BAB VII PENUTUP
7.2 Saran
Berdasarkan hasil penelitian yang telah dilakukan, saran yang dapat diberikan sebagai berikut:
1. Penelitian perlu dilakukan lebih lanjut mengenai mekanisme platelet rich plasma pada fase inflamasi setelah pemasangan implan yang dilapisi dengan platelet rich plasma.
2. Penelitian perlu dilakukan dalam jangka waktu yang lebih lama untuk mengetahui proses penyembuhan luka selesai.
45 DAFTAR PUSTAKA
1. Karasutisna T. Implan gigi untuk dokter gigi umum (diagnosis dan implantasi). Makalah Universitas Padjadjaran Fakultas Kedokteran Gigi. Bandung; 2004: 3-7
2. Saputri DNE, Dyah N, Abdulgani N. Jumlah total dan diferensial leukosit mencit (musculus) pada evaluasi in vivo antikanker ekstrak spons laut aaptos suberitoides.
Bagian Program Studi Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam Institut Teknologi Sepuluh Nopember.
3. Chandra IA. Pemberian gel nanochitosan-prp topikal menurunkan ekspresi MMP-1 dan meningkatkan jumlah kolagen pada jaringan luka tikus wistar [Tesis]. Denpasar:
Universitas Udayana; 2014
4. Astuti LA. Pengaruh kecepatan sentrifugasi, durasi sentrifugasi, dan penggunaan antikoagulan (EDTA dan Citrate Acid 3,8%) terhadap kuantitas platelet rich plasma (PRP) [Tesis]. Makassar: Universitas Hasanuddin; 2015.
5. Mahanani ES, Wardhani P. Perbandingan efektifitas metode preparasi platelet rich plasma (PRP) dalam menghasilkan konsentrasi platelet yang besar
6. Eppley, BL, & Woodell, JE. Platelet Quantification and Growth factor Analysis from Platelet-Rich Plasma : Implications for Wound Healing. American Society of Plastic Surgeon. 2004; vol 114(6): 1502-8.
7. Mappangara S, Burhanuddin DP, Djais AI. Hubungan kualitas darah dengan konsentrasi TGF-β1 pada PRP: Dentofasial. 2014 Juni 13 (2): 80-5
8. Rofi’i, Dwikora N. Effect of making method of platelet rich plasma on platelet and growth factor (PDGF-BB & TGF-β1) consentration. Journal of Orthopaedic and Traumatology Surabaya. 2012; Vol.1(1)
9. Indrianti MD, Tana S, Mardiati SM. Hematolofi kelinci (lepus sp.) setelah perlakuan implantasi material stainless stell aisi 316l selama 2,5 bulan. Buletin Anatomi dan Fisiologi. 2015 vol. 23 (2): 80-81
10. Moldovan S. Dental implants: a comprehensive review. Continuing Education Course 2013: 3-6
11. Nair L and Laurencin C. Polymers as biomaterials for tissue engineering and controlled drug delivery. In K. Lee, and D. Kaplan (Eds.). Tissue Engineering I. Springer. 2006;
Vol. 102: 47-90
46 12. Mc Glumphy EA dan Larsen PE. Contemporary implant Dentistry, In Peterson Implant Dentistry, Contemporary Oral and Maxilofacial Surgery, Fourth ed. Mosby, St Louis.
2003.
13. Block, MS. And Achong, RM. Osseointegration in peterson’s oral and maxillofacial surgery. Milloro, M (editor). Edisi ke 2 BC Decker Inc. Ontario; 2004.
14. Pearce, Evelyn C. Anatomi dan fisiologi untuk paramedis. PT. Gramedia Pustaka Utama.
Jakarta; 2006: 75-8
15. Brooker, Christine. Kamus saku keperawatan. EGC. Jakarta; 2006: 42-5 16. Sadikin, Muhammad. Biokimia darah. Widya Medika. Jakarta; 2002: 12-3
17. Hardjoeno H dkk. Interprestasi hasil tes laboratorium diagnostik. Hasanuddin University Press (LEPHASS). Makassar; 2007: 12-9
18. Kurniati I. Pemberian platelet rich plasma topikal meningkatkan proses regenerasi jaringan luka pada tikus putih [Tesis]. Denpasar: Universitas Udayana; 2012: 75-6
19. Panjaitan B, Gunanti, Noviana D, Ulum MF, Sukmana I. Pengaruh implantasi porous tantalum berlapis hidroksiapatit terhadap gambaran darah merah tikus sprague. Jurnal Kedokteran Hewan 2014 Sep (8): 151-3.
20. David S Perdanakusuma. Anatomi fisiologi kulit dan penyembuhan luka. From Caring to Curing, Pause Before You Use Gauze. Surabaya 5: September. 2007.
21. Ali AS, Ismoyowati, Indrasanti D. Jumlah eritrosit, kadar hemoglobin dan hematokrit pada berbagai jenis itik lokal terhadap penambahan probiotik dalam ransum. Jurnal Ilmiah Peternakan 2013 Sep 1(3): 1001-13
22. Effendi S. peranan leukosit sebagai anti inflamasi alergik dalam tubuh. Bagian Histologi Fakultas Kedokteran Universitas Sumatera Utara; 2003.
23. Crane, D,dan Evert, P .A. M. Platelet rich plasma (PRP) matrix grafts. Practical Pain Management. 2008.
24. Kathleen M, Alan D. Platelet-rich plasma: Support for its use in wound healing. Yale J Biology and Medicine 2010; 83: 1-9
25. Malik S, Sood M, Bindal D. Platelet-rich plasma: a recent innovation in dentistry. J Innovation Dent 2011. 1(3).
26. Kaur P, Puneet, Dahiya V. Platelet-Rich Plasma: A Novel Bioenginereing Concept:
Trends Biomater. Artif. Organs. 2011; 25(2): 86-90.
47 27. Greene, RM, Johnson B, O’Grady K, Toriumi DM. Blood Products in wound healing. in:
Friedman CD, Gosain AK, Hom DB, Hebda PA. (editors). Essential tissue healing of the face and neck. Shelton, Connecticut: BC Decker Inc; 2009: 379-87.
28. Puspita KY. Pengaruh chlorhexidine gluconate 0,12% terhadap keberhasilan perawatan periimplantitis mucositis. Bali: universitas Mahasaraswati; 2014
29. Sabirin IPR, Maskoen AM, Hernowo BS. Peran ekstrak etanol topikal daun mengkudu (Morinda citrifolia L.) pada penyembuhan luka ditinjau dari imunoekspresi CD34 dan kolagen pada tikus galur wistar. MKB 45(4) Des; 2013.
30. Cohen IK, Diegelmann RF, Yager DR, Wornum IL, Graham M, Crossland MC. Wound care and wound healing. Dalam: Schwartz SI, Spencer S, Fischer D, Galloway, penyunting. Principles of surgery. Edisi ke-7. New York. 1999; 263-96.
31. Junquiera LC, Carneiro J. Basic histology: text and atlas. Edisi ke-11. New York; 2005.
32. Nafarin M. Penyembuhan luka. Available from:
https://www.academia.edu/8095315/Penyembuhan_Luka. Accessed February 23, 2016 33. Thrall MA, Weiser G, Allison R and Campbell TW. Veterinary hematology and clinical
chemistry: John Wiley & Sons; 2012.
34. Arosa FA, Pereira CF and Fonseca AM. Red blood cells as modulators of T cell growth and survival. Curr Pharm Des. 2004; 10(2): 191-201.
35. Plock JA, Rafatmehr N, Sinovcic D, Schnider J, Sakai H, Tsuchida E, Banic A and Erni D. Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic skin in mice. Am J Physiol Heart Circ Physiol.2009; 297(3): 2.
36. Gottrup F. Oxygen in wound healing and infection. World J Surg. 2004; 28(3): 312-5.
37. Holsworth REJR, Cho YI and Weidman J. Effect of hydration on whole blood viscosity in firefighters. Altern Ther Health Med. 2013; 19(4): 44-9.
38. Carson JL, Terrin ML and Jay M. Anemia and postoperative rehabilitation. Can J Anaesth. 2003; 50(6 Suppl): 60-4.
39. Lindholm PF, Annen K and Ramsey G. Approaches to minimize infection risk in blood banking and transfusion practice. Infect Disord Drug Targets. 2011; 11(1): 45-56.
40. Zheng H, Wu JJ and Wang J. Evaluation of effectiveness and analy;sis of goal-directed blood transfusion in peri-operation of major orthopedic surgery in elderly patients. Exp Ther Med. 2013; 5(2): 511-6.
41. Bennet T, Abee C, Henricson R. Nonhuman primatas in biomedical research, biology and academic. San Diego; 1995: 53-7
48 42. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, dkk. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci. 2004; 30(2): 145-51.
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58 Analisa Data
Your temporary usage period for IBM SPSS Statistics will expire in 6987 days.
MEANS TABLES=RBC_0 HGB_0 HCT_0 RBC_3 HGB_3 HCT_3 RBC_7 HGB_7 HCT_7 RBC_14 HGB_14 HCT_14 BY Kelompok
/CELLS=MEAN COUNT STDDEV MEDIAN MIN MAX.
Means
Notes
Output Created 13-NOV-2016 05:10:45
Comments
Input Active Dataset DataSet0
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data File 6
Missing Value Handling Definition of Missing For each dependent variable in a table, user-defined missing values for the dependent and all grouping variables are treated as missing.
Cases Used Cases used for each table have no missing values in any independent variable, and not all dependent variables have missing values.
59
Resources Processor Time 00:00:00.02
Elapsed Time 00:00:00.19
[DataSet0]
Case Processing Summary
Cases
Included Excluded Total
N Percent N Percent N Percent
60
EXAMINE VARIABLES=RBC_0 HGB_0 HCT_0 RBC_3 HGB_3 HCT_3 RBC_7 HGB_7 HCT_7 RBC_14 HGB_14 HCT_14
/PLOT BOXPLOT STEMLEAF NPPLOT /COMPARE GROUPS
Output Created 13-NOV-2016 05:11:21
Comments
Input Active Dataset DataSet0
61
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data File 6
Missing Value Handling Definition of Missing User-defined missing values for dependent variables are treated as missing.
Cases Used Statistics are based on cases with no missing values for any dependent variable or factor /PLOT BOXPLOT STEMLEAF NPPLOT
Resources Processor Time 00:00:21.84
Elapsed Time 00:00:19.97
62
63
5% Trimmed Mean 24.9944
Median 24.9000
64
5% Trimmed Mean 26.4167
Median 26.2000
65
5% Trimmed Mean 26.9889
Median 27.0000
66
5% Trimmed Mean 29.3630
Median 30.2000
67
*. This is a lower bound of the true significance.
a. Lilliefors Significance Correction
68
69
70 HGB_0
HGB_0 Stem-and-Leaf Plot Frequency Stem & Leaf 1.00 6 . 1 2.00 7 . 23 2.00 8 . 26 1.00 9 . 3
71
Stem width: 1.00
Each leaf: 1 case(s)
72
73 HCT_0
HCT_0 Stem-and-Leaf Plot Frequency Stem & Leaf 3.00 2 . 223 3.00 2 . 677 Stem width: 10.00
Each leaf: 1 case(s)
74
75
76 RBC_3
RBC_3 Stem-and-Leaf Plot Frequency Stem & Leaf 3.00 3 . 689 1.00 4 . 0 2.00 4 . 78 Stem width: 1.00
77
Each leaf: 1 case(s)
78
79 HGB_3
HGB_3 Stem-and-Leaf Plot Frequency Stem & Leaf 3.00 7 . 136 2.00 8 . 22 1.00 9 . 2 Stem width: 1.00
80
Each leaf: 1 case(s)
81
82 HCT_3
HCT_3 Stem-and-Leaf Plot Frequency Stem & Leaf 2.00 2 . 23 2.00 2 . 57 2.00 3 . 00 Stem width: 10.00
83
Each leaf: 1 case(s)
84
85 RBC_7
RBC_7 Stem-and-Leaf Plot Frequency Stem & Leaf 1.00 Extremes (=<3.6) 5.00 4 . 00124 Stem width: 1.00
Each leaf: 1 case(s)
86
87
88 HGB_7
HGB_7 Stem-and-Leaf Plot Frequency Stem & Leaf 2.00 7 . 14 2.00 7 . 89 1.00 8 . 1 1.00 8 . 9
89
Stem width: 1.00
Each leaf: 1 case(s)
90
91 HCT_7
HCT_7 Stem-and-Leaf Plot Frequency Stem & Leaf 1.00 Extremes (=<23) 4.00 2 . 6678 1.00 3 . 0 Stem width: 10.00
92
Each leaf: 1 case(s)
93
94 RBC_14
RBC_14 Stem-and-Leaf Plot Frequency Stem & Leaf 2.00 3 . 99 1.00 4 . 1 3.00 5 . 457 Stem width: 1.00
95
Each leaf: 1 case(s)
96
97 HGB_14
HGB_14 Stem-and-Leaf Plot Frequency Stem & Leaf 2.00 7 . 15 1.00 8 . 2 3.00 9 . 158 Stem width: 1.00
98
Each leaf: 1 case(s)
99
100 HCT_14
HCT_14 Stem-and-Leaf Plot Frequency Stem & Leaf 2.00 2 . 56 4.00 3 . 0012 Stem width: 10.00
Each leaf: 1 case(s)
101
102
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