Kelompok I : Kelompok kontrol
KESIMPULAN DAN SARAN
1. Ekstrak daun widuri pada dosis 50, 100 dan 150 mg/KgBB mampu
mengurangi berat tumor pada mencit dan dapat meningkatkan indeks
apoptosis sel berturut-turut sebesar 20,9 %; 21,5 % dan 24,6 % serta dapat
meningkatkan ekspresi caspase-3 secara signifikan. Oleh karena itu ekstrak
daun widuri sangat berpotensi untuk dikembangkan menjadi obat
fitofarmaka
2. Dari uji toksisitas akut didapatkan hasil bahwa Lethal Dose Concentration
(LD50) dari ekstrak daun widuri adalah sebesar 4000 mg/kgBB. Berdasarkan
tabel yang diambil dari metode Loomis (1978) dalam Jenova (2009) dosis
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