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Fig. 1. Phosphoinositol cycle (PI-cycle). Lithium blocks the enzyme,inositol monophosphatase preventing the conversion of inositol-1-phos-accumulation of inositol monophosphates and a depletion of(steps blocked by lithium are shown by bold arrows)
Fig. 2. 500 MHz H NMR spectrum from 3.51 to 3.66 ppm of rat brain1extracts. GLY, glycine; MI, myo-inositol.
Fig. 6 shows a typical 202.3 MHz31and Table 1 illustrate the brain concentrations of IPphosphatesinositol, there was a significant group effect with IPbrain extract
Fig. 7. Whole rat brain concentrations of IP 1PE following chronicsaline, lithium or sodium valproate treatment and acute treatment of either1saline or D-amphetamine

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