Supplemental Digital Content 3.
3A. Logistic regression analysis of independent predictors of ICU admission in Australian children with severe complications of influenza, 2008-2017
Variables Unadjusted ORs P-value Adjusted ORs1 P-value Age
Less than 5 years Reference 0.028 Reference 0.28
5 or more years 1.44 (1.04-2.00) 0.76 (0.47-1.25) Underlying medical conditions
No Reference <0.001 Reference 0.002
Yes 2.53 (1.81-3.53) 2.23 (1.35-3.71)
Chronic lung disease2,3
No Reference 0.003 Reference 0.020
Yes 1.93 (1.24-3.01) 2.20 (1.13-4.30)
Neurologic3
No Reference 0.001 Reference 0.019
Yes 2.31 (1.43-3.74) 2.65 (1.17-6.00)
Neuromuscular3
No Reference 0.013 Reference 0.008
Yes 2.63 (1.70-5.90) 5.44 (1.57-18.90)
Lab -proven bacterial coinfection
No Reference <0.001 Reference 0.06
Yes 2.62 (1.60-4.23) 1.99 (0.96-4.13)
SEIFA
Most disadvantaged Reference 0.006 Reference 0.73
Second quintile 1.07 (0.60-1.92) 0.52 (0.22-1.22) Third quintile 0.58 (0.34-0.97) 0.66 (0.32-1.36) Fourth quintile 0.46 (0.28-0.78) 0.35 (0.17-0.73) Least disadvantaged 0.64 (0.37-1.09) 0.57 (0.24-1.11)
1 Multivariable models adjusted for: age, sex, SEIFA, underlying medical conditions and vaccination for seasonal influenza.
2 Includes asthma and cystic fibrosis.
3 Multivariable models adjusted for: age, sex, SEIFA and chronic lung disease, neurological or neuromuscular.
3B. Logistic regression analysis of independent predictors of the requirement for mechanical ventilation in Australian children with severe complications of influenza, 2008-2017.
Variables Unadjusted ORs P-value Adjusted ORs1 P-value Age
Less than 5 years Reference 0.001 Reference 0.38
5 or more years 0.53 (0.36-0.78) 0.77 (0.44-1.38) Underlying medical conditions
No Reference 0.004 Reference 0.040
Yes 1.77 (1.20-2.59) 1.85 (1.03-3.32)
Chronic lung disease2,3
No Reference 0.17 Reference 0.12
Yes 1.40 (0.86-2.29) 1.81 (0.85-3.83)
Neurologic3
No Reference 0.004 Reference 0.20
Yes 2.10 (1.28-3.45) 1.75 (0.74-4.13)
Neuromuscular3
No Reference 0.08 Reference 0.019
Yes 2.00 (0.90-4.45) 3.87 (1.25-12.00)
Lab -proven bacterial coinfection
No Reference <0.001 Reference 0.14
Yes 2.76 (1.69-4.51) 1.80 (0.82-3.96)
SEIFA
Most disadvantaged Reference 0.06 Reference 0.72
Second quintile 1.24 (0.66-2.31) 0.59 (0.21-1.65) Third quintile 0.65 (0.35-1.20) 0.73 (0.32-1.69) Fourth quintile 0.53 (0.29-0.97) 0.57 (0.25-1.29) Least disadvantaged 0.86 (0.47-1.59) 0.65(0.27-1.58)
1 Multivariable models adjusted for: age, sex, SEIFA, underlying medical conditions and vaccination for seasonal influenza.
2 Includes asthma and cystic fibrosis.
3 Multivariable models adjusted for: age, sex, SEIFA and chronic lung disease, neurological or neuromuscular
