ATOM INDONESIA
Author's Responses
Article : #425 Name of All Authors :
Article Title : Characterization Uptake and Cytotoxic of Radioiodine in MCF-7 and SKBR-3 Breast Cancer Cell Lines
E-mail :
Line # Editor’s Comments Author's Responses
Abstra ct, line
12 16
significantly is not suitable sentence for
comparison, statements should be revised. Change is done Abstra
ct line 18 - 22
to be sensitive or high sensitive? You did not expose cells with therapeutic dose, this sentence
need to be revised
Change is done
19
“among women” change with “among cancer patient women” (among women is questionable, but among cancer patient women is well known).
“It present ………….that” change with “ As systemic disease it often that”
Breast cancer is a common malignancy among cancer patient women.
As systemic disease, it requires adjuvant theraphy with hormone or anticancer drugs after surgery, with the aim to eliminate an occult micrometastatic disease and improving disease-free and overall survival[1].
25 Omit the word “Clearly” ….. Done
26 such as targeted therapy…….selectively that are Revised 27 Omit “and are highly desirable Revised 31 ……..the rate of patient survival……. done 35 Point should be behind [2, 5, 6] done 37 NIS (natrium iodine symporter, NaI), that means
one sodium ion (Na+), and one iodine ion (I-)?
Natrium iodide symporter (NIS) is a protein as co- transpoter of 2 Na+ and one I- from extracellular to intracellular of thyroid cells.
38
its gradient (it is not clear, do you mean Na+ and I- ions?). Change with “ it ionic concentration gradient”. Beside in thyroid
done 39 ….is also expressed…….. 80% in invasive breast
cancer that…… Done
40
“ductal breast cancer” change with “ and it is commonly located in the glandular duct”
(invasive and ductal, information of behavior and position ).
“ In principal” will be nicer change with
“therefore
Ductal is a name one of histopathology breast cancer types, which is invasive. We revised the sentence with only write invasive breast cancer
Done 43 “However” will be nicer if it changes with
“There are” Done
45-47 This statement is confusing. “This condition”
need explanation Revised
51 “Yet” will nicer if it changes with “ On the other
hand” done
56 … “is to compare”…… will be nicer if it changes
with “ to characterize or to investigate? ” Done 58 “repsented” should be “represented” revised
69-70
Thank you to a person could be mentioned at acknowledement. In the text it will be nice if just formal statement, for example “Hacat cells were obtained from ...(institution)”
done
115 Type of cells and the sample numbers of each
type should be stated. done
145- 152
What is the different between statement at line
145 – 148 and that at line 148 – 150 ?. revised 154-
156
Your work is to compare the uptake of MCF-7 with Hacal, whereas Nakamoto did between MCF-7 and MCF3B (with behavior was not mentioned). These two studies was incomparable.
Revised 156-
162
It should be there is explanation (reason) why this
uptake need to be increased? The explanation added 165 NIS (natrium iodine), the same question for line
37 Answer as well as above
245-
246 This statement is not clear, should be revised Revised and per as reviewer advice, the statement should put in introduction.
278 …….in MCF-7 cells are two-fold of SKBR.
Please provided with quantitative data
Revised Refer to figure 3.
286- 295
These statements are confusing, and should be
revised Revised
296- 302
These statements are not explained clearly, and should be revised (example: what do you mean with time residence at line 298 and these conditions at line 302?,…..)
Revised
Residence is change with retention
306- 309
You did not measure the dose, how could take the result of your study related to the dose? The statement should be revised
Revised
In our study, normal cells, which receive certain amount of radioiodine, do not show any toxic effect.
Final comments and recommendations:
1. The reason of using two types radioisotopes (I125 and I131) should be mentioned.
2. The reference number in the text should be put in front of the end point of statement.
(………..[x].)
3. I appreciate this study, the result was interesting.
The writer still need to be supervised in preparing the manuscript publication.
This paper is recommended to be [ ] Accepted without further revision [ ] Accepted with minor revision [ x ] Major Revision is required [ ] Rejected
