Appendix 3: Meta-analysis of associations between first-degree family history of breast cancer (A), ovarian cancer (B), and cervical cancer (C) and risk of endometrial cancer.
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Win AK, Reece JC, and Ryan S. Family history and risk of endometrial cancer: a systematic review and meta-analysis. Obstet Gynecol 2014;124.
The authors provided this information as a supplement to their article.
© Copyright 2014 American College of Obstetricians and Gynecologists.
Heterogeneity between groups: p = 0.171
Overall Fixed-effect (I-squared = 44.6%, p = 0.042) Olson et al. (1999)
Random-effects Parazzini et al. (1994)
Cohort Study
Yang et al. (Type II) (2013) Henderson et al. (1983) Nelson et al. (1993)
Schildkraut et al. (1989) Gruber & Thompson (1996)
Random-effects
Fixed-effect (I-squared = 16.6%, p = 0.303) Reis & Beji (2009)
Overall Random-effects
Lorenzo Bermejo et al. (sisters) (2004) Kazerouni et al. (2002)
Yang et al. (Type I) (2012)
Lorenzo Bermejo et al. (mother) (2004)
Fixed-effect (I-squared = 60.3%, p = 0.028) Case-control
Lucenteforte et al. (2009)
0.96 (0.88, 1.04) 1.20 (0.60, 2.50)
1.06 (0.86, 1.26) 1.20 (0.80, 1.80) RR (95% CI)
1.93 (1.27, 2.93) 0.56 (0.12, 2.26) 1.15 (0.94, 1.40)
1.20 (0.70, 2.20) 0.80 (0.60, 1.20)
1.00 (0.82, 1.18) 1.06 (0.89, 1.22) 2.86 (1.32, 6.25)
1.02 (0.89, 1.15) 1.21 (0.94, 1.54) 0.96 (0.78, 1.20)
0.80 (0.67, 0.96) 0.93 (0.75, 1.13)
0.93 (0.83, 1.02) 1.30 (0.80, 2.20)
100.00 0.74 Weight
2.66
% Weight
0.96 0.58 12.56
1.18 7.38
%
25.39 0.11
7.38 15.07
31.61 18.41
74.61 1.36
0.96 (0.88, 1.04) 1.20 (0.60, 2.50)
1.06 (0.86, 1.26) 1.20 (0.80, 1.80) RR (95% CI)
1.93 (1.27, 2.93) 0.56 (0.12, 2.26) 1.15 (0.94, 1.40)
1.20 (0.70, 2.20) 0.80 (0.60, 1.20)
1.00 (0.82, 1.18) 1.06 (0.89, 1.22) 2.86 (1.32, 6.25)
1.02 (0.89, 1.15) 1.21 (0.94, 1.54) 0.96 (0.78, 1.20)
0.80 (0.67, 0.96) 0.93 (0.75, 1.13)
0.93 (0.83, 1.02) 1.30 (0.80, 2.20)
100.00 0.74 Weight
2.66
0.96 0.58 12.56
1.18 7.38
%
25.39 0.11
7.38 15.07
31.61 18.41
74.61 1.36
1
0 2 4 6
Breast Cancer
Win AK, Reece JC, and Ryan S. Family history and risk of endometrial cancer: a systematic review and meta-analysis. Obstet Gynecol 2014;124.
The authors provided this information as a supplement to their article.
© Copyright 2014 American College of Obstetricians and Gynecologists.
Heterogeneity between groups: p = 0.595
Overall Fixed-effect (I-squared = 0.0%, p = 0.591) Lucenteforte et al. (2009)
Kelsey et al. (1982)
Gruber & Thompson (1996)
Reis & Beji (2009)
Cohort
Schildkraut et al. (1989)
Fixed-effect (I-squared = 15.0%, p = 0.308) Study
Fixed-effect (I-squared = 0.0%, p = 0.568) Parazzini et al. (1994)
Olson et al. (1999) Nelson et al. (1993)
Lorenzo Bermejo et al. (mother) (2004) Lorenzo Bermejo et al. (sisters) (2004) Case-control
1.13 (0.85, 1.41) 2.00 (0.40, 9.00) 3.50 (0.90, 13.40)
1.90 (0.80, 4.20)
5.49 (2.43, 12.73)
0.60 (0.10, 4.20)
1.07 (0.71, 1.43) RR (95% CI)
1.23 (0.78, 1.68) 0.80 (0.30, 2.10)
1.60 (0.50, 5.60) 1.22 (0.78, 1.92)
0.97 (0.63, 1.43) 1.74 (0.97, 2.87)
100.00 0.43 0.20
%
2.76
0.30
1.90
60.64
% Weight
39.36 9.86
1.23 24.57
49.90 8.85
1.13 (0.85, 1.41) 2.00 (0.40, 9.00) 3.50 (0.90, 13.40)
1.90 (0.80, 4.20)
5.49 (2.43, 12.73)
0.60 (0.10, 4.20)
1.07 (0.71, 1.43) RR (95% CI)
1.23 (0.78, 1.68) 0.80 (0.30, 2.10)
1.60 (0.50, 5.60) 1.22 (0.78, 1.92)
0.97 (0.63, 1.43) 1.74 (0.97, 2.87)
100.00 0.43 0.20
%
2.76
0.30
1.90
60.64 39.36 9.86
1.23 24.57
49.90 8.85
1
0 2 4 6
Ovarian Cancer
Win AK, Reece JC, and Ryan S. Family history and risk of endometrial cancer: a systematic review and meta-analysis. Obstet Gynecol 2014;124.
The authors provided this information as a supplement to their article.
© Copyright 2014 American College of Obstetricians and Gynecologists.
Heterogeneity between groups: p = 0.788
Overall Fixed-effect (I-squared = 0.0%, p = 0.961) Case-control
Lorenzo Bermejo et al. (sisters) (2004) Fixed-effect (I-squared = 0.0%, p = 0.818) Olson et al. (1999)
Lorenzo Bermejo et al. (mother) (2004) Study
Lucenteforte et al. (2009) Henderson et al. (1983) Gruber & Thompson (1996)
Cohort
Fixed-effect (I-squared = 0.0%, p = 0.921)
1.19 (0.83, 1.55) 1.26 (0.60, 2.32) 1.11 (0.39, 1.82) 0.70 (0.20, 2.40)
1.21 (0.80, 1.76) RR (95% CI)
1.80 (0.20, 14.30) 5.16 (0.56, 246.10) 1.40 (0.30, 2.20)
1.22 (0.80, 1.64)
100.00
%
17.68 25.56 10.81
56.76
% Weight
0.26 0.00 14.49
74.44
1.19 (0.83, 1.55) 1.26 (0.60, 2.32) 1.11 (0.39, 1.82) 0.70 (0.20, 2.40)
1.21 (0.80, 1.76) RR (95% CI)
1.80 (0.20, 14.30) 5.16 (0.56, 246.10) 1.40 (0.30, 2.20)
1.22 (0.80, 1.64)
100.00
%
17.68 25.56 10.81
56.76 0.26 0.00 14.49
74.44
1
0 2 4 6
Cervical Cancer
Win AK, Reece JC, and Ryan S. Family history and risk of endometrial cancer: a systematic review and meta-analysis. Obstet Gynecol 2014;124.
The authors provided this information as a supplement to their article.
© Copyright 2014 American College of Obstetricians and Gynecologists.
