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Appendix 1: Study quality assessment of included studies using Newcastle-Ottawa Scale

*represents the individual criterion within the sub-group was full-filled

-means the individual criterion within the sub-group was not full-filled

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Quality Assessment Criteria Acceptable (*) Not acceptable (-)

Paterno et al.

(2018)

Paterno et al.

(2017)

Wellsandt et al. (2017)

Ahmed et al.

(2017)

Kyritsis et al. (2016)

Grindem et al.

(2016)

Granan et al.

(2015)

Paterno et al.

(2010)

Selection

Representativeness of exposed cohort?

Representativeness of average in communinty (age/sex/primary ACLR/completed rehabilitation/RTS clearance/risk of ACL reinjury)

- * - - - * * -

Selection of non- exposed cohort? Selected from the same community as exposed cohort

* * * * * * * *

Ascertainment of exposure? Secured records, Structured interview

* * * * * * * *

Demonstration that outcome of interest was not present at start of study?

Clearance to return to high-level (level 1 or 2) sports/play/athletic activity by physician and rehabilitation team

* * * * * * * *

Comparability

Study controls for age and sex? Yes Age +

Sex – (-)

Age + Sex + (*)

Age + Sex + (*)

Age + Sex + (*)

Age + Sex – (-)

Age + Sex + (*)

Age + Sex + (*)

Age + Sex + (*) Study controls for any additional

factors?

Type of graft, Time since surgery, Time to reinjury/graft failure, Cause of re-injury, Height, Weight, BMI,

* * * * * * * *

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Objective functional meaures (Isokinetic quadriceps strength test, Hop tets: single leg hop for distance, triple hop for distance, crossover hop for distance, 6m timed hop, runnign t test), Postural stability (balance test), S

ubjective/self report

outcomes:Psychological measures (TSK-11, ACL-RSI); KOOS, IKDC, GRS and KOS-ADLS;

Biomechanical measures, A-P knee laxity etc

Outcome

Assessment of outcome? Independent blind assessment record linkage

- * * * * * * *

Was follow-up long enough for outcomes to occur?

Follow-up ≥ 2 years * * * * * * * -

Adequacy of follow-up of cohorts? Complete follow-up, or participants lost to follow-up unlikely to introduce bias

* * * - * * - *

Overall Quality Score (Maximum = 9) 6 9 8 7 7 9 8 7

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