Hasil Penilaian Peer Review - Undip PAK Repository

(1)

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU PEER REVIEW KARYA ILMIAH : JURNAL ILMIAH

Judul Jurnal Ilmiah (Artikel) : Synthesis of Colloidal Silver, Platinum, and Mixture of Silver-Platinum Nanoparticles Using Pulsed Laser Ablation as a Constrast Agent in Computed Tomography

Nama/ Jumlah Penulis

:

4 Orang

Status Pengusul

:

Penulis pertama/ Penulis ke 3 / Penulis Korespondesi **

Identitas Jurnal Ilmiah

:

a. Nama Jurnal : Iranian Journal of Medical Physics b. Nomor ISSN : 1735-160X

c. Vol, No., Bln Thn : Vol 19, Issue 1, January and February 2022 d. Penerbit : Mashhad University of Medical Sciences e. DOI artikel (jika ada) : 10.22038/IJMP.2021.51781.1849

f. Alamat web jurnal : https://ijmp.mums.ac.ir/article_17441.html

Alamat Artikel : https://ijmp.mums.ac.ir/article_17441_a3051ffa204833f 57c34684c5b5cc545.pdf

g. Terindex Kategori Publikasi Jurnal Ilmiah :

√

(beri pada kategori yang tepat)

: Scopus

Jurnal Ilmiah Internasional/Internasional Bereputasi Jurnal Ilmiah Nasional Terakreditasi Jurnal Ilmiah Nasional Tidak Terakreditasi

Hasil Penilaian Peer Review :

Komponen Nilai Reviewer

Nilai Rata-rata

Yang Dinilai Reviewer I Reviewer II

a. Kelengkapan unsur isi jurnal (10%) 4 3,9 3,95

b. Ruang lingkup dan kedalaman pembahasan

11 11,8 11,4

(30%)

c. Kecukupan dan kemutahiran data/informasi dan

11 11,8 11,4

metodologi (30%)

d. Kelengkapan unsur dan kualitas penerbit (30%) 10 11,9 10,95

Total = (100%)

36 39,4 37,7

Nilai untuk Pengusul : (60% x 37,7) = 22,62

Semarang, 5 Maret 2022

Reviewer 1 Reviewer 2

Prof. Dr. Kusworo Adi, S.Si., M.T.

NIP. 197203171998021001

Bidang ilmu/Unit kerja : Fakultas Sains dan Matematika/Fisika

Dr. Eng. Eko Hidayanto, S.Si., M.Si.

NIP. 197301031998021001

Bidang ilmu/Unit kerja : Fakultas Sains dan

Matematika/Fisika

(2)

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU

PEER REVIEW

KARYA ILMIAH : JURNAL ILMIAH

Judul Jurnal Ilmiah (Artikel) : Synthesis of Colloidal Silver, Platinum, and Mixture of Silver-Platinum Nanoparticles Using Pulsed Laser Ablation as a Constrast Agent in Computed Tomography

Nama/ Jumlah Penulis : 4 Orang

Status Pengusul : Penulis pertama/ Penulis ke 3 / Penulis Korespondesi **

Identitas Jurnal Ilmiah : a. Nama Jurnal : Iranian Journal of Medical Physics b. Nomor ISSN : 1735-160X

c. Vol, No., Bln Thn : Vol 19, Issue 1, January and February 2022 d. Penerbit : Mashhad University of Medical Sciences e. DOI artikel (jika ada) :

10.22038/IJMP.2021.51781.1849

f. Alamat web jurnal : https://ijmp.mums.ac.ir/article_17441.html

Alamat Artikel : https://ijmp.mums.ac.ir/article_17441_a3051ffa204833f 57c34684c5b5cc545.pdf

g. Terindex : Scopus

Kategori Publikasi Jurnal Ilmiah : (beri

√

pada kategori yang tepat)

Hasil Penilaian

Peer Review

:

Jurnal Ilmiah Internasional /Internasional Bereputasi Jurnal Ilmiah Nasional Terakreditasi

Jurnal Ilmiah Nasional Tidak Terakreditasi

Nilai Maksimal Jurnal Ilmiah

Nasional Nasional Nilai Akhir Komponen Internasional Terakreditasi Tidak

Yang

Yang Dinilai Terakreditasi

√

Diperoleh

a. Kelengkapan unsur isi jurnal (10%) 4,00 4

b. Ruang lingkup dan kedalaman 12,00 11

pembahasan (30%)

c. Kecukupan dan kemutahiran 12,00 11

data/informasi dan metodologi (30%)

d. Kelengkapan unsur dan kualitas 12,00 10

terbitan/jurnal (30%)

Total = (100%) 40,00 36

Nilai Pengusul = 60% x 36 = 21,6

Semarang, 4 Maret 2022 Reviewer 1

Prof. Dr. Kusworo Adi, S.Si., M.T.

NIP. 197203171998021001 Unit Kerja : Fisika

Bidang Ilmu: Fisika Catatan Penilaian artikel oleh Reviewer :

1. Kesesuaian dan kelengkapan unsur isi jurnal:

Kesesuaian dan kelengkapan unsur jurnal sudah sesuai Guide of Author pada Iranian Journal of Medical Physics yang meliputi Introduction, Materials and Methods, Results, Discussion, Conclusion, Acknowledgment, References.

Substansi publikasi sesuai dengan bidang ilmu penulis yaitu fisika laser yang saling terkait antar bagian (skor=4,00) 2. Ruang lingkup dan kedalaman pembahasan:

Makalah sudah sesuai dengan ruang lingkup jurnal yaitu Radiology, Nuclear Medicine and Imaging. Pada makalah ini dengan topik tentang Contras Agent untuk CT yang merupakan bagian dari topik pada jurnal ini. Pembahsaan sangat komprehensif yang membandingkan dengan penelitian lain dengan mencatumkan 7 dari 26 referensi sebagai rujukan, sehingga pembahasan dilakukan dengan sangat baik (skor=11,00)

3. Kecukupan dan kemutakhiran data/informasi dan metodologi:

Hasil penelitian cukup memberikan informasi pada bidang fisika laser yang disertai metodologi yang cukup baik untuk mencapai hasil yang diharapkan. Referensi sejumlah 26, 12 referensi dibawah 10 tahun dan 14 referensi diatas 10 tahun serta medukung topik yang dibahas (skor = 11,00)

4. Kelengkapan unsur dan kualitas terbitan:

Iranian Journal of Medical Physics termasuk dalam kategori Jurnal Internasional Bereputasi dengan editorial board lebih dari empat negara dan kontributor lebih dari 4 negara, SSN:1735-160X, E-ISSN:1735-7241, terindeks scopus dengan SJR=0,241 (2020)/Q4 dan proses review jurnal bagus (skor=10,00)

√

(3)

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU

PEER REVIEW

KARYA ILMIAH : JURNAL ILMIAH

Judul Jurnal Ilmiah (Artikel)

:

Synthesis of Colloidal Silver, Platinum, and Mixture of Silver-Platinum Nanoparticles Using Pulsed Laser Ablation as a Constrast Agent in Computed Tomography

Nama/ Jumlah Penulis

:

4 Orang

Status Pengusul

: Penulis pertama/ Penulis ke 3 / Penulis Korespondesi **

Identitas Jurnal Ilmiah

:

a. Nama Jurnal : Iranian Journal of Medical Physics

b. Nomor ISSN : 1735-160X

c. Vol, No., Bln Thn : Vol 19, Issue 1, January and February 2022 d. Penerbit : Mashhad University of Medical Sciences e. DOI artikel (jika ada) :

10.22038/IJMP.2021.51781.1849

f. Alamat web jurnal : https://ijmp.mums.ac.ir/article_17441.html

Alamat Artikel : https://ijmp.mums.ac.ir/article_17441_a3051ffa204833f

57c34684c5b5cc545.pdf

g. Terindex : Scopus

Kategori Publikasi Jurnal Ilmiah : Beri √ pada kategori yang tepat)

Hasil Penilaian

Peer Review

:

Jurnal Ilmiah Internasional/Internasional Bereputasi Jurnal Ilmiah Nasional Terakreditasi Jurnal Ilmiah Nasional Tidak Terakreditasi

Nilai Maksimal Jurnal Ilmiah

Nasional Nasional

Nilai Akhir Komponen Internasional Terakreditasi

Tidak

Yang

Yang Dinilai

Terakreditasi

√ Diperoleh

a. Kelengkapan unsur isi jurnal (10%) 4 3,9

b. Ruang lingkup dan kedalaman ₁₂ 11,8

pembahasan (30%)

c. Kecukupan dan kemutahiran ₁₂ 11,8

data/informasi dan metodologi (30%)

d. Kelengkapan unsur dan kualitas ₁₂ 11,9

terbitan/jurnal (30%)

Total = (100%)

40

39,4

Nilai Pengusul = 60% x 39,4 = 23,64

Semarang, 05 Maret 2022 Reviewer 2

Dr. Eng. Eko Hidayanto, S.Si., M.Si.

NIP. 197301031998021001 Unit Kerja : Fisika

Bidang Ilmu: Fakultas Sains dan Matematika Catatan Penilaian artikel oleh Reviewer :

1. Kesesuaian dan kelengkapan unsur isi jurnal:

Sangat sesuai dan lengkap mulai dari abstrak, pendahuluan, prosedur eksperimen, hasil dan pembahasan, sampai pada kesimpulan dan dafar pustaka yang digunakan.

2. Ruang lingkup dan kedalaman pembahasan:

Paper ini membahas tentang Sintesis Koloid Perak, Platinum, dan Campuran Nanopartikel PerakPlatinum Menggunakan Pulsed Laser Ablation sebagai Agen Kontras dalam Computed Tomography.

3. Kecukupan dan kemutakhiran data/informasi dan metodologi:

Data-data hasil yang diperoleh dalam penelitian mutakhir dengan didukung metodologi yang tepat.

4. Kelengkapan unsur dan kualitas terbitan:

Karya ini diterbitkan dalam jurnal berkualitas Q4 dengan SJR 0,24 oleh Mashhad University of Medical Sciences dengan unsur-unsur yang lengkap serta kualitas yang baik.

√

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Save to PDF i:( Add to List More ... ) Iranian Journal of Medical Physics • Volume 19, Issue 1, Pages 49 - 57 • January 2022

Document type Article Source type Journal ISSN 1735160X DOI

10.22038/IJ M P.2021.51781.1849 View more v

Synthesis of Colloidal Silver, Platinum, and Mixture of Silver-Platinum Nanoparticles Using Pulsed Laser Ablation as a Contrast Agent in Computed

Tomography

Khumaeni, Alia i8i ; Alhamid, Mohammad Zamakhsari": Anam, Choirul": Budiono, Arib

� Save all to author list

a Physics Department, Diponegoro University, Central Java, Tembalang, Semarang, Indonesia b Loekmono HadiGeneral Hospital, Central Java, Kudus, Indonesia

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Abstract Author keywords

Reaxys Chemistry database information Indexed keywords

SciVal Topics Funding details

Abstract

Introduction: The development of nanoparticles as computed tomography contrast agents has increased significantly. However, few reports have been published on the use of silver and platinum nanoparticles as contrast agents. These nanomaterials are a good candidatefor contrast agents because of their high atomic number and high durability against corrosion. Material and Methods: Experimentally, a Nd:YAG laser (1064 nm, 45 m], 10 Hz) was focused on a high-purity metal plate including Ag and Pt plates, which are placed in deionized water medium. Colloidal nanoparticles of Ag and Pt were then mixed to obtain a mixture composition of Ag and Pt with ratios of Ag:Pt of 75:25%, 50:50%, 25:75%,

respectively.The Ag, Pt, and Ag-Pt NPs mixture were then examined as contrast agents in CT scan.

Results: The imaging results of the quantitative analysiswere measured in the Hounsfield Unit(HU), showing 13.5, 12.8, 13.3, 14.1, and 17.3 HU for colloidal 100% AgNPs, colloidal Ag and Pt NPs with volume ratios of Ag:Pt of 75:25%, 50:50%, 25:75%, and colloidal 100%Pt NPs, respectively. Conclusion: Results reveal the highest absorbent power was found in the colloidal contrast agent of Pt NPs 100% is 17.3 HU, followed by the 25:75% Ag-Pt NPs is 14.1 HU. The higher HU value for platinum can be attributed to its

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Iranian Journal of Medical Physics

ijmp.mums.ac.ir

The Role of Crocetin-Loaded PLGA Nanoparticles as a Pre- Treatment Agent on Indocyanine-Photodynamic Therapy of Breast Cancer Cell

Samaneh Soudmand Salarabadi

¹

, Maryam Hashemi

²

, Ameneh Sazgarnia

¹

*

1. Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences ,Mashhad, Iran A R T I C L E I N F O A B S T R A C T

Article type:

Original Paper

Introduction: Photodynamic therapy (PDT) can be considered as a non-invasive method for cancer treatment. One of the most commonly of a water-soluble dye photosensitizer (PS) used in photothermal therapy (PTT) and PDT is Indocyanine Green (ICG). However, high cytotoxicity in high concentration and instability in aqueous media were limited its application. It was shown that using nanoparticles or plant extracts in combination with PS could improve PDT efficiency. In this study, anti-cancer properties of crocetin (Crt) loaded PLGA (Poly lactic-co-glycolic acid) nanoparticles (NPs) were utilized to increase the PDT efficacy with ICG on the MCF-7 cells.

Material and Methods: Crt was encapsulated into PLGA NPs and its particle size distribution and encapsulation efficiency were evaluated. IC10 of Crt, PLGA-Crt NPs and ICG was determined by MTT assay in MCF-7 cancer cells. At these concentrations, the cells were pre-treated with Crt or PLG-Crt, then treated with ICG and finally exposure to near infrared (NIR) laser with 2.5 W powers at different times. The cells viability was evaluated by the MTT assay.

Results: The findings showed no dark cytotoxicity due to ICG (12.9 μM), Crt or PLGA-Crt alone. But NIR laser irradiation in the presence of ICG after cells pre-treatment by the Crt or PLGA-Crt NPs leads to induce cell death to (61.6 ±7) % and (75.5 ±5) %, respectively (P<0.05).

Conclusion: The results demonstrated that PLGA-Crt NPs in combination with ICG could improve PDT outcomes more efficiently in comparison with Crt and ICG. Therefore, this method could be effective in breast cancer therapy with low cytotoxicity.

Article history:

Received: Mar 14, 2021 Accepted: Apr 14, 2021 Keywords:

Crocetin (Crt) Poly Lactic-Co-Glycolic Acid (PLGA)

Nanoparticles (NPs) Photodynamic Therapy (PDT)

Indocyanine Green (ICG) Breast Cancer

►

Please cite this article as:

Soudmand Salarabadi S, Hashemi M, Sazgarnia A. The Role of Crocetin-Loaded PLGA Nanoparticles as a Pre-Treatment Agent on Indocyanine-Photodynamic Therapy of Breast Cancer Cell. Iran J Med Phys 2022; 19: 58-65. 10.22038/IJMP.2021.56373.1942.

.

Introduction

Photodynamic therapy (PDT) has attracted considerable attention as a non-invasive therapeutic technique for cancer because of low cost, short treatment time and low systemic toxicity properties [1-4]. In this method, a light-sensitive agent named photosensitizer (PS) conducts to cancer cells and after stimulation by specific wavelength, singlet oxygen converts into various reactive oxygen species (ROS) that led to the death of tumor cells [5-8]. The effect of PS on cancer cells could be influenced by different factors such as the type or concentration of Ps [9] and the amount of light radiation [10]. On the other hand, the combination of PDT and a secondary treatment can be designed to increase the effectiveness of PDT [7] and reduce toxicity due to the use of a lower dose of PS. recently, more attention has been focused on the using of plant extracts in combination with PDT for cancer treatment [3, 11]. Another approach to enhance PDT is using nanoparticles (NPs) to improve the solubility of hydrophobic PSs, controlled release and increase the concentration of PSs at desired sites

[12, 13]. Various types of NPs such as liposomes, quantum dots, gold NPs, polymers, micelles, magnetic NPs, dendrimers, and carbon-based NPs have been developed to improve PSs efficiency [12].

One of the most commonly used PS is Indocyanine green (ICG) or 4, 5-Benzoindotricarbocyanine, a tricarbocyanine dye with amphiphilic molecular structure [14, 15]. This PS is approved by the U.S.

Food and Drug Administration (FDA) [10, 16].

Compared to other sensitizers, ICG shows the unique specifications such as strong absorption (between 700 and 800 nm) and emission peaks at the NIR region [10], high accumulation in tumor tissue and water solubility [17, 18]. The problems associated with ICG are high cytotoxicity at high concentration [19] and instability in aqueous media [17].

Recently, the attention to medicinal herbs has been paid, significantly in the treatment of tumors. Saffron, as coloring for foods in plant Crocus sativus L, has been suggested to treat different diseases, especially cancer [20-22]. Crocetin (Crt) is a carboxylic

*Corresponding Author: Tel: +98 5138002323; Fax: +98 5138002320; Email: sazgarniaa@mums.ac.ir

(10)

Iranian Journal of Medical Physics

ijmp.mums.ac.ir

Dosimetric Comparison between Dynamic Wave Arc and Co- Planar Volumetric Modulated Radiotherapy for Locally Advanced Pancreatic Cancer

Alshaymaa Abdelghaffar

¹

. Noriko Kishi

²

, Ryo Ashida

³

, Yukinori Matsuo

²

, Hideaki Hirashima

²

, Nobutaka Mukumoto

²

, Michio Yoshimura

²

, Mitsuhiro Nakamura

⁴

, Ahmed El Sayed Mohamed

⁵

, Elsayed Mostafa Ali

⁵

, Mohamed Soliman Gaber

⁵

, Takashi Mizowaki

²

1. Department of Clinical Oncology, Sohag University Hospital, Sohag University, Sohag, Egypt; and Guest Research Associate, Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

2. Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

3. Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan; and Department of Radiation Oncology, Kobe City Medical Center General Hospital, Kobe, Japan.

4. Department of Information Technology and Medical Engineering, Human Health Sciences, Graduate School of Medicine, Kyoto University; and Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

5. Department of Clinical Oncology, Sohag University Hospital, Sohag University, Sohag, Egypt.

A R T I C L E I N F O A B S T R A C T Article type:

Original Paper

Introduction: Dose reduction to the duodenum is important to decrease gastrointestinal toxicities in patients with locally advanced pancreatic cancer (LAPC) treated with definitive chemoradiotherapy. We aimed to compare dynamic wave arc (DWA), a volumetric-modulated beam delivery technique with simultaneous gantry/ring rotations passing the waved trajectories, with coplanar VMAT (co-VMAT) with respect to dose distributions in LAPC cases.

Material and Methods: DWA and co-VMAT plans were created for 13 patients with LAPC. The prescribed dose was 45.6 or 48 Gy in 15 fractions. The dose volume indices (DVIs) for target volumes and organs at risk were compared between the corresponding plans. Gamma passing rate, monitor unit (MU), and beam-on time were also compared.

Results: DWA significantly reduced the duodenal V39Gy, V42Gy, and V45Gy by 1.1, 0.8, and 0.2 cm³, and increased the liver mean dose and D2cm3 of the spinal cord planning volume by 1.0 and 1.5 Gy, respectively.

Meanwhile, there was no significant difference in the target volumes except for D2% of PTV (111.5% in DWA vs. 110.5% in co-VMAT). Further, the gamma passing rate was similar in both plans. MU and beam- on time increased in DWA by 31 MUs and 15 seconds, respectively.

Conclusion: DWA generated significantly lower duodenal doses in LAPC cases, albeit with slight increasing liver and spinal cord doses and increasing MU and the beam delivery time. Further evaluation is needed to know how the dose differences would affect the clinical outcomes in chemoradiotherapy for LAPC.

Article history:

Received: Feb 16, 2021 Accepted: Apr 27, 2021 Keywords:

Radiotherapy Planning Computer-Assisted Pancreas Cancer

Volumetric Modulated Arc Therapy

►

Please cite this article as:

Abdelghaffar A. Kishi N, Ashida R, Matsuo Y, Hirashima H, Mukumoto N, Yoshimura M, Nakamura M, Mohamed AE, Ali EM, Gaber MS, Mizowaki T. Dosimetric Comparison between Dynamic Wave Arc and Co-Planar Volumetric Modulated Radiotherapy for Locally Advanced Pancreatic Cancer. Iran J Med Phys 2022; 19: 1-8. 10.22038/IJMP.2021.55707.1923.

.

Introduction

Pancreatic cancer has poor prognosis and is one of the leading causes of cancer-related deaths worldwide [1]. Surgical resection is the standard treatment for early stage pancreatic cancer, but 30-35% of patients are in a locally advanced stage upon diagnosis [2].

These patients with locally advanced pancreatic cancer (LAPC) are commonly treated with systemic chemotherapy, but the median overall survival is only 11.9-13.6 months [3]. A previous study on LAPC patients treated with first-line chemotherapy reported that 41% of the patients died without developing any

distant metastases [4]. Chemoradiotherapy plays an important role in the treatment of LAPC [5].

Delivering high doses to the target organ while avoiding the organs-at-risk (OARs) is important in radiotherapy. The pancreas is surrounded by radiosensitive organs, such as the duodenum, stomach, liver, colon, and kidneys. During irradiation to the irregularly shaped target volume using three- dimensional conformal radiation therapy (3D-CRT), it is inevitable for these radiosensitive organs to be irradiated with high doses, thus causing gastrointestinal (GI) toxicities such as ulcer,

*Corresponding Author: Tel: +81-75-751-3762; Fax: +81-75-771-9749; Email: ymatsuo@kuhp.kyoto-u.ac.jp