1. Mulyarjo. Epidemiologi dan Gambaran Klinik Karsinoma Nasofaring. In: Kentjono WA, LunardhiJH, editor. Simposium KankerNasofaring Dan Demo Biopsi Nasofaring Dengan Teknik Aspirasi Jarum Halus. Surabaya. 2003;1-7
2. Caraway NP, Katz RL. Lymph Nodes. In: Koss Leopold G, editor. Koss’’ Diagnostic Cytology And Its Histopatology Bases. Volume II. 5th edition. Philadelphia : Lippincott Williams & Wilkins. 2006; 1186-225
3. Kocjan G. Fine Needle Aspiration Cytology. Diagnostic Principles and Dilemas. New York : Springer. 2006; 216-7
4. AlAlwan NA. Fine Needle Aspiration Cytology Versus Histopathology in Diagnosing Lymph node Lesion. Volume 2. 1996; 320-5
5. Miliauskas Jhon, Heerde Peter van. Lymph Nodes. In; Orell Svante R., Sterrett Gregory F., Whitaker Darrel, editor. Fine Needle Aspiration Cytology, Ed 4th . Elsevier. 2005; 83-100
6. Wakely Paul E. Aspiration and Touch Preparation of Lymph Nodes. In: Atkinson Barbara F, editor. Atlas of Diagnostic Cytopathology. Ed 2nd. Philadelphia: Saunders. 2004; 412-58,748-64
7. Cibas ES, Wakely PE. Lymph nodes. In: Cibas, Edmund S., Ducatman, Barbara S, editor. Cytology Diagnostic principles and clinical correlates. Ed 2nd. Saunders. 2004; 307-41
8. Immunohistochemistry available at:
9. Sudiana IK. Teknologi Ilmu Jaringan dan Imunohistokimia. Jakarta : Sagung Seto. 2005; 35-50
10. Immunostaining Techniques Immunohistochemistry / immunocytochemistry
available at:
http://www.milipore.com/immunodetection/id3/immunostainingtechniques 11. HER2/neu available at: http://en.wikipedia.org/wiki/HER2/neu
12. Patterns of HER-2/neu Amplification and Overexpression in Primary and Metastatic Breast Cancer available at: http://jnci.oxfordjournals.org/cgi/content/full/93/15/1141 13. Background available at:http://www.thedoctorsdoctor.com/labtests/Her_2.htm
14. Andrijono. Kanker Ovarium. Dalam: Sinopsis Kanker Ginekologi. Jakarta. 2004;109 15. Significance of her2 oncogen expression in primary nasopharyngeal carcinoma
available at: http://www.ncbi.nlm.nih.gov/pubmed/11702662
16. Absence of evidence for HER2 amplification in nasopharynx available at: http://www.ncbi.nlm.nih.gov/pubmed/11850071
17. Bales CE. Laboratory Techniques. In: Koss Leopold G, editor. Koss’’ Diagnostic Cytology And Its Histopatology Bases. Volume II. 5th edition. Philadelphia : Lippincott Williams & Wilkins. 2006; 1616-7, 1670
18. Dhingra PL. Tumours of Nasopharynx. In: Diseases of Ear, Nose and Throat. Ed 4th. Elsevier: India. 2007; 230-5
19. Mills SE. The nose, paranasal sinuses, and nasopharynx. In: Mills SE, editor. Sternberg’s Diagnostic Surgical Pathology. Vol 1. Ed 4th. Philadelphia : Lippincott Williams & Wilkins. 2004; 963-77
20. Chan JKC. Tumours of the Nasopharynx. In: Barnes Leon, Eveson John W, et al, editor. Head and Neck Tumours. Lyon: France. 2005; 82-97
21. Rosai Juan. Respiratory tract. In: Ackerman’s Surgical Pathology. Vol 1. Ed: 8th. New York: Mosby. 1996; 289-98
22. Wei WI. Nasopharyngeal Cancer. In: Bailey BJ, Johnson JT, editor. Head & Neck Surgery-otolayngology. Vol 2. Ed 4th. Philadelphia: Lippinctt Williams & Wilims.2006;1658-68
23. Balogh Karoly. The Head and Neck. In: Rubin Emanuel, Farber JL, editor. Pathology. Vol II. Ed 3rd. Lippincott Williams & Willkins. 1301-33
24. Kumar Vinay, Cotran RS, Robbins SL. The Lung and the Upper Respiratory Tract. In: Robbins Basic Pathology. Ed 7th. Elsevier: Philadelphia. 2oo3;507
25. Stevens Alan, Lowe James. Oral and ENT pathology. In: Pathology. Ed 2nd. Mosby: New York. 2000; 236-7
26. Lubis M. Nadjib Dahlan. The Technical Procedure and The Value of Fine Needle Aspiration Biopsy of the Nasopharynx. Dalam: Kentjono WA, Lunardhi JH. Simposium Kanker Nasofaring dan Demo Biopsi Nasofaring dengan Teknik Aspirasi Jarum Halus. Surabaya. 2003; 5365
27. Dabbs David. Immunohistology of Metastatic Carcinoma of Unknown Primary. In: Dabbs David, editor. Diagnostic Immunohistochemistry, Ed 2nd. Elsevier. 2006; 180-4
28. Lymphoepithelioma available at: http://En.Wikipedia.Org/Wiki/Lymphoepithelioma 29. Notoatmodjo Soekidjo. Dalam: Metodologi Penelitian Kesehatan. Rineka Cipta:
30. Deteksi Dini Kanker “Nasofaring” available at: www.balipost.co.id/balopostcetak/2004/6/20/ink1.html
31. Lymphoepithelioma available at : http://en.wikipedia.org/wiki/Lymphoepithelioma 32. Nasopharyngeal carcinoma available at: www.pubmedcentral.nih.gov/articleren
Lampiran 2
Data Klinis Pasien Penelitian, Diagnosa Si-BAJAH, dan Luas Tampilan Imunositokimia HER2/neu
GEJALA KLINIK Si-BAJAH
Tampilan imunositokimia HER2/neu pada sediaan metastasis KNF tipe squamous cell carcinoma
Tampilan imunositokimia HER2/neu pada sediaan metastasis KNF tipe undifferentiated cell carcinoma No. Slide S E X Umur (Thn) Limfadeno- pati di leher Ggn hidung Ggn telinga Kepala sakit uni/bi- lateral Eksoftal- mus KET. 0 +1 +2 +3 0 +1 +2 +3 08061428A ♀ 58 9 9 9 9 9 - 9 - - - 08071536A ♀ 65 9 9 9 9 - - - - - - 9 - - - 08071581A ♂ 44 9 9 9 9 - - 9 - - - 08071675A ♀ 53 9 9 9 9 - - - - 9 - - - 08071714A ♀ 43 9 9 9 9 - - - - - - 9 - - - 08081730A ♂ 56 9 9 9 9 - - - 9 - - - 08071792A ♀ 51 9 9 9 9 - - - 9 -- - - 08092139A ♂ 47 9 9 9 9 - - - - - 9 - - 08102387A ♂ 60 9 9 9 9 - - - - - - 9 - - - 08112418A ♂ 60 9 9 9 9 - - - - - 9 - - 08112438A ♂ 22 9 9 9 9 - - - - - 9 - - 08112806A ♀ 43 9 9 9 9 9 massa nasofaring + - - - 9 - - 08112592A ♀ 54 9 9 9 9 - CT scan massa + - - - 9 - - 08122655A ♂ 24 9 9 9 9 - - - - - - 9 - - - 08122682A ♀ 64 9 9 9 9 9 CT scan massa + - - - 9 - - 08122712A ♀ 24 9 9 - 9 Wajah kebas, sengau tdk bisa bilang ’B’ - - - 9 - - 08112820A ♀ 46 9 9 9 - - - - -- - - - 9 - - 08122838A ♀ 36 9 9 9 9 9 - - - - 9 - - 08122856A ♂ 17 9 9 9 - - - - - - 9 - - 08122857A ♂ 55 9 9 9 9 - - - - - 9 - - 09010129A ♀ 14 9 9 9 9 9 - 9 A/3114/08 ♂ 42 9 9 9 9 9 massa nasofaring + - 9 - - - A/3115/08 ♂ 43 9 9 9 9 9 massa nasofaring + - 9 - - - A/3289/08 ♂ 49 9 9 9 9 9 massa nasofaring + - - - - 9 - -- -
Lampiran 3
Data Klinis Pasien Penelitian, Diagnosa Si-BAJAH, dan Histopatologi
GEJALA KLINIK SI-BAJAH
No. Slide S E X Umur (Thn) Limfadeno- pati di leher Ggn hidung Ggn telinga Kepala sakit uni/bi- lateral Eksoftal- mus KET. Squamous cell carcinoma Undifferentiated
carcinoma Konfirmasi Histopatologi
08061428A ♀ 58 9 9 9 9 9 - 9 - -
08071536A ♀ 65 9 9 9 9 - - - 9 Undifferentiated ca
08071581A ♂ 44 9 9 9 9 - - 9 - -
08071675A ♀ 53 9 9 9 9 - - 9 - Nonkeratinizing squamous cell ca
08071714A ♀ 43 9 9 9 9 - - - 9 -
08081730A ♂ 56 9 9 9 9 - - 9 - -
08071792A ♀ 51 9 9 9 9 - - 9 - Non keratinizing squamous cell ca
08092139A ♂ 47 9 9 9 9 - - - 9 - 08102387A ♂ 60 9 9 9 9 - - - 9 - 08112418A ♂ 60 9 9 9 9 - - - 9 - 08112438A ♂ 22 9 9 9 9 - - - 9 - 08112806A ♀ 43 9 9 9 9 9 massa nasofaring + - 9 Undifferentiated ca 08112592A ♀ 54 9 9 9 9 - CT scan massa + - 9 Undifferentiated ca 08122655A ♂ 24 9 9 9 9 - - - 9 - 08122682A ♀ 64 9 9 9 9 9 CT scan massa + - 9 -
08122712A ♀ 24 9 9 - 9 Wajah kebas, sengau tdk bisa bilang ’B’ - 9 - 08112820A ♀ 46 9 9 9 - - - - 9 - 08122838A ♀ 36 9 9 9 9 9 - - 9 Undifferentiated ca 08122856A ♂ 17 9 9 9 - - - - 9 - 08122857A ♂ 55 9 9 9 9 - - - 9 - 09010129A ♀ 14 9 9 9 9 9 - - 9 - A/3114/08 ♂ 42 9 9 9 9 9 massa
nasofaring + 9 - Non keratinizing squamous cell ca A/3115/08 ♂ 43 9 9 9 9 9 massa
nasofaring +
9 - Non keratinizing squamous cell ca A/3289/08 ♂ 49 9 9 9 9 9 massa
nasofaring +
- 9 Undifferentiated ca A/3290/08 ♂ 50 9 9 9 9 9 massa
Lampiran IV
Gambar: Luas tampilan imunositokimia HER2/neu pada sediaan metastasis Karsinoma nasofaring ke KGB leher, tipe quamous cell carcinoma dan undifferentiated carcinoma
Gbr.1. Luas tampilan imunositokimia HER2/neu 0
Gbr.1. Luas tampilan imunositokimia HER2/neu +1
Gbr.1. Luas tampilan imunositokimia HER2/neu +2
DATA, KUESIONER & PERSETUJUAN MENGIKUTI PENELITIAN
TAMPILAN IMUNOSITOKIMIA HER2/NEU PADA BIOPSI ASPIRASI METASTASISKARSINOMA NASOFARING KELENJAR LIMFE
NAMA : NO. PA. :
UMUR : HARI / TGL :
RAS/SUKU :
PEKERJAAN :
ALAMAT/TELP : Keluhan Utama : Limfadenopati di leher ……….
Keluhan Tambahan : 1. Gejala khas di hidung : ………
2. Gejala khas pendengaran :……….
3. Kepala sakit unilateral atau bilateral :……….
4. Gangguan neurologik syaraf otak :……….
5. Eksoptalmus :……….
6. Masa terlihat pada nasofaring :……….
Pemeriksaan Penunjang : ………..
………..
Saya menyatakan bersedia untuk dilakukan biopsi aspirasi pada benjolan di leher untuk mengetahui diagnosa terhadap penyakit saya ini, dan selanjutnya di proses untuk melihat tampilan imunositokimia HER2/NEU , yang diteliti oleh: Nama : dr. Lidya Imelda Laksmi (PPDS Patologi Anatomi FK-USU) No.Reg. : 17426 Medan,……….2009