ATOM INDONESIA JOURNAL Referee’s Report
Article No. : # 435
Title of Paper : Characterization Uptake and Cytotoxic of Radioiodine in MCF-7 and SKBR-3 Breast Cancer Cell Lines
Referee Name :
Comment on Descriptions 1. Title
[ ] Appropriate [X] Should be changed
2. Abstract
Yes[X] No[ ] Is the length reasonable?
Yes[X] No[ ] Is it an appropriate summary of the content?
3. Main Text
Yes[ ] No[X] Is there anything new in this work?
Yes[ ] No[X] Is the relation to previous studies adequately stated?
Yes[X] No[ ] Are the assumption(s) and/or method(s) described comprehensively?
Yes[ ] No[X] Are the new results adequately emphasized?
Line # Referee’s Comments
1
The title should be slightly changed to:
Uptake and Cytotoxic Characterization of Radioiodine in MCF-7 and SKBR-3 Breast Cancer Cell Lines
14 The abstract should be written in a single paragraph 19 …It presents
45 ..have been reported elsewhere […] (references are required here) 69 Were MCF-7 and Hacat cells certified?
73-74 Sentence needs revising: Hacat is normal keratin cells, and in this investigation they were used as a control.
91 …The cells were…
152 Replace the word “non-significant” with “insignificant”
152-
153 Why insignificant difference? Please discuss the reasons!
163- 173
These earlier findings should be put in the introduction section instead of in the discussion section
164-
165 It is co-transports ….
166-
167 Sodium gradient serves as…… and is maintained by … 245-
256 This paragraph is not appropriate here. It should be put in the introduction section.
262- 273
This paragraph needs revising since there is lack of clarity due mostly to poor English grammar!
Also, why the percentages of colony formations 500 cells are different from those of 1000 cells?
274- 282
Please check the grammar!
Also, why the xytotoxic effect of radioiodine in MCF-7 cells are two-fold compared with that of SKBR-3cells?
283-
286 Why no effect for the control cells?
283-
295 Please check the grammar!
289- 295
This is not your experimental result. Quote the reference(s)!
What is the relationship between the first and second sentences in this paragraph?
310- 315
This statement is probably incorrect. There are various research showing that radioiodine therapy has increased further cancer risks.
Check this websites:
http://www.breastcancer.org/research-news/20070604-2
http://www.cancernetwork.com/thyroid-cancer/increased-risk-second-malignancies- radioactive-iodine-therapy-thyroid-cancer
http://erc.endocrinology-journals.org/content/early/2012/07/31/ERC-12-0176.full.pdf 324-
331 Put this paragraph in the experimental section!
Final comments and recommendations:
There are various grammatical errors in the manuscript; thus the authors are suggested to do grammar checks and ask someone whose English is excellent to assist them.
The authors are required to revise the manuscript as suggested above
This paper is recommended to be [ ] Accepted without further revision [X] Accepted with minor revision [ ] Major Revision is required [ ] Rejected
