Supplemental Table 1. Baseline Characteristics for Patients with Stage IA NSCLC who Received Early SBRT (0-30 days after diagnosis) versus Delayed Wedge Resection (90-120 days after diagnosis)
Patient Characteristic Early SBRT
(n = 570) Delayed Wedge Resection
(n = 475) P-value
Age (median, IQR), years 75 (69, 81) 71 (64, 77) < 0.001
Female Sex, n (%) 330 (58) 269 (57) < 0.68
Race, n (%) < 0.001
White 538 (94) 411 (87)
Black 28 (5) 45 (9)
Other 3 (1) 16 (3)
Unknown 1 (0) 3 (1)
CDCC Score, n (%)1 < 0.001
0 278 (49) 168 (35)
1 176 (31) 174 (37)
2 76 (13) 90 (19)
3+ 40 (7) 43 (9)
Clinical T Status, n (%) < 0.004
T1a 14 (2) 29 (6)
T1b 266 (47) 235 (49)
T1c 290 (51) 211 (44)
Tumor Size (median, IQR), cm 2.0 (1.5, 2.4) 1.8 (1.4, 2.2) < 0.001
Tumor Location, n (%) < 0.23
Main bronchus 1 (0) 0 (0)
Right upper lobe 191 (34) 194 (41)
Right middle lobe 25 (4) 15 (3)
Right lower lobe 92 (16) 65 (14)
Left upper lobe 166 (29) 125 (26)
Left lower lobe 81 (14) 68 (14)
Unknown 14 (2) 0 (0)
Histology, n (%) < 0.01
Adenocarcinoma 325 (57) 280 (59)
Squamous cell carcinoma 239 (42) 177 (37)
Large cell carcinoma 6 (1) 18 (4)
Insurance Status, n (%) < 0.002
Uninsured 6 (1) 13 (3)
Private Insurance/Managed Care 89 (16) 88 (19)
Medicaid 14 (2) 26 (5)
Medicare 444 (78) 335 (71)
Other Government Insurance 10 (2) 2 (0)
Unknown 7 (1) 11 (2)
Facility Type, n (%) < 0.03
Community Cancer Program 21 (4) 35 (7)
Comprehensive Community Clinic 246 (43) 201 (42)
Academic/Research Program 204 (36) 173 (36)
Integrated Network Cancer Center 99 (17) 65 (14)
Unknown 0 (0) 1 (0)
Hospital Volume Quartile, n (%) < 0.02
First Quartile (Lowest Volume) 17 (3) 19 (4)
Second Quartile 42 (7) 57 (12)
Third Quartile 125 (22) 117 (25)
Fourth Quartile (Highest Volume) 386 (68) 282 (59)
Distance from Hospital (median, IQR), miles 12.7 (5.7, 30.0) 9.8 (4.7, 24.0) < 0.004
Income2, n (%) < 0.44
1 CDCC = Charlson comorbidity score
First Quartile 127 (22) 105 (22)
Second Quartile 129 (23) 110 (23)
Third Quartile 161 (28) 113 (24)
Fourth Quartile 145 (25) 141 (30)
Unknown 8 (1) 6 (1)
Education3, n (%) < 0.24
First Quartile 91 (16) 102 (21)
Second Quartile 193 (34) 146 (31)
Third Quartile 168 (29) 134 (28)
Fourth Quartile 113 (20) 88 (19)
Unknown 5 (1) 5 (1)
Year of Diagnosis, (median, IQR) 2013 (2011, 2014) 2011 (2008, 2014) < 0.001
2 NCDB codes income level as average household income of the zip code where the patient lives
3 NCDB codes education level as the number of adults age 25 or older in the patient's zip code who did not graduate from high school
Supplemental Table 2. Cox Proportional Hazards Analysis Evaluating Overall Survival of Patients with Stage IA NSCLC who Received Early SBRT (0-30 days after diagnosis) versus Delayed Wedge Resection (90-120
days after diagnosis)
Characteristic Hazard Ratio 95% Confidence Interval P-value
Treatment Group
SBRT 0-30 days after diagnosis Ref Ref Ref
Wedge resection 90-120 days after diagnosis 0.61 [0.50, 0.76] < 0.001
Age 1.01 [1.00, 1.02] 0.07
Sex
Male Ref Ref Ref
Female 0.75 [0.62, 0.90] 0.002
Race
White Ref Ref Ref
Black 0.57 [0.36, 0.91] 0.02
Other 0.84 [0.39, 1.83] 0.66
CDCC Score
0 Ref Ref Ref
1 1.25 [1.01, 1.55] 0.04
2 1.44 [1.09, 1.90] 0.01
3+ 2.04 [1.47, 2.84] < 0.001
Clinical T Status
T1a Ref Ref Ref
T1b 0.91 [0.51, 1.62] 0.75
T1c 0.75 [0.36, 1.56] 0.44
Tumor Size 1.03 [1.00, 1.07] 0.05
Tumor Location
Right upper lobe Ref Ref Ref
Right middle lobe 0.93 [0.59, 1.47] 0.75
Right lower lobe 1.19 [0.90, 1.56] 0.23
Left upper lobe 0.97 [0.77, 1.22] 0.80
Left lower lobe 1.19 [0.89, 1.58] 0.24
Histology
Adenocarcinoma Ref Ref Ref
Squamous cell carcinoma 1.16 [0.96, 1.40] 0.11
Large cell carcinoma 0.91 [0.50, 1.66] 0.76
Insurance Status
Uninsured Ref Ref Ref
Private Insurance/Managed Care 1.68 [0.72, 3.93] 0.23
Medicaid 1.42 [0.52, 3.87] 0.49
Medicare 1.67 [0.72, 3.88] 0.23
Other Government Insurance 1.05 [0.31, 3.56] 0.94
Facility Type
Community Cancer Program Ref Ref Ref
Comprehensive Community Clinic 1.16 [0.66, 2.05] 0.60
Academic/Research Program 1.14 [0.64, 2.04] 0.65
Integrated Network Cancer Center 0.93 [0.52, 1.69] 0.82
Hospital Volume Quartile
First Quartile Ref Ref Ref
Second Quartile 0.88 [0.44, 1.75] 0.72
Third Quartile 0.87 [0.44, 1.73] 0.70
Fourth Quartile 0.91 [0.46, 1.81] 0.80
Distance from the hospital 1.00 [1.00, 1.00] 0.20
Income
First Quartile Ref Ref Ref
Second Quartile 0.94 [0.70, 1.26] 0.70
Third Quartile 0.98 [0.72, 1.32] 0.87
Fourth Quartile 1.00 [0.70, 1.42] 1.00
Education
First Quartile Ref Ref Ref
Second Quartile 0.98 [0.74, 1.31] 0.90
Third Quartile 0.97 [0.70, 1.34] 0.84
Fourth Quartile 0.95 [0.65, 140] 0.79
Year of Diagnosis
2004-2007 Ref Ref Ref
2008-2011 1.31 [0.96, 1.79] 0.09
2012-2015 1.04 [0.74, 1.46] 0.80
Supplemental Table 3. Baseline Characteristics for Patients with Stage IA NSCLC who Received Early SBRT (0-30 days after diagnosis) versus Delayed Wedge Resection (90-120 days after diagnosis): Propensity Score
Matched Analysis
Patient Characteristic Early SBRT
(n = 279) Delayed Wedge
Resection (n = 279)
P-value Absolute Standardized Difference (%)
Age (median, IQR), years 73 (67, 79) 73 (67, 79) 0.74 1.6
Female Sex, n (%) 153 (55) 159 (57) 0.61 4.3
Race, n (%) 0.95
White 256 (92) 258 (92) 2.5
Black 20 (7) 18 (6) 2.8
Other 3 (1) 3 (1) 0.0
CDCC Score, n (%)4 0.94
0 111 (40) 115 (41) 2.9
1 103 (37) 96 (34) 5.3
2 44 (16) 45 (16) 1.0
3+ 21 (8) 23 (8) 2.6
Clinical T Status, n (%) 0.58
T1a 9 (3) 11 (4) 3.6
T1b 130 (47) 140 (50) 7.2
T1c 140 (50) 128 (46) 8.6
Tumor Size (median, IQR), cm 2.0 (1.5, 2.4) 1.9 (1.5, 2.3) 0.39 5.9
Tumor Location, n (%) 0.96
Right upper lobe 105 (38) 113 (41) 5.9
Right middle lobe 10 (4) 11 (4) 1.9
Right lower lobe 40 (14) 38 (14) 2.0
Left upper lobe 81 (29) 75 (27) 4.8
Left lower lobe 43 (15) 42 (15) 1.0
Histology, n (%) 0.84
Adenocarcinoma 158 (57) 163 (58) 3.6
Squamous cell carcinoma 117 (42) 111 (40) 4.4
Large cell carcinoma 4 (1) 5 (2) 2.3
Insurance Status, n (%) 0.50
Uninsured 4 (1) 7 (3) 7.9
Private Insurance/Managed Care 42 (15) 47 (17) 4.8
Medicaid 10 (4) 10 (4) 0.0
Medicare 223 (80) 213 (76) 8.2
Other Government Insurance 0 (0) 2 (1) 6.9
Facility Type, n (%) 0.55
Community Cancer Program 15 (5) 11 (4) 6.3
Comprehensive Community Clinic 127 (46) 115 (41) 8.7
Academic/Research Program 95 (34) 105 (38) 7.5
Integrated Network Cancer Center 42 (15) 48 (17) 5.9
Hospital Volume Quartile, n (%) 0.84
First Quartile (Lowest Volume) 11 (4) 9 (3) 3.9
Second Quartile 27 (10) 24 (9) 3.6
Third Quartile 69 (25) 64 (23) 4.2
Fourth Quartile (Highest Volume) 172 (62) 182 (65) 7.5
Distance from Hospital (median, IQR), miles 12.6 (5.2, 30.4) 11.8 (5.5, 30.5) 0.98 2.4
Income5, n (%) 0.89
First Quartile 60 (22) 61 (22) 0.9
Second Quartile 72 (26) 66 (24) 5.1
4 CDCC = Charlson comorbidity score
5 NCDB codes income level as average household income of the zip code where the patient lives
Third Quartile 69 (25) 76 (27) 5.7
Fourth Quartile 78 (28) 76 (27) 1.6
Education6, n (%) 0.76
First Quartile 51 (18) 57 (20) 5.5
Second Quartile 97 (35) 93 (33) 3.1
Third Quartile 85 (30) 77 (28) 6.3
Fourth Quartile 46 (16) 52 (19) 5.5
Year of Diagnosis, (median, IQR) 2012 (2010, 2014) 2013 (2010, 2014) 0.62 3.3
6 NCDB codes education level as the number of adults age 25 or older in the patient's zip code who did not graduate from high school
