Material Transfer Agreement (MTA)
Concerning the Joint Research Activities for Commercial Purposes between Bogor Agricultural University (IPB), INDONESIA and Kao Corporation, JAPAN (Kao)
Bogor Agricultural University (IPB), for the purposes of this agreement acting on behalf of the Republic of Indonesia,
Institution : Bogor Agricultural University/Institut Pertanian Bogor
Address : Kampus IPB Dramaga, Jalan Raya Dramaga, Bogor
16680, Jawa Barat, Indonesia
Provider Department and Scientist : Biopharmaca Research Center and Dr. Irmanida Batubara
(hereinafter referred to as “Provider“),
and the Recipient
Institution : Kao Corporation
Address : 2606 Akabane, Ichikai-machi, Haga, Tochigi 321-3497,
Japan
Recipient Department and Scientist : Biological Science Research and Takehiro Tsutsumi
(hereinafter referred to as “Recipient“)
The Parties wish to define the modalities of transfer and use of Material as part of the Joint collaborative research ( “Research”) and in compliance with the provisions of the J o i n t C o l l a b o r a t i v e Agreement concerning “Evaluation of effective functions based on extracts derived from Indonesian plants (“Extracts”); Appendix 1 till 4 form an integral part of this MTA. In response to the Recipient’s request for the above-identified Material from the Provider, the Recipient agrees to the following terms in consideration of receipt of the Material.
1. Materials embraced by this agreement are exclusively extracts of biological materials as
mutually agreed in the non-commercial MTA dated on 9th of March, 2015 (“Non-commercial
MTA”), which were already transferred by Provider to the Recipient.
The Material will be used for: commercial research purposes to develop prospective products agreed by both Parties on beauty and health care agent. Use of the materials for any other purposes shall be agreed by Parties in separate agreement.
To the extent necessary, the Material will be provided with accompanying know-how or data by the Provider.
which constitute an unmodified functional subunit or product expressed by the transferred Material.
3. The Recipient will use the Material solely for commercial research purposes as listed in Appendix 2 a n d 3 at the Recipient’s premises and under the direction and direct supervision of the Recipient Scientist. The Research with the Material will be conducted within the Recipient’s collaborative research with the Provider.
4. The Recipient is obliged to inform the Provider about feedback details obtained by the Recipient, in writing by use of Appendix 4 as part of the monitoring procedure as to the use of the transferred Material:
a) In case of any changes of the Material identified by the Recipient in the course of its use without undue delay.
b) In case of any other feedback (data collected, results) within s i xt y (60) da ys upon completion of the research
For the avoidance of doubt, the Recipient acknowledges that the on-going and/or subsequent transfer of Material by the Provider is dependent upon the Recipient’s compliance with the aforementioned obligation of this clause. In case of feedback concerning presentation of the results in conferences or publications, Article 15 shall apply.
5. Provider and Recipient agree that all inventions, ideas, data, know-how, negative know-how, concepts, developments, designs, discoveries, improvements or innovations (collectively, “Invention(s)”) and its derivatives arising during the course of performing the Research shall be joint property of Provider and Recipient.
6. According to the Convention on Biological Diversity and the Nagoya Protocol, the Parties agreed to mention the country of origin of the Material used, their derivatives, and genetic information obtained.
7. Benefit sharing from commercialization of the products using transferred material shall be arranged and mutually agreed in a separate agreement by the time the product is launched. If there are Genetic Resources and Traditional knowledge related to Genetic Resources (“GR” and “TKGR”) used for commercial purposes, the local community through the Provider are entitled to benefit sharing arising from using GR and TKGR.
8. If applicable: The Recipient agrees to actively involve the following researcher from IPB in the analysis of the Material as well as preparation and/or drafting of publications concerning the transferred Material (Name, institution and contact details):
Prof Dr Ir Latifah K Darusman
Dr Irmanida Batubara, SSi., MSi
Drs Edy Djauhari, MSi
Rudi Heryanto, SSi., MSi
10. Any Intellectual Property resulting from the Research shall be jointly owned by Parties. Neither Party shall independently file any patent application covering the inventions or publish any scientific article without the prior written consent of the other Party.
11. If both Parties decide to file an application for or otherwise be eligible to patent or obtain any other industrial property right with respect to patentable Inventions based on the Inventions, both Parties agree to file the patent application jointly. In this case, the patent applicant for join application shall be in the name of Parties. Researchers who contributed to the Invention shall be named as inventors of the Invention.
12. It is understood that no right to any license of the Material is given or implied by this Agreement. The Parties’ names will be used for no endorsements.
13. The Material is experimental in nature and it is provided without any warranties, express or implied, including any warranty of merchantability or fitness for a particular purpose. To the extent permitted by law, liability shall be restricted to willful intent and gross negligence; to the extent permitted by law, liability for consequential damages shall be explicitly excluded.
14. It is explicitly stated that it shall be at the sole discretion of the Provider how to proceed with the Material as referred to in clause 1 after completion of the Recipient’s study on said Material. The Recipient has to inform the Provider about the completion of the studies with the Material without undue delay.
The Parties agree that within ten working days after being informed about the completion of the studies, the Provider shall state in writing the measures to be taken by the Recipient.
If applicable, the Recipient shall make available any reference material and documentation of all species determined (i.e. having ascribed Linnean species names) to LIPI Biology Research Centre Cibinong as the national reference collection for Biodiversity in Indonesia. If new species will be described holotypes of these species will be deposited at LIPI Biology Research Centre in Cibinong.
15. The Recipient fully acknowledges the obligation to foster scientific knowledge by publications. Recipient and Provider agree that the results obtained in the conduct of the Research shall in principle, as stated in the Joint Collaborative Agreement, be published in joint publications, however in compliance with the rules of good scientific practice, i.e. with authorship according to the scientific input to the publication.
For the avoidance of doubt, and in case the results obtained under this MTA could give rise to industrial intellectual property rights, the Parties agree to treat such results confidential for the time necessary to enable the Parties to take the appropriate steps with undue delay, however in compliance with Article 13 of this MTA.
16. This MTA shall be governed by the laws of Indonesia. If dispute cannot be settled by amicable settlement within ninety (90) days after the start of such discussion, dispute shall be resolved at court Bogor state (Pengadilan Negeri Bogor).
17. The Parties agree that the Non-commercial MTA shall be terminated on entering into this MTA.
For the Provider: For the Recipient:
Name : Prof. Dr. Anas M. Fauzi Name : Tadashi Hase
Position : Vice Rector for Research and Collaboration, IPB
Position : Vice President-R&D-Core Technology - Biological Science Research
Date : Date :
Signature : Signature :
Providing Scientist: Receiving Scientist:
Name : Dr. Irmanida Batubara Name : Takehiro Tsutsumi
Date : Date :
APPENDIX 1: Instructions for recipients
1. Please fill in the form clearly. Especially name and address are important to receive Research Materials. Principal investigator’s address should be the place where researchers are working but not technical license offices are located. If researcher’s address and affiliation have been changed, please stress the change.
2. Any shipping costs are in responsibility of the recipient. Any payment for the Research Materials will be independent of whether or not the material is available without restriction.
3. Always only Principal Investigator (PI) / persons with permanent work contract / persons in legal responsibility of the research institution are eligible to sign the MTA. Technical assistants, students, postdoctoral researchers, research associates should not sign. “Authorized Representative” can be left empty if “Principal Investigator” is the same as “Authorized Representative”.
4. “Title” of the Principal Investigator should be the “institutional title”, for example, like “Professor”, “Team leader”, “project leader”, “Supervisor”, and so on, but should not be “PhD” or “student” or “scientist”.
5. Forms sent by FAX will be NOT accepted, because print-outs are often unclear. To send forms more quickly, clearly scanned (min 150 dpi) and saved as a PDF file can be sent by an attachment of e-mail of the counterpart.
6. “Purpose” of the Research Materials need to be described; recipient needs to describe the details of the used of the Research Materials (appendix 3).
7. Please ensure that you provide for feedbacks as laid down in Article 4 of the MTA. If not, you may not be able to receive/bring/send the Research Materials for next time even if the MTA is correctly filled, unless you contribute to the research community at The Consortium by the feedback of the Research Materials.
APPENDIX 2: Details statement of the purposes
I hereby state that the materials are only required for:
APPENDIX 3 : Details of transferred materials
No Code Scientific name Part of
plant
Solvent for extraction
Estimated amount (g)
1 IPB 1A Zingiber purpureum rhizome Water 5
2 IPB 1B Zingiber purpureum rhizome Ethanol 50% 5
3 IPB 1C Zingiber purpureum rhizome Ethanol 95% 5
4 IPB 1D Zingiber purpureum rhizome n-hexane 5
5 IPB 2A Murraya paniculata Leaves Water 5
6 IPB 2B Murraya paniculata Leaves Ethanol 50% 5
7 IPB 2C Murraya paniculata Leaves Ethanol 95% 5
8 IPB 2D Murraya paniculata Leaves n-hexane 5
9 IPB 3A Syzygium Polyanthum Leaves Water 5
10 IPB 3B Syzygium Polyanthum Leaves Ethanol 50% 5
11 IPB 3C Syzygium Polyanthum Leaves Ethanol 95% 5
12 IPB 3D Syzygium Polyanthum Leaves n-hexane 5
13 IPB 4A Justicia gendarussa Leaves Water 5
14 IPB 4B Justicia gendarussa Leaves Ethanol 50% 5
15 IPB 4C Justicia gendarussa Leaves Ethanol 95% 5
16 IPB 4D Justicia gendarussa Leaves n-hexane 5
17 IPB 5A Guazuma ulmifolia Leaves Water 5
18 IPB 5B Guazuma ulmifolia Leaves Ethanol 50% 5
19 IPB 5C Guazuma ulmifolia Leaves Ethanol 95% 5
20 IPB 5D Guazuma ulmifolia Leaves n-hexane 5
21 IPB 6A Drymoglossum
piloselloides
Leaves Water 5
22 IPB 6B Drymoglossum
piloselloides
Leaves Ethanol 50% 5
23 IPB 6C Drymoglossum
piloselloides
Leaves Ethanol 95% 5
24 IPB 6D Drymoglossum
piloselloides
Leaves n-hexane 5
25 IPB 7A Eleutherine americana rhizome Water 5
26 IPB 7B Eleutherine americana rhizome Ethanol 50% 5
27 IPB 7C Eleutherine americana rhizome Ethanol 95% 5
28 IPB 7D Eleutherine americana rhizome n-hexane 5
29 IPB 8A Stachytarpheta mutabilis Leaves Water 5
30 IPB 8B Stachytarpheta mutabilis Leaves Ethanol 50% 5
31 IPB 8C Stachytarpheta mutabilis Leaves Ethanol 95% 5
32 IPB 8D Stachytarpheta mutabilis Leaves n-hexane 5
33 IPB 9A Curcuma alba rhizome Water 5
34 IPB 9B Curcuma alba rhizome Ethanol 50% 5
35 IPB 9C Curcuma alba rhizome Ethanol 95% 5
36 IPB 9D Curcuma alba rhizome n-hexane 5
37 IPB 10A Piper albae Fruit Water 5
38 IPB 10B Piper albae Fruit Ethanol 50% 5
39 IPB 10C Piper albae Fruit Ethanol 95% 5
40 IPB 10D Piper albae Fruit n-hexane 5
41 IPB 11A Zingiber zerumbet rhizome Water 5
No Code Scientific name Part of plant
Solvent for extraction
Estimated amount (g)
43 IPB 11C Zingiber zerumbet rhizome Ethanol 95% 5
44 IPB 11D Zingiber zerumbet rhizome n-hexane 5
45 IPB 12A Zingiber officinale rhizome Water 5
46 IPB 12B Zingiber officinale rhizome Ethanol 50% 5
47 IPB 12C Zingiber officinale rhizome Ethanol 95% 5
48 IPB 12D Zingiber officinale rhizome n-hexane 5
49 IPB 13A Merremia mammosa Tuber Water 5
50 IPB 13B Merremia mammosa Tuber Ethanol 50% 5
51 IPB 13C Merremia mammosa Tuber Ethanol 95% 5
52 IPB 13D Merremia mammosa Tuber n-hexane 5
53 IPB 14A Graptophyllum pictum Leaves Water 5
54 IPB 14B Graptophyllum pictum Leaves Ethanol 50% 5
55 IPB 14C Graptophyllum pictum Leaves Ethanol 95% 5
56 IPB 14D Graptophyllum pictum Leaves n-hexane 5
57 IPB 15A Coleus Atropurpureus Leaves Water 5
58 IPB 15B Coleus Atropurpureus Leaves Ethanol 50% 5
59 IPB 15C Coleus Atropurpureus Leaves Ethanol 95% 5
60 IPB 15D Coleus Atropurpureus Leaves n-hexane 5
61 IPB 16A Parameria laevigata Stem Water 5
62 IPB 16B Parameria laevigata Stem Ethanol 50% 5
63 IPB 16C Parameria laevigata Stem Ethanol 95% 5
64 IPB 16D Parameria laevigata Stem n-hexane 5
65 IPB 17A Gynura Procumbens Leaves Water 5
66 IPB 17B Gynura Procumbens Leaves Ethanol 50% 5
67 IPB 17C Gynura Procumbens Leaves Ethanol 95% 5
68 IPB 17D Gynura Procumbens Leaves n-hexane 5
69 IPB 18A Nasturtium montanum Leaves Water 5
70 IPB 18B Nasturtium montanum Leaves Ethanol 50% 5
71 IPB 18C Nasturtium montanum Leaves Ethanol 95% 5
72 IPB 18D Nasturtium montanum Leaves n-hexane 5
73 IPB 19A Blumea balsamifera Leaves Water 5
74 IPB 19B Blumea balsamifera Leaves Ethanol 50% 5
75 IPB 19C Blumea balsamifera Leaves Ethanol 95% 5
76 IPB 19D Blumea balsamifera Leaves n-hexane 5
77 IPB 20A Nyctanthes arbortristis Flower Water 5
78 IPB 20B Nyctanthes arbortristis Flower Ethanol 50% 5
79 IPB 20C Nyctanthes arbortristis Flower Ethanol 95% 5
80 IPB 20D Nyctanthes arbortristis Flower n-hexane 5
81 IPB 21A Curcuma mangga rhizome Water 5
82 IPB 21B Curcuma mangga rhizome Ethanol 50% 5
83 IPB 21C Curcuma mangga rhizome Ethanol 95% 5
84 IPB 21D Curcuma mangga rhizome n-hexane 5
85 IPB 22A Averrhoa bilimbi Leaves Water 5
86 IPB 22B Averrhoa bilimbi Leaves Ethanol 50% 5
87 IPB 22C Averrhoa bilimbi Leaves Ethanol 95% 5
88 IPB 22D Averrhoa bilimbi Leaves n-hexane 5
89 IPB 23A Pimpinella puruatjana Herbs Water 5
No Code Scientific name Part of plant Solvent for extraction Estimated amount (g)
91 IPB 23C Pimpinella puruatjana Herbs Ethanol 95% 5
92 IPB 23D Pimpinella puruatjana Herbs n-hexane 5
93 IPB 24A Averrhoa carambola Leaves Water 5
94 IPB 24B Averrhoa carambola Leaves Ethanol 50% 5
95 IPB 24C Averrhoa carambola Leaves Ethanol 95% 5
96 IPB 24D Averrhoa carambola Leaves n-hexane 5
97 IPB 25A Persea gratissima Leaves Water 5
98 IPB 25B Persea gratissima Leaves Ethanol 50% 5
99 IPB 25C Persea gratissima Leaves Ethanol 95% 5
100 IPB 25D Persea gratissima Leaves n-hexane 5
101 Nuric Product of PT
biofarindo
1 bottle (30 capsule)
102 Philary Product of PT
biofarindo
1 bottle (30 capsule)
103 Biolangsing Product of PT
biofarindo
1 bottle (30 capsule)
104 Biovigra Product of PT
biofarindo
1 bottle (30 capsule)
105 Sambiloto Product of PT
biofarindo
1 bottle (60 capsule)
106 Pegagan Product of PT
biofarindo
1 bottle (60 capsule)
107 Jati Belanda Product of PT
biofarindo
1 bottle (60 capsule)
108 Temu putih Product of PT
biofarindo
1 bottle (60 capsule)
109 Beras Kencur Product of PT
Biofarindo
2 box (@ 5 sachets)
110 Alora Instan Product of PT
Biofarindo
1 box (@ 10 sachets)
111 Java tea drink Biopharmaca
prototype product
5 pieces
112 Cajuput candy
Biopharmaca prototype product
5 pieces
APPENDIX 4 : The list of feedback of materials used, based on recipient feedback.
No. Feedback details* Remarks
1 Data repository On line (http://www.___); access code
2 Business plan (tentative titles, source of data, authorships)
Targeted ingredients or products
*) e.g. data/result obtained, publication, conferences etc.
