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BAB V. KESIMPULAN DAN SARAN

B. Saran

1. Perlu dilakukan modifikasi metode ekstraksi dan standarisasi terhadap

ekstrak etil asetat tomat untuk menjamin kualitas sediaan.

2. Perlu dilakukan uji efek antioksidan secara kuantitatif dari sediaan krim

DAFTAR PUSTAKA

Agarwal, S., Rao, A.V., 2000. Role of Antioxidant Lycopene in cancer and heart diseases. Journal of the American College of Nutrition, Vol. 19, No. 5, pp.563–569.

Anief, M., 2000, Ilmu Meracik Obat, Teori dan Praktek, Gadjah Mada University Press, Yogyakarta, pp. 148, 168-169.

Anonim, 1995, Tanaman Obat Indonesa, http://www.nusaku.com/forum/ showthread.php?t=4947, diakses pada tanggal 25 Oktober 2013.

Anonim, 2000, Texapon, http://www.trade-chem.com/products/MSDS/SLES.pdf, diakses pada tanggal 25 oktober 2013.

Anonim, 2003, Lycopene: An antioxidant for good health,

http://www.lycopene.org/global/templates/cda/frontdoor.html diakses pada 19 April 2013.

Allen, L.V., 1999, The Basic of Compounding, International Journal of

Pharmaceutical Compounding, 385-389.

Aulton. M. E., 2007, Aulton’s Pharmaceutics the Design and Manufacture of

Medicines, 3rd ed, Churchill Livingstone Elsevier, Philadelphia, pp. 153.

Armstrong, N.A., dan James, K.C., 1996, Pharmaceutical Experimental Design

and Interpretation, Tylor and Francis, USA, pp.131-165.

Bolton, 1997, Pharmaceutical Statistics Practical and Clinical Applications, 3rd ed., Marcel Dekker Inc., New York, pp.610-619.

Boylan, J.C., Cooper, J., Chowhan, Z.T., 1986, Handbook of Pharmaceutical

Exipients, America Pharmaceutical Association, Washington, pp.63-65,

227, 229-300, 334-335.

Brannon, H., 2007, Skin Anatomy, http://www.dermatology.about.com/

skinanatomy, diakses pada 17 Februari 2013.

Cahyono, B., 1998, Tomat Usaha Tani dan Penanganan Pascapanen, Kanisius, Yogyakarta.

Canene-Adams K., Clinton, S.K., King, J.L., Lindshield, B.L., Wharton, C., Jeffery, E., & Erdman, J.W.Jr., 2004, The growth of the Dunning hyadiR- 3327-H transplantable prostate adenocarcinoma in rats fed diets containing tomato, broccoli, lycopene, or receiving finasteride treatment, FASEB J, 18: A886 (591.4).

Cazedey, E.C.L., Carvalho, F.C., Fiorentino, F.A.M., Gremiao, M.P.D.G., Salgado, H.R.N., 2009, Corrositex®, BCOP dan HET-CAM as Alternative Methods to Animal Experimentation, Braz J Pharm Sci, Vol 45, pp.532- 534.

Cheppy, 2001, Budi Daya Tanaman Obat Komersial, Penebar Swadaya, Jakarta, pp. 1-2, 120.

Cimpean, A.M., Ribatti, D., Raica, M., 2008, The Chick Embryo Chorioallantoic

Membrane as a Model to Study Tumor Metastasis, Springer Science,

11:311-319.

Clinton, S.K., Emenhiser, C., Schwartz, S.J., Bostwick, D.G., Williams, A.W., Moore, B.J., Erdman, J.W.J., 1996, Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, Cancer Epidemiol

Biomarkers Prev, 5:823–33.

D’Arcy, P.F., dan Howard, E.M., 1996, A New Anti-inflamantory Test, Utilizing The Chorioallantooic Membrane og The Chick Embyo, Br J. Pharmacol

Chemother, pp. 29, 378-387.

Dehpour, A.A., Ebrahimzadeh, M.A., Fazel, N.S., dan Mohammad, N.S., 2009, Antioxidant Activity of Methanol Extract of Ferula Assafoetida and Its Essential Oil Composition, Grasas Aceites, 60(4), 405-412.

Depkes RI, 1986, Sediaan Galenik, Departemen Kesehatan Republik Indonesia, Jakarta, pp. 5-26.

Direktorat Jendral Pengawasan Obat dan Makanan RI, 1979, Farmakope

Indonesia, Edisi 3, Departemen Kesehatan RI, Jakarta, p. 506.

Direktorat Jendral Pengawasan Obat dan Makanan RI, 1995, Farmakope

Indonesia, Edisi IV, Depkes RI, Jakarta, pp.6.

Dukes G.R., 1990, General Considerations for Stability Testing of Topical

Pharmaceutical Formulations in Topical Drug Delivery Formulations,

Elya, B., Dewi, R., Budiman, M.H., 2013, Antioxidant Cream of Solanum lycopersicum L., International Journal of PharmTech Research, Vol.5, No.1, USA, pp. 233-238.

Fuhramn, B., Elis, A., Aviram, M., 1997, Hypocholesterolemic effect of lycopene and b-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophage, Biochem Biophys

Res Commun, 233:658–662.

Genaro, R.A., 1990, Rhemingtons Pharmaceutical Science, 18th ed., Mack Printing Company, USA, pp. 267.

Giovannucci, E., 1999, Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature, Cancer Inst., J.Natl., 91:317–331.

Gupta, P., dan Garg, S., 2002, Recent Advances in Semisolid Dosage Forms for Dermatological Application, Pharmaceutical Technology, pp. 144-162.

Harmita, 2006, Buku Ajar Analisis Fisikokimia, Departemen Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, Depok, pp. 15-22.

Heather, A.E., dan Adam, C.W., 2012, Transdermal and Topical Drug Delivery:

Principles and Practice, A John Wiley & Sons Inc., New Jersey, pp.265,

281.

Istyastono, E.P., 2012, Mengenal Peranti Lunak R-2.14.0 for Windows : Aplikasi

Statistika Gratis dan Open Source, Penerbit Universitas Sanata Dharma,

Yogyakarta, p. 21.

Ikatan Sarjana Farmasi Indonesia, 1971, Formularium Medicamentorum

Selectum, Cetakan IV, ISFI Cabang Jawa Timur, Surabaya.

Jatmika, A., 1998, Aplikasi Enzim Lipase dalam Pengolahan Minyak Sawit dan MinyakInti Sawit Untuk Produk Pangan, Warta Pusat Penelitian Kelapa

Sawit, 6 (1) : 31 - 37.

Junquera, L.C., dan Kelley, O.R., 1997, Histologi Dasar, Terj. Dari Basic

Histologi, oleh Jan Tamboyang, EGC, Jakarta, pp. 357-364.

Klarwasser,G.Z., Gorlitz, K., Hafemann, B., Klee, D., Klosterhalfen, B., 2001, The Chorioallantoic Membrane of The Chick Embryo as a Simple Model for The Study of The Angiogenic an Inflamantory Response to Biomaterials, J Mater Sci : Mater med, 12, 195-199.

Koleva, I.I., van Beek, T.A., Linssen, J.P.H., de Groot, A., dan Evstatieva, L.N., 2002, Screening of Plant Extracts For Antioxidant Activity: A Comparative Study on Three Testing Methods, Phytochemical Analysis, 13, 8-17.

Lambers, et al., 2006, Natural Skin Surface pH is on Average below 5, which is Beneficial for Its Resident Flora, International Journal Cosmet Sci., 28 (5), 357-370.

Lachman, L., 1994, Teori dan Praktek farmasi Industri, Edisi 3, diterjemahkan oleh Siti Suyatmi, UI Press, Jakarta, pp. 1092-1144.

Levy, J., Bosin, E., Feldmen, B., Giat, Y., Miinster, A., Danilenko, M., Sharoni, Y., 1995, Lycopene is a more potent inhibitor of human cancer cell proliferation than either a-carotene or b-carotene, Nutr Cancer, 24:257– 266.

Lieberman, H. A., Rieger, M. M., Banker, G. S., 1996, Pharmaceutical Dosage

Forms : Disperse Systems, 2nd ed., Marcel Dekker Inc., New York, pp. 78- 79, 90-91.

List, P.H., dan Schmidt, P.C., 1989, Phytopharmaceutical Technology, Heyden & Son Limited, London, pp. 107-109.

Mario T.P., dan Sujarweni W., 2006, SPSS untuk Paramedis, Penerbit Ardana Media, Yogyakarta, p.55.

Martin, A., Swarbrick, J., Cammarata, A., 1993, Physical Pharmacy, 3rd ed., Lea & Febiger, Philadelphia, pp.522-537.

Mascio, P.D., Kaiser, S., Sies, H., 1989, Lycopene as The Most Efficient

Biological Carotenoid Singlet Oxygen Quencher, Archives of

Biochemistry and Biophysics, 274(2):532-8.

Mitchell, H.L., 1972, How PEG Helps the Hobbyist Who Work With Wood, Departement of Agriculture, USA.

Mitsui, T., 1997, New Cosmetic Science, Elsevier Science, Amsterdam, pp. 346.

Muth, J.E.De., 1999, Basic Statistic and Pharmaceutical Statistical Applications, Marcel Dekker Inc., New York, pp. 265-294.

Narendran, H., Koorapati, S., Mamidibathula, L., 2013, Formulation and Evaluationof Aceclofenac Lycopene Transemulgel, World Jurnal of

Nguyen, M.L., dan Schwartz, S.J., 1999, Lycopene: chemical and biological properties, Food Tech, 53:38–45.

Nielloud, F., Mestres, G. M., 2000, Pharmaceutical Emulsions and Suspensions, Marcel Dekker Inc., New York, pp. 561.

Pangkahila, W., 2007, Anti-Aging Medicine: Memperlambat Penuaan,

Meningkatkan Kualitas Hidup, PT. Kompas Media Nusantara, Jakarta, pp.

13-19.

Prakash, A., Rigelhof, F., Miller, E., 2010, Antioxidant Activity,

http://www.medallionlabs.com, diakses tanggal 03 November 2013.

Prakash, A., 2001, Antioxidant Activity, Medallion Laboratories : Analithycal

Progres, Vol 19 No : 2. 1 – 4.

Reynold, J.E.F., 1982, Martindale The Extra Pharmacopeia, 28th ed., Pharmaceutical Press, London, pp. 266, 1311.

Rowe, C.R., Sheskey, P.J., Owen, S.C., 2006, Handbook of Pharmaceutical

Excipients, 5th ed., Pharmaceutical Press, USA, pp.155, 301, 545, 624, 626, 651, 687.

Rowe, C.R., Sheskey, P.J., Owen, S.C., 2009, Handbook of Pharmaceutical

Excipients, 6th ed., Pharmaceutical Press, USA, pp. 441, 592, 697, 754.

Różańska, S., Broniarz-Press, L., Różański, J., Mitkowski, P., Ochowiak, M., Woziwodzki, S., 2012, Extensional viscosity and stability of oil-in-water emulsions with addition poly(ethylene oxide), Procedia Engineering, Vol. 42, pp. 733-741.

Rudianto, A., 2010, Uji Daya Antiinflamasi Ekstrak Herba Pegagan (Centellae asiaticae Herba) Menggunakan Metode Hen’s Egg Test Chorioallantoic Membrane (HET-CAM), Skripsi, Universitas Santa Dharma, Yogyakarta.

Schramm, L. L., 2005, Emulsions, Foams, and Suspensions: Fundamentals and

Applications, Wiley-VCH, Weinheim, p. 190.

Sibuea, P., 2003, Antioksidan Senyawa Ajaib Penangkal Penuaan Dini, Sinar Harapan, Yogyakarta.

Sinko, P. J., 2006, Martin’s Physical Pharmacy and Pharmaceutical Sciences, 5th Ed., diterjemahkan oleh Djajadisastra, J., Hadinata, A. H., Penerbit Kedokteran EGC, Jakarta, 711.

Soeratri W., dan Purwanti T., 2004, Pengaruh Penambahan Asam Glikolat

Terhadap Efektivitas Sediaan Tabir Surya Kombinasi anti UV-A dan anti UV-B dalam Basis Gel, Majalah Farmasi Airlangga, 4(3), 73-75.

Sudardjat, S.S., dan Gunawan, I., 2003, Likopen (Lycopene), Majalah Gizi Medik

Indonesia, Vol. 2 No. 5, pp. 7-8.

Suhartono, 2008., Analisis Data Statistik dengan R, Jurusan Statistika ITS, Surabaya, p.115.

Sunarmani dan Tanti, K., 2008, Parameter Likopen Dalam Standarisasi Konsentrat Buah Tomat, Penelitian, Balai Besar Penelitian dan Pengembangan Pascapanen Pertanian.

Swarbrick, J., James, C.B., 2007, Encyclopedia of Pharmaceutical Technology, 3rd Ed., (Vol. 1), Marcel Dekker Inc., USA, pp. 1556-1560.

Tjiang, B.J., 1978, Kriteria dan Penetapan Stabilitas Obat, Proceeding Kongres

Ilmiah Farmasi III, Yogyakarta, 47–50.

Tsang, G., 2005, Lycopene in Tomatoes and Prostate Cancer,

http://www.healthcastle.com, diakses pada tanggal 25 Oktober 2013.

Voigt, R., 1994, Buku Pelajaran Teknologi Farmasi, Gadjah Mada University Press, Yogyakarta, pp.141-145, 399-443.

Widyastuti, N., 2010, Pengukuran Antioksidan dengan Metode Cuprac, DPPH, dan Frap serta Korelasinya dengan Fenol dan Flavonoid pada Enam Tanaman, Skripsi, Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Institut Pertanian Bogor, Bogor.

Wilkinson, J.B., dan Moore, R.J., 1982, Harry’s Cosmeticology, Chemical Publishing Company Inc, New York, pp. 66, 241.

Young, A., 1972, Practical Cosmetic Sciensce , Mills & Boon Limited, London, pp. 17-21, 53-55, 102.

Zechmeister, L., Lerosen, A.L., Went, F.W., Pauling, L., 1941, Prolycopene, a naturally occuring sterioisomer of lycopene, Proc Natl Acad Sci USA, 21:468–474.

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