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FORMULASI DAN EVALUASI EMULGEL DARI KOMBINASI AVOBENZONE DAN OKTILMETOKSISINAMAT
SEBAGAI TABIR SURYA
ABSTRAK
Latar belakang: Dewasa ini, penggunaan tabir surya dalam bentuk krim, losion, gel dan emulsi banyak digunakan untuk melindungi kulit dari sinar matahari. Sediaan tabir surya diformulasikan menggunakan kombinasi Avobenzone dan Oktilmetoksisinamat sebagai penyerap ultraviolet A dan ultraviolet B dalam bentuk emulgel karena memilki system penghantaran obat yang baik dibandingkan sediaan lain.
Tujuan: Penelitian ini bertujuan untuk memformulasikan Avobenzone dan Oktilmetoksisinamat yang berfungsi sebagai tabir surya dalam sediaan emulgel.
Metode: Emulgel tabir surya dibuat menggunakan Hidroksipropilmetilselulosa (HPMC), propilen glikol, metil paraben dan propil paraben sebagai basis gel dan Avobenzone, Oktilmetoksisinamat, paraffin cair, dan variasi konsentrasi Tween 20 yaitu F1: 0,1%; F2: 0,5%; F3: 1%; F4: 1,5%; F5: 2%; F6: 2,5%; dan F7: 3% sebagai basis emulsi. Pengujian sediaan meliputi pengamatan organoleptis, pengamatan homogenitas, penentuan tipe emulsi, pH, viskositas, ukuran partikel menggunakan mikroskop selama penyimpanan 8 minggu dimana pengukuran dilakukan setiap 1 minggu dalam suhu kamar,iritasi terhadap kulit manusia, dan penentuan nilai SPF sediaan.
Hasil: Hasil penelitian menunjukkan bahwa sediaan emulgel tabir surya berwarna putih susu dan tidak berbau. Hasil pengamatan stabilitas emulgel tabir surya formula 7 menggunakan Tween 20 dengan konsentrasi 3% menunjukkan emulgel yang paling stabil karena tidak mengalami perubahan organoleptis, pembentukan krim (creaming) pada emulgel terjadi setelah 8 minggu, memiliki viskositas paling tinggi, memiliki ukuran rata-rata partikel paling kecil 20,89 µm, tidak mengiritasi kulit, dan memiliki nilai SPF paling tinggi yaitu 13,26±0,03. Sediaan emulgel tabir surya yang dibuat memiliki pH 4,83-6,16 dan memiliki tipe emulsi minyak dalam air.
Kesimpulan: Dapat disimpulkan bahwa semakin tinggi konsentrasi Tween 20 maka semakin stabil sediaan emulgel dan nilai SPF sediaan tabir surya yang dihasilkan termasuk dalam kategori maksimal yaitu SPF antara 8-15.
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FORMULATION AND EVALUATION OF EMULGEL WITH COMBINATION OF AVOBENZONE AND OCTYLMETHOXYCINNAMATE AS SUNSCREEN
ABSTRACT
Background: Nowadays, sunscreens in cream, lotion, gel and emulsion forms are widely used to protect skin from sunshine. Sunscreen preparation is formulated using Avobenzone and Octylmethoxycinnamate combinations as ultraviolet A and ultraviolet B absorber in emulgel form since its drug delivery system which better than another preparation.
Purpose: This research purpose was to formulated Avobenzone and Octylmethoxycinnamate of which function as sunscreen in emulgel preparation.
Method: Emulgel sunscreen was made using Hydroxypropilmethylcelulose (HPMC), propylene glycol, methyl paraben and propyl paraben as gel basic and using Avobenzone, Octylmethoxycinnamate, dilute paraffin, and some variant of Tween 20 concentrations as F1: 0.1%; F2: 0.5%; F3: 1%; F4: 1.5%; F5: 2%; F6: 2.5%; and F7: 3% as emulsion basic. Preparations was tested, included organoleptic and homogeneity observations, emulsion types determination, pH, viscosity, particle size by microscop for 8 weeks which the measuring was done every 1 week at room temperature, human skin irritation, and SPF value determination.
Results: Results of the research showed that emulgel sunscreen preparation has milk white color and scentless. Result of stability observation, formula 7 emulgel sunscreen using 3% concentration of Tween 20 showed be themost stable emulgel since it did not under go organoleptic changes, creaming on emulgel occured after 8 weeks, highest viscosity, smallest mean of particle size is 20.89 µm, didn’t cause skin irritation, and has highest SPF value as 13.26±0.03. Emulgel sunscreen preparation which had been made has pH of 4.83-6.16 and had oil in water (o/w) emulsion type.
Conclusion: It can be conclude that as higher as concentration of Tween 20 will make emulgel preparation more stable and the SPF value of sunscreen obtain include in maximal category SPF value between 8 to 15.
