Hariono, B. 1991. A Study lead (Pb) levels in animal and the environment with ParticularReference to the Fruit Bat (Petrapus sp.) Ph. D. Thesis, The University of Queensland, Brisbane. Australia

Hariono, B. 2006. Efek Pemberian Plumbum (Timah hitam) Organik Pada Tikus Putih (Ratusnorvegicus). Bagian Patalogik FKH UGM. J. Sain Vet.

Vol. 24, No. 1.

Hartono, R. 1992. Buku Teks Histologi Vaternier. Edisi ke-3. Jakarta. UI Press.

Hayed, W., Keesey, J., Ross, P.F., Sthar, H.M. 1977. Analytical Methods Manual.

Lowa State University Press.Ames. Lowa.

Heat, A.G. 1987. Water Pollution and Fish Physiology. USA. CRC Press. Inc.

245 hlm.

Hirano, S. N., Sato, S., Yoshida, S., Kitagawa. 1987. Chimical Modification of Chitin and Chitosan. And Their Novel Application in: Industrial Polysaccharides. Yalpin. M. (Ed). Elsevier. Amsterdam.

Imaduddin., Saiful., Keman. S. 2000. Kemampuan Larutan Asam Asetat 25%

Terhadap Penurunan Kandungan Logam Berat Pb Dalam Daging Ikan Bandeng (Chanos chanos forsk). Forum Ilmu Kesehatan Masyarakat. Th XIX. No. 18.

Junquera, L.C., Carneiro, J., Kelly, R. O., Alih Bahasa Jan Tambayong. 1995.

Histologi Dasar. Edisi ke-8. Jakarta. EGC. Halm; 370-387.

Kawamura, M.., Mitsuhasi, H., Tanibe, H., Yoshi. 1993. Adsorption of Metal Ions on Polyaminated Highly Pronschitosan Chelatin Resin. Ind. Eng. Chem.

Res 32; 386-391.

Klasaaen, C.D., Amdur, M.O., Doull. J. 1986. Toxicology The Basic Science of Paisons. Macmilan Publishing Company. New York.

Kusumawati, N. 2009.Pemanfaatan Limbah Kulit Udang Sebagai Bahan Baku Pembuatan Membran Ultrafiltrasi. Inotek, Vol. 13, No. 2,

Kim, S.D., Park-Yoon, B. 2001. Effect on The Removal of Pb²⁺ from Aqueous Solution by Crob Shell. J. of Chem. Tech and Biotech. 76: 1179-84.

Knoor, D. 1982. Function Properties of Chitin and Chitosan. Journal of Food Science 48; 36-41

Knoor, D. 1984. Function Properties of Chitin and Chitosan. Journal of Food Science 48; 36-41

Lee, K.M., Cho, Y.S., Kim, J., Jan, Y.J., Shin, H.K., Park, A.s. 2005. Du-Zhong (Eucomnia Ulmoides Oliv). Cortex Water Extract Alters Heme Biosyntetis and Erythrocyte Antooxidant Defense System in Lead-Administered Rats.

Journal Of Medicine Food, 8; 86-92.

Missoun, F., Slimani, M., Aoues, A. 2010. Toxic effect of lead on kidney function in rat wistar. African Journal of Biochemistry Research. Vol. 4(2), pp. 21-27. www. Academicjournals.org/AJBR. Diunduh 10 Agustus 2013.

Muzzarelli, R.A.A., Rochetti, V., Stanic., Weekx. M. 1997. Methods for the determination of the degree of acetylation of chitin and chitosan. Chitin Handbook. European Chitin Soc. Grottamare.

Nabib, R. 1987. Patalogi Khusus Vateriner. Edisi ke-2. Bogor. Proyek Peningkatan/Pengembangan Perguruan Tinggi ITB.

Napitupulu, R. R. J. 2008. Pengaruh Pemberian Kalsium Secara Oral Terhadap Kadar Plumbum Dalam Darah Mencit (Mus musculus L). Sekolah Pasca Sarjana. Universitas Sumatera Utara. Medan.

Nordberg, G. 1998. Metal. Chimical Properties and Toxicity. In. Stellman Jm (ed). Encyclopedia of Occupational Health and Safety. 4 ed. Geneva. ILO.

Palar, H. 1994. Pencemaran dan Toksikologi Logam Berat. Jakarta. Rineka Cipta.

Palar, H. 2004. Pencemaran dan Toksikologi Logam Berat. Jakarta. Rineka Cipta.

Pringgoutomo, S., Himawan, S., Tjarta, A. 2002.Patalogi I (Umum).Edisi 1.

Jakarta.

Price, S.A., Wilson, M.L. 2005. Patofisiologi Konsep Klinis Proses-Proses Penyakit. Edisi 6. Penerbit Buku Kedokteran EGC. Jakarta.

Purwoningsih, E. 2008. Pengaruh Berat Molekul Kitosan Terhadap Kadar Plumbum (Pb) Darah dan Aktivitas Enzim δ-ALAD (Delta Aminolevulinic Acid Dehydratase) Mencit Albino (Mus musculus L.)

Roesli.R.M.A. 2008. Diagnosis dan Etiologi Gangguan Ginjal Akut. Bandung (Diagnosis dan Pengolahan Gangguan Ginjal Akut) ; Pusat Penerbitan Ilmiah Bagian Ilmu Penyakit Dalam. FK UNPAD/ RS dr Hasan Sadikin;

2008, P.41-66

Rahmadani., Susanti. D., Soripada. T. A., Silaban. R. 2011. Pemanfaatan Kitosan Dari Limbah Cangkang Bekicot Sebagai Adsorben Logam Tembaga.

Penelitian Program PKMP Tahun Anggaran 2011. Universitas Negeri Medan.

Rohman, T., Utami, U.B., Mahmud. 2009. Pengaruh Konsentrasi Kitosan terhadap Kerekter Membran Kitosan. J.Sains dan Terapan Kimia. Vol. 2, No. 1. 14-24.

Roberts, G.A.F. 1978. Determination of the Degree of N-Acetylation of Chitin and Chitosan. Chitin Handbook. Hal 127-132. European Chitin Soc.

Grottamare.

Sinaga, S. 2009. Deteksi Logam Berat Plumbum (Pb) dan Kadmium (Cd) Pada Hati dan Ginjal Babi yang Dipasarkan di Pasar Tradisional Wilayah Karawang. UNPAD. http;//blogs. Unpad.ac.id/saulsinaga/2010. Diunduh tanggal 20 Desembar 2012.

Salah, M., Farghali. A.A., Azmy.H., Khedr. M. 2013. Biological Compatibility of carbon nanotubes for treatmen of Pollution of Nile tilapia (Oreochromis niloticus) by lead acetate. Life Science Journal, 2013:10(2).

Sahidi, F., Janak. K.V.A., You.J.J. 1999. Food Aplication Of Chitin and Chitosan.

J. Food Sci and Technology. 10; 37-51

Syarif, A. 2007. Farmakologi dan Terapi. Edisi ke-5.Depertemen Farmakologi dan Terapeutik. Fakultas Kedokteran UI. Jakarta.

Schnellman. R.G., Goldstein. R.S. 2001. Toxic Responses of kidney. In Klaasen CD, editor. Casarett and doull’s txicology the basic sciences of posions.

New York. The Mc Graw-Hill.P.417-430.

Seely. J. C. 1999. Pathology of The Mouse. Kidney. In. Maronpot. Reference and Atlas. 1st ed. Cache River Press.P:226.

Suntoro, S. H. 1983. Metode Pewarnaan Histologi dan Histokimia. Bharata Karya Aksara. Jakarta. 48.

Suhardi. 1993. Khitin dan Khitosan. Buku Monograf. Pusat Antar Universitas Pangan dan Gizi UGM. Yogyakarta. Sumeru.

Underwood. J. C. E.1992.General and System Pathology. New York. Churchill Livingstone. P: 23-765.

Widowati, W., Sastiono, A., Jusuf. R. 2008. Efek Toksologi Logam. Pencegahan dan Penanggulangan.Edisi 1.Yogyakarta.

Winarno, F.G., Fardiaz, S. 1973. Dasar Teknologi Pangan. Depertemen Teknologi Hasil Pertanian-Fetemeta. Edisi I. Yogyakarta.

WHO. 1977. Lead. Environmental Health, Criteria No.3. Published Under The Join Sponsorship of United Nation Enviroment and The Wo. 15-19; 68-74.rld Health Organization, Geneva

Lampiran 1; Berat Ginjal Tikus Putih (Rattus sp.) Setelah Perlakuan Pb dan Pb+Kitosan Dengan Konsentrasi Berbeda (mg)

K P1 P2 P3 P4 P5 P6 Lampiran 2; Berat Tubuh Tikus Putih (Rattus sp.) Setelah Perlakuan Pb dan Pb+Kitosan

Dengan Konsentrasi Berbeda (g) K P1 P2 P3 P4 P5 P6

Lampiran 3; Hasil Uji KruskalWallis Dari Kerusakan Makrostruktur Ginjal

Perlakuan N Mean Rank

Lampiran 4 : Hasil Uji Mann-Whitney Kerusakan Makrostruktur Ginjal\

K-P1

Kerusakan Makro Mann-Whitney Test U ,000

Wilcoxon W 15,000

Z -2,835

Asym.Sig (2-tailed) ,005

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,136

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Asym.Sig (2-tailed) ,134

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Asym.Sig (2-tailed) 1,000

Exact Sig. [ 2*(1-tailed Sig.)] 1,000a K-P5

Perlakuan N Mean Rank Sum of Ranks

Kerusakan makro K 5 5,50 27,50

P5 5 5,50 27,50

Total 10

Asym.Sig (2-tailed) 1,000

Exact Sig. [ 2*(1-tailed Sig.)] 1,000a

Asym.Sig (2-tailed) ,317

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Asym.Sig (2-tailed) ,121

Exact Sig. [ 2*(1-tailed Sig.)] ,151a

Wilcoxon W 18,000

Z -2,154

Asym.Sig (2-tailed) 0,31

Exact Sig. [ 2*(1-tailed Sig.)] ,056a

Asym.Sig (2-tailed) ,005

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,005

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,014

Exact Sig. [ 2*(1-tailed Sig.)] ,016a P2-P3.

Perlakuan N Mean Rank Sum of Ranks

Kerusakan Makro P2 5 5,70 28,50

P3 5 5,30 26,50

Total 10

Asym.Sig (2-tailed) ,811

Exact Sig. [ 2*(1-tailed Sig.)] ,841a

Asym.Sig (2-tailed) ,136

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Asym.Sig (2-tailed) ,136

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Wilcoxon W 24,500

Z -,775

Asym.Sig (2-tailed) ,439

Exact Sig. [ 2*(1-tailed Sig.)] ,548a

Asym.Sig (2-tailed) ,134

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Asym.Sig (2-tailed) ,13

Exact Sig. [ 2*(1-tailed Sig.)] ,310a

Asym.Sig (2-tailed) ,513

Exact Sig. [ 2*(1-tailed Sig.)] ,690 P4-P5

Test Statistic

Asym.Sig (2-tailed) 1,000

Exact Sig. [ 2*(1-tailed Sig.)] 1,000 P4-P6

Asym.Sig (2-tailed) ,317

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Asym.Sig (2-tailed) ,317

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Lampiran 5; Hasil uji Kruskal Wallis Kerusakan Mikrostruktur Ginjal

Perlakuan N Mean Rank

Test statistic

Kerusakan mikro

Chi-square 20,796

df 6

Asymp.Sig. [2*(1-tailed Sig.)] ,002

Lampiran 6: Hasil Uji Mann-Whitney Kerusakan Mikrostruktur Ginjal K-P1

Asym.Sig (2-tailed) ,005

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,042

Exact Sig. [ 2*(1-tailed Sig.)] ,095a

Asym.Sig (2-tailed) ,166

Exact Sig. [ 2*(1-tailed Sig.)] ,222a

K-P4

Asym.Sig (2-tailed) ,166

Exact Sig. [ 2*(1-tailed Sig.)] ,222a

Asym.Sig (2-tailed) ,513

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Asym.Sig (2-tailed) ,513

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Wilcoxon W 17,500

Z -2,449

Asym.Sig (2-tailed) ,014

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) ,017

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) ,017

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) ,004

Exact Sig. [ 2*(1-tailed Sig.)] ,008a P1-P6

Perlakuan N Mean Rank Sum of Ranks

Kerusakan Mikro P1 5 8,00 40,00

P6 5 3,00 15,00

Total 10

Asym.Sig (2-tailed) ,004

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,606

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Asym.Sig (2-tailed) ,606

Exact Sig. [ 2*(1-tailed Sig.)] ,690a

Z -2,425

Asym.Sig (2-tailed) ,015

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) ,015

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) 1,000

Exact Sig. [ 2*(1-tailed Sig.)] 1,000a

Asym.Sig (2-tailed) ,065

Exact Sig. [ 2*(1-tailed Sig.)] ,095a P3-P6

Perlakuan N Mean Rank Sum of Ranks

Kerusakan Mikro P3 5 7,10 35,50

Asym.Sig (2-tailed) ,065

Exact Sig. [ 2*(1-tailed Sig.)] ,095a

Asym.Sig (2-tailed) 0,65

Exact Sig. [ 2*(1-tailed Sig.)] 0,95a

Asym.Sig (2-tailed) ,065

Exact Sig. [ 2*(1-tailed Sig.)] ,095 P5-P6

Z ,000

Asym.Sig (2-tailed) 1,000

Exact Sig. [ 2*(1-tailed Sig.)] 1,000a Lampiran 7: Hasil uji normalitas residu Pb pada ginjal Perlakuan Kolmogorov-Smirnova

Statistic df Sig Statistic df Sig.

Lampiran 8; Hasil Uji Homogenitas Residu Pb Pada Ginjal Levene

Lampiran 9; Hasil Uji Kruskal Wallis Residu Pb Pada Ginjal

Perlakuan N Mean Rank

Lampiran 10 : Hasil Uji Mann-Whitney Residu Pb Pada Ginjal K-P1

Mann-Whitney Test U ,000

Wilcoxon W 15,000

Z -2,611

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a K-P5

Perlakuan N Mean Rank Sum of Ranks

Residu Pb K 5 5,60 28,00

Asym.Sig (2-tailed) ,916

Exact Sig. [ 2*(1-tailed Sig.)] 1,000a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Mann-Whitney Test U ,000

Wilcoxon W 15,000

Z -2,611

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a P1-P6

Perlakuan NMean Rank Sum of Ranks

Residu Pb P1 5 8,00 40,00

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a P2-P3

Perlakuan N Mean Rank Sum of Ranks

Residu Pb P2 5 7,50 37,50

Asym.Sig (2-tailed) ,036

Exact Sig. [ 2*(1-tailed Sig.)] ,032a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Wilcoxon W 15,000

Z -2,611

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,076

Exact Sig. [ 2*(1-tailed Sig.)] ,095a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a P4-P5

Perlakuan N Mean Rank Sum of Ranks

Residu Pb P4 5 8,00 40,00

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Asym.Sig (2-tailed) ,009

Exact Sig. [ 2*(1-tailed Sig.)] ,008a

Lampiran 11: Nilai mean dan Std.Dev dari Residu Ginjal Pada Tikus Putih (Rattus sp.) Setelah Perlakuan

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