DAFTAR PUSTAKA
Abulnaja, K.O., 2009. Changes in the Hormone and Lipid Profile of Obese Adolescent Saudi Females with Acne Vulgaris. Brazilian Journal of Medical and Biological Research, 42 (6): 501-505.
Adégbidi, H., Koudoukpo, C., Atadokpèdé, F., Ango-Padonou, F., dan Yédomon, H.G., 2014. Epidemiological and Clinical Aspects of Acne in the Dermatology Department of the Teaching Hospital Parakou (Benin).
Journal of Cosmetics, Dermatological Sciences and Applications, 4:
129-134.
Aksu, A.E.K., et al. 2012. Acne: Prevalence and Relationship with Dietary Habits
in Eskisehir, Turkey. JEADV, 26: 1503-1509.
Al-Kubaisy, W., Abdullah, N.N., Kahn, S.M., and Zia, M., 2014. Sociodemographic Characteristics of Acne among University Students in Damascus, Syria. Epidemiology Research International.
American Academy of Dermatology, 2014. Acne. Available from:
[Accessed May 12, 2014].
Anggrenni, O., 2014. Studi Retrospektif Pasien Akne Vulgaris di RSUP H. Adam Malik Medan Periode Tahun 2010-2012. Tesis Program Magister Kedokteran Klinik Departemen Ilmu Kesehatan Kulit dan Kelamin Fakultas
Arshdeep, D.D., 2013. What’s New in the Management of Acne?. Indian J Dermatol Venereol Leprol, 79: 279-87.
Axelsson, J., Ingre, M., Åkerstedt, T., and Holmbäck, U., 2005. Effects of Acutely Displaced Sleep on Testosterone. J Clin Endocrinol Metab, 90: 4530–4535.
Bagatin et al., 2014. Acne Vulgaris: Prevalence and Clinical Forms in
Adolescents from São Paulo, Brazil. An Bras Dermatol 89(3): 428-35
Behrman, R.E., Kliegman, R.M., and Jenson, H.B., 2003. Nelson Textbook of Pediatrics. 17th ed. Elsevier.
Bhambri, S., Del Rosso, J.Q., and Bhambri, A., 2009. Pathogenesis of Acne Vulgaris : Recent Advances. Journal of Drugs in Dermatology.
Bhate, K. and Williams, H.C., 2013. Epidemiology of Acne Vulgaris.
Bogino, E.A., Kebede, M.G., and Kahsay, A.B., 2014. Acne at Ayder Referral Hospital among Patients Attending Dermatologic Clinic, Mekelle, Northern Ethiopia, September 2014. Science Journal of Clinical Medicine, 3(6):
129-134.
Böhm, M., et al., 2002. Evidence for Expression of Melanocortin-1 Receptor in Human Sebocytes In Vitro and In Situ. J Invest Dermatol, 118: 533-539.
Caperton C et al., 2014. Double-Blind, Placebo-Controlled Study Assessing the
Effect of Chocolate Consumption in Subjects with a History of Acne Vulgaris. J Clin Aesthet Dermatol, 7(5): 19-23.
Capitanio, B., Sinagra, J.L., Ottaviani, M., Bordignon, V., Amantea, A., and Picardo, M., 2009. Acne and Smoking. Dermato-Endocrinology, 1 (3):
129-135.
Carolyn, I.J., Jeffrey, S.D., and Michael, S.K., 2001. Acne Scarring: A Classification System and Review of Treatment Options. Journal of the American Academy of Dermatology, 45 (1): 109–117.
Colrain, I.M. and Baker, F.C., 2011. Changes in Sleep as a Function of Adolescent Development. Neuropsychol Rev, 21: 5–21.
Costa, A., Moisés, T.A., and Lage, D., 2010. Acne and Diet: Truth or Myth?. An Bras Dermatol, 85 (3): 346-53.
Dahlan, M.S. 2012. Analisis Multivariat Regresi Logistik, Seri 9. Jakarta:
Epidemiologi Indonesia.
Dahlan, M.S. 2014. Statistik untuk Kedokteran dan Kesehatan; Deskriptif, Bivariat, dan Multivariat Dilengkapi Aplikasi Menggunakan SPSS. Jakarta:
Epidemiologi Indonesia.
Dahlan M.S. 2009. Penelitian Diagnostik; Dasar-Dasar Teoretis dan Aplikasi dengan Program SPSS dan Stata. Jakarta: Salemba Medika.
Del Rosso, J.Q., 2007. Study Results of Benzoyl Peroxide 5% Clindamycin 1% Topical Gel, Adapalene 0,1%, and Use in Combination for Acne Vulgaris. J drugs dermatol, 6 (6): 616-622.
Dhamayanti, M., 2013. Overview Adolescent Health Problems and Services.
Jakarta : IDAI. Available from: [Accessed April 17, 2014].
Do, J.E., Cho, S., In, S., Lim, K., Lee, S., and Lee, E, 2009. Psychosocial Aspects of Acne Vulgaris: A Community-based Study with Korean Adolescents.
Ann Dermatol, 21 (2): 125-129.
Dougan P dan Rafikhah N., 2014. Dark and White Chocolate Consumption and Acne Vulgaris: A Case-Control Study. Asian J Clin Nutr, 6(2): 35-40.
Downie, M.M.T., Sanders, D.A., and Kelaey, T., 2002. Modelling the remission of individual acne lesions in vitro. British Journal of Dermatology, 147:
869–878.
Dreno, B. and Poli, F., 2003. Epidemiology of Acne. Dermatology, 206(1): 7-10.
Eichenfield, L.F. et al., 2013. Evidence-Based Recommendations for the
Diagnosis and Treatment of Pediatric Acne. Pediatrics : Official Journal of the American Academy of Pediatrics, 131: S163–S186.
Fabbrocini, G., et al., 2010 Acne Scars: Pathogenesis, Classification and
Treatment. Dermatology Research and Practice.
Ferdowsian, H.R. and Levin, S., 2010. Does Diet Really Affect Acne?. Skin Therapy Letter, 15(3): 1-2.
Freedberg, I.M., Tomic-Canic, M., Komine, M., and Blumenberg, M., 2001. Keratins and the Keratinocyte Activation Cycle. J Invest Dermatol, 116:
633-640.
Ganceviciene, R., Graziene, V., Böhm, M, and Zouboulis, C.C., 2007. Increased In Situ Expression of Melanocortin-1 Receptor in Sebaceous Glands of Lesional Skin of Patients with Acne Vulgaris. Experimental Dermatology,
16: 547-552.
Ghodsi, S.Z., Orawa, H., and Zouboulis, C.C., 2009. Prevalence, Severity, and Severity Risk Factors of Acne in High School Pupils: A Community-Based Study. Journal of Investigative Dermatology, 129: 2136-2141.
Granner, D.K., 2006. Keragaman Sistem Endokrin. In: Murray, R.K., Granner, D.K., dan Rodwell, V.W. 27th ed. Biokimia Harper. Jakarta : EGC, 455-477.
Guy, R., Green, M.R., and Kealey, T., 1996. Modeling Acne In Vitro. J Invest Dermatol, 106: 176–182.
Handelman, G.J., Packer, L., Cross, C.E., 1996. Destruction of Tocopherols, Carotenoids, and Retinol in Human Plasma by Cigarette Smoke. Am J Clin Nutr, 63: 559-65.
Hanisah, A., Omar, K., and Shah, S.A., 2009. Prevalence of Acne and its Impact on the Quality of Life in School-Aged Adolescents in Malaysia. J Primary Health Care, 1 (1): 20–25
Harahap, M., 1998. Ilmu Penyakit Kulit. Jakarta : Hipokrates, 35-45.
Harrison, W.J., Bull, J.J., Seltman, H., Zouboulis, C.C., and Philpott, M.P., 2007. Expression of Lipogenic Factors Galectin-12, Resistin, SREBP-1, and SCD in Human Sebaceous Glands and Cultured Sebocytes. Journal of Investigative Dermatology, 127: 1309–1317.
Hughes, B.R., Morris, C., Cunliffe, W.J., and Leigh, I.M., 1996. Keratin Expression in Pilosebaceous Epithelia in Truncal Skin of Acne Patiens.
British Journal of Dermatology, 134: 247-256.
Huynh, M., Gupta, R., and Koo, J.Y.M., 2013. Emotional Stress as A Trigger for Inflammatory Skin Disorders. Semin Cutan Med Surg, 32:68-72.
Ingham E.E., Eady, A., Goodwin C.E., Cove J.H., and Cunliffe W.J., 1992. Pro- Inflammatory Levels of Interleukin-1α-like Bioactivity are Present in the Majority of Open Comedones in Acne Vulgaris. J Invest Dermatol, 98:
895–901.
Isard, O., et al., 2011. Propionibacterium acnes Activates the IGF-1/IGF-1R
Ismail, N.H., Manaf, Z.A., and Azizan, N.Z., 2012. High Glycemic Load Diet, Milk, and Ice Cream Consumption are Related to Acne Vulgaris in Malaysian Young Adults: A Case Control Study. BMC Dermatology,
12(13).
J.McWilliam, 2009. Acne Vulgaris : Clinical Features, Assessment and Treatment. Nursing Standard, 23(34): 49-56.
Jarrousse, V., Castex-Rizzi, N., Khammari, A., Charveron, M., and Dréno, B., 2007. Modulation of Integrins and Filaggrin Expression by Propionibacterium Acnes Extracts on Keratinocytes. Arch Dermatol Res,
299:441–447.
Khani, S. and Tayek, J.A., 2001. Cortisol Increases Gluconeogenesis in Humans: its Role in the Metabolic Syndrome. Clinical Science, 101: 739–747.
Khunger N and Kumar C., 2012. A Clinico-Epidemiological Study of Adult Acne: Is It Different from Adolescent Acne?. Indian J Dermatol Venereol Leprol,
78(3): 335-41.
Klaz, I., Kochba, I., Shohat, T., Zarka, S., and Brenner, S., 2006. Severe Acne Vulgaris and Tobacco Smoking in Young Men. Journal of Investigative Dermatology, 126: 1749-1752.
Knutsen-Larson, S., Dawson, A.L., Dunnick, C.A., and Dellavalle, R.P., 2012. Acne Vulgaris: Pathogenesis, Treatment, and Needs Assessment. Dermatol Clin, 30: 99–106.
Kuiri-Hänninen, T., Haanpää, M., Turpeinen, U., Hämäläinen, E., Dunkel, L., dan Sankilampi, U., 2013. Transient Postnatal Secretion of Androgen Hormones is Associated with Acne and Sebaceous Gland Hypertrophy in Early Infancy. J Clin Endocrinol Metab, 98(1): 199-206.
Kurokawa, I. et al., 2009. New Developments in Our Understanding of Acne
Pathogenesis and Treatment. Experimental Dermatology, 18: 821–832.
Kursunluoglu, L., et al., 2009. Insulin-like Growth factor-I and Insulin –like
Growth Factor Binding Protein-3 Polymorphism in Patients with Thyroid Dysfunction. Archives of Medical Research, 40: 42-47.
Kurzen, H., et al., 2004. Phenotypical and Molecular Profiling of the
Extraneuronal Cholinergic System of the Skin. J Invest Dermatol, 123: 937
–949.
Leproult, R. and Van Cauter, E., 2011. Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men. JAMA, 305: 2173–2174.
Li, Z., Wen-Hwa, L., Anthonavage, M., and Eisinger, M., 2006. Melanocortin-5 Receptor: A Marker of Human Sebocyte Differentiation. Peptides, 27:
413-420.
Lomri, A., Lemonnier, J., Delannoy, P., and Marrie, P.J., 2001. Increased Expression of Protein Kinase Ca, Interleukin-1a, and RhoA Guanosine 59-Triphosphatase in Osteoblasts Expressing the Ser252Trp Fibroblast Growth Factor 2 Apert Mutation: Identification by Analysis of Complementary DNA Microarray. J Bone Miner Res, (16): 705–712.
Mancini, A.J., 2008. Incidence, Prevalence, and Patophysiology of Acne. Johns Hopkins Advanced Studies in Medicine, 8 (4): 100-105.
Mannocci, A., et al., 2012. Association between Smoking Habits and Acne
Vulgaris, A Case Control Study. IJPH, 9 (3).
Mannocci, A., Semyonov, L., Saulle, R., and Boccia, A., 2010. Evaluation of the Association between Acne and Smoking: Systematic Reviewand Meta-Analysis of Cross-Sectional Studies. IJPH, 7 (3): 256-261.
Mantzoros, C.S., 2011. Leptin in Human Physiology and Pathophysiology. Am J Physiol Endocrinol Metab, 301: E567–E584.
Mcdowell, A., et al., 2005. Propionibacterium Acnes Types I and II Represent
Phylogenetically Distinct Groups. J. Clin. Microbiol, 43(1): 326-334.
Melnik, B. and Schmitz, G., 2008. FGFR2 Signalling and the Pathogenesis of Acne. JDDG, 9 (6): 721–728.
Movita, T., 2013. Acne Vulgaris. CDK-203, 40(4): 269-272.
Mukhtar, Z., Haryuna, T.S.H., Effendy, E., Betty, dan Zahara, D., Desain Klinis dan Statistika Kedokteran. Medan: USU Press.
Munawar, S., Afzal, M., Aftab, M., Rizvi, F., and Chaudry, M.A., 2009. Precipitating Factors of Acne Vulgaris in Females. Ann. Pak. Inst. Med. Sci., 5(2): 104-107.
Netea, S.A., et al., 2013. Chocolate Consumption Modulates Cytokine Production
Nguyen, T.T., 2013. Acne Treatment: Easy Ways to Improve Your Care. The
Journal of Family Practice, 62 (2): 82-89.
Noorbala, M.T., Mozaffary, B., and Noorbala, M., 2013. Prevalence of Acne and its Impact on the Quality of Life in High School-Aged Adolescents in Yazd, Iran. Journal of Pakistan Association of Dermatologists, 23(2): 168-172.
Novak, P.D., 1998. Kamus Saku Kedokteran Dorland. Jakarta: EGC.
Ottaviani, M., Alestas, T., Flori, E., Mastrofrancesco, A., Zouboulis, C.C., and Picardo, M., 2006. Peroxidated Squalene Induces the Production of Inflammatory Mediators in HaCaT Keratinocytes: A Possible Role in Acne Vulgaris. Journal of Investigative Dermatology, 126: 2430–2437.
Passi, S., De Pità, O., Puddu, P., and Littarru, G.P., 2002. Lipophilic Antioxidant in Human Sebum and Aging. Free Radic Re, 36: 471-477.
Pavlovsky, L. and Friedman, A., 2007. Pathogenesis of Stress –Associated Skin Disorders: Exploring the Brain-Skin Axis. Curr Probl Dermatol, 35:
136-145.
Philips, N., Auler, S., Hugo, R., and Gonzalez, S., 2011. Beneficial Regulation of Matrix Metalloproteinases for Skin Health. Enzyme Res.
Pindha, I.S., 2004. Akne Vulgaris. In: Soetjiningsih. 2004. Buku Ajar Tumbuh Kembang Remaja dan Permasalahannya. Jakarta : Sagung Seto, 107-117.
Portugal, M., Barak, V., Ginsburg, I., and Kohen, R., 2007. Interplay Among Oxidants, Antioxidants, and Cytokines in Skin Disorders: Present Status and Future Considerations Biomedicine & Pharmacotherapy, 61: 412-422.
Ray, C., Trivedi, P., dan Sharma, V., 2013. Acne and its Treatment Lines.
International Journal of Research in Pharmaceutical and Biosciences, 3
(1): 1-16.
Raza, K., Talwar, V., Setia, A., and Katare, O.P., 2012. Acne: An Understanding of the Disease and its Impact on Life. Int. J. Drug Dev. & Res., 4 (2): 14-20.
Reynolds, A.C., et al., 2012. Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men. PLoS ONE, 7(7).
Rizvi et al., 2010. Pre-Examination Stress in Second Year Medical Students in A Government College. J Ayub Coll Abbottabad, 22(2): 152-155.
Rohr, U.D., 2002. The Impact of Testosterone Imbalance on Depression and Women’s Health. Maturitas, 41 (1): S25-S46.
Sahib, A.S., Al-Anbari, H.H., and Abu Raghif, A.R., 2013. Oxidative Stress in Acne Vulgaris: An Important Therapeutic Target. J Mol Pathophysiol, 2:
27-31.
Sarici, G., Cinar, S., Armutcu, F., Altinyazar, C., Koca, R., and Tekin, N.S., 2010. Oxidative Stress in Acne Vulgaris. JEADV, 24: 763-767.
Savage, L.J. and Layton, A.M., 2010. Treating Acne Vulgaris: Systemic, Local, and Combination Therapy. Expert Rev Clin Pharmacol, 13(4): 563-580.
Schmid S.M., Hallschmid, M., Jauch-Chara, K., Lehnert, H., and Schultes, B., 2012. Sleep Timing may Modulate the Effect of Sleep Loss on Testosterone.
Clin Endocrinol, 77: 749–754.
Schröder, J.M. and Harder, J., 2006. Antimicrobial Skin Peptides and Proteins.
Cell. Mol. Life Sci, 63: 469–486.
Setiawan, E., 2014. Kamus Besar Bahasa Indonesia. Jakarta: Badan
Pengembangan dan Pembinaan Bahasa, Available from:[Accessed May 28, 2014].
Shaheen, B. and Gonzalez, M., 2013. Acne Sans P.acnes. Journal of the European Academy of Dermatology and Venereology, 27: 1–10.
Shen, Y., et al. 2012. Prevalence of Acne Vulgaris in Chinese Adolescents and
Adults: A Community-based Study of 17.345 Subjects in Six Cities. Acta Derm Venereol, 92: 40-44.
Smith, R.N., Braue, A., Varigos, G.A., and Mann, N.J., 2008. The Effect of a Low Glycemic Load Diet on Acne Vulgaris and the Fatty Acid Composition of
Skin Surface Tryglycerides.
Soldin, O.P., Makambi, K.H., Soldin, S.J., dan O’Mara, D.M., 2011. Steroid Hormone Levels Associated with Passive and Active Smoking. Setroids, 76
(7): 653-659.
Stawiski, M.A., 2003. Akne dan Keadaan Terkait. In: Price, S.A., 6th ed.
Patofisiologi : Konsep Klinis Proses-Proses Penyakit. Jakarta : EGC,
1422-9.
Stevens, M.S. and Benbadis, S.R., 2013. Normal Sleep, Sleep Physiology, and
Sleep Deprivation. Available from :
May 29, 2014].
Stewart, M.E., Downing, D.T., Cook, J.S., Hansen J.R., dan Strauss, J.S., 1992. Sebaceous Gland Activity and Serum Dehydroepiandrosterone Sulfate
Levels in Boys and Girls.
Strauss, J.S., et al., 2007. Guidelines of care for acne vulgaris management. J Am Acad Dermatol, 56: 651-63.
Tasli, L., et al., 2013. Insulin-Like Growth Factor-I Gene Polymorphism in Acne Vulgaris. Journal of the European Academy of Dermatology and Venereology, 27: 254-257.
Thiboutot, D. and WenChieh, C., 2003. Update and Future of Hormonal Therapy in Acne. Dermatology, 206 (1): 57-67.
Thiboutot, D., Harris, G., Iles, V., Cimis, G., Gilliand, K., and Hagari, S., 1995. Activ ity of the Typ e 1 5 α-Reductase Exhibits Regional Differences in Isolated Sebaceous Glands and Whole Skin. J Invest Dermatol, 105:
Thiboutot, D.M., Knaggs, H., Gilliland, K., and Hagari, S., 1997. Activity of Type 1 5α-Reductase is greater In the Follicular Infrainfundibulum Compared with the Epidermis. British Journal of Dermatology, 136: 166-171.
Thielitz, A. and Gollnick, H., 2013. Recent Therapeutic Developments for Acne: Advances in the Pathophysiology of Acne. Available from:
[Accessed May 10, 2014].
Titus, S. and Hodge, J., 2012. Diagnosis and Treatment of Acne. Am Fam Physician, 86(8): 734-740.
Tjekyan, R.M.S., 2008. Kejadian dan Faktor Risiko Akne Vulgaris. Media Medika Indonesiana, 43(1): 37-43.
Toyoda, M. and Morohashi, M., 2003. New Aspects in Acne Inflammation.
Dermatology 2003, 206:17-23.
Trisnawati, S.K. and Setyorogo, S., 2013. Faktor Risiko Kejadian Diabetes Melitus Tipe II Di Puskesmas Kecamatan Cengkareng Jakarta Barat Tahun 2012. Jurnal Ilmiah Kesehatan, 5(1): 6-11.
Tsoy, N. 2013. The Influence of Dietary Habits on Acne. World J Med Sci., 8(3):
212-216.
Wahyuni, A.S., 2007. Statistika Kedokteran. Jakarta: Bamboedoea
Communication.
Wasitaatmadja, S.M., 2010. Akne, Erupsi Akneiformis, Rosasea, Rinofima. In: Djuanda, A., Hamzah, M. & Aisah, S., 6th ed.
Ilmu Penyakit Kulit dan
Williams, H.C., Dellavale R.P., and Garner, S., 2011. Acne Vulgaris. Lancet, 379:
361-72.
Witte, E., Witte, K., Warszawska, K., Sabat, R., Wolk, K., 2010. Interleukin-22: A Cytokine Produced by T, NK and NKT Cell Subsets, with Importance in the Innate Immune Defense and Tissue Protection. Cytokine Growth Factor Rev, 21: 365–379.
Wittert, G., 2014. The Relationship between Sleep Disorders and Testosterone in Men. Asian Journal of Andrology, 16: 262–265.
Wyrzykowska, N., Wyrzykowski, M., Żaba. R.W., Silny, W., dan Grzymisławski, M., 2013. Diet and Acne Vulgaris. Przegląd Gastroenterologiczny, 8 (2): 93–97.
Yaykasli, K.O., Turan, H., Kaya, E., and Hatipoglu, O.F., 2013. Polymorphisms in the Promoters of MMP-2 and TIMP-2 Genes in Patients with Acne Vulgaris. Int J Clin Exp Med, 6 (10): 967-972.
Youn S.W., Park, E.S., Lee, H.D., Huh, C.H., and Park, K.C., 2005. Does Facial Sebum Excretion Really Affect the Development of Acne?. The British
Journal of Dermatology. Available from:
Zouboulis, C.C., et al., 2002. Corticotropin-Releasing Hormone: An Autocrine
Hormone that Promotes Lipogenesis in Human Sebocytes. PNAS, 99 (10):
7148–7153.
Zouboulis, C.C., 2003. Sebaceous Gland in Human Skin - the Fantastic Future of a Skin Appendage. J Invest Dermatol, 120: xiv-xv.
Zouboulis, C.C., 2009. Zileuton, A New Efficient and Safe Systemic Anti-Acne Drug. Dermato-Endocrinology, 1(3): 188-192.
Zouboulis, C.C., Seltmann, H., and Alestas, T., 2010. Zileuton Prevents the Activation of the Leukotriene Pathway and Reduces Sebaceous Lipogenesis.