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IN SILICO EVALUATION OF POTENT FOR PPAR? AGONIST OF LIGNAN DERIVATIVES FROM MYRISTICA FRAGRANS HOUTT SEEDS.

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Fig. 1: Binding interaction pattern of TZD docked (purple) and imposed against co-crystal ligand (aryloxy phenyl-propanoic light colored is Loop 11/12, and wire-greacids-yellow) with H3 and H11 in complex with PPARγ
Fig. 3: Imposition of 20 lignan derivatives compounds (grey colored carbons), ariloxypropanoic acid (yellow colored carbon) and TZD (purple colored carbon)of nutmeg seeds against PPAR
Fig. 4: Binding interaction of macelignaninti PPAR. (a) Macelignan imposed against TZD in same position, (b) hydrogen bond interaction (green colored line) of macelignan and hydrogen bond network of PPAR(His323, Tyr473, His449, and Sr289) and hydrophobic

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