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Behavioral economics such as those explored here are not useful for all studies of tobacco products. For example, issues of quantifying the effects of market changes at the population level would not be suitable for a behavioral economics approach. Such questions would be better addressed by standard economics approaches. Other limitations of the specific behavioral economics methods discussed here include satiation during laboratory self- administration studies and practical limitations such as building suitable laboratory space. In hypothetical purchase task studies, the experimenter is reliant on self-report measures and in the naturalistic assessment of demand studies, manipulations exist in an open economy and these studies are time- consuming to conduct. Many of these limitations have fueled the development of assessment methodologies in subsequent epochs.

An important ethical consideration in conducting this research is exposing current tobacco users to novel tobacco products. Users of combustible tobacco products, unfortunately, are already exposing themselves to the most harmful form of tobacco products and one that is a leading cause of excess

morbidity and mortality worldwide. Consistent with the Institute of Medicine’s report (Institute of Medicine, 2012), exposing them to potentially less harmful, noncombustible products, in the context of a controlled experiment, informs decisions that could lead to better population health without increasing risk. Some special populations require additional consideration. For example, individuals who are seeking to quit or cut back on smoking, or adolescents who smoke, may not be ethically appropriate to include in studies where real tobacco products are provided. However, the hypothetical purchase task and hypothetical ETM methodologies are better suited for these special populations.

Conclusion

Collectively, these findings show the utility and power of behavioral economics for informing tobacco regulatory decisions. Over the last 25 years, this method has evolved to address the broad array of questions and conditions necessary to understand tobacco purchasing and consumption and has been useful in studying other forms of addiction. Along with the evolution of methods, the quantification of demand and substitution has also matured. These epochs of innovation, as discussed above, have ranged from very laborious, intensive laboratory studies to mimicking the actual tobacco marketplace. The results of these studies suggest that tobacco products can function as robust reinforcers that are sensitive to the broad range of market and environmental conditions. These studies may be used to contribute to tobacco regulatory science and inform public policy with the aim of improving public health.

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