• Tidak ada hasil yang ditemukan

Inferior Frontal Gyrus

Gyrus Oxytocin and Leptin

Processes stimuli from the gut;

inhibits automatic responses of motor system in “go/no go” situation;

selection process; emotional function, specifically empathy

Table 3: Summary of research conclusions for each associated brain region.

IV. Conclusion

Functional connectivity analyses of resting state fMRI data showed that the connectivities between the pituitary gland and eleven cortical and subcortical regions show negative association with BMI. We hypothesized these brain regions were

functionally connected to the pituitary gland through specific pituitary hormones that are connected to BMI. Through some known specific influences of hormonal associations and data associating these cortical and subcortical regions with the drive to eat, our study suggested that decreased pituitary gland functional connectivities might be associated with obesity (see Table 3).

V. List of References

Adam, T. C., & Epel, E. S. (2007). Stress, eating and the reward system. Proceedings from the 2006 Meeting of the Society for the Study of Ingestive Behavior, 91(4), 449–458. doi:10.1016/j.physbeh.2007.04.011

Adult Obesity Facts | Overweight & Obesity | CDC. (n.d.).

https://www.cdc.gov/obesity/data/adult.html. Accessed 27 April 2017 Amar, A. P., & Weiss, M. H. (2003). Pituitary anatomy and physiology. Neurosurgery

Clinics of North America, 14(1), 11–23, v.

Auffret, J., Viengchareun, S., Carre, N., Denis, R. G. P., Magnan, C., Marie, P.-Y., et al.

(2012). Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. The FASEB Journal, 26(9), 3728–3737. doi:10.1096/fj.12-204958

Beauchamp, M. S., & Martin, A. (2007). Grounding Object Concepts in Perception and Action: Evidence from FMRI Studies of Tools. Cortex, 43(3), 461–468.

doi:10.1016/S0010-9452(08)70470-2

Bigler, E. D., Mortensen, S., Neeley, E. S., Ozonoff, S., Krasny, L., Johnson, M., et al.

(2007). Superior Temporal Gyrus, Language Function, and Autism.

Developmental Neuropsychology, 31(2), 217–238.

doi:10.1080/87565640701190841

Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., et al. (2010).

Toward discovery science of human brain function. Proceedings of the

National Academy of Sciences, 107, 4734–4739.

doi:10.1073/pnas.0911855107

Björkstrand, E., & Uvnäs-Moberg, K. (1996). Central oxytocin increases food intake and daily weight gain in rats. Physiology & Behavior, 59(4–5), 947–952.

doi:10.1016/0031-9384(95)02179-5

Björntorp, P. (2001). Do stress reactions cause abdominal obesity and comorbidities? Obesity Reviews, 2(2), 73–86. doi:10.1046/j.1467- 789x.2001.00027.x

Born, J. M., Lemmens, S. G., Martens, M. J., Formisano, E., Goebel, R., & Westerterp- Plantenga, M. S. (2011). Differences between liking and wanting signals in the human brain and relations with cognitive dietary restraint and body mass index. The American Journal of Clinical Nutrition, 94(2), 392–403.

doi:10.3945/ajcn.111.012161

Brenner, M., & Hearing, V. J. (2009). What are melanocytes really doing all day long…? : from the ViewPoint of a keratinocyte: Melanocytes – cells with a secret identity and incomparable abilities. Experimental dermatology, 18(9), 799. doi:10.1111/j.1600-0625.2009.00912.x

Caballero, B., Finglas, P., & Toldra, F. (Eds.). (2016). Pituitary Gland: Pituitary Hormones. The Enclyopedia of Food and Health, 4, 392–400.

Catani, M., Jones, D. K., Donato, R., & ffytche, D. H. (2003). Occipito-temporal connections in the human brain. Brain, 126(9), 2093–2107.

doi:10.1093/brain/awg203

Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain, 129(3), 564–583.

doi:10.1093/brain/awl004

Cenquizca, L. A., & Swanson, L. W. (2006). An Analysis of Direct Hippocampal

Cortical Field CA1 Axonal Projections to Diencephalon in the Rat. The Journal of comparative neurology, 497(1), 101–114. doi:10.1002/cne.20985

Chalew, S., Nagel, H., & Shore, S. (1995). The Hypothalamic-Pituitary-Adrenal Axis in Obesity. Obesity Research, 3(4), 371–382. doi:10.1002/j.1550-

8528.1995.tb00163.x

Chirico, V., Cannavò, S., Lacquaniti, A., Salpietro, V., Mandolfino, M., Romeo, P. D., et al. (2013). Prolactin in obese children: a bridge between inflammation and metabolic-endocrine dysfunction. Clinical Endocrinology, 79(4), 537–544.

Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., et al. (1998). A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature, 392(6674), 398.

Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., et al.

(2003). Chronic stress and obesity: A new view of “comfort food.”

Proceedings of the National Academy of Sciences of the United States of America, 100(20), 11696–11701. doi:10.1073/pnas.1934666100

Dallman, M. F., Pecoraro, N. C., & la Fleur, S. E. (2005). Chronic stress and comfort foods: self-medication and abdominal obesity. Brain, Behavior, and Immunity, 19(4), 275–280. doi:10.1016/j.bbi.2004.11.004

Damasio, H., Grabowski, T. J., Tranel, D., Hichwa, R. D., & Damasio, A. R. (1996). A neural basis for lexical retrieval. Nature, 380(6574), 499–505.

doi:10.1038/380499a0

Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., & Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight

regulation. Gastrointestinal/Endocrine and metabolic diseases, 7(6), 613–616.

doi:10.1016/j.coph.2007.10.008

DelParigi, A., Chen, K., Salbe, A. D., Reiman, E. M., & Tataranni, P. A. (2005). Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast.

NeuroImage, 24(2), 436–443. doi:10.1016/j.neuroimage.2004.08.035 Doron, N. N., & Ledoux, J. E. (2000). Cells in the posterior thalamus project to both

amygdala and temporal cortex: A quantitative retrograde double-labeling study in the rat. Journal of Comparative Neurology, 425(2), 257–274.

doi:10.1002/1096-9861(20000918)425:2<257::AID-CNE8>3.0.CO;2-Y Drazen, D. L., Vahl, T. P., D’Alessio, D. A., Seeley, R. J., & Woods, S. C. (2005). Effects of

a Fixed Meal Pattern on Ghrelin Secretion: Evidence for a Learned Response Independent of Nutrient Status. Endocrinology, 147(1), 23–30.

doi:10.1210/en.2005-0973

Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O’Rahilly, S., & Fletcher, P. C. (2007).

Leptin Regulates Striatal Regions and Human Eating Behavior. Science, 317(5843), 1355. doi:10.1126/science.1144599

Fletcher, P. C., Frith, C. D., Baker, S. C., Shallice, T., Frackowiak, R. S. J., & Dolan, R. J.

(1995). The Mind’s Eye—Precuneus Activation in Memory-Related Imagery.

NeuroImage, 2(3), 195–200. doi:10.1006/nimg.1995.1025

Gautier, J. F., Chen, K., Salbe, A. D., Bandy, D., Pratley, R. E., Heiman, M., et al. (2000).

Differential brain responses to satiation in obese and lean men. Diabetes, 49(5), 838. doi:10.2337/diabetes.49.5.838

Geliebter, A., Ladell, T., Logan, M., Schweider, T., Sharafi, M., & Hirsch, J. (2006).

Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite, 46(1), 31–35. doi:10.1016/j.appet.2005.09.002

Green, J. J., Taylor, B., & Hollander, E. (2011). Oxytocin and autism.

doi:10.1017/CBO9781139017855.024

Greenman, Y., Tordjman, K., & Stern, N. (1998). Increased body weight associated with prolactin secreting pituitary adenomas: weight loss with normalization of prolactin levels. Clinical Endocrinology, 48(5), 547–553.

Heatherton, T. F., Polivy, J., Herman, C. P., & Baumeister, R. F. (1993). Self-

Awareness, Task Failure, and Disinhibition: How Attentional Focus Affects Eating. Journal of Personality, 61(1), 49–61. doi:10.1111/j.1467-

6494.1993.tb00278.x

Israel Liberzon, M. D., Anthony P. King, P. D., Jennifer C. Britton, P. D., K. Luan Phan, M. D., James L. Abelson, M. D., & Stephan F. Taylor, M. D. (2007). Paralimbic and Medial Prefrontal Cortical Involvement in Neuroendocrine Responses to Traumatic Stimuli. American Journal of Psychiatry.

doi:10.1176/appi.ajp.2007.06081367

Jacobson, L., & Sapolsky, R. (1991). The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*. Endocrine Reviews, 12(2), 118–134. doi:10.1210/edrv-12-2-118

Jéquier, E., & Tappy, L. (1999). Regulation of Body Weight in Humans. Physiological Reviews, 79(2), 451.

Joëls, M. (2008). Functional actions of corticosteroids in the hippocampus. Stress Hormone Actions in Brain, in Health and DiseasePossibilities for New

Pharmacotherapies, 583(2–3), 312–321. doi:10.1016/j.ejphar.2007.11.064 Kelley, A. E. (2004). Ventral striatal control of appetitive motivation: role in

ingestive behavior and reward-related learning. Foundations and Innovations in the Neuroscience of Drug Abuse, 27(8), 765–776.

doi:10.1016/j.neubiorev.2003.11.015

Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005). Corticostriatal-

hypothalamic circuitry and food motivation: Integration of energy, action and reward. Purdue University Ingestive Behavior Research Center Symposium.

Dietary Influences on Obesity: Environment, Behavior and Biology, 86(5), 773–

795. doi:10.1016/j.physbeh.2005.08.066

Killgore, W. D. ., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun- Todd, D. A. (2003). Cortical and limbic activation during viewing of high- versus low-calorie foods. NeuroImage, 19(4), 1381–1394.

doi:10.1016/S1053-8119(03)00191-5

Kita, H. (2001). Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice

preparations. Neuroscience, 105(4), 871–879. doi:10.1016/S0306- 4522(01)00231-7

Kjaer, T. W., Nowak, M., & Lou, H. C. (2002). Reflective Self-Awareness and Conscious States: PET Evidence for a Common Midline Parietofrontal Core. NeuroImage, 17(2), 1080–1086. doi:10.1006/nimg.2002.1230

Kobayakawa, T., Ogawa, H., Kaneda, H., Ayabe-Kanamura, S., & Saito, S. (1999).

Spatio-temporal Analysis of Cortical Activity Evoked by Gustatory Stimulation in Humans. Chemical Senses, 24(2), 201–209.

doi:10.1093/chemse/24.2.201

Koehl, M., Darnaudéry, M., Dulluc, J., Van Reeth, O., Moal, M. L., & Maccari, S. (1999).

Prenatal stress alters circadian activity of hypothalamo–pituitary–adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender.

Journal of Neurobiology, 40(3), 302–315. doi:10.1002/(SICI)1097- 4695(19990905)40:3<302::AID-NEU3>3.0.CO;2-7

Komura, Y., Tamura, R., Uwano, T., Nishijo, H., Kaga, K., & Ono, T. (2001).

Retrospective and prospective coding for predicted reward in the sensory thalamus. Nature, 412(6846), 546.

Konrad, C., Engelien, A., Schöning, S., Zwitserlood, P., Jansen, A., Pletziger, E., et al.

(2008). The functional anatomy of semantic retrieval is influenced by gender, menstrual cycle, and sex hormones. Journal of Neural Transmission, 115(9), 1327. doi:10.1007/s00702-008-0073-0

Kumar, J., Völlm, B., & Palaniyappan, L. (2015). Oxytocin Affects the Connectivity of the Precuneus and the Amygdala: A Randomized, Double-Blinded, Placebo-

Controlled Neuroimaging Trial. International Journal of

Neuropsychopharmacology, 18(5), pyu051. doi:10.1093/ijnp/pyu051 Lang, A. E., Lozano, A., Tasker, R., Duff, J., Saint-Cyr, J., & Trépanier, L. (1997).

Neuropsychological and behavioral changes and weight gain after medial pallidotomy. Annals of Neurology, 41(6), 834–835.

doi:10.1002/ana.410410624

Lee, H.-J., Macbeth, A. H., Pagani, J. H., & Scott Young 3rd, W. (2009). Oxytocin: The great facilitator of life. Progress in Neurobiology, 88(2), 127–151.

doi:10.1016/j.pneurobio.2009.04.001

Lilly, R., Cummings, J. L., Benson, D. F., & Frankel, M. (1983). The human Klüver-Bucy syndrome. Neurology, 33(9), 1141–1141. doi:10.1212/WNL.33.9.1141

Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., et al. (1997).

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic- Pituitary-Adrenal Responses to Stress. Science, 277(5332), 1659–1662.

Lundstrom, B. N., Ingvar, M., & Petersson, K. M. (2005). The role of precuneus and left inferior frontal cortex during source memory episodic retrieval.

NeuroImage, 27(4), 824–834. doi:10.1016/j.neuroimage.2005.05.008 Machielsen, W. C. M., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., & Witter, M. P.

(2000). fMRI of visual encoding: Reproducibility of activation. Human Brain Mapping, 9(3), 156–164. doi:10.1002/(SICI)1097-

0193(200003)9:3<156::AID-HBM4>3.0.CO;2-Q

Mastronardi, C. A., Walczewska, A., Yu, W. H., Karanth, S., Parlow, A. F., & McCann, S.

M. (2000). The Possible Role of Prolactin in the Circadian Rhythm of Leptin

Secretion in Male Rats. Proceedings of the Society for Experimental Biology and Medicine, 224(3), 152–158. doi:10.1111/j.1525-1373.2000.22414.x Mesulam, M. M. (2000). Paralimbic (Mesocortical) Areas. In Principles of Behavioral

and Cognitive Neurology (pp. 49–54). New York, US: Oxford University Press.

Accessed 8 March 2017

Mummery, C., Patterson, K., Price, C. J., Ashburner, J., Frackowiak, R. S. J., & Hodges, J.

R. (n.d.). A voxel-based morphometry study of semantic dementia:

relationship between temporal lobe atrophy and semantic memory. - PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/10632099.

Accessed 21 March 2017

Nooner, K. B., Colcombe, S. J., Tobe, R. H., Mennes, M., Benedict, M. M., Moreno, A. L., et al. (2012). The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry. Frontiers in Neuroscience, 6.

doi:10.3389/fnins.2012.00152

Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J.

G. (1991). Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides, 12(1), 113–118. doi:10.1016/0196-

9781(91)90176-P

Olson, I. R., Plotzker, A., & Ezzyat, Y. (2007). The Enigmatic temporal pole: a review of findings on social and emotional processing. Brain, 130(7), 1718–1731.

doi:10.1093/brain/awm052

Pasquali, R., Gagliardi, L., Vicennati, V., Gambineri, A., Colitta, D., Ceroni, L., &

Casimirri, F. (1999). ACTH and cortisol response to combined corticotropin

releasing hormone-arginine vasopressin stimulation in obese males and its relationship to body weight, fat distribution and parameters of the metabolic syndrome. , Published online: 01 April 1999; | doi:10.1038/sj.ijo.0800838, 23(4). doi:10.1038/sj.ijo.0800838

Pennick, M. R., & Kana, R. K. (2012). Specialization and integration of brain

responses to object recognition and location detection. Brain and Behavior, 2(1), 6–14. doi:10.1002/brb3.27

Pivonello, R., De Martino, M. C., De Leo, M., Lombardi, G., & Colao, A. (2008).

Cushing’s Syndrome. Pituitary Disorders, 37(1), 135–149.

doi:10.1016/j.ecl.2007.10.010

Pons | anatomy. (2002). Encyclopedia Britannica.

https://www.britannica.com/science/pons-anatomy. Accessed 29 March 2017

Puce, A., Allison, T., Asgari, M., Gore, J. C., & McCarthy, G. (1996). Differential Sensitivity of Human Visual Cortex to Faces, Letterstrings, and Textures: A Functional Magnetic Resonance Imaging Study. Journal of Neuroscience, 16(16), 5205–5215.

Purnell, J. Q., Lahna, D. L., Samuels, M. H., Rooney, W. D., & Hoffman, W. F. (2014).

Loss of pons-to-hypothalamic white matter tracks in brainstem obesity.

International Journal of Obesity, 38(12), 1573–1577.

Riem, M. M. E., Bakermans-Kranenburg, M. J., Pieper, S., Tops, M., Boksem, M. A. S., Vermeiren, R. R. J. M., et al. (2011). Oxytocin Modulates Amygdala, Insula, and Inferior Frontal Gyrus Responses to Infant Crying: A Randomized Controlled

Trial. Genotype, Circuits, and Cognition in Autism and Attention- Deficit/Hyperactivity Disorder, 70(3), 291–297.

doi:10.1016/j.biopsych.2011.02.006

Rilling, J. K., Winslow, J. T., O’Brien, D., Gutman, D. A., Hoffman, J. M., & Kilts, C. D.

(2001). Neural correlates of maternal separation in rhesus monkeys.

Biological Psychiatry, 49(2), 146–157. doi:10.1016/S0006-3223(00)00977-X Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin

receptor genetic variation relates to empathy and stress reactivity in

humans. Proceedings of the National Academy of Sciences of the United States of America, 106(50), 21437. doi:10.1073/pnas.0909579106

Rolls, E. T. (2011). Taste, olfactory and food texture reward processing in the brain and obesity. International Journal of Obesity, 35(4), 550–561.

doi:10.1038/ijo.2010.155

Rolls, E. T., Critchley, H. D., Browning, A. S., Hernadi, I., & Lenard, L. (1999).

Responses to the Sensory Properties of Fat of Neurons in the Primate Orbitofrontal Cortex. Journal of Neuroscience, 19(4), 1532–1540.

Rolls, E. T., & Grabenhorst, F. (2008). The orbitofrontal cortex and beyond: From affect to decision-making. Progress in Neurobiology, 86(3), 216–244.

doi:10.1016/j.pneurobio.2008.09.001

Rosenbaum, M., Sy, M., Pavlovich, K., Leibel, R. L., & Hirsch, J. (2008). Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. The Journal of Clinical Investigation, 118(7), 2583–2591.

doi:10.1172/JCI35055

Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., et al. (2013). Oxytocin enhances brain reward system responses in men viewing the face of their female partner. Proceedings of the National Academy of

Sciences, 110(50), 20308–20313. doi:10.1073/pnas.1314190110

Sclafani, A., Rinaman, L., Vollmer, R., & Amico, J. (2007). Oxytocin Knockout Mice Demonstrate Enhanced Intake of Sweet and Non-Sweet Carbohydrate Solutions. American journal of physiology. Regulatory, integrative and comparative physiology, 292(5), R1828–R1833.

doi:10.1152/ajpregu.00826.2006

Sherman, S. M. (2007). The thalamus is more than just a relay. Sensory systems, 17(4), 417–422. doi:10.1016/j.conb.2007.07.003

Smith, S. R. (1996). THE ENDOCRINOLOGY OF OBESITY. Endocrinology and

Metabolism Clinics, 25(4), 921–942. doi:10.1016/S0889-8529(05)70362-5 Sone, M., Nagata, H., Takekoshi, S., & Osamura, Y. R. (2001). Expression and

localization of leptin receptor in the normal rat pituitary gland. Cell and Tissue Research, 305(3), 351–356. doi:10.1007/s004410100407

Stellar, E. (1994). The physiology of motivation. Psychological Review, 101(2), 301–

311. doi:10.1037/0033-295X.101.2.301

Stephan, E., Pardo, J. V., Faris, P. L., Hartman, B. K., Kim, S. W., Ivanov, E. H., et al.

(2003). Functional neuroimaging of gastric distention. Journal of Gastrointestinal Surgery, 7(6), 740–749. doi:10.1016/S1091- 255X(03)00071-4

Swick, D., Ashley, V., & Turken, A. U. (2008). Left inferior frontal gyrus is critical for response inhibition. BMC Neuroscience, 9(1), 102. doi:10.1186/1471-2202-9- 102

The Pituitary Gland and Hypothalamus. (n.d.). In OpenStax College, Anatomy and Physiology.

Uher, R., Treasure, J., Heining, M., Brammer, M. J., & Campbell, I. C. (2006). Cerebral processing of food-related stimuli: Effects of fasting and gender. Behavioural Brain Research, 169(1), 111–119. doi:10.1016/j.bbr.2005.12.008

van der Laan, L. N., de Ridder, D. T. D., Viergever, M. A., & Smeets, P. A. M. (2011).

The first taste is always with the eyes: A meta-analysis on the neural correlates of processing visual food cues. NeuroImage, 55(1), 296–303.

doi:10.1016/j.neuroimage.2010.11.055

Vicennati, V., & Pasquali, R. (2000). Abnormalities of the Hypothalamic-Pituitary- Adrenal Axis in Nondepressed Women with Abdominal Obesity and Relations with Insulin Resistance: Evidence for a Central and a Peripheral Alteration.

The Journal of Clinical Endocrinology & Metabolism, 85(11), 4093–4098.

doi:10.1210/jcem.85.11.6946

Walther, K., Birdsill, A. C., Glisky, E. L., & Ryan, L. (2010). Structural brain differences and cognitive functioning related to body mass index in older females.

Human Brain Mapping, 31(7), 1052–1064. doi:10.1002/hbm.20916

Wang, G.-J., Volkow, N. D., Telang, F., Jayne, M., Ma, J., Rao, M., et al. (2004). Exposure to appetitive food stimuli markedly activates the human brain. NeuroImage, 21(4), 1790–1797. doi:10.1016/j.neuroimage.2003.11.026

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