362. CHEMISTRY PART IIC

A course of approximately forty-five lectures in physical chemistry, twenty- five lectures in inorganic chemistry and twenty-five lectures in organic chemistry, with demonstrations, tutorials and practical work throughout the year. This is

a

general course giving less detailed development than Chemistry TIA and

will be

taken by students with

a

second physical science as

a

major subject.

Svm.лaus. (i) Physical Chemistry. Thermodynamic quantities and functions of state. First law of thermodynamics. КΡirchoff's law. The second law of thermo- dynamics: reversible and spontaneous processes ; entropy, work content and free energy ; conditions for equilibrium and spontaneous change. Measurement, evaluation and tabulation of thermodynamic quantities. Thermodynamics of gases, ideal and non-ideal. Phase equilibrium : the phase rule ; one and two component systems ; ideal and non-ideal solutions, activity of

a

component. Chemical equili- brium and free energy change for gaseous reactions, for reactions involving pure solids and liquids, and for reactions in solution. The third law of thermodynamics.

Electrochemistry: Transference numbers. Ionic activity coefficients. Debye-Hiickel theory. Onsager-Fuoss limiting conductance theory. Applications of conductance measurements. Electromotive force of cells, standard electrode potentials. Appli- cations of e.m.f. measurements. Quantum chemistry: Results of application

of

quantum theory to hydrogen molecule and correlation with spectral data : intro- duction to molecular spectroscopy, free rotation, rotation-vibration spectra for diatomic molecules, introduction to nuclear magnetic resonance spectroscopy.

Molecular dipole moments. Debye equation and measurement of dipole moments.

Chemical kinetics, rate laws for reversible reactions and second order reactions, steady state approximation, transition state theory, elementary reaction mechanisms, catalysis.

Inorganic Chemistry. Use of the hydrogen atom wave-equation for the predictions of the shapes and relative sizes of atomic orbitals ; bonding from the viewpoint of the Valence-bond and L.C.A.O.-Molecular orbital theories ; treat- ment of certain homonuclear and heteronuclear diatomics and poly-atomics.

Valence-bond theory—Resonance hybrids and energies, promotion energies, overlap criterion and hybridization : the use of some physical properties in sug- gesting

a

"true" structure.

Molecular-orbital theory—Bonding and anti-bonding orbitals, bond length and bond dissociation energies.

Comparison of the Valence-bond and L.C.A.O. theories. Experimental methods used in inorganic chemistry for the determination of molecular structure.

Properties of chemical bonds-Bond energies, bond lengths, electronegativity differences, bond order.

Co-ordination chemistry—Types of donor atoms, types of ligands, isomeriza

-

tion reactions, determination of the configurations of complexes, unusual stereo- chemistries, stabilization of valency states through co-ordination, thermodynamic stability and kinetic lability, mechanisms of substitution and isomerization reactions,

electron-transfer, uses of radiochemical techniques, applications of co-ordination compounds. Aspects of the chemistry of Groups III, IV, V, VI, and VII of the periodic table.

Organic chemistry. A study of mono-functional and poly-functional aliphatic and aromatic compounds and an introduction to the electronic interpretation of organic reactions.

LлвoaлтoRY WORK. Seven hours per week. The laboratory work will consist of courses in inorganic, organic and physical chemistry related to the above syllabuses.

A record of efficiency in performance and understanding of experiments will be kept and short tests may be given. This information will have a bearing on the final performance of the student in the subject.

The practical classes for this subject are taken in the Chemistry Building.

The department supplies all the apparatus for which a fee of $20 must be paid to the University Branch of the National Bank, using a specially stamped bank slip obtained from the department. Evidence of payment must be produced to the department before practical classes begin.

Воокs. (a) Recommended for preliminary reading:

Wells, A. F.—The Third Dimension in Chemistry. (O.U.P.)

Kauzmann, W.—Quantum Chemistry. Chapter I only. (Academic Press.) Campbell, J. A.—Why do Chemical Reactions Occur? (Prentice-Hall, 1965.)

(b) Prescribed text-books:

(i) For those not proceeding to Chemistry Part IIIC.

*Moore, W. J.—Physical Chemistry. (4th ed., Longmans.)

or Cole, R. H., and Coles, J. S. Physical Principles of Chemistry. (Freeman.) Denbigh, K.—The Principles of Chemical Equilibrium. (С.U.Р.)

Roberts, J. D., and Caserio, M. C.—Вasiс Principles of Organic Chemistry.

(Benjamin.)

or Klotz, I. Introduction to Chemical Thermodynamics. (Benjamin.)

*Morrison, R. T., and Boyd, R. N.—Organic Chemistry. (Allyn and Bacon.) Gero, A.—Textbook of Organic Chemistry. (Wiley, 1963.)

(ii) For those proceeding to Chemistry Part IIIC.

*Glasstone, S.—Textbook of Physical Chemistry. (2nd ed., Macmillan.) or Barrow, G. M.—Physical Chemistry. (McGraw-Hill, 1961.)

or Sheehan, W. F. Physical Chemistry. (Allyn & Bacon, 1961.)

*Cartmell, E. and Fowles, G. W. A.—Valency and Molecular Structure.

(2nd ed., Butterworth.) (iii) For all students.

Bell, C. F., and Lott, K. A. K. Modern Approach to Inorganic Chemistry.

( Butterworth.)

(c) Recommended for general reading and reference:

Cotton, F. A., and Wilkinson, G.—Advanced Inorganic Chemistry. (Inter- science.)

Addison, W. E.—Structural Principles in Inorganic Compounds. (Longman.) Gray, H. B. Electrons and Chemical Bonding. (W. A. Benjamin.)

Gould, E. S.-Inorganic Reactions and Structure. (2nd ed., Holt.)

Fedder, J. N., and Nechvatal, 1.—Basic Organic Chemistry. (Wiley, 1966.) Coulson, C. A.—Valence. (2nd ed., O.U.P.)

Sidgwick, N. V.—The Chemical Elements and Their Compounds, 2 vols.

(0.U.P.)

Wells, A. F.—Structural Inorganic Chemistry. (3rd ed., O.U.P.)

Latimer, W. 1.—The Oxidation States of the Elements. (Prentice-Hall.) Moelwyn-Hughes, E. A. Physical Chemistry. (Pergamon Press.)

Steiner, L. E. Introduction to Chemical Thermodynamics. (2nd ed., McGraw- Hill.)

Sanderson, R. T.—Chemical Periodicity. (Reinhold, 1960.)

Glasstone, S. Introduction to Electrochemistry. (Van Nostrand.) 88

Findlay, A., and Kitchener, J. A. Practical Physical Chemistry. (8th ed., Longmans.)

Wilson, J. M., et al.—Experiments in Physical Chemistry. (Pergaman Press.) Remy, H.--Treatise on Inorganic Chemistry. 2 vols. (Elsevier.)

Ketelaar, J. A. A.—Chemical Constitution. (2nd ed., Elsevier.)

Kolthoff, I. M., and Sandell, E. B.—Textbook of Quantitative Inorganic Analysis. (Macmillan.)

Emeléus, H. J., and Anderson, J. S.--lllоdеrп Aspects of Inorganic Chemůtry.

(3rd ed., Routledge.)

Barnard, A. K.—Theoretical Basis of Inorganic Chemistry. (1st ed., McGraw- Hill.)

Bailar, J. C.—Chemistry of Co-ordination Compounds. (Reinhold.) EXAMINATION. One 3-hour paper in Physical Chemistry, one 2-hour paper in Organic Chemistry and one 3-hour paper in Inorganic Chemistry. Students who have not maintained a satisfactory standard in the laboratory course through- out the year will be required to take a practical examination.

391. CHEMISTRY PART IITA

A course of approximately fifty-five lectures in inorganic chemistry, sixty lectures in organic chemistry and sixty lectures in physical chemistry, with laboratory work throughout the year. Membership of this class will be determined by performance in Chemistry IIA (or in Chemistry IIB or IIC. in exceptional cases).

SYLLABUS.

(i) Inorganic Chemistry. Advanced treatment of inorganic chemistry with particular reference to the application of physical and theoretical methods to the solution of inorganic problems. Special emphasis will be placed on the chemistry of the transition metals using an integrated approach of thermodynamic, kinetic, structural and valence viewpoints in addition to topics contained in the Chemistry IIIC syllabus. Recent advances in the field of organo-metallic compounds and the chemistry of lanthanide and actinide elements will be discussed. Inorganic Polymer Chemistry will be covered.

(ii) Organic Chemistry. An advanced treatment of the chemistry of aliphatic and aromatic systems, including alicyclic and heterocyclic systems. The chemistry of natural products. The mechanisms of organic reactions. The stereochemistry of carbon compounds.

(iii) Physical Chemistry. Thermodynamics (classical and statistical), electro- chemistry, kinetics of chemical reactions, photochemistry and free radical reactions, spectroscopy, atomic and molecular structure, surface chemistry. Physical chemistry of polymers.

LABORATORY WoRi. Experiments dealing with qualitative and quantitative analysis, inorganic and organic; preparation of pure substances; physio-chemical measurements.

The practical classes for this subject are taken in the Chemistry Building.

The department supplies all the apparatus for which a fee of $30 must be paid to the University Branch of the National Bank using a specially stamped bank slip obtained from the department. Evidence of payment must be produced to the department before practical classes begin.

Instruction will be given in the methods for systematic consultation of chemical literature and students will make a study of the original literature on selected topics.

Booкs. (a) Recommended for preliminary vacation reading:

Fieser, L. F., and Fieser, M.-Introduction to Organic Chemistry, (Latest edition, D. C. Heath.)

Hinshelwood, C. N.—Structure of Physical Chemůtry. • (Oxford.) Ketelaar, J. A. A.—Chemical Constitution. (2nd ed» Elsevier.)

Guggenheim, E. A. Boltгmann's Distribution Law. (North Holland.) 67

(b) Prescribed text-books:

The text-books prescribed for Chemistry Part IIA, together with:

Dodd, R. E.—Chemical Spectroscopy. (Elsevier.)

*Wild, F.—Characterisation of Organic Compounds. (2nd ed., C.U.P.) 'Mann, F. G., and Saunders, B. C. Practical Organic Chemistry. (4th ed.,

Longmans.)

*Cotton, F. A., and Wilkinson, G.—Advanced Inorganic Chemistry. (Inter- science.)

*Dyer, J. R. Applications of Absorption Spectroscopу of Organic Compounds.

(Prentice-Hall.)

Turner, E. E., and Harris, M. 1.—Organic Chemistry. (Longmans.) Cram, D. J. and Hammond, G. S.—Organic Chemistry. (2nd ed., McGraw-

Hill.)

Hickinbottom, W. J.—Reactions of Organic Compounds. (Longmans.)

*Lewis, J., and Wilkins, R. G. (eds.)—Modern Co-Ordination Chemistry.

(Interscience.)

Ferguson, L.

N.—The

Modern Structural Theory of Organic Chemistry.

(Prentice-Hall, 1963.)

Sykes, A. G.—Kinetics of Inorganic Reactions (Pergamon, 1966.) (c) Recommended for general reading and reference:

Orgel, L. E. Introduction to Transition Metal Chemistry. (Methuen.) Basolo, F., and Pearson, R. G.—Mechanisms of Inorganic Reactions. (Wiley.) Sidgwick, N. V.—The Chemical Elements and Their Compounds, ^{2 vols.}

(0.U.P.)

Wells, A. F—Structural Inorganic Chemistry. (2nd ed., O.U.P.) Remy, H.—Treatise on Inorganic Chemistry. 2 vols. (Elsevier.)

Phillips, C. S. G., and Williams, R. J. P. Inorganic Chemistry, Vols. I and II (O.U.P.)

Latimer, W. 1.—The Oxidation States of the Elements. (Prentice-Hall.) Skoog, D. A., and West, D. M. Fundamentals of Analytical Chemistry.

(Holt, Rinehart & Winston.)

Butler, J. N.—Ionic Equilibrium. (Addison-Wesley.) Kitchener, J. A. Ion-Exchange Resins. (Methuen.)

Brown, G. H., and Sallee, E. M.-Quantitative Chemistry. (Prentice-Hall.) Cook, G. B., and Duncan, J. F.—Modern Radiochemical Practice. (O.U.P.) Badger, G. M.—The Structure and Reactions of the Aromatic Compounds.

(C.U.P.)

Clar, E. Polycyclic Hydrocarbons, 2 vols. (Academic Press.) Fieser, L. F., and Fieser, М.—Steroids. (Reinhold.)

Fieser, L. F., and Fieser, M.—Organic Chemistry. (3rd ed., Reinhold.) Simonsen, J. L.—The Terpenes, Vols. 1-5. (2nd ed., C.U.P.)

Sidgwick, N. V.—Organic Chemistry of Nitrogen. (O.U.P.)

Elderfield, R. (ed.)—Heterocyclic Compounds, Vols. 1, 2, 3, 4, 5 and 6.

(Wiley.)

Venkataraman, K. :The Chemistry of the Synthetic Dyes, 2 vols. (Academic Press.)

Whitham, G. H.—Alicyclic Chemistry. (Oldbourne.) Adams, R. Organic Reactions. (Wiley.)

Weygand, C.—Organic Preparations. (Interscience.)

Foerst, W.—Newer Methods of Preparative Organic Chemistry. (Inter- science.)

Hammett, L. P.—Physical Organic Chemistry. (McGraw-Hill.) Eliel, E. L.—Stereоchemistry of Carbon Compounds. (McGraw-Hill.) Albert, A. Heterocyclic Chemistry. (Athlone Press.)

Badger, G. M.—The Chemistry of Heterocyclic Compounds. (Academic Press.) Katritzky, A. R., and Lagowski, J. M. Heterocyclic Chemistry. (Methuen.) Rodd. E. H. (ed.)—Chemistry of Carbon Compounds. (Elsevier.)

Gould, E. S. Mechanism and Structure in Organic Chemistry. (Holt.) Hine, J.—Physical Organic Chemistry. (2nd ed., McGraw-Hill.) Walling, C.—Free Radicals in Solution. ^(Wiley.)

Noyes, W. A., and Leighton, P. A.—The Photochemistry of Gases. (Rein- hold.)

68

Steaeie, E. W. R.—Atomic and Free Radical Reactions. (Reinhold.) Knox, J. H.—Gas Chromatography. (Methuen, 1962).

Bradley, J. N.—Shock Waves in Chemistry and Physics. (Methuen, 1962.) Porter, G. (ed.)-Progress in Reaction Kinetics, Vol. I. (Pergamon, 1961.) Murrell, J. N., Kettle, S. F. A., and Tedder, J. M.—Valence Theory. (Wiley,

1965.)

Cottrell, T. L.—Strength of Chemical Bond.r. (Butterworth.)

Ballhausen, C. J, and Gray, H. B. Molecular Orbital Theory. (Benjamin, 1964.)

Slater, J. C.—Electronic Structure of Molecules, Vol. 1. (McGraw-Hill, 1963.) Brand, J. C. D., and Speakman, J. C.—Molecular Structure. (Arnold, 1960.) Golden, S. Introduction to Theoretical Physical Chemistry. (Addison-Wesley,

1961.)

Cross, A. D.—An Introduction to Practical Infra-red Spectroscopy. (Butter..

worth.)

Jackman, L. M.—Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry. (Pergamon.)

Nakanishi, K.—Infra-red Absorption Spectroscopy—Practical. (Holden-Day, Inc., San Francisco and Nankodo Company Ltd., Tokyo.)

Gillam, A. E., and Stern, E. S. An. Introduction to Electronic Absorption, Spectroscopy in Organic Chemistry. (2nd ed., Arnold, 1957.)

Bellamy, L. J.—The Infra-red Spectra of Complex Molecules. (2nd ed., Methuen, 1958.)

Glasstone, S., Laidler, K. J., and Eyring,'1.—The Theory of Rate Processes.

(McGraw-Hill.)

Glasstone, S: Theoretical. Chemistry. (Van Nostrand.)

Herzberg, G. Atomic Spectra and Atomic Structure. (Dover.) Herzberg, G.—Spectra of Diatomic Molecules. (Van Nostrand.) Kauzmann, W.—Quantum Chemistry. (Academic Press.)

Frost, A. A., and Pearson, R. G. Kinetics and Mechanism. (2nd ed., Wiley.) Aston, G. S., and Fritz, J. J.—Thermodynamics and Statistical Thermo-

dynamics. (Wiley.)

Partington, J. R.-An Advanced Treatise on Physical Chemistry, 5 vols.

(Longmans.)

Hill, T. L: Introduction to Statistical Thermodynamics. (Addison-Wesley, 1960.)

MacInnes, D. A.—The Principles of Electrochemistry. (Reinhold.)

Kortuem, G., and Bockris, J. O'M.—Textbook of Electrochemůtry, Vol. IL (Elsevier.)

Adamson, A. W. Physical Chemistry of Surfaces. (Interscience.)

Shaw, D. J: Introduction to Colloid and Surface Chemistry. (Butterworth.).

Flory, P. J. Principles of Polymer Chemistry. (Cornell U. P.) Stille, J. K.—Introduction to Polymer Chemistry. (Wiley.)

Gimbiett, F. G. R.—Inorganic Polymer Chemistry. (Butterworth, 1963.) Rossotti, F. J. C., and Rossotti, H.—The Determination of Stability Constants.

(McGraw-Hill, 1961.)

Tanford, C.—Physical Chemistry of Macromolecules. (Wiley.)

Ехnмгхлттoх. Two 3-hour papers in Inorganic Chémistry; two 3-hour papers in Organic Chemistry and two 3-hour papers in Physical Chemistry.

374. CHEMISTRY PART IIIB

A course of approximately fifty lectures in organic chemistry and thirty-five lectures in physical and inorganic chemistry, with twelve hours of laboratory work

per week.

SYLLABUS:

(i) Organic Chemistry. An advanced course covering selected topics in the syllabus for Chemistry Part IIIA.

(ii) Physical and Inorganic. Chemistry. Reaction kinetics, thermodynamics, surface chemistry, chemistry of chelate compounds, radio-chemistry; co-ordination

69

chemistry of metals : nature of metal-ligand bonds, properties of metals and ligands, model metal-enzyme systems. Physical chemistry of macromolecules, with special reference to biological macromolecules.

Lлвоклтoку WORK. A minimum of twelve hours per week on experiments dealing with preparation of pure substances, qualitative and quantitative analysis, inorganic and organic; physico-chemical measurements.

The practical classes for this subject are taken in the Chemistry Building.

The department supplies all the apparatus for which a fee of $30 must be paid to the University Branch of the National Bank using a specially stamped bank slip obtained from the department. Evidence of payment must be produced to the department before practical classes begin.

Instruction will be given in the methods for systematic consultation of chemical literature and students will make a study of the original literature on selected topics.

Воокs. (a) Recommended for preliminary vacation reading:

Fieser, L. F., and Fieser,

1.—Introduction to Organic Chemistry.

(Latest edition. D. C. Heath and Co.)

Hinshelwood, C.

N.—Structure of Physical Chemistry.

(Oxford.) Guggenheim, E.

A. Boltzmann's Distribution Law.

(North Holland.).

(b) Prescribed text-books:

The text-books prescribed for Chemistry Part IIB, together with:

*Mann, F. G.,

and

Saunders, B.

C.—Practical Organic Chemistry.

(4th ed., Longmans.)

*Wild,

F.—Characterization of Organic Compounds.

(2nd ed., C.U.P.) Ferguson, L.

N.—The Modern Structural Theory of Organic Chemistry.

(Prentice-Hai.)

*Dyer, J.

R.—Applications of Absorption Spectroscopy of Organic Compounds.

(Prentice-Hall.)

Turner, E. E., and Harris, M. 1.—Organic

Chemistry.

(Longman.) (c) Recommended for general reading and reference:

Latimer,

W. M.—The Oxidation States of the Elements.

(Prentice-Hall.) Cotton, F. A., and Wilkinson,

G.-Advanced Inorganic Chemistry.

^(Inter-

science.)

Lewis, J.,

and

Wilkins, R. G. (eds.)—Mоdеrп

Coordination Chemistry.

^(Inter- science.)

Orgel, L.

E.—Introduction to Transition Metal Chemistry.

(Methuen.) Bellamy, L.

J.—The Infra-red Spectra of Complex Molecules. (2nd

^ed.,

Methuen, 1958.)

Cross, A. D. An

Introduction to Practical Infra-red Spectroscopy.

(Butter- worth.)

Flett, M. St.

C.—Characteristic Frequencies of Chemical Groups

in

the Infra- Red.

(Elsevier, 1963.)

Jackman, L.

M.-Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry.

(Pergamon.)

Nakanishi,

K.—lnfr

а-red Absorption Spectroscopу—Practical. (Holden-Day, Inc., San Francisco ; Nankodo Co., Tokyo.)

Gillam, A. E., and Stern, E.

S.—A

п

Introduction to Electronic Absorption Spectroscop

у

in Organic Chemistry.

(2nd ed., Arnold, 1957.)

Johnson, F. H., Eyring, H., and Polissar, M.

J.—The Kinetic Basis of Mole- cular Biology.

^(Wiley.)

Glasstone, S., Laidler, K. J.,

and

Eyring,

1.—The Theory of Rate Processes.

(McGraw-Hill.)

Frost, A. A.,

and

Pearson, R.

G. Kinetics and Mechanism.

(2nd ed., Wiley.) Kitchener, J.

A. Ion-Exh

апgе

Resins.

(Methuen.)

)oelwyn-Hughes, E.

A. Physical Chemistry.

(Pergamon Press.)

Partington, J. R.—An

Advanced Treatise on Physical Chemistry,

5 vols.

(Longmans.)

Bak, B.—Elementary

Introduction to Molecular Spectra.

(North Holland.) Hickinbottom, W.

J.—Reactions of Organic Compounds.

(Longmans.) Clar,

E. Polycyclic Hydrocarbons,

2 vols. (Academic Press.)

70

Fieser, L. F., and Fieser, M.—Organic Chemistry. (Reinhold.) Hine, J. Physical Organic Chemistry. (2nd ed., McGraw-Hill.) Gould, E. S. Mechanism and Structure in Organic Chemistry. (Holt.) Albert, A. Heterocyclic Chemistry. (Athlone Press.)

Badger, G. M.-The Chemistry of Heterocyclic Compounds. (Academic Press.) Rodd, E. H. (ed.)-Chemistry of Carbon Compounds. (Elsevier.)

Elderfield, R. (ed.)—Heterocyclic Compounds, Vols. 1-6. (Wiley.) Badger, G. M.—The Structure and Reactions of Aromatic Compounds.

(C.U.Р.)

Eliel, E. L.—Stereochemistry of Carbon Compounds. (McGraw-Hill,) Tanford, C.—Physical Chemistry of Macromolecules. .(Wiley.) Jones, M. M. Elementary Co-ordination Chemistry. (Prentice-Hall.) Morawetz, H.-Macromolecules in Solutśoп. (Interscience, 1965.)

Еawг1NАrioN. One 3-hour paper and one 2-hour paper in Organic Chemistry and one 3-hour paper in Inorganic and Physical Chemistry combined.