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ATOM INDONESIA

Author's Responses

Date: Oct. 14th, 2019

Article : #950

Article Title : Radiomitigative Effects of Approved Hematopoietic Drugs on Mice Exposed to Lethal Total-body Irradiation

We appreciate careful Referee’s review of our manuscript. We have addressed your concerns to the best of our ability. All of the revisions have been underlined with red in the revised

manuscript.

1. Comments: “hematopoetic” should be changed to “hematopoietic”.

Response: We changed to “hematopoietic” as you indicated. (P1, abstract)

2. Comments: “but not Japan” should be changed to “but not in Japan”.

Response: We changed to “but not in Japan” as you indicated. (P1, L37)

3. Comments: “effort” should be changed to “efforts”.

Response: We changed to “efforts” as you indicated. (P1, L41)

4. Comments: “has been” should be changed to “have been”.

Response: We changed to “have been” as you indicated. (P2, L42)

5. Comments: “administered the medications” should be changed to “administered with the medications”.

Response: We changed to “administered with the mediations” as you indicated. (P2, L78)

6. Comments: “The irradiated mice were administered” should be changed to “The irradiated mice were administered with”.

Response: We changed to “The irradiated mice were administered with” as you indicated.

(P2, L91)

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7. Comments: “weighted” should be changed to “weighed”.

Response: We changed to “weighed” as you indicated. (P2, L115)

8. Comments: “compare with” should be changed to “compare to”.

Response: We changed to “compare to” as you indicated. (P3, L157)

9. Comments: “Administration” should be changed to “The administration”.

Response: We changed to “The administration” as you indicated. (P3, L183)

10. Comments: “surivival” should be changed to “survival”.

Response: We changed to “survival” as you indicated. (P3, L210)

11. Comments: “increaseng” should be changed to “increasing”.

Response: We changed to “increasing” as you indicated. (P3, L251)

12. Comments: “hematopoetic” should be changed to “hematopoietic”.

Response: We changed to “hematopoietic” as you indicated. (P4, L315) 13. Comments: “a number of” should be changed to more appropriate phrase.

Response: We changed to “many” as you indicated. (P4, L322)

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We appreciate Editor’s comments of our manuscript. We have addressed your concerns to the best of our ability. All of the revisions have been underlined with red in the revised manuscript.

Comments: There is only 12 of 28 references are less than 5 years old. It would be better if the authors could use more current references (published within 10 years).

Response: As suggested, the cited references have been revised as shown below.

Line# Original version Revised version 343 1. JF Weiss, MR Landauer. Int J Radiat

Biol. 85(7) (2009) 539.

1. VK Singh, PL Romaine, VL Newman et al. Expert Opin Ther Pat.

26

(12) (2016) 1399-1408.

350 4. J Kim, S Lee, B Jeon et al. Andrologia.

43 (2011) 87.

4. VK Singh, VL Newman, Seed TM.

Cytokine. 71 (1) (2015) 22-37.

352 5. PV Vittorio, EA Amey. Radiat Res. 44 (1970) 434.

5.

HM Mehta, M Malandra, SJ Corey. J Immunol. 195 (4) (2015) 1341-9.

358 8. M Toyama, T Hamasaki, T Uto et al.

Anticancer Res. 32(7) (2012) 2639.

8. Samura Ya, Said HS, Elsherbiny NM et al. Life Sci. 157 (2016) 187-199.

364 11. Paolino W and Vercellino E, Panminerva Med. 2 (1960) 5-8.

11. YF Cheng, GH Young, TM Chiu et al. Exp Dermatol. 25 (2) (2016) 162- 164.

375

16. I Kawamura, M Mitsuyama, K Nomoto.

Immunopharmacol. Immunotoxicol. 12 (1990) 331.

16. T Horii, K Yoshinaga, N Kobayashi, et al. Biol Pharm Bull.

37

(4) (2014) 642-7.

381 19. H Sasaki, DA Schmitt, M Kobayashi et al. Nat. Immun. 12 (1993) 152.

19. T Sugiyama, K Fujiwara, Y Ohashi et al. Ann Oncol. 25 (5) (2014) 1011-7.

387

22. International Atomic Energy Agency.

Safety reports series No. 2. Diagnosis and treatment of radiation injuries. IAEA (1998) 13.

22. W Qi, Q Shen, Zhang L et al. Exp Ther Med. 11 (6) (2016) 2221-2224.

389 23. PV Vittorio and EA Amey. Radiat Res.

44 (1970) 434.

23. IV Gilevich, TV Fedorenko, IA Pashkova et al. Bull Exp Biol Med.

162

(5) (2017) 684-686.

391 24. J Xue, G Du, J Shi et al. Chin Med J (Engl). 127 (2014) 1677.

24. SJ Chan, C Love, M Spector et al . Neurochem Int. 107 (2017) 57-65.

393 25. DC Liang,LY Shih, IJ Chai et al.

Pediatr Hematol Oncol. 19(6) (2002) 399.

25. SQ Zhao, JM Li. Zhonggouo Shi Yan Xue Ye Xue Za Zhi. 23 (3) (2015) 871-7.

395 26. A Schneider, C Kruger, T Steigleder et al. J Clin Invest. 115(8) (2005) 2083.

26. U Gutti, SR Pasupuleti, I Sahu et al.

Crit Rev Oncol Hematol. 108 (2016) 175-186.

397 27. J Jiang, F Tian, Y Cai et al. Anal Bioanal Chem. 406(25) (2014) 6265.

27. LN Varghese, JP Defour, C Pecquet et al. Front Endocrinol. 8 (2017) 59.

399

28. RL Levine and G Wernig. Hematology Am Soc Hematol Educ Program. 510 (2006) 233.

28. R Morris, NJ Kershaw, Babon JJ.

Protein Sci. 27 (12) (2018) 1984-2009.

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