Supplementary Table 1. Literature overview of age at natural menopause in BRCA mutation carriers.
Author Design No. Population Outcome Adjusted for
Collins et al (23) Retrospective cohort Prospective follow up
1840 Women from breast cancer families 445 BRCA1 vs. 559 non-carrier
relatives 374 BRCA2 vs. 462 non-carrier relatives
NM (n=344; 19%)
47 (11%) BRCA1 vs. 139 (25%) non-carriers 49 (13%) BRCA2 vs. 109 (24%) non-carriers
Year of birth (continuous) BMI (continuous) Parity (never, ever)
Use fertility drugs (never, ever) Regular cigarette smoking (never, ever)
Regular alcohol use (never, ever)
Median ANM (years)
51 BRCA1 vs. 52 non-carriers 51 BRCA2 vs. 51 non-carriers Risk of NM (adj. HR)*
BRCA1 (HR 1.03, 95%CI 0.75-1.40) BRCA2 (HR 1.01, 95%CI, 0.71-1.42) Finch et al (20) Matched cohort
Prospective follow up
1816 Women from breast cancer families 908 BRCA vs. 908 non-carriers
561 BRCA1 vs. 341 BRCA2
NM (n=470; 26%)
217 (24%) carriers vs. 253 (28%) non- carriers
NA
Median ANM (years)
49.0 carriers vs. 50.3 non-carriers; p=0.001 NM ≤ 45 years
56 (22%) carriers vs. 31 (14%) non-carriers;
p=0.03 NM ≤ 40 years
12 (5%) carriers vs. 3 (1%) non-carriers;
p=0.04 Lin et al (21) Retrospective comparative
cohort
Cross-sectional measurement
1147 BRCA mutation carriers from cancer risk program
238 BRCA1 vs. 144 BRCA2 Healthy women, population based (n=765)
NM (n=191; 17%)
86 (23%) carriers vs. 105 (14%) non-carriers
Parity (0,1,2,≥3)
Smoking (never, past current) OC use (never, ever)
Median ANM (years)
50 carriers vs. 53 non-carriers; p<0.001 50 BRCA1 vs. 49 BRCA2; p=0.231 Risk of NM (adj. HR)*
BRCA (HR 3.98, 95%CI 2.87-5.53) Rzepka-Górska
et al (22)
Retrospective cohort 135 a. Breast cancer patients after treatment
45 BRCA1 vs. 90 non-carriers
NM (n=90; 67%)
30 (67%) carriers vs. 60 (67%) non-carriers NA Mean ANM (years)
45.3 carriers vs. 48.2 non-carriers; p=0.028 36 b. Healthy BRCA1 mutation carriers
opting for RRSO NM (n=21; 58%) NA
Mean ANM (years)
45.7 carriers van Tilborg et al Retrospective cohort
Cross-sectional measurement
3586 Women from breast cancer families 1208 BRCA vs. 2211 non-carriers
708 BRCA1 vs. 500 BRCA2
NM (n=516; 15%)
122 (10%) carriers vs. 394 (18%) non- carriers
Smoking (current/former/never) Hormonal contraceptive use (ever/never)
Parity status (ever/never) Stratified for birth cohort Median ANM (years)
53 carriers vs. 53 non-carriers Risk of NM (adj. HR)*
BRCA (HR 1.06, 95%CI 0.87-1.30) Clustered on family ANM= age of natural menopause; BMI= body mass index; CI=confidence interval; HR= hazard ratio; NA= not applicable; NM= natural menopause; OC= oral contraceptive;
RRSO= risk reducing salpingo-oophorectomy.
