APPENDICES
Appendix 1 Search Strategy for PubMed
Database: PubMed
Limitations: humans; date <2005-01-01 to 2015-08-31>
Search Strategy:
1. “Spasms, Infantile”[Mesh]
2. “infantile spasm”[tw] OR “infantile spasms”[tw] OR “spasm, infantile”[tw] OR “spasms, infantile”[tw]
3. “west syndrome”[tw] OR “west syndromes”[tw] OR “syndrome, west”[tw] OR “syndromes, west”[tw]
4. OR (#1-3)
5. “Drug Therapy”[Mesh] OR “drug therapy”[tw] OR “therapy, drug”[tw] OR “drug
therapies”[tw] OR “therapies, drug” OR “pharmacotherapy”[tw] OR “pharmacotherapies”[tw]
6. “anticonvulsants”[MeSH Terms] OR “anticonvulsant”[tw] OR “anticonvulsive agents”[tw]
OR “agents, anticonvulsive”[tw] OR “anticonvulsive drugs”[tw] OR “drugs,
anticonvulsive”[tw] OR “anticonvulsant drugs”[tw] OR “drugs, anticonvulsant”[tw] OR
“antiepileptic agents”[tw] OR “agents, antiepileptic”[tw] OR “antiepileptics”[tw] OR
“antiepileptic drugs”[tw] OR “drugs, antiepileptic”[tw]
7. acetazolamide[mh] OR acetazolamide[tw] OR carbamazepine[mh] OR carbamazepine[tw]
OR clobazam[mh] OR clobazam[tw] OR clonazepam[mh] OR clonazepam[tw] OR
diazepam[mh] OR diazepam[tw] OR eslicarbazepine[mh] OR eslicarbazepine[tw] OR ethosuximide[mh] OR ethosuximide[tw] OR felbamate[mh] OR felbamate[tw] OR gabapentin[mh] OR gabapentin[tw] OR lacosamide[mh] OR lacosamide[tw] OR lamotrigine[mh] OR lamotrigine[tw] OR levetiracetam[mh] OR levetiracetam[tw] OR midazolam[mh] OR midazolam[tw] OR nitrazepam[mh] OR nitrazepam[tw] OR
oxcarbazepine[mh] OR oxcarbazepine[tw] OR perampanel[mh] OR perampanel[tw] OR piracetam[mh] OR piracetam[tw] OR phenobarbital[mh] OR phenobarbital[tw] OR
phenytoin[mh] OR phenytoin[tw] OR pregabalin[mh] OR pregabalin[tw] OR primidone[mh]
OR primidone[tw] OR retigabine[mh] OR retigabine[tw] OR rufinamide[mh] OR
rufinamide[tw] OR valpro*[mh] OR valpro*[tw] OR stiripentol[mh] OR stiripentol[tw] OR sultiame[mh] OR sultiame[tw] OR sulthiame[mh] OR sulthiame[tw] OR tiagabine[mh] OR tiagabine[tw] OR topiramate[mh] OR topiramate[tw] OR vigabatrin[mh] OR vigabatrin[tw] OR zonisamide[mh] OR zonisamide[tw]
8. OR (#5-7)
9. “Diet Therapy”[Mesh] OR “diet therapy”[tw] OR “therapy, Diet”[tw] OR “Diet Therapies”[tw] OR “Therapies, Diet”[tw]
10. “Ketogenic Diet”[Mesh] OR “ketogenic diet”[tw] OR “ketogenic diets”[tw] OR “Diet, Ketogenic” OR “Diets, Ketogenic”[tw]
11. “Diet, Carbohydrate-Restricted”[Mesh] OR “Diet, Carbohydrate-Restricted”[tw] OR
“Carbohydrate-Restricted Diet”[tw] OR “Carbohydrate-Restricted Diets”[tw] OR “Diet, Carbohydrate Restricted”[tw] OR “Diets, Carbohydrate-Restricted”[tw] OR “Diet, Low Carbohydrate”[tw] OR “Carbohydrate Diet, Low”[tw] OR “Carbohydrate Diets, Low”[tw] OR
“Diets, Low Carbohydrate”[tw] OR “Low Carbohydrate Diet”[tw] OR “Low Carbohydrate Diets”[tw]
12. “Atkins Diet”[tw] OR “Diet, Atkins”[tw]
13. atkin*[tw] AND (“Diet”[Mesh] OR diet[tw]) 14. OR (#9-13)
15. “Treatment Outcome”[Mesh] OR “treatment outcome”[tw] OR “Outcome, Treatment”[tw]
16. “Clinical Effectiveness”[tw] OR “Clinical Effectiveness”[tw] OR “Effectiveness, Clinical”[tw] OR “Effectivenesses, Clinical”[tw] OR “Clinical Efficacy”[tw] OR “Efficacy, Clinical”[tw] OR “Treatment Effectiveness”[tw] OR “Effectiveness, Treatment”[tw] OR
“Treatment Efficacy”[tw] OR “Efficacy, Treatment”[tw]
17. OR (#15-16)
18. “Case Reports”[Publication Type] OR “case report”[tw] OR “case reports”[tw]
19. “abstract report”[tw] OR “abstract reports”[tw]
20. “Letter” [Publication Type] OR “letter”[tw]
21. “Editorial” [Publication Type] OR “editorial”[tw]
22. OR (#18-21)
23. #4 AND (#8 OR #14) AND #17 24. #23 NOT #22
Appendix 2 Search Strategy for EMBASE
Database: EMBASE
Limitations: humans; date <2005-01-01 to 2015-08-31>
Search Strategy:
1. “infantile spasm”/exp[EMTREE]
2. “infantile spasm” OR “infantile spasms” OR “spasm, infantile” OR “spasms, infantile”
3. “west syndrome” OR “west syndromes” OR “west syndromes” OR “syndrome, west” OR
“syndromes, west”
4. OR (#1-3)
5. “drug therapy”/syn[EMTREE]
6. “anticonvulsive agent”/syn[EMTREE]
7. “anticonvulsant therapy”/syn[EMTREE]
8. “acetazolamide”/exp OR acetazolamide OR “carbamazepine”/exp OR carbamazepine OR
“clobazam”/exp OR clobazam OR “clonazepam”/exp OR clonazepam OR “diazepam”/exp OR diazepam OR “eslicarbazepine”/exp OR eslicarbazepine OR “ethosuximide”/exp OR
ethosuximide OR “felbamate”/exp OR felbamate OR “gabapentin”/exp OR gabapentin OR
“lacosamide”/exp OR lacosamide OR “lamotrigine”/exp OR lamotrigine OR
“levetiracetam”/exp OR levetiracetam OR “midazolam”/exp OR midazolam OR
“nitrazepam”/exp OR nitrazepam OR “oxcarbazepine”/exp OR oxcarbazepine OR
“perampanel”/exp OR perampanel OR “piracetam”/exp OR piracetam OR “phenobarbital”/exp OR phenobarbital OR “phenytoin”/exp OR phenytoin OR “pregabalin”/exp OR pregabalin OR
“primidone”/exp OR primidone OR “retigabine”/exp OR retigabine OR “rufinamide”/exp OR rufinamide OR valpro* OR “stiripentol”/exp OR stiripentol OR “sultiame”/exp OR sultiame OR
“sulthiame”/exp OR sulthiame OR “tiagabine”/exp OR tiagabine OR “topiramate”/exp OR topiramate OR “vigabatrin”/exp OR vigabatrin OR “zonisamide”/exp OR zonisamide 9. OR (#5-8)
10. “diet therapy”/syn[EMTREE]
11. “ketogenic diet”/syn[EMTREE]
12. “low carbohydrate diet”/syn[EMTREE]
13. “atkins diet”
14. atkin* AND (“diet”/syn) 15. OR (#10-14)
16. “treatment outcome”/exp[EMTREE] OR “treatment outcome” OR “therapy outcome”
17. “drug efficacy”/syn[EMTREE] OR efficacy OR effectiveness 18. OR (#16-17)
19. “case report”/exp[EMTREE] OR “case report” OR “case report”:it
20. “abstract report”/exp[EMTREE] OR “abstract report” OR “abstract report”:it OR
“conference abstract”:it
21. “letter”/exp[EMTREE] OR “letter” OR “letter”:it
22. “editorial”/exp[EMTREE] OR “editorial” OR “editorial”:it 23. OR (#19-22)
24. #4 AND (#9 OR #15) AND #18 25. #24 NOT #23
