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The role of ancient genetic variation on human adaptation: Insights from trans-species and introgressed variation

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Academic year: 2024

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Figure 2.1. Schematic of the criteria for identifying the SP sets used in this study. A previous study(Leffler et al., 2013) reported a set of 125 candidate regions with two or more non-coding human-chimp shared polymorphisms (SP) within 4 kb
Figure 2.2. Functional annotations available for the expanded cbSP regions. Summary of the annotations of each type available for cbSP regions, including tagging variants in high LD with cbSPs
Figure 2.3. cbSPs are eQTLs in diverse tissues. cbSP regions are enriched for eQTL activity in many tissues compared to genomic background levels
Figure 2.4. Genome- and phenome-wide association studies link cbSPs to diverse traits
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Illustrative examples of diverse functions associated with cbSP regions Discussion Did introgressed archaic variants influence modern human circadian biology? Discussion Methods Future directions

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