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BAB VI. SIMPULAN DAN SARAN

B. Saran

Perlu dilakukan penelitian ekspresi LMP-2A secara serial untuk mengkonfirmasi peran EBV sebagai tumor inisiator pada karsinoma kolorektal pada tahap progresivitas awal penyakit.

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DAFTAR PUSTAKA

Aaltonen, L., Johns, L., Jarvinen, H., Mecklin J.P., Houlston, R. 2007. Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin Cancer Res 13: 356–361

Ahmad, A., and Stefani, S. 2006. Distant metastases of colorectal carcinoma: a study of 256 male patients. J. Surg. Oncol. 33:194–197.

Ahsan, H., Neugut, A.I., Garbowski, C.G. et al. Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Ann Intern Med 2008; 128: 900–5.

Allen, M. D., Young, L. S., and Dawson, C. W. 2005. The Epstein-Barr virus-encoded LMP2-A and LMP2-B proteins promote epithelial cell spreading and motility. J. Virol. 79:1789–1802.

Ambrose, H. E., Wagner, S. D.. 2004. Alpha6-integrin is expressed on germinal centre B cells and modifies growth of a B-cell line. Immunology 111:400–406.

Andersson-Anvret, M., Forsby, N., Klein, G., Henle, W. 2007. Relationship between the Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: correlated nucleic acid hybridization and histopathological examination. Int. J. Cancer 20:486–494.

Axel, G., Sargent, D. 2004. Survival of Patients With Advanced Colorectal Cancer Improves With the Availability of Fluorouracil- Leucovorin, Irinotecan, and Oxaliplatin in the Course of Treatment. Journal Of Clinical Oncology Vol 22. No: 7.

Babcock, G. J., Decker, L. L., Volk, M., Thorley-Lawson, D. A. 2008. EBV persistence in memory B cells in vivo. Immunity 9:395–404.

Babcock, G. J., Hochberg, D., Thorley-Lawson, A. D. 2000. The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 13:497–506. Brooks, L., Yao, Q. Y., Rickinson, A. B., Young, L. S. 2002. Epstein-Barr

virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts. J. Virol. 66:2689–2697.

Budiani D.R., et al., 2005. Penentuan Skor Histologis Tampilan Antigen Hasil Pengecatan Imunohistokimia. Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, p:5.

Budiani D.R., et al., 2006. Tampilan LMP1 Pada Karsinoma Kolon Suku Jawa Berdasarkan Klasifikasi Duke: Indikasi Adanya Keterkaitan Antara Infeksi Virus Epstein-Barr Pada Keganasan Kolon. Bagian

commit to user

Patologi Anatomi dan Laboratorium Riset Biomedik, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, p:1-10.

Busson, P., McCoy, Gilligan, K., Tursz, T., Raab-Traub, N. 2002. Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma. J. Virol. 66:3257–3262.

Chao, C., Lotz , M. M., Clarke, A. C., Mercurio, A. M. 2006. A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 56:4811–4819.

Chen, S.-Y., Lu, J., Shih,Y.C., Tsai. 2002. Epstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal regulated kinase. J. Virol. 76:9556–9561.

Cyster, J. G. 2009. Chemokines and cell migration in secondary lymphoid organs. Science 286:2098–2102.

Dajee, M., Lazarov, M., Zhang, J., Cai,Y. T., Green, C. L, Russell, A. J., Marinkovich, M. P, Tao, S., Lin, Q, Kubo, Y.,. Khavari, P. A. 2003. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421:639–643.

Danes, S.1984. Heritable colon cancer syndromes: long-term b-lymphocyte suspension cultures derived from colonic mucosal biopsies. Carlsberg Res. Commun. Vol. 49, p. 187-195, 1984

Farwell, D. G., McDougall, J. K., Coltrera, M. D. 2009. Expression of Epstein-Barr virus latent membrane proteins leads to changes in keratinocyte cell adhesion. Ann. Otol. Rhinol. Laryngol. 108:851–859. Hartati ED, 2005. Perbedaan Skor Histologis Ekspresi Protein EBNA1 dan

LMP1 pada Karsinoma Sel Transisional Kandung Kemih Berdierensiasi Baik dan buruk., Skripsi Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Sebelas Maret. Surakarta. p : 26-33.

Houlston, R.S., Tomlinson I.P.2001. Polymorphisms and colorectal tumor risk. Gastroenterology 121: 282–301

Henle, W., and Henle, G. 2009. Seroepidemiology of the virus, p. 61–78. In M. A. Epstein and B. G. Achong (ed.), The Epstein-Barr virus. Springer- Verlag, Berlin, Germany.

Heussinger, N., Buttner , M., Ott, G., Brachtel, E. 2004. Expression of the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) in EBV-associated nasopharyngeal carcinoma. J. Pathol. 203:696–699.

Hochberg, D., Souza, T., Catalina, M., Sullivan, J. L., Luzuriaga, K., Thorley- Lawson, D. A. 2004. Acute infection with Epstein-Bar virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells. J. Virol. 78:5194–5204.

commit to user

Hynes, R. O. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673–687.

Jayne, D.G., Thorpe, H. C. 2007. Five-year follow-up of the Medical

Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. British Journal of Surgery 2010; 97: 1638–1645

Jerome, G.et al. 2007. The adaptive immunologic microenvirontment in colorectal cancer: A novel perspective. Departement of immunology, University Descartes, Paris.Cancer research 2007.

Kieff, E., Rickinson, A. B. 2001. Epstein-Barr virus and its replication, p. 2511–2574.

Knipe, D. M., Howley, P. M. 2004. Virology, 4th ed., vol. 2. Lippincott Williams and Wilkins, New York, N.Y.

Kronborg, O., Fenger, C., Olsen, J et al. Randomized study of screening for colorectal cancer with faecal-occult blood test. Lancet 2006; 348: 1467– 71.

Li, H., Zhuang, H., Wang, Q., Pang, J. C.2004. Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells. Oncogene -23:4488–4494.

Lin, C. T. 2009. Relationship between Epstein-Barr virus infection and nasopharyngeal carcinoma pathogenesis. Chinese journal of cancer 28 (8)

Liu, H.X., Ding, Y.Q., Li, X. 2003. Investigation of Epstein-barr virus in

Chinese colorectal tumors. World Journal of

Gastroenterology;9(11):2464-2468

Lo, A. K., Liu, Y., Wang, X. H., Huang, D. P., Yuen, P. W., Wong, Y. C,. Tsao, G. S. 2003. Alterations of biologic properties and gene expression in nasopharyngeal epithelial cells by the Epstein-Barr virus-encoded latent membrane protein 1. Lab. Investig. 83:697–709.

Lo, A. K., Yuen, P. W., Liu, Y. , Wang, X. H., Cheung, A. L., Wong, Y. C., Tsao, S. W.. 2001. Downregulation of hemidesmosomal proteins in nasopharyngeal carcinoma cells. Cancer Lett. 163:117–123.

Lu, J., Chua, H. H. , Chen, S. Y.,. Chen, J.Y., Tsai, C. H. 2003. Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins. Cancer Res. 63:256–262.

Lu, T. T., Cyster, J. G.. 2002. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science 297:409–412.

Maschler, S., Wirl, G., Spring, H., Bredow, D. V., Reichmann, E. 2005. Tumor cell invasiveness correlates with changes in integrin expression and localization. Oncogene 24:2032–2041.

commit to user

Mercurio, A. M., Rabinovitz, I. 2001. Towards a mechanistic understanding of tumor invasion—lessons from the alpha6beta 4 integrin. Semin. Cancer Biol. 11:129–141. Cells 7:581–596.

Morrison, J. A., Klingelhutz. A. J., Raab-Traub, N.. 2003. Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells. J. Virol. 77:12276–12284.

NCCN. 2012.National Comprehensive Cancer Network Treatment guidelines for patient colon and rectal cancer. American cancer society version IV, 2012.

Pusponegoro, A.D. 2004. Epidemiologi keganasan saluran cerna. Jakarta. Multi disciplinary cancer management of solid tumor; breast, colorectal, and sarcomas today & tomorrow. 2004: 36-42

Rex, D.K. Colonoscopy: A review of its yield for cancer and adenomas by indication. Am J Gastroenterol 2005; 3: 353–65.

Sastroasmoro, S., Ismael, S. 2008. Dasar – Dasar Metodologi Penelitian Klinis, Edisi 3. Sagung Seto, Jakarta.p:331.

Simatupang, E., Budiani,DR. 2012, Perbedaan Ekspresi EBNA-1 Berkaitan Infeksi EBV pada Low Grade dan High Grade Karsinoma Kolorektal. Sjamsuhidajat, R., Jong, W. 2006. Buku ajar ilmu bedah. EGC. Jakarta. Bab :

35, hal : 615-681

Soravia, C., Berk, T., Madlensky, L.. Genotypephenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 2008; 62: 1290–301.

Scholler F et al Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt. Journal of Virology 74: 10681-10689 (2000)

Selgrad. Recent progress in defining the epidemiology of Eipstein-Barr virus infection and cervical neoplasia. J Natl Cancer institute. 2007.84: 394- 398.

Stahtea XN, Roussidis AE, Kanakis I. Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation. Int J Cancer. 2007 Dec 15;121(12):2808-14.

Traverso, G., Shuber, A., Levin, B.2002. Detection of APC mutations in fecal DNA from patients with colorectal tumors. N Engl J Med 2002; 346: 311–20.

Taeyo, C. 2009. Epstein-Barr Virus and its role in human cancers. Critical Review in Oncology/Hematology 2009; 45:1-36.

commit to user

Wilson J.B., Bell J.L., Levine A.J. 1996. Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. Embo J, 15, 3117-26.

Yasuda, K. Nirei, T. 2010. Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer. Radiation Oncology 2011, 6:49

Zavoral, M., Sudharak, S. Colorectal Cancer Screening in Europe. World Journal of Gastroenterology December2009; 15 (47): 1407-1415.

Dalam dokumen Emerson Patoluhon Simatupang S5606005 (Halaman 92-97)

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