Meta-analysis of Family History and Endometrial Cancer Risk

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Appendix 2: Meta-analysis of associations between first-degree family history of colorectal cancer and risk of endometrial cancer for women aged <55 years versus women aged ≥55 years ( A), and women with an affected parent versus and affected sibling (B).

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Overall (I-squared = 0.0%, p = 0.823) Gruber & Thompson (1996)

Lucenteforte et al. (2009) Study

Schildkraut et al. (1989)

1.82 (0.92, 2.72) 1.80 (1.00, 3.20)

2.80 (1.00, 7.70) RR (95% CI)

1.60 (0.60, 4.10)

100.00 66.54

7.17 % Weight

26.29 %

1.82 (0.92, 2.72) 1.80 (1.00, 3.20)

2.80 (1.00, 7.70) RR (95% CI)

1.60 (0.60, 4.10)

100.00 66.54

7.17 26.29

%

Women aged <55

(A)

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Overall (I-squared = 0.0%, p = 0.866) Study

Olson et al. (1999)

Lucenteforte et al. (2009) Nelson et al. (1993)

1.23 (0.84, 1.62) RR (95% CI)

1.50 (0.40, 5.30)

1.40 (0.80, 2.40) 1.17 (0.80, 1.70)

100.00 % Weight

2.50 23.44 74.07

%

1.23 (0.84, 1.62) RR (95% CI)

1.50 (0.40, 5.30)

1.40 (0.80, 2.40) 1.17 (0.80, 1.70)

100.00 2.50

23.44 74.07

%

Women aged >=55

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Overall (I-squared = 16.9%, p = 0.300) Lucenteforte et al. (2009)

Study

Gruber & Thompson (1996)

Lorenzo Bermejo et al. (mother) (2004)

1.19 (0.96, 1.42) 1.90 (1.00, 3.50) RR (95% CI)

1.80 (1.00, 3.40)

1.14 (0.92, 1.39)

100.00 3.29

% Weight

%

3.57

93.14 1.19 (0.96, 1.42) 1.90 (1.00, 3.50) RR (95% CI)

1.80 (1.00, 3.40)

1.14 (0.92, 1.39)

100.00 3.29

%

3.57

93.14 Parents

(B)

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Overall (I-squared = 0.0%, p = 0.784) Lucenteforte et al. (2009)

Study

Lorenzo Bermejo et al. (sisters) (2004) Gruber & Thompson (1996)

1.49 (0.83, 2.16) 1.20 (0.50, 2.70) RR (95% CI)

1.69 (0.98, 2.71) 1.30 (0.30, 6.30)

100.00 36.34 58.77

%

4.89 1.49 (0.83, 2.16) 1.20 (0.50, 2.70) RR (95% CI)

1.69 (0.98, 2.71) 1.30 (0.30, 6.30)

100.00 36.34

% Weight

58.77 %

4.89 Siblings