Metaregression duration of mechanical ventilation ~ mean duration of mechanical ven-

10.6 Duration of MV

10.6.2 Metaregression duration of mechanical ventilation ~ mean duration of mechanical ven-

10.6.2 Metaregression duration of mechanical ventilation ~ mean duration of mechanical ven-

Mixed-Effects Model (k = 32; tau^2 estimator: DL)

logLik deviance AIC BIC AICc

-75.7878 47.7771 157.5757 161.9729 158.4328

tau^2 (estimated amount of residual heterogeneity): 2.0911 (SE = 1.1334) tau (square root of estimated tau^2 value): 1.4461

I^2 (residual heterogeneity / unaccounted variability): 57.23%

H^2 (unaccounted variability / sampling variability): 2.34 R^2 (amount of heterogeneity accounted for): 23.67%

Test for Residual Heterogeneity:

QE(df = 30) = 70.1429, p-val < .0001 Test of Moderators (coefficient 2):

QM(df = 1) = 7.3761, p-val = 0.0066 Model Results:

estimate se zval pval ci.lb ci.ub intrcpt 0.4504 0.8677 0.5191 0.6037 -1.2503 2.1512 slope -0.2634 0.0970 -2.7159 0.0066 -0.4534 -0.0733 **

---Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Mean duration of mechanical ventilation

T reatment eff ect (mean diff erence)

0 10 20 30 40 50

−20 −15 −10 −5 0 5 10

Coutinho et al. 2016

Machado et al. 2017 França et al. 2017

Burtin et al. 2009 Eggmann et al. 2018 Fossat et al. 2018

Hickmann 2018

Kho et al. 2019 Gerovasili et al. 2009

Routsi et al. 2012 Abu−Khaber et al. 2013

Kho et al. 2015

Fischer et al. 2016 Shen et al. 2017

Kurtoglu et al. 2015 Acqua et al. 2017

Dos Santos et al. 2018 Shaolin et al. 2019

Chen S et al. 2011 Dong et al. 2014

Yosef−Brauner et al. 2014 Dong et al. 2016

Moss et al. 2016 Maffei et al. 2017 McWilliams et al. 2018

Winkelman et al. 2018 Schweickert et al. 2009Hodgson et al. 2016

Chen YH et al. 2012 Denehy et al. 2013

Kayambu et al. 2015

Amundadottir at al. 2019

Figure 83: Metaregression bubble plot: Hospital LOS vs Mean ICU LOS

10.6.2.1 Metaregression duration of mechanical ventilation ~ mean duration of mechanical ventilation adjusted for ICU mortality

Table 203: List of studies with mean duration of MV and ICU mortality

group trialname year MV_duration_mean ICU_mortality

Cycling Coutinho et al. 2016 11.93 0.32

Cycling Machado et al. 2017 21.94 0.2245

Cycling FranĂ§a et al. 2017 5.228 0.6842

Cycling Burtin et al. 2009 7.871 0.2

Cycling Eggmann et al. 2018 7.018 0.1652

Cycling Fossat et al. 2018 5.831 0.1827

Cycling Hickmann 2018 6.874 0.3158

Cycling Kho et al. 2019 10.39 0.2727

NMES Gerovasili et al. 2009 9 0.2245

NMES Routsi et al. 2012 20.79 0.3571

NMES Abu-Khaber et al. 2013 10.49 0.125

NMES Kho et al. 2015 17.88 0.1176

NMES Fischer et al. 2016 4.667 0.07407

NMES Shen et al. 2017 7.68 0.08

NMES Kurtoglu et al. 2015 17.03 0

NMES Acqua et al. 2017 7.56 0.24

NMES Dos Santos et al. 2018 12.38 0.4231

NMES Shaolin et al. 2019 6.218 NA

PPR Chen S et al. 2011 48.52 0.1026

PPR Dong et al. 2014 6.141 0

PPR Yosef-Brauner et al. 2014 14.55 0

PPR Dong et al. 2016 11 0.04717

PPR Moss et al. 2016 11.84 0.1333

PPR Maffei et al. 2017 0.8771 0

PPR McWilliams et al. 2018 11.16 0.1373

PPR Winkelman et al. 2018 11.72 0.09259

PPR Schweickert et al. 2009 5.514 0.2212

PPR Hodgson et al. 2016 7.014 0.06

PPR Chen YH et al. 2012 44.87 0.1111

PPR Denehy et al. 2013 4.722 0.08

PPR Kayambu et al. 2015 19.41 0.08

PPR Amundadottir at al. 2019 11 0.02

Table 204: List of studies by group

Cycling NMES PPR

8 10 14

Table 205: Descriptive statistics

parameter n mean sd p25 median p75 min max

ICU_mortality 31 0.16 0.15 0.08 0.12 0.22 0.00 0.68

MV_duration_mean 32 12.47 10.28 6.71 10.44 12.93 0.88 48.52

Mixed-Effects Model (k = 31; tau^2 estimator: DL)

logLik deviance AIC BIC AICc

-73.0607 43.9401 154.1213 159.8573 155.6598

tau^2 (estimated amount of residual heterogeneity): 1.7590 (SE = 1.0719) tau (square root of estimated tau^2 value): 1.3263

I^2 (residual heterogeneity / unaccounted variability): 51.40%

H^2 (unaccounted variability / sampling variability): 2.06 R^2 (amount of heterogeneity accounted for): 40.13%

Test for Residual Heterogeneity:

QE(df = 28) = 57.6111, p-val = 0.0008 Test of Moderators (coefficients 2:3):

QM(df = 2) = 10.3689, p-val = 0.0056 Model Results:

estimate se zval pval ci.lb ci.ub intrcpt 0.0201 0.9076 0.0222 0.9823 -1.7588 1.7990 MV_duration_mean -0.2819 0.0943 -2.9899 0.0028 -0.4667 -0.0971 **

ICU_mortality 4.2772 2.8979 1.4759 0.1400 -1.4026 9.9570 ---Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

10.6.2.2 Metaregression duration of mechanical ventilation ~ mean duration of mechanical ventilation (<15 days)

Table 206: List of studies with mean ICU LOS

group trialname year MV_duration_mean

Cycling Coutinho et al. 2016 11.93

Cycling FranĂ§a et al. 2017 5.228

Cycling Burtin et al. 2009 7.871

Cycling Eggmann et al. 2018 7.018

Cycling Fossat et al. 2018 5.831

Cycling Hickmann 2018 6.874

Cycling Kho et al. 2019 10.39

NMES Gerovasili et al. 2009 9

NMES Abu-Khaber et al. 2013 10.49

NMES Fischer et al. 2016 4.667

NMES Shen et al. 2017 7.68

NMES Acqua et al. 2017 7.56

NMES Dos Santos et al. 2018 12.38

NMES Shaolin et al. 2019 6.218

PPR Dong et al. 2014 6.141

PPR Yosef-Brauner et al. 2014 14.55

PPR Dong et al. 2016 11

PPR Moss et al. 2016 11.84

PPR Maffei et al. 2017 0.8771

PPR McWilliams et al. 2018 11.16

PPR Winkelman et al. 2018 11.72

PPR Schweickert et al. 2009 5.514

PPR Hodgson et al. 2016 7.014

PPR Denehy et al. 2013 4.722

PPR Amundadottir at al. 2019 11

Table 207: List of studies by group

Cycling NMES PPR

7 7 11

Table 208: Descriptive statistics: mean ICU LOS

n mean sd p25 median p75 min max

25 8.3 3.2 6.1 7.7 11 0.9 14.6

Mixed-Effects Model (k = 25; tau^2 estimator: DL)

logLik deviance AIC BIC AICc

-52.3121 41.3934 110.6241 114.2808 111.7670

tau^2 (estimated amount of residual heterogeneity): 2.1952 (SE = 1.1781) tau (square root of estimated tau^2 value): 1.4816

I^2 (residual heterogeneity / unaccounted variability): 63.95%

H^2 (unaccounted variability / sampling variability): 2.77 R^2 (amount of heterogeneity accounted for): 18.24%

Test for Residual Heterogeneity:

QE(df = 23) = 63.8071, p-val < .0001 Test of Moderators (coefficient 2):

QM(df = 1) = 5.1341, p-val = 0.0235 Model Results:

estimate se zval pval ci.lb ci.ub intrcpt 0.5970 1.0431 0.5723 0.5671 -1.4476 2.6415 MV_duration_mean -0.2877 0.1270 -2.2659 0.0235 -0.5366 -0.0388 * ---Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Covariate MV_duration_mean

T reatment eff ect (mean diff erence)

2 4 6 8 10 12 14

−10 −5 0 5

Coutinho et al. 2016 França et al. 2017

Burtin et al. 2009 Eggmann et al. 2018 Fossat et al. 2018

Hickmann 2018

Kho et al. 2019 Gerovasili et al. 2009

Abu−Khaber et al. 2013 Fischer et al. 2016

Shen et al. 2017 Acqua et al. 2017

Dos Santos et al. 2018 Shaolin et al. 2019

Dong et al. 2014

Yosef−Brauner et al. 2014 Dong et al. 2016

Moss et al. 2016 Maffei et al. 2017

McWilliams et al. 2018

Winkelman et al. 2018 Schweickert et al. 2009

Hodgson et al. 2016

Denehy et al. 2013 Amundadottir at al. 2019

Figure 84: Metaregression bubble plot: duration of MV (<15 days)

10.6.2.3 Metaregression duration of mechanical ventilation ~ mean duration of mechanical ventilation (<15 days) adjusted for ICU mortality

Table 209: List of studies with mean duration of MV and ICU mortality

group trialname year MV_duration_mean ICU_mortality

Cycling Coutinho et al. 2016 11.93 0.32

Cycling FranĂ§a et al. 2017 5.228 0.6842

Cycling Burtin et al. 2009 7.871 0.2

Cycling Eggmann et al. 2018 7.018 0.1652

Cycling Fossat et al. 2018 5.831 0.1827

Cycling Hickmann 2018 6.874 0.3158

Cycling Kho et al. 2019 10.39 0.2727

NMES Gerovasili et al. 2009 9 0.2245

NMES Abu-Khaber et al. 2013 10.49 0.125

NMES Fischer et al. 2016 4.667 0.07407

NMES Shen et al. 2017 7.68 0.08

NMES Acqua et al. 2017 7.56 0.24

NMES Dos Santos et al. 2018 12.38 0.4231

NMES Shaolin et al. 2019 6.218 NA

PPR Dong et al. 2014 6.141 0

PPR Yosef-Brauner et al. 2014 14.55 0

PPR Dong et al. 2016 11 0.04717

PPR Moss et al. 2016 11.84 0.1333

PPR Maffei et al. 2017 0.8771 0

PPR McWilliams et al. 2018 11.16 0.1373

PPR Winkelman et al. 2018 11.72 0.09259

PPR Schweickert et al. 2009 5.514 0.2212

PPR Hodgson et al. 2016 7.014 0.06

PPR Denehy et al. 2013 4.722 0.08

PPR Amundadottir at al. 2019 11 0.02

Table 210: List of studies by group

Cycling NMES PPR

7 7 11

Table 211: Descriptive statistics

parameter n mean sd p25 median p75 min max

ICU_mortality 24 0.17 0.16 0.07 0.14 0.23 0.00 0.68

MV_duration_mean 25 8.35 3.20 6.14 7.68 11.00 0.88 14.55

Mixed-Effects Model (k = 24; tau^2 estimator: DL)

logLik deviance AIC BIC AICc

-49.2275 36.8416 106.4549 111.1671 108.5602

tau^2 (estimated amount of residual heterogeneity): 1.7784 (SE = 1.0801)

Dalam dokumen Safety and Efficacy of Rehabilitation in Critically - A Systematic Review and Metaanalysis of Randomised Controlled Trials (Halaman 192-200)