xviii Association between serum ferritin level and growth disorder in
children with beta thalassemia major
Johan Christian Silaen
Department of Child Health, Medical School, University of Sumatera Utara, , Hakimi, Nelly Rosdiana, Melda Deliana, Siska
Mayasari Lubis
Haji Adam Malik General Hospital, Medan, Indonesia
Abstract
Background: Beta thalassemia is a genetic hematologic disorder with anemia that needs a lifetime transfusion. It remains endocrinopathies including delayed puberty, diabetes mellitus, growth disorder and final height in adulthood. Several studies revealed association between hemosiderosis and growth disorder during transfusion measured by serum ferritin level but still few in Indonesia.
Objective : To determine the association between serum ferritin level and growth disorder in children with beta thalasemia major.
Methods :This was a case control study with a total of 60 child age 5 until 18 years old devided to thalassemia children as case group and non thalassemia children as control group. Serum ferritin, child height, parental height, and bone age were measured. Association between serum ferritin level and growth disorder was assessed using Fisher exact test. Statistical analysis using P value < 0.05 being considered significant.
Result : Serum ferritin level was significantly differed and related from both groups. Odds Ratio (OR) 4.75 indicated a strong relationship with ferritin level > 2000 µg/L.
Conclusion : There was a significant association between serum ferritin level and growth disorder in children with beta thalassemia major.
Keywords :child, beta thalassemia, major, growth, ferritin
xix Hubungan kadar serum ferritin terhadap gangguan pertumbuhan pada
penderita talasemia beta mayor
Johan Christian Silaen
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Uniersitas Sumatera Utara, Rumah Sakit Umum Pusat Haji Adam Malik Medan
, Hakimi, Nelly Rosdiana, Melda Deliana, Siska Mayasari Lubis
Abstrak
Latar belakang: Talasemia beta mayor merupakan kelainan hematologi genetik dengan anemia yang memerlukan transfuse darah seumur hidup. Hal ini akan menimbulkan berbagai kelainan endokrin, pubertas terlambat, diabetes mellitus, gangguan pertumbuhan termasuk tinggi badan akhir saat dewasa. Beberapa studi menyatakan hubungan antara hemosiderosis dengan gangguan pertumbuhan yang diukur dengan kadar serum ferritin namun studi di Indonesia masih sedikit.
Tujuan : Untuk mengetahui hubungan serum ferritin terhadap gangguan pertumbuhan pada penderita talasemia beta mayor.
Metode : Penelitian ini adalah penelitian case control dengan total 60 anak usia 5 sampai 18 tahun yang dibagi menjadi kelompok kasus yaitu penderita talasemia beta mayor dan kelompok kontrol bukan talasemia beta mayor.Pada penelitian ini dialkukan pemeriksaan serum ferritin, tinggi badan anak, tinggi badan orang tua dan bone age. Gangguan pertumbuhan dianalisis dengan menggunakan uji Fisher exact dengan nilai kemaknaan p < 0.05.
Hasil : Serum ferritin berbeda dan berhubungan bermakna secara signifikan pada kedua kelompok (p <0.001) dan Odds Ratio (OR) 4.750 yang mengindikasikan hubungan kuat pada nilai ferritin > 2000 µg/L.
Kesimpulan : Terdapat hubungan yang bermakna antara serum ferritin dengan gangguan pertumbuhan pada penderita talasemia beta mayor
Kata Kunci : talasemia beta mayor, pertumbuhan, ferritin
