A course of one lecture and two hours of laboratory work per week throughout the year. The course will cover the fundamental principles of cytology and genetics In viruses, bacteria, fungi, higher plants and anl- mals, including the human species.
SYLLABUS The nature of the genetic material. Structure and replication of the genetic material. Polyploidy. The segregation of genes. Sex-linked inheritance. Linkage and recombination of genes. The cytoplasm in here- dity. Mutation. Gene action and protein synthesis. Elementary population and evolutionary genetics.
PRACTICAL WORK Two hours per week throughout the year.
A list of equipment to be provided by students will be posted in the department. Students must call at the department office on February 1, 20 or 21 to be assigned to a laboratory group.
BOOKS
Prescribed textbook:
Burns G W The Science of Genetics, 2nd ed Collier-Macmillan Internt) ed
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GENETICS
Recommended for reference:
Srb A M Owen R D & Edgar R S General Genetics, 2nd ed Freeman 1965
Dobzhansky T Genetics of the Evolutionary Process Columbia Univ Press
Herskowitz I H Basic Principles of Molecular Genetics, Nelson McKusick V A Human Genetics, 2nd ed Prentice-Hall
White M J D The Chromosomes, Chapman & Hall 1973 Swanson C P Merz T& Young W J Cytogenetics, Prentice-Hall Garber E D Cytogenetics an Introduction, McGraw-Hill
Fincham J R S Microbial and Molecular Genetics, English Universities Press
Hartman P E & Suskind S R Gene Action, Prentice-Hall Harris H Human Biochemical Genetics, North-Holland Strickberger M W Genetics, Macmillan
Fincham J R S & Day P R Fungal Genetics, 2nd ed Blackwell
EXAMINATION One 2-hour written paper. A 2-hour practical examination at the end of the year. Practical tests may also be held during the year.
300 LEVEL
301-306 ADVANCED GENETICS
These six units each occupy four weeks. There will be four lectures, a 2-hour tutorial and ten hours practical work per week. The following books are recommended for the use of students taking any or all of the units:
BOOKS
Recommended for preliminary reading:
Students are strongly advised to prepare for these units by reading at least one or two of the following and may consult staff members for guidance:
Carlson E A The Gene—A Critical History, Saunders
Hartman P E & Suskind S R Gene Action, 2nd ed Prentice-Hall Haynes R H & Hanawalt P C eds The Molecular Basis of Life, Freeman Whitehouse H L K Towards an Understanding of the Mechanism of
Heredity, 2nd ed Arnold.
Watson J Molecular Biology of the Gene 2nd ed, Benjamin
EXAMINATIONS 1 % hour paper in the examination period after the conclusion of each unit. Practical work may be assessed and practical tests may be held In any unit.
301 BIOCHEMICAL AND DEVELOPMENTAL GENETICS
Gene function in higher organisms (eukaryotes): special aspects of replication, transcription and translation. Transport, stabilization and life of m-RNA. Regulation of gene activity: activation in the zygote and in interspecific heterocaryons; determination and differentiation; trans- determination; nuclear transplantation. Dosage compensation; genetic regulation of metabolism; isozymes; models of control systems. Integra- tion of the genotype in development: gene-action systems, treodes;
pattern formation and morphogenesis; current problems In developmental biology.
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GENETICS PRACTICAL WORK Practical work In this unit is designed as an intro- duction to the techniques of molecular biology and biochemical genetics.
Methods for studying nucleic acid and protein biosynthesis, for charac- terizing these macromolecules and investigating their functional relation- ships are emphasized. Isotopic tracer techniques, electrophoresis, and enzyme assay procedures are included.
BOOKS
Recommended for preliminary reading:
Harris H Nucleus and Cytoplasm, 2nd ed OUP Recommended for reference:
Davidson E H Gene Activity In Early Development, Academic Press Harris H Cell Fusion, OUP
Loomis W F ed Papers on Regulation of Gene Activity during Develop- ment, Harper & Row
Markert C L & Ursprung H Developmental Genetics, Prentice-Hall Trinkaus J P Cells Into Organs the Forces that Shape the Embryo, Pren-
tice-Hall
Waddington C H New Patterns In Genetics and Development, Columbia UP
302 POPULATION GENETICS
The unit examines the role of genes in populations of organisms at the theoretical and applied level. Hardy-Weinberg equilibrium. Selection, Drift, Mating Systems. Heterosis and Epistasis. Genetic Homeostasis.
Balanced polymorphism and co-adaptation. Genetic Load. Genetic Assimi- lation. Genetics of Biological Control.
BOOKS
Recommended for reference:
Dobzhansky T Genetics of the Evolutionary Process, Columbia UP Mettler L E & Gregg T C Population Genetics and Evolution, Prentice-
Hall
Falconer D S Introduction to Quantitative Genetics, Oliver & Boyd Wallace B Topics In Population Genetics, Norton
Ford E B Ecological Genetics 3rd ed, Chapman & Hall
303 MICROBIAL AND MOLECULAR GENETICS
A course of lectures and practicals designed for students who desire to master the concepts of microbial genetics and molecular biology well enough to be able to apply them to their own problems and to compre- hend original papers. The course will stress genetical analysis, in the various novel genetic systems which have been found iп micro-organisms, especially in bacteria and their viruses. It is intended also to cover the integration of genetic studies with biochemical and physical analyses of the synthesis structure and function of писlеiс acids and proteins.
Books
Recommended for reference:
Mendelstam J & McQuillen K Biochemistry of Bacterial Growth, Black- well
Hayes W The Genetics of Bacteria and their Viruses, 2nd ed Blackwell Stent G S Moiecuiar Biology of Bacterial Viruses, Freeman
127
GENETICS
304 HUMAN GENETICS
A course designed to demonstrate the special contributions of human genetics to the overall sum of genetic knowledge. Relation of mutation to protein structure and function in man. laemoglobin and enzyme vari- ants, harmless and harmful. Inborn errors of metabolism in man. The techniques used in human genetics. Consanguinity, quantitative Inheri- tance and congenital malformations.
BOO Ks
Recommended for reference:
Hamerton J L General Cytogenetics Vol I Academic 1970
Harris H The Principles of Human Biochemical Genetics, North-Holland McKusick V A Human Genetics, 2nd ed Prentice-Hall
LI C C Human Genetics, McGraw-Hill
Stern C Principles of Human Genetics, 3rd ed Freeman
Stanbury J B et al ed Metabolic Basis of Inherited Disease, 3rd ed McGraw-Hill
305 CYTOGENETICS
The chromosome as a macromolecular structure. Mitosis and endomitosis.
Giant chromosomes (polytene and lampbrush). The mechanism of meio- sis. Principles of chromosomal rearrangement. Chromosomal polymorph- ism In natural populations and its adaptive significance. Karyotype evolu- tion and the role of chromosomal rearrangements in race- and species- formation. Anomalous chromosome cycles and mechanisms of meiosis.
Cytogenetics of hybrids. Simple and complex sex chromosome mechan- isms. The cytogenetics of parthenogenesis. Heteropycnosis, genetic inert- ness and inactivation and the timing of DNA replication.
BOOКS
Recommended for reference:
Dobzhansky T Genetics of the Evolutionary Process Columbia Univ Press
John B & Lewis K R The Meiotic System, Springer-Verlag White M J D Animal Cytology and Evolution, 3rd ed CUP
306 GENETICS OF FUNGI and HIGHER PLANTS.
The analysis and interpretation of genetic differences in fungi and higher plants and the genetic properties of plant species. The effects of different breeding systems. Artificial and natural selection. Biostatistics. Biocheml- cal basis of adaptation within populations. Chromosome botany. Recom- bination systems. Genecology and speciation. The genetics of plastids.
BOOKS
Recommended for reference:
Stebbins G L Processes of Organic Evolution, Prentice Hall Allard A W Principles of Plant Breeding, Wiley
Baker H G & Stebbins G L The Genetics of Colonizing Species, Aca- demic Press
Kershaw R D Quantitative and Dynamic Ecology, Edward Arnold Stebbins G L Chromosomal Evolution In Higher Plants, Prentice-Hall Scagel R F et al Plant Diversity: An Evolutionary Approach, Wadsworth Kirk J T O& Tilney-Bassett R A E The Plastids, Freeman
Esser К & kuenen R The Genetics of Fungi, Springer Verlag Grant V Plant Speciation, Columbia UP
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GEOGRAPHY