Table S1: Definitions of variables examined in this study (excluding those directly involved in the calculation of KDRI). HLA, human leukocyte antigen; DBD, donation after brain death; DCD, donation after circulatory death; FSGS, focal segmental glomerulosclerosis; GN, glomerulonephritis; MPGN, membranoproliferative glomerulonephropathy.
Variable Definition
Donor Factors
Donor Gender Reported as male
Donor BMI Donor Body Mass Index = Weight (kg)/Height (m
2), calculated at the time of death
Donor Smoking History Known or former smoker of tobacco products
Donor CPR Donor required a period of cardiopulmonary resuscitation in the peri- mortem period
Donor Inotropes Donor required infusion of one or more vasoactive agents in the peri- mortem period
Donor Oliguria Donor recorded urine output < 20mL/hr within 12 hours of organ procurement
Procurement Factors
Transplant out of Region Kidney transplanted in a different region (state) from which it was procured
aProcurement Biopsy Biopsy taken at the time of organ procurement. Result not considered in this study.
Ischaemic Time Time (to the closest hour) from aortic cross clamp (DBD) or cessation of circulation (DCD), to reperfusion of kidney within recipient.
Immunological Factors
HLA Mismatch Total number of mismatches at the HLA A, B and DR loci (0 – 6) PRA Recipient Panel Reactive Antibody (%) – historical maximum recorded Recipient Factors
Recipient Gender Reported as male
Recipient Age Age at the time of transplant (years)
Dialysis Years Length of time on transplant waitlist, for this transplant (years) Previous Transplants Recipient had kidney transplant (failed) prior to current transplant
Aetiology Renal Disease Primary cause of renal disease, as identified in ANZDATA, categorised as:
1. High Risk Glomerulonephropathy – Primary FSGS, Membranous GN, MPGN
Recipient BMI Body Mass Index = Weight (Kg) / Height (m
2), calculated at time of transplant
Recipient Smoking History Known or former smoker of tobacco products
CAD Confirmed or suspected diagnosis of coronary artery disease at the time of entry to the transplant waitlist
PVD Confirmed or suspected diagnosis of peripheral vascular disease at the time of entry to the transplant waitlist
CVA Confirmed or suspected cerebrovascular disease (stroke or TIA) at the time of entry to the transplant waitlist
Recipient Diabetes - T2DM - T1DM
Confirmed diagnosis of:
Type 2 Diabetes Mellitus Type 1 Diabetes Mellitus
a
Transplant regions in Australia: 1. Queensland 2. New South Wales/Australian Capital Territory 3.
Victoria/Tasmania 4. South Australia/Northern Territory 5. Western Australia
Table S2. Summary statistics: Donor, procurement, immunological and recipient variables in the total population, according to the KDPI quintile
Variable Total 1st Quintile 2nd Quintile 3rd Quintile 4th Quintile 5th Quintile p value
n 2923 478 513 673 638 621
Donor Factors
Gender - Male 1627 (56) 326 (68) 285 (56) 357 (53) 344 (54) 315 (51) < 0.001
BMI - Median 26.42 24.49 25.95 26.53 27.55 27.68 < 0.001
IQR (23.55-30.12) (21.91-26.88) (22.59-29.41) (23.67-30.47) (24.61-31.98) (24.49-31.14)
Smoking History (%) 1818 (62) 284 (59) 296 (58) 421 (63) 445 (70) 372 (60) < 0.001 Donor CPR (%) 1195 (40) 235 (49) 210 (41) 305 (45) 225 (35) 180 (29) < 0.001 Donor Oliguria (%) 374 (13) 56 (12) 74 (14) 70 (10) 80 (13)) 94 (15) 0.08 Donor Inotropes 2583 (89) 439 (92) 451 (88) 594 (88) 566 (89) 533 (86) 0.05 Procurement Factors
Transplant out of Region
323 (11) 68 (14) 67 (13) 54 (8) 71 (11) 63 (10) 0.01
Procurement Biopsy 285 (10) 18 (4) 35 (7) 49 (7) 57 (9) 126 (20) < 0.001
Total Ischaemic Time 11 11 11 11 12 12 0.12
IQR (9-14) (8-14) (8-14) (8-14) (9-14) (9-14)
Immunological Variables
HLA Mismatch (Mean) 3.65 (1.69) 3.58 (1.75) 3.65 (1.73) 3.76 (1.65) 3.63 (1.68) 3.62 (1.64) 0.45
n 2899 469 510 671 634 615
Maximum PRA (Mean) 12.03 12.63 12.81 11.23 11.80 12.02 0.35
n 2793 448 491 642 606 606
Recipient Variables
Gender - Male 1829 (63) 285 (60) 310 (60) 447 (66) 398 (62) 389 (63) 0.13
Recipient Age - Median 53yrs 52yrs 52yrs 51yrs 54yrs 56yrs < 0.001
IQR (44-61) (42-59) (42-60) (42-60) (46-62) (47-63)
Dialysis Years - Median 3.29yrs 2.79yrs 3.12yrs 3.24yrs 3.61yrs 3.55yrs 0.005
IQR (1.74-5.45) (1.51-4.97) (1.71-5.46) (1.88-5.36) (1.83-5.55) (1.78-5.69)
Previous Transplant 378 (13) 69 (14) 79 (15) 81 (12) 91 (14) 58 (9) 0.02
Aetiology Renal Disease
High Risk GN 346 (12) 45 (9) 65 (13) 98 (15) 65 (10) 73 (12) 0.05
Low Risk GN 387 (13) 75 (16) 65 (13) 85 (13) 90 (14) 72 (12) 0.32
IgA 415 (14) 77 (16) 72 (14) 88 (13) 82 (13) 96 (15) 0.42
Diabetes 391 (13) 52 (11) 78 (15) 82 (12) 91 (14) 88 (14) 0.23
Non-recurrent Disease 806 (28) 138 (29) 140 (27) 188 (28) 176 (28) 164 (26) 0.93
Other 578 (20) 91 (19) 93 (18) 132 (20) 134 (21) 128 (21) 0.75
Recipient BMI (mean) 26.94 (4.84) 26.63 (4.89) 27.01 (5.16) 27.20 (4.81) 27.02 (4.67) 26.77 (4.71) 0.22
n 2834 461 501 653 612 607
Smoking History 1347 (47) 196 (41) 234 (46) 327 (49) 285 (46) 205 (49) 0.07
n 2895 473 509 668 626 619
Coronary Artery Disease
697 (24) 97 (20) 124 (24) 139 (21) 160 (25) 177 (29) 0.005
Peripheral Vascular Disease
339 (12) 50 (10) 64 (12) 63 (9) 87 (14) 75 (12) 0.14
Cerebrovascular Disease
194 (7) 29 (6) 25 (5) 50 (7) 46 (7) 44 (7) 0.40
Recipient Diabetes 582 (20) 74 (16) 104 (20) 122 (18) 139 (22) 143 (23) 0.01
T1DM 63 (2) 14 (3) 15 (3) 13 (2) 13 (2) 8 (1) 0.27
T2DM 519 (18) 60 (13) 89 (17) 109 (16) 126 (20) 135 (22) 0.001
Table S3. Summary statistics: Donor, procurement, immunological and recipient variables in the 5
thquintile across KDPI five-point increments
Variable 5th Quintile KDPI 81 – 85 KDPI 86 – 90 KDPI 91 – 95 KDPI 96 - 100 p value
n 621 192 169 155 105
Donor Factors
Gender - Male 315 (51) 95 (49) 84 (50) 86 (55) 50 (48) 0.57
Donor BMI (Median) 27.68 26.67 28.26 27.34 28.01 0.49
IQR (24.49-31.14) (23.91-31.56) (24.84-30.86) (24.30-31.14) (24.75-30.48)
Smoking History 372 (60) 121 (63) 105 (62) 89 (57) 57 (54) 0.41
Donor CPR 180 (29) 64 (33) 52 (31) 41 (26) 23 (22) 0.17
Donor Oliguria 94 (15) 25 (13) 26 (15) 24 (15) 19 (18) 0.70
Donor Inotropes 533 (86) 156 (81) 138 (82) 142 (92) 97 (92) 0.003
Procurement Factors
Transplant out of Region 63 (10) 30 (16) 8 (5) 13 (8) 12 (11) 0.01
Procurement Biopsy 126 (20) 20 (10) 28 (16) 39 (25) 39 (37) < 0.001
Total Ischaemic Time 12 11hrs 11hrs 11 hrs 12hrs 0.25
IQR (9-14) (9-14) (9-15) (9-14) (9-16)
Immunological Factors
HLA Mismatch (mean) 3.62 (1.64) 3.43 (1.68) 3.75 (1.59) 3.68 (1.64) 3.65 (1.66) 0.32
n 615 192 166 155 102
Maximum PRA (mean) 12.02 11.63 (23.04) 11.87 (22.63) 14.05 (25.86) 10.05 (21.48) 0.42
n 606 185 167 150 104
Recipient Variables
Gender - Male 389 (63) 118 (61) 113 (67) 93 (60) 65 (62) 0.60
Recipient Age (median) 56yrs 55yrs 55yrs 55yrs 59yrs 0.09
IQR (47-63) (47-62) (45-61) (48-64) (49-64)
Dialysis Years (median) 3.55yrs 3.24 yrs 3.61 yrs 3.95 yrs 3.32 yrs 0.20
IQR (1.78-5.69) (1.76-5.31) (1.82-6.28) (1.94-5.80) (1.68-5.59)
Previous Transplant 58 (9) 19 (10) 16 (9) 17 (11) 6 (6) 0.53
Aetiology Renal Disease
High Risk GN 73 (12) 22 (11) 23 (14) 14 (9) 14 (13) 0.59
Low Risk GN 72 (12) 20 (10) 16 (9) 25 (16) 11 (10) 0.24
IgA 96 (15) 34 (18) 29 (17) 20 (13) 13 (12) 0.45
Diabetes 88 (14) 24 (13) 29 (17) 19 (12) 16 (15) 0.52
Non-recurrent Disease 164 (26) 52 (27) 37 (22) 48 (31) 27 (26) 0.32
Other 128 (21) 40 (21) 35 (21) 29 (19) 24 (23) 0.88
Recipient BMI (median) 26.77 (4.71) 26.74 (4.52) 26.86 (4.96) 26.66 (4.77) 26.82 (4.61) 0.97
n 607 188 166 150 103
Smoking History 205 (49) 93 (49) 89 (53) 80 (52) 43 (41) 0.24
n 619 191 168 155 105
Coronary Artery Disease 177 (29) 53 (28) 53 (31) 34 (22) 37 (35) 0.10
Peripheral Vascular Disease
75 (12) 22 (11) 23 (14) 20 (13) 10 (10) 0.76
Cerebrovascular
Disease 44 (7) 14 (7) 11 (7) 12 (8) 7 (7) 0.97
Recipient Diabetes 143 (23) 41 (21) 50 (30) 33 (21) 19 (18) 0.12
T1DM 8 (1) 4 (2) 2 (1) 1 (0.7) 1 (1) 0.67
T2DM 135 (22) 37 (19) 48 (28) 32 (21) 18 (17) 0.09
Table S4. Univariate regression for study variables, dependent variable i) recipient eGFR at 1-year post-transplant (linear regression), and ii) sub-optimal outcome (logistic regression). Recipient eGFR capped at 90mL/min.
Univariate Linear Regression
Dependent Variable – Recipient 1-Year eGFR
Univariate Logistic Regression
Dependent Variable – Sub-optimal
Outcome Total Study
Population
5
thQuintile Cohort Total Study Population
5
thQuintile Cohort B-Coefficient
(95% CI) P
value B-Coefficient (95% CI) p
value Odds Ratio (95% CI) P
value Odds Ratio (95% CI)
p value
Donor Variables
KDPI -0.36
(-0.38, -0.33)
< 0.001 -0.56 (-0.77, -0.35)
<0.001 1.03 <0.001
(1.03, 1.04) KDPI Quintile
1st Quintile Constant 1.00
2nd Quintile -9.48
(-11.45, -7.51)
< 0.001 2.56
(1.33, 4.91) 0.005 3rd Quintile -16.28
(-18.12, -14.43)
< 0.001 3.75
(2.04, 6.90)
<0.001
4th Quintile -22.02
(-23.89, -20.15)
< 0.001 5.10
(2.80, 9.30)
<0.001 5th Quintile -28.86
(-30.76, -26.96)
< 0.001 12.96
(7.26, 23.15)
<0.001
KDPI
81 - 85 Constant 1.00
86 - 90 -0.74
(-3.77, 2.29)
0.63 1.87
(1.11, 3.23) 0.02
91 - 95 -4.71
(-7.81, -1.61)
0.003 2.74
(1.62, 4.64)
< 0.001
96 - 100 -8.40
(-11.94, -4.85)
< 0.001 4.36
(2.48, 7.64)
< 0.001
Donor Male 4.28
(2.92, 5.64)
< 0.001 2.97
(0.61, 5.33)
0.01 0.77
(0.61, 0.96)
0.02 0.80
(0.56, 1.14) 0.22
Donor Smoking 0.04
(-1.36, 1.44)
0.95 1.34
(-1.07, 3.75)
0.28 0.93
(0.74, 1.17)
0.55 0.98
(0.68, 1.42) 0.94
Donor CPR 4.57
(3.19, 5.95)
< 0.001 2.26
(-0.33, 4.86)
0.09 0.60
(0.47, 0.77)
<
0.001 0.77
(0.51, 1.16) 0.21
Inotropes -0.13
(-2.24, 1.38)
0.90 -3.33
(-6.72, 0.06)
0.05 1.38
(0.94, 2.02)
0.10 1.47
(0.84, 2.56) 0.17
Oliguria -0.13
(-2.24, 1.97)
0.90 -0.71
(-4.07, 2.65)
0.68 1.32
(0.98, 1.81)
0.10 1.15
(0.70, 1.87) 0.58
Procurement Factors
Transplant Out of Region
2.65 (0.49, 4.81)
0.02 0.60
(-3.27, 4.48)
0.76 0.57
(0.37, 0.87)
0.01 0.65
(0.34, 1.26) 0.20
Ischaemic Time >
12 hrs -1.80
(-3.23, -0.38)
0.01 -2.51
(-4.95, 0.07)
0.04 1.34
(1.07, 1.70)
0.01 1.32
(0.91, 1.92) 0.14
Procurement Biopsy
-6.91 (-9.25, -4.57)
< 0.001 -1.15 (-4.15, 1.85)
0.45 2.44
(1.80, 3.32)
<
0.001 1.66
(1.09, 2.55) 0.02
Immunological Factors
HLA Ag Mismatch 0.03 (-0.44, 0.37)
0.86 -0.25
(-0.98, 0.47)
0.49 1.09
(1.02, 1.17)
0.01 1.14
(1.02, 1.27) 0.02
PRA -0.03
(-0.06, 0.00)
0.06 -0.05
(-0.11, 0.00)
0.04 1.01
(1.00, 1.01)
0.01 1.00
(0.99, 1.01) 0.99
Recipient Demographics
Recipient Age -0.13 (-0.18, -0.07)
0.001 0.02
(-0.08, 0.13)
0.68 1.00
(0.99, 1.01)
0.50 1.00
(0.99, 1.02) 0.91
Recipient - Male -0.03 (-1.43, 1.37)
0.97 1.31
(-1.13, 3.75)
0.29 0.95
(0.75, 1.20)
0.68 0.88
(0.61, 1.27) 0.50
Recipient BMI -0.54 (-0.68, -0.40)
<0.001 -0.48
(-0.73, -0.23)
< 0.001 1.03 (1.01, 1.06)
0.01 1.07
(1.03, 1.11) 0.001
BMI < 25kg/m2 0 0 1.00 1.00
BMI 25 – 30kg/m2 -4.02 (-5.61, -2.43)
<0.001 -1.76
(-4.49, 0.97)
0.21 1.32
(1.00, 1.74)
0.05 1.27
(0.81, 1.98) 0.29 BMI > 30 kg/m2 -6.23
(-7.95, -4.50)
<0.001 -5.09
(-8.12, -2.06)
0.001 1.57
(1.18, 2.10)
0.002 2.16
(1.36, 3.44) 0.001
Previous Transplant
2.99 (0.97, 5.01)
0.004 0.46
(-3.56, 4.50)
0.82 0.82
(0.58, 1.16)
0.26 0.80
(0.42, 1.53) 0.51
Dialysis Years -0.40 (-0.65, -0.15)
0.002 -0.08
(-0.53, 0.36)
0.72 1.08
(1.04, 1.12)
<
0.001 1.04
(0.98, 1.11) 0.20
< 1 year 1.36
(-0.77, 3.49)
0.21 1.18
(-2.59, 4.95)
0.54 0.53
(0.34, 0.82)
0.004 0.58
(0.30, 1.12) 0.11
1 – 10 years 0 0 1.00 1.00
> 10 years -2.71
(-7.37, 1.94)
0.25 -3.38
(-13.42, 6.66)
0.51 2.43
(1.38, 4.29)
0.002 3.28
(0.87, 12.38)
0.08
Recipient Co- morbidities
High Risk GN -1.56 (-3.68, 0.56)
0.15 -2.79
(-6.45, 0.87)
0.14 1.64
(1.21, 2.22)
0.001 2.00
(1.20, 3.34) 0.01
Smoking History -1.91 (-3.28, -0.55)
0.010 -1.49
(-3.86, 0.88)
0.22 1.16
(0.93, 1.46)
0.19 1.00
(0.70, 1.44) 0.99
Coronary Artery
Disease -1.75
(-3.36, -0.15)
0.03 1.87
(-0.78, 4.52)
0.17 1.19
(0.93, 1.54)
0.17 1.02
(0.68, 1.52) 0.94
Peripheral Vascular Disease
-1.07 (-3.22, 1.09)
0.33 2.48
(-1.22, 6.19)
0.19 1.50
(1.09, 2.06)
0.01 1.11
(0.64, 1.90) 0.72
Stroke 0.94
(-1.83, 3.71)
0.51 0.91
(-3.70, 5.53)
0.70 1.35
(0.89, 2.04)
0.16 1.67
(0.87, 3.19) 0.12
Diabetes (T2DM) -1.30 (-3.10, 0.50)
0.16 2.44
(-0.49, 5.37)
0.10 1.65
(1.26, 2.14)
<
0.001 1.50
(0.99, 2.28) 0.06
Post-Transplant Events
Rejection within 1
year -8.70
(-10.29, -7.12)
< 0.001 -7.26 (-9.83, -4.69)
< 0.001 3.14 (2.49, 3.95)
<
0.001 2.18
(1.49, 3.19)
< 0.001
Delayed Graft Function
-6.61 (-8.08, -5.14)
< 0.001 -3.21 (-5.63, -0.80)
0.01 2.81
(2.23, 3.53)
<
0.001 1.69
(1.17, 2.45) 0.005
Table S4. Univariate regression for study variables, dependent variable i) recipient eGFR at 1-year post-transplant (linear regression) and ii) sub-optimal outcome (logistic regression).
Univariate Linear Regression
Dependent Variable – Recipient 1-Year eGFR
Univariate Logistic Regression
Dependent Variable – Sub-optimal
Outcome Total Study
Population
5
thQuintile Cohort Total Study Population
5
thQuintile Cohort B-Coefficient
(95% CI)
P value
B-Coefficient (95% CI)
p value
Odds Ratio (95% CI)
P value
Odds Ratio (95% CI)
p value
Donor Variables
KDPI -0.38
(-0.40, -0.36)
< 0.001 -0.56 (-0.77, -0.35)
<0.001 1.03 <0.001
(1.03, 1.04) KDPI Quintile
1st Quintile Constant 1.00
2nd Quintile -10.82 (-13.02, -8.63)
< 0.001 2.56
(1.33, 4.91) 0.005 3rd Quintile -18.01
(-20.07, -15.95)
< 0.001 3.75
(2.04, 6.90)
<0.001 4th Quintile -23.89
(-25.97, -21.80)
< 0.001 5.10
(2.80, 9.30)
<0.001 5th Quintile -30.95
(-33.06, -28.87) < 0.001 12.96
(7.26, 23.15)
<0.001
KDPI
81 - 85 Constant 1.00
86 - 90 -0.74
(-3.77, 2.29)
0.63 1.87
(1.11, 3.23) 0.02
91 - 95 -4.71
(-7.81, -1.61)
0.003 2.74
(1.62, 4.64)
< 0.001
96 - 100 -8.40
(-11.94, -4.85)
< 0.001 4.36
(2.48, 7.64)
< 0.001
Donor Male 4.77
(3.28, 6.26)
< 0.001 2.97
(0.61, 5.33)
0.01 0.77
(0.61, 0.96)
0.02 0.80
(0.56, 1.14) 0.22
Donor Smoking 0.15
(-1.39, 1.69)
0.85 1.34
(-1.07, 3.75)
0.28 0.93
(0.74, 1.17)
0.55 0.98
(0.68, 1.42) 0.94
Donor CPR 5.12
(3.61, 6.64)
< 0.001 2.26
(-0.33, 4.86)
0.09 0.60
(0.47, 0.77)
<
0.001 0.77
(0.51, 1.16) 0.21
Inotropes -0.55
(-2.87, 1.76)
0.64 -3.33
(-6.72, 0.06)
0.05 1.38
(0.94, 2.02)
0.10 1.47
(0.84, 2.56) 0.17
Oliguria -0.24
(-2.02, 2.50)
0.84 -0.71
(-4.07, 2.65)
0.68 1.32
(0.98, 1.81)
0.10 1.15
(0.70, 1.87) 0.58
Procurement Factors
Out of Region 2.52
(0.14, 4.90)
0.04 0.60
(-3.27, 4.48)
0.76 0.57
(0.37, 0.87)
0.01 0.65
(0.34, 1.26) 0.20
Ischaemic Time >
12 hrs
-2.06 (-3.63, -0.49)
0.01 -2.51
(-4.95, 0.07)
0.04 1.34
(1.07, 1.70)
0.01 1.32
(0.91, 1.92) 0.14
Procurement
Biopsy -7.39
(-9.96, -4.81)
< 0.001 -1.15 (-4.15, 1.85)
0.45 2.44
(1.80, 3.32)
<
0.001 1.66
(1.09, 2.55) 0.02
Immunological Factors
HLA Ag Mismatch 0.04 (-0.40, 0.49)
0.85 -0.25
(-0.98, 0.47)
0.49 1.09
(1.02, 1.17)
0.01 1.14
(1.02, 1.27) 0.02
PRA -0.03
(-0.06, 0.00)
0.09 -0.05
(-0.11, 0.00)
0.04 1.01
(1.00, 1.01)
0.01 1.00
(0.99, 1.01) 0.99
Recipient Demographics
Recipient Age -0.16 (-0.22, -0.10)
0.001 0.02
(-0.08, 0.13)
0.68 1.00
(0.99, 1.01)
0.50 1.00
(0.99, 1.02) 0.91
Recipient - Male -0.07 (-1.61, 1.48)
0.93 1.31
(-1.13, 3.75)
0.29 0.95
(0.75, 1.20)
0.68 0.88
(0.61, 1.27) 0.50
Recipient BMI -0.53 (-0.69, -2.37)
<0.001 -0.48
(-0.73, -0.23)
< 0.001 1.03 (1.01, 1.06)
0.01 1.07
(1.03, 1.11) 0.001
BMI < 25kg/m2 0 0 1.00 1.00
BMI 25 – 30kg/m2 -4.38 (-6.14, -2.63)
<0.001 -1.76
(-4.49, 0.97)
0.21 1.32
(1.00, 1.74)
0.05 1.27
(0.81, 1.98) 0.29 BMI > 30 kg/m2 -6.35
(-8.26, -4.44)
<0.001 -5.09
(-8.12, -2.06)
0.001 1.57
(1.18, 2.10)
0.002 2.16
(1.36, 3.44) 0.001
Previous Transplant
3.32 (1.09, 5.54)
0.004 0.46
(-3.56, 4.50)
0.82 0.82
(0.58, 1.16)
0.26 0.80
(0.42, 1.53) 0.51
Dialysis Years -0.40 (-0.68, -0.12)
0.004 -0.08
(-0.53, 0.36)
0.72 1.08
(1.04, 1.12)
<
0.001 1.04
(0.98, 1.11) 0.20
< 1 year 1.12
(-1.22, 3.47)
0.35 1.18
(-2.59, 4.95)
0.54 0.53
(0.34, 0.82)
0.004 0.58
(0.30, 1.12) 0.11
1 – 10 years 0 0 1.00 1.00
> 10 years -2.45
(-7.58, 2.67)
0.35 -3.38
(-13.42, 6.66)
0.51 2.43
(1.38, 4.29)
0.002 3.28
(0.87, 12.38)
0.08
Recipient Co- morbidities
High Risk GN -1.54 (-3.87, 0.80)
0.20 -2.79
(-6.45, 0.87)
0.14 1.64
(1.21, 2.22)
0.001 2.00
(1.20, 3.34) 0.01
Smoking History -2.29 (-3.80, -0.79)
0.003 -1.49
(-3.86, 0.88)
0.22 1.16
(0.93, 1.46)
0.19 1.00
(0.70, 1.44) 0.99
Coronary Artery Disease
-1.82 (-3.59, -0.05)
0.04 1.87
(-0.78, 4.52)
0.17 1.19
(0.93, 1.54)
0.17 1.02
(0.68, 1.52) 0.94
Peripheral
Vascular Disease -0.91 (-3.28, 1.46)
0.45 2.48
(-1.22, 6.19)
0.19 1.50
(1.09, 2.06)
0.01 1.11
(0.64, 1.90) 0.72
Stroke 1.50
(-1.54, 4.55)
0.33 0.91
(-3.70, 5.53)
0.70 1.35
(0.89, 2.04)
0.16 1.67
(0.87, 3.19) 0.12
Diabetes (T2DM) -1.55 (-3.54, 0.44)
0.13 2.44
(-0.49, 5.37)
0.10 1.65
(1.26, 2.14)
<
0.001 1.50
(0.99, 2.28) 0.06
Post-Transplant Events
Rejection within 1 year
-9.37 (-11.11, -7.62)
< 0.001 -7.26 (-9.83, -4.69)
< 0.001 3.14 (2.49, 3.95)
<
0.001 2.18
(1.49, 3.19)
< 0.001
Delayed Graft Function
-6.91 (-8.54, -5.29)
< 0.001 -3.21 (-5.63, -0.80)
0.01 2.81
(2.23, 3.53)
<
0.001 1.69
(1.17, 2.45) 0.005
