LAMPIRAN B PERHITUNGAN BERAT

LAMPIRAN A

PERHITUNGAN PERSENTASE HASIL

Reaksi:

Piroksikam + 4-nitrobenzoil klorida O-(4-nitrobenzoil)piroksikam

M : 0,010 mol 0,017 mol - B : 0,010 mol 0,010 mol 0,010 mol S : - 0,007 mol 0,010 mol

BM O-(4-nitrobenzoil)piroksikam = 480.45

Berat teoritis O-(4-nitrobenzoil)piroksikam = 0,010 mol

×

480.45 = 4.8045 gram Hasil O-(4-nitrobenzoil)piroksikam yang didapat = 2,5464 gram

Jadi, persentase hasil =

teoritis secara senyawa Berat

sintesis hasil senyawa

Berat _{x 100%}

= 8045 , 4

5464 ,

2 _{x 100%}

LAMPIRAN B

PERHITUNGAN BERAT

Piroksikam = mol x BM

= 0,010 mol x 331,35 = 3,3135 gram 4-nitrobenzoil klorida = mol x BM

= 0,017 mmol x 185,5 = 3,1535 gram

Piridin = mol x BM

= 0.05 mol x 79,10 = 3,9550 gram

Volume piridin =

ρ

berat

=

9827

,

0

9550

,

3

LAMPIRAN C

PERHITUNGAN % HAMBATAN NYERI SENYAWA UJI

O-(4-NITROBENZOIL)PIROKSIKAM DAN SENYAWA PEMBANDING

PIROKSIKAM

LAMPIRAN D

HASIL UJI HSD ANTARA KELOMPOK SENYAWA UJI

O-(4-NITROBENZOIL)PIROKSIKAM, SENYAWA PEMBANDING

PIROKSIKAM, DAN KONTROL CMC-NA 0,5%

Post Hoc Tests

Multiple Comparisons

Dependent Variable: GELIAT Tukey HSD

(I)Dosis (J)Dosis

Mean Difference

(I-J)

Std. Error Sig.

95% Confidence Interval Lower Bound Upper Bound 1 2 11.40000* 3.17719 .030 .6198 22.1802

9 -7.40000* 3.17719 .433 -18.1802 3.3802 10 5.80000 3.17719 .759 -4.9802 16.5802 11 _-59.20000* _{3.17719 .000 -69.9802 -48.4198}

LAMPIRAN E

HASIL UJI ED50 SENYAWAO-(4-NITROBENZOIL)PIROKSIKAM

* * * * * * * * P R O B I T A N A L Y S I S * * * * * * * * *

Observed and Expected Frequencies Cell Counts and Residuals

Numbe

0.02 -3.338 -5.682 -1.962 0.03 -2.782 -4.928 -1.519 0.04 -2.364 -4.362 -1.185 0.05 -2.023 -3.902 -.913 0.06 -1.734 -3.510 -.681 0.07 -1.480 -3.167 -.478 0.08 -1.252 -2.860 -.295 0.09 -1.046 -2.581 -.129 0.1 -.855 -2.325 .024 0.15 -.067 -1.267 .661 0.2 .559 -.431 1.174 0.25 1.097 .278 1.621 0.3 1.579 .906 2.032 0.35 2.026 1.473 2.426 0.4 2.451 1.992 2.821 0.45 2.861 2.465 3.231

0.5 3.265 2.897 3.668

LAMPIRAN F

HASIL UJI ED50 SENYAWA PIROKSIKAM

* * * * * * * * P R O B I T A N A L Y S I S * * * * * * * * *

Cell Counts and Residuals

Numb

Confidence Limits

Probabilit

Estimat e

Lower Bound

Upper Bound PROBI

T

0.01 -4.503 -7.554 -2.789 0.02 -3.559 -6.239 -2.049 0.03 -2.960 -5.405 -1.579 0.04 -2.510 -4.779 -1.225 0.05 -2.143 -4.270 -.937 0.06 -1.831 -3.837 -.691 0.07 -1.558 -3.457 -.475 0.08 -1.313 -3.118 -.281 0.09 -1.090 -2.810 -.105 0.1 -.885 -2.526 .058 0.15 -.036 -1.356 .736 0.2 .639 -.434 1.282 0.25 1.217 .349 1.759 0.3 1.737 1.038 2.202 0.35 2.219 1.656 2.631 0.4 2.676 2.213 3.069 0.45 3.118 2.711 3.533

0.5 3.553 3.159 4.033

LAMPIRAN G

SKEMA SINTESIS O-(4-NITROBENZOIL)PIROKSIKAM

17 mmol 4-nitrobenzoil klorida + THF 10 ml

10 mmol piroksikam + 30 ml THF + 2 ml piridin

reflux selama waktu tertentu , KLT tiap jam sampai noda piroksikam (-)

uapkan THF, + NaOH 1N 10 ml sambil diaduk lalu dicuci air 2x @100ml aduk selama 15 menit

tuang campuran didalam BG, + etil asetat 30 ml pisahkan fase etil asetat,

fase etil asetat + Na Sulfat Anhidrat

rekristalisasi dengan etanol

LAMPIRAN H

LAMPIRAN I