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Supplemental Figure 1. Clusters inferred at 0.5% genetic distance threshold with 3 years of diagnoses and at least 5 diagnoses in the past 12 months.

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Supplemental Table 1. Estimates of time to most recent common ancestor (tMRCA) for 13 clusters identified at 0.5% genetic distance threshold with 3 years of diagnoses and at least 5 diagnoses in the past 12 months, including median tMRCA and 95% highest posterior density (HPD).

Cluster Cluster Size tMRCA median tMRCA 95% HPD

1 17 4.1 3.1–5.5

2 6 2.4 1.4–3.7

3 18 2.0 1.4–2.9

4 18 4.7 3.6–6.3

5 21 4.4 3.2–5.8

6 22 7.4 4.8–10.4

7 15 6.5 4.3–8.9

8 17 6.1 4.7–8.0

9 16 7.4 5.2–10.1

10 16 7.3 5.1–9.8

11 16 7.7 6.0–9.7

12 6 3.9 2.6–5.6

13 7 1.8 1.5–2.5

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