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Supplemental Digital Content Figure S1.

Our main independent variable, chronic stress, was categorized for analyses as high (2 or more), medium (1) and low (0), as has been previously done with analyses in MESA. [37] We chose not to examine chronic stress as a continuous variable (0-5) due to its skewed distribution. The histogram is presented below.

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Table S1

Correlations between measures of visceral and subcutaneous fat and body mass index, measured at exam 2/3 Visceral Fat (Sq Cm) Subcutaneous Fat (SqC m) Ratio VF / Subcut

Visceral Fat (Sq Cm) -- - -

Subcutaneous Fat (Sq Cm) 0.32 - -

Ratio VF / Subcut 0.58 -0.47 -

Body mass index (kg/m2) 0.57 0.80 -0.09

All Pearson correlation coefficients were statistically significant at p < 0.01

Table S2

Correlations between continuous chronic stress burden score with measures of adiposity and inflammation Chronic Stress Burden Total Score

Measures of adiposity

Visceral Fat (Sq Cm) 0.008 (p=0.73)

Subcutaneous Fat (Sq Cm) 0.14 (p = <0.01)

Ratio VF / Subcut -0.10 (p=<0.01)

Body mass index (kg/m2) 0.11 (p = <0.01)

Measures of inflammation (log transformed)

IL-6 0.03 (p=0.14)

Leptin 0.12 (p=<0.01)

Resistin -0.01 (p = 0.58)

TNF-alpha -0.02 (p = 0.44)

CRP 0.03 (p = 0.17)

Adiponectin 0.03 (p = 0.28)

All Pearson correlation coefficients were statistically significant at p < 0.01

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