Appendix A. Pubmed MEDLINE Search Strategy
Search entries using PubMed’s advance search builder:
1. “Hypertension, Pulmonary"[Mesh] OR ("pulmonary"[tiab] AND "hypertension"[tiab]) (40673)
2. "Thoracic Surgery"[Mesh] OR thoracic surger*[tiab] (16384)
3. "Thoracic Surgical Procedures"[Mesh] OR thoracic surgical procedure*[tiab] (249178) 4. "Cardiac Surgical Procedures"[Mesh] OR Cardiac Surgical Procedure*[tiab] (162638) 5. "Cardiovascular Surgical Procedures"[Mesh] OR Cardiovascular Surgical Procedure*[tiab]
(277527)
6. heart surger*[tiab] OR cardiac surger*[tiab] OR heart operation*[tiab] OR thoracic operation*[tiab] OR cardiac operation*[tiab] (39927)
7. Coronary Artery Bypass[tiab] (30377)
8. "Cardiopulmonary Bypass"[Mesh] OR cardiopulmonary bypass[tiab] (30939)
9. heart bypass[tiab] OR "Heart Bypass, Right"[Mesh] OR "Heart Bypass, Left"[Mesh] OR right heart bypass[tiab] OR left heart bypass[tiab] (3360)
10. CABG[tiab] (12641)
11. coronary artery surger*[tiab] (1958)
12. Myocardial Revascularization*[tiab] (3895)
13. valve repair*[tiab] OR mitral valve repair*[tiab] (4116) 14. valve replacement*[tiab] (21146)
15. "Heart Valve Prosthesis"[Mesh] OR Heart Valve Prosthesis[tiab] OR Valve Prosthesis[tiab] OR Heart Valve Prosthesis Implantation[mesh] OR Heart Valve Prosthesis Implantation[tiab] (36807)
16. "Heart Transplantation"[Mesh] OR Heart Transplant*[tiab] (33306)
17. #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR
#14 OR #15 OR #16 (433958)
18. randomized controlled trial[pt] (360789) 19. controlled clinical trial[pt] (87005) 20. randomized[tiab] (309450)
21. placebo[tiab] (155475) 22. drug therapy[sh] (1652923) 23. randomly[tiab] (210374) 24. trial[tiab] (353697) 25. groups[tiab] (1361353)
26. #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 (3320230) 27. (animals[mesh] NOT humans[mesh]) (3865660)
28. #26 NOT #27 (2852677) 29. #1 AND #17 AND #28 (1235)
Aggregated search:
(“Hypertension, Pulmonary"[Mesh] OR ("pulmonary"[tiab] AND "hypertension"[tiab])) AND ("Thoracic Surgery"[Mesh] OR thoracic surger*[tiab] OR "Thoracic Surgical Procedures"[Mesh]
OR thoracic surgical procedure*[tiab] OR "Cardiac Surgical Procedures"[Mesh] OR Cardiac Surgical Procedure*[tiab] OR "Cardiovascular Surgical Procedures"[Mesh] OR Cardiovascular Surgical Procedure*[tiab] OR heart surger*[tiab] OR cardiac surger*[tiab] OR heart operation*[tiab] OR thoracic operation*[tiab] OR cardiac operation*[tiab] OR Coronary Artery Bypass[tiab] OR "Cardiopulmonary Bypass"[Mesh] OR cardiopulmonary bypass[tiab] OR heart bypass[tiab] OR "Heart Bypass, Right"[Mesh] OR "Heart Bypass, Left"[Mesh] OR right heart bypass[tiab] OR left heart bypass[tiab] OR CABG[tiab] OR coronary artery surger*[tiab] OR Myocardial Revascularization*[tiab] OR valve repair*[tiab] OR mitral valve repair*[tiab] OR valve replacement*[tiab] OR "Heart Valve Prosthesis"[Mesh] OR Heart Valve Prosthesis[tiab]
OR Valve Prosthesis[tiab] OR Heart Valve Prosthesis Implantation[mesh] OR Heart Valve Prosthesis Implantation[tiab] OR "Heart Transplantation"[Mesh] OR Heart Transplant*[tiab]) AND ((randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug therapy[sh] OR randomly[tiab] OR trial[tiab] OR groups[tiab]) NOT (animals[mesh] NOT humans[mesh])) (1235)
Appendix B. Meta-analysis results on Additional Hemodynamic Variables
Appendix B. Meta-analysis results on Additional Hemodynamic Variables
Inhaled Aerosolized Vasodilators vs Placebo Inhaled Aerosolized Vasodilators vs IV Vasodilators
Outcome Na ESb (95% CI) P value
(I2 %) Na ESb (95% CI) P value
I2 (%) Hemodynamic variables
HR (beats/min)
3 (84/81) -3.16 (-8.56, 2.24) 0.25 (16%)
5 (144/76) -4.23 (-9.08, 0.63) 0.09 (48%) PCWP
(mmHg)
4 (98/96) 0.09 (-2.51, 2.69) 0.94 (48%)
3 (90/39) -2.23 (-6.59, 2.12) 0.31 (70%) CVP
(mmHg)
3 (84/81) -0.80 (-2.30, 0.70) 0.30 (0%)
- - -
CI (Lmin-1m2)
- - - 4 (104/65) 0.4 (-0.38, 1.26) 0.30
(94%) SPAP
(mmHg)
4 (98/96) -0.07 (-5.74, 5.59) 0.98 (37%)
- - -
SVR
(dyneseccm-5) - - - 4 (134/66) 45.48 (-566.52, 657.48) 0.88
(96%) Numbers in bold indicate a significant treatment effect (P < 0.05). The new critical P value for significance after applying the Bonferroni correction is 0.004.
aNumber of trials pooled (number of subjects in inhaled group/number of subjects in control group)
bEffect size (ES); mean difference for hemodynamic variables and length of stay in ICU and hospital, odds ratio for mortality
Abbreviations: 95% CI, 95% confidence interval; CI, cardiac index; CVP, central venous pressure; HR, heart rate; PCWP, pulmonary capillary wedge pressure; SPAP, systolic pulmonary artery pressure; SVR, systemic vascular resistance.
